Bal, IsmailMacit, MeltemAlasiri, AliNamli, Onur CemArshad, Muhammad SohailAhmad, ZeeshanKucuk, Israfil2025-07-152025-07-1520252310-286110.3390/gels110604482-s2.0-105009101762https://doi.org/10.3390/gels11060448https://hdl.handle.net/20.500.14517/8050In the present study, we developed a moxifloxacin (MXF)-encapsulated liposome-enriched alginate nanocomposite hydrogel coating. MXF was encapsulated in soy lecithin (SL:MXF:2:1) via the probe sonication method with an average efficiency of 80%. Two different manufacturing methods, including a micropipetting and a T-shaped microfluidic junction (TMJ) device technique, were used to incorporate the MXF-encapsulated liposomes into hydrogel matrices and layered as a coating on polymeric substrate material. Drug encapsulation and its incorporation into the hydrogel matrix significantly enhanced its stability and facilitated a prolonged drug release profile. A relatively rapid drug release was observed in the MXF-encapsulated liposome-loaded polymeric particulate layer developed via the micropipetting than the TMJ device technique. The findings confirmed sustained drug release behavior due to a hydrogel particulate structural uniformity conferred by the micromachine device, TMJ. Thus, these nanocomposite hydrogel coatings achieved can serve as a promising candidate for the treatment of ophthalmic or mucosal membrane infections.eninfo:eu-repo/semantics/closedAccessMoxifloxacinLiposomeT-Shaped Microfluidic Junction DeviceHydrogelProlonged Drug DeliveryArticleQ1Q3116WOS:00151505700000140558747