Inan, AsumanSenbayrak, SenihaAyan, SalihaKaplan, MerveErol, Serpil2026-04-212026-04-2120261300-932X2602-284210.5578/flora.2026011470https://hdl.handle.net/123456789/9016https://doi.org/10.5578/flora.2026011470Introduction: Staphylococcus aureus is a microorganism of increasing importance among community-and hospital-acquired pathogens. This study aimed to identify factors affecting prognosis by examining the epidemiological, clinical, and laboratory characteristics of patients with S. aureus bacteremia. Materials and Methods: This is a descriptive study that included 170 patients diagnosed with S. aureus bacteremia at a tertiary hospital between January 1, 2015, and January 1, 2020. Patients under 18 years of age and those with non-S. aureus growth in their cultures were excluded. Logistic regression analysis was used to determine factors associated with mortality. Results: Ninety-four (55.3%) of the patients were male. The mean age was 66.7 +/- 12.8 (18-95) years. Blood cultures revealed methicillin-susceptible S. aureus in 126 patients (74%), and methicillin-resistant S. aureus in 44 patients (26%). At least one complication developed in 33 patients (19%). The mortality rate in patients with complications (36.5%) was higher than in those without complications (12.1%). Appropriate antibiotic treatment was initiated within 24 hours in 114 patients (67.1%), between 24 and 48 hours in 18 patients (10.6%), and later than 48 hours in 19 patients (11.2%). Antibiotic treatment was changed after diagnosis in 61 patients (35.9%). Persistent bacteremia (lasting longer than seven days) was detected in 21 patients (21.4%). The mean duration of treatment was 12.4 +/- 7.8 days. One hundred twenty-six patients (68%) survived, while 54 (32%) died. Mortality was found to be higher in patients with fever and hospital-acquired bacteremia at the time of diagnosis, and lower in patients with confusion and invasive mechanical ventilation. Conclusion: S. aureus bacteremia is a significant problem due to its complications and treatment challenges. The study found that high fever and hospital-acquired bacteremia are factors associated with mortality. Close monitoring of patients with fever and hospital-acquired S. aureus bacteremia is recommended in terms of mortality.trinfo:eu-repo/semantics/openAccessMortalityStaphylococcus AureusBacteremiaArticle