Yucel, Zeynep Pinar KelesKeles, Gonca CayirAvci, BahattinCetinkaya, Burcu OzkanPeriodontoloji / Periodontology2024-05-252024-05-25202071602-16221757-999610.3290/j.ohpd.a450862-s2.0-85090494462https://doi.org/10.3290/j.ohpd.a45086https://hdl.handle.net/20.500.14517/2129keles, zeynep pinar/0000-0001-9139-8752Purpose: A novel acute-phase protein, YKL-40, is known as an inflammation-associated glycoprotein. YKL-40 is shown to be linked to inflammation, endothelial dysfunction and tissue remodeling secreted by various cells and is also considered to be stimulated by cytokines such as interleukin-6 (IL-6). The present study aimed to investigate YKL-40 and IL-6 levels in saliva and gingival crevicular fluid (GCF) of patients with chronic periodontitis (CP) after non-surgical periodontal therapy for the first time. Materials and Methods: Twenty-six CP patients and 26 periodontally healthy individuals were enrolled. Clinical measurements were recorded; saliva and GCF samples were obtained at baseline and 1 and 3 months after nonsurgical periodontal therapy. Levels of YKL-40 and IL-6 in saliva and GCF were analysed by ELISA. Results: Salivary and GCF YKL-40 and IL-6 levels were found to be statistically significantly higher in CP patients compared to healthy controls at baseline (p < 0.001). At 1 and 3 months after the completion of treatment, both YKL-40 and IL-6 levels in saliva and GCF had statistically significantly decreased compared with baseline values in CP patients (p < 0.001). On the other hand, no statistically significant difference was observed between 1 and 3 months in terms of salivary and GCF YKL-40 and IL-6 levels or any of the clinical findings (p > 0.016). Conclusion: Salivary and GCF YKL-40 levels may be useful to evaluate resolution of periodontal inflammation. Within the limits of this study, YKL-40 acute-phase protein might be a potential biomarker for detection of periodontitis and monitoring the response to periodontal therapy.eninfo:eu-repo/semantics/closedAccessafter-treatmentgingival crevicular fluidhumaninterleukin-6salivaYKL-40 proteinConference ObjectQ4Q1184815822WOS:00056717010002032895666