Hassani, F.M.Abasi, M.Kolahdouz, S.Zarasvandi, A.M.Taghizadeh, M.Davoudi, M.Alibemani, M.2026-03-152026-03-1520252476-348910.22034/nmrj.2025.04.0052-s2.0-105029959049https://doi.org/10.22034/nmrj.2025.04.005https://hdl.handle.net/20.500.14517/8944The integration of artificial intelligence (AI) and nanotechnology in dentistry marks a transformative advancement across implant dentistry, periodontology, orthodontics, and oral surgery. AI technologies, including machine learning and deep learning, enhance diagnostic accuracy, treatment planning, and predictive modeling, enabling personalized and efficient patient care. Concurrently, nanotechnology improves dental biomaterials and implant surface properties, promoting osseointegration, antimicrobial effects, and tissue regeneration. This review comprehensively explores recent innovations and clinical applications of AI and nanotechnology, addressing their synergistic roles in improving outcomes, reducing complications, and advancing therapeutic approaches. Despite promising benefits, challenges related to ethical considerations, data privacy, cost, accessibility, and regulatory compliance remain. Future research directions emphasize the need for robust validation, cost-effectiveness, and interdisciplinary collaboration to optimize the safe and equitable adoption of these technologies. The ongoing convergence of AI and nanotechnology holds great potential to revolutionize dental care, balancing technological innovation with clinical expertise for improved patient outcomes. © 2025 Tehran University of Medical Sciences. All rights reserved.eninfo:eu-repo/semantics/closedAccessArtificial IntelligenceDental DiagnosticsDental ImplantsNanotechnologyArticle