Ferhatoglu, Murat FerhatKartal, AbdulcabbarFiliz, Ali IlkerKebudi, Abut2024-05-252024-05-25202070960-89231708-042810.1007/s11695-020-04597-y2-s2.0-85084067733https://doi.org/10.1007/s11695-020-04597-yhttps://hdl.handle.net/20.500.14517/2158Kartal, Abdulcabbar/0000-0001-7536-3146Purpose Many studies evaluating the effect of intragastric botulinum toxin type A injection (IG-BTxA) for the treatment of obesity have been published. However, none of these studies combined this procedure with a calorie-restricting high-protein diet. Herein, we aimed to evaluate the effects of IG-BTxA application combined with a calorie-restricting high-protein diet. Materials and Methods This prospective cohort study is conducted with eighty-seven grade 2 obese patients treated between January 2019 and August 2019. Group 1: IG-BTxA + refused to consult the dietitian; group 2: IG-BTxA + get calorie-restricting high-protein diet; group 3: only get a calorie-restricting high-protein diet. Loss of weight, treatment adaptation (visual analog scale score), the status and changes of comorbid conditions, and changes in eating behaviors (Self-Regulation of Eating Behaviour Questionnaire score) were assessed. Results Loss of weight, treatment adaptation, and positive behavioral change in eating preferences were significantly higher in group 2 (p = 0.01; p = 0.001; p < 0.01, respectively). Additionally, the decrease in medication requirement for diabetes and hypertension was higher in group 2 (p < 0.05). Conclusion IG-BTxA application before calorie-restricting high-protein diet facilitates adaptation to the new diet style and helps to lose weight faster in grade 2 obese patients. Also, more positive results were achieved in terms of controlling comorbid diseases.eninfo:eu-repo/semantics/closedAccessObesityBotoxHigh-protein dietGastroscopyBotulinum toxin type aArticleQ2Q230934723479WOS:00052849890000332306298