Akif TÜRERUğur MERCANOsman KELAHMETOĞLUYonca Betil KABAKDeniz Gokce MERALAğız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery2024-05-252024-05-25201902458-958610.5505/yeditepe.2019.83792https://doi.org/10.5505/yeditepe.2019.83792https://search.trdizin.gov.tr/tr/yayin/detay/312179/the-effects-of-a-single-high-dose-injection-of-vitamin-d-on-healing-of-condylar-fractures-in-osteoporotic-ratshttps://hdl.handle.net/20.500.14517/1847Aim: In this study we have tried to show the effects of a singlehigh-dose ınjection of vitamin d on healing of condylar fractures in osteoporotic rats.Materials and method: This study included sixteen femalewistar rats. All rats were overiectomized. Osteoporotic ratswere randomly divided into two groups of eight animals/group. Group D animals received a single high dose of vitamin D (50.000 IU/kg) intraperitoneally and group C (control)animals received saline (0.05 mL) intraperitoneally. All injections were given immediately after condylar fracture. All ratswere euthanized after 28 days, examined histopathologicaland immunohistochemical.Results: Histopathological and immunohistochemical evaluations were done. Histopathological scores between groupD and C were found statistically significant. TGFβ1 and osteopentin levels in group D were found higher than group C.Conclusion: We have determined that a single high-dose injection of vitamin D given immediately after surgery increasedTGFβ and osteopontin levels and enhanced new bone formation at condylar fractures of osteoporotic rats.eninfo:eu-repo/semantics/openAccess[Fen > Diş Hekimliği > Diş Hekimliği]Article1517076312179