Recent Innovations and Developments in MOF-Based Aptasensors

Abstract

Metal-organic framework (MOF)-based aptasensors represent a cutting-edge technology with remarkable potential for biosensing applications. These sensors combine the distinctive characteristics of MOFs with high specificity of aptamers, enabling precise and sensitive detection of target analytes in various fields. In this context, there are different points that should be concerned including achieving efficient immobilization of aptamers on MOF surfaces while maintaining their bioactivity, enhancing MOF stability under physiological conditions, and optimizing sensor regeneration and reusability. Moreover, the synthesis, scalability, functionalization, biocompatibility, and cost considerations pose significant hurdles that require interdisciplinary collaboration and innovative solutions. These types of sensors could be used for the development of portable and miniaturized sensor platforms for point-of-care diagnostics, and design of smart and responsive sensing systems for personalized medicine, precision agriculture, and wearable health monitoring. By exploring the unique properties and functionalities of MOFs and aptamers, this review highlights the potential of MOF-based aptasensors in enabling precise and selective recognition of target analytes for various applications such as environmental monitoring, food safety, biomedical diagnostics, etc. Additionally, by outlining future perspectives such as nanomaterial integration, miniaturization, and personalized sensing solutions, we aim to inspire further research and advancements in the field. © 2025 Elsevier B.V., All rights reserved.