The Value of miR-155 Expression in Predicting Early and Long-Term Outcome of Coronary Artery Bypass Grafting Surgery

Abstract

BackgroundThe role of the expression of micro ribonucleic acid-155 (miR-155) in the modulation of inflammatory processes leading to the development of arterial atherosclerosis has been studied, but it is still not clear whether the change in the expression of miR-155 can predict the outcomes after the vascularization procedure.ObjectiveWe assessed the value of assessing preoperative miR-155 expression for determining the severity of coronary artery involvement and then determined the association of the expression of this micro ribonucleic acid (microRNA) and poorer outcome of coronary artery bypass surgery.MethodsThe background information was collected by reviewing the hospital database. To assess the level of miR-155, quantitative reverse transcriptase-polymerase chain reaction was set up using the Taq Polymerase plus PacMan (TaqMan) Assay kit. To evaluate the outcomes after surgery, patients were asked by telephone calls.ResultsThe mean miR-155 expression value in the patients with one, two, and three involved coronaries was 1.57 +/- 0.21, 1.27 +/- 0.28, and 1.23 +/- 0.29 respectively indicating a lower level of expression in those with three-vessel disease as compared to other disease subgroups. The Gensini score was adversely associated with the level of miR-155 expression. The miR-155 expression level in patients who died in the hospital was significantly lower than in surviving patients. The presence of long-term major cardiovascular adverse events was associated with a lower level of miR-155 expression. These findings were also obtained after adjusting for background factors.ConclusionDecreased expression of the miR-155 is associated with increased risk of mortality and long-term complications after coronary artery bypass surgery.