Akin, Ilke MunganKanburoglu, Mehmet KenanTayman, CuneytOncel, Mehmet YektaImdadoglu, TimucinDilek, MustafaKoc, EsinPedodonti / Pedodontic2024-05-252024-05-252022170340-61991432-107610.1007/s00431-021-04358-82-s2.0-85123408502https://doi.org/10.1007/s00431-021-04358-8https://hdl.handle.net/20.500.14517/1062Hekimoğlu, Berna Saygın/0000-0003-1135-5272; Hakyemez Toptan, Handan/0000-0002-6966-8514; Oncel, Mehmet Yekta/0000-0003-0760-0773; Yalınbaş, E.Esin/0000-0003-3762-4418; AKIN, Mustafa Ali/0000-0001-6102-2703; Arcagök, Baran Cengiz/0000-0002-4834-9127; Karagol, Belma Saygili/0000-0003-3728-9613; Surmeli Onay, Ozge/0000-0002-7658-3594; Kanburoglu, Mehmet Kenan/0000-0001-6859-6689; Uygun, Saime Sundus/0000-0002-6694-8115; CANER, İBRAHİM/0000-0002-6756-122XThe literature on neonates with SARS-CoV-2 is mainly concerned with perinatal cases, and scanty data are available about environmentally infected neonates. To fill knowledge gaps on the course and prognosis of neonatal cases, we analyzed 1-year data from the Turkish Neonatal Society in this prospective cohort study of neonates with postnatal transmission. Data from 44 neonatal intensive care units (NICUs), of neonates with positive RT-PCR results at days 5-28 of life, were extracted from the online registry system and analyzed. Of 176 cases, most were term infants with normal birth weight. Fever was the most common symptom (64.2%), followed by feeding intolerance (25.6%), and cough (21.6%). The median length of hospitalization was 9 days, with approximately one quarter of infants receiving some type of ventilatory support. Myocarditis (5.7%) was the most common complication during follow-up. Among the clinical findings, cough (odds ratio [OR]: 9.52, 95% confidence interval [CI]: 4.17-21.71), tachypnea (OR: 26.5, 95% CI: 9.59-73.19), and chest retractions (OR: 27.5, 95% CI: 5.96-126.96) were associated with more severe clinical disease. Also, there were significant differences in the C-reactive protein level, prothrombin time (PT), partial thromboplastin time, international normalized ratio, and days in the NICU (p = 0.002, p = 0.012, p = 0.034, p = 0.008, and p < 0.001, respectively) between patients with mild-moderate and severe-critical presentations. A PT above 14 s was a significant predictor of severe/critical cases, with a sensitivity of 64% and specificity of 73%. Conclusions: Our data showed that late-onset COVID-19 infection in neonates who need hospitalization can be severe, showing associations with high rates of ventilatory support and myocarditis. Cough, tachypnea, and retractions on admission suggest a severe disease course.eninfo:eu-repo/semantics/openAccessSARS-CoV-2COVID-19NewbornPostnatalArticleQ1Q1181519331942WOS:00074539640000135061093