Zarepour, AtefehKhosravi, ArezooIravani, SiavashZarrabi, AliGenetik ve Biyomühendislik / Genetic and Bio-Engineering2024-10-152024-10-15202402192-26402192-265910.1002/adhm.2024021022-s2.0-85205567093https://doi.org/10.1002/adhm.202402102https://hdl.handle.net/20.500.14517/6898https://doi.org/10.1002/adhm.202402102Iravani, Siavash/0000-0003-3985-7928Biohybrid micro/nanorobots hold a great potential for advancing biomedical research. These tiny structures, designed to mimic biological organisms, offer a promising method for targeted drug delivery, tissue engineering, biosensing/imaging, and cancer therapy, among other applications. The integration of biology and robotics opens new possibilities for minimally invasive surgeries and personalized healthcare solutions. The key challenges in the development of biohybrid micro/nanorobots include ensuring biocompatibility, addressing manufacturing scalability, enhancing navigation and localization capabilities, maintaining stability in dynamic biological environments, navigating regulatory hurdles, and successfully translating these innovative technologies into clinical applications. Herein, the recent advancements, challenges, and future perspectives related to the biomedical applications of biohybrid micro/nanorobots are described. Indeed, this review sheds light on the cutting-edge developments in this field, providing researchers with an updated overview of the current potential of biohybrid micro/nanorobots in the realm of biomedical applications, and offering insights into their practical applications. Furthermore, it delves into recent advancements in the field of biohybrid micro/nanorobotics, providing a comprehensive analysis of the current state-of-the-art technologies and their future applications in the biomedical field. This review is about biohybrid micro/nanorobots, a class of micro/nanorobotics composed of a biological part and an artificial sector. It also explores recent advancements in biomedical applications of biohybrid micro/nanorobots by focusing on their potential usage in targeted drug delivery, tissue engineering, cancer therapy, and imaging-guided therapy. imageeninfo:eu-repo/semantics/openAccessbiohybrid micro/nanorobotsbiomedical applicationsdiagnosticstargeted drug deliverytissue engineeringReviewQ1Q1WOS:00132707920000139373299