Naser, AbdulrahmanIsgandarov, KhaganiGuvenc, Tolga SinanGuvenc, Rengin CetinSahin, Muslum2024-05-252024-05-2520220066-782X1678-417010.36660/abc.202106412-s2.0-85135535968https://doi.org/10.36660/abc.20210641https://hdl.handle.net/20.500.14517/1077Güvenç, Tolga Sinan/0000-0002-6738-266XBackground: The accurate determination of low-density lipoprotein cholesterol (LDL-C) is important to reach guidelinere-commended LDL-C concentrations and to reduce adverse cardiovascular outcomes in diabetic patients. The commonly used Friedewald equation (LDL-Cf), gives inaccurate results in diabetic patients due to accompanying diabetic dyslipidemia. Recently two new equations - Martin/Hopkins (LDL-Cmh) and Sampson (LDL-Cs) - were developed to improve the accuracy of LDL-C estimation, but data are insufficient to suggest the superiority of one equation over the other one. Objective: The present study compared the accuracy and clinical usefulness of novel Martin/Hopkins and Sampson equations in diabetic patients. Methods: This study included 402 patients with diabetes. Patients' cardiovascular risk and LDL-C targets were calculated per European guidelines. Calculated LDL-Cmh, LDL-Cs, and LDL-Cf concentrations were compared with direct LDL-C concentration (LDL-Cd) to test agreement between these equations and LDL-Cd. A p-value <0.05 was accepted as statistically significant. Results: Both LDL-Cmh and LDL-Cs had a better agreement with LDL-Cd as compared to LDL-Cf, but no statistical differences were found among novel equations for agreement with LDL-Cd (Cronbach's alpha 0.955 for both, p=1). Likewise, LDL-Cmh and LDL-Cs showed a similar degree of agreement with LDL-Cd in determining whether a patient was in a guideline-recommended LDL-C target (96.3% for LDL-Cmh and 96.0% for LDL- Cs), which were marginally better than LDL-Cf (94.6%). In patients with a triglyceride concentration >400 mg/dl, agreement with LDL-Cd was poor, regardless of the method used. Conclusion: Martin/Hopkins and Sampson's equations show a similar accuracy for calculating LDL-C concentrations in patients with diabetes, and both equations were marginally better than the Friedewald equation.eninfo:eu-repo/semantics/openAccessMetabolic DiseasesAtherosclerosisDyslipidemiasCoronary Artery DiseaseDiabetes MellitusLipoproteinsLDLCholesterolLDLArticleQ3Q21192225232WOS:000841701300003357666173