Taskiran-Sag, AslihanUyanik, Handan UzuncakmakUyanik, Sadik AhmetOztekin, Nese2024-05-252024-05-25202071052-30571532-851110.1016/j.jstrokecerebrovasdis.2020.1049232-s2.0-85085754668https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104923https://hdl.handle.net/20.500.14517/2137TASKIRAN SAG, Aslihan/0000-0001-7542-106XObjective: In this prospective study, we aimed to investigate the presence and evolu-tion of cerebellar cognitive affective syndrome in a cohort of isolated cerebellar stroke with no known cognitive or psychiatric impairment. We tried to distinguish the unconfounded effect of cerebellar lesions on neuropsychological processing. Methods: After a meticulous exclusion procedure based on possible confounders, we recruited 14 patients and 13 age-matched healthy controls to the study, prospec-tively. All of the patients had a detailed initial neuropsychological assessment at the first week and a follow-up assessment at the 4th month after stroke. Results: The prevalence of cognitive or behavioral-affective abnormalities in our cohort were 86% and 64% respectively. The patients exhibited mild and transient affective-behavioral abnormalities except for depressive symptoms that persisted in the sub-acute stage. They scored lower in general cognitive performance as revealed by mini mental test (p=0.001). Memory, executive functions, attention and working memory, central processing speed, and linguistic abilities were impaired (p<0.001; p=0.001; p=0.007; p=0.05; p<0.001 respectively). Improvement was evident only in memory domain of the cognitive functions in the subacute stage. Cognitive impairment was more likely with a medial or posterolateral infarct (p=0.014). Behavioral-affective abnormalities were not associated with a specific location in our cohort. Age seemed to negatively correlate with the recovery in general cogni-tive performance on the follow-up. Conclusions: These findings show that acute denervation of cerebellocortical projections leads to mild affective-behavioral abnormalities, and full-blown cerebellar cognitive affective syndrome is rare. How-ever, cognition was significantly affected after an acute cerebellar infarct even in a previously healthy, non-demented pure population.eninfo:eu-repo/semantics/closedAccessCerebellar cognitive affective syndromeSchmahmann's syndromeCerebellumCognitionStrokeArticleQ3Q2298WOS:00056180880001032689613