Terzioglu, KadriyeSancar, OzgurEkerbicer, Hasan CetinOzturk, Raziye TulumenEpozturk, Kursat2025-05-312025-05-3120202233-82762233-826810.5415/apallergy.2020.10.e29https://doi.org/10.5415/apallergy.2020.10.e29https://hdl.handle.net/20.500.14517/7942Epozturk, Kursat/0000-0002-0839-8944; Tulumen Ozturk, Raziye/0000-0001-9503-661X; Ekerbicer, Hasan Cetin/0000-0003-0064-3893Background: Acetylsalicylic acid/aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used drugs that may cause hypersensitivity reactions in a substantial proportion of patients. Physicians ought to be aware of these situations. Objective: We aimed to present the clinical characteristics and rates of tolerability to cyclooxygenase (COX)-2 inhibitor analgesics in patients who had admitted due to multiple cross-reactive type of NSAID hypersensitivity. Methods: The files of the patients who had admitted with multiple NSAIDs-induced symptoms were investigated retrospectively. Age, sex, underlying diseases, clinical manifestation, skin test results, and drug provocation test results were analyzed. Results: In 105 patients with multiple cross-reactive type of NSAID hypersensitivity, we found the rate of cross-reactivity to any of the relatively safe alternatives including paracetamol, meloxicam, and nimesulide to be 16.1%. The rate of cross-reactivity to these relatively safe drugs was significantly higher in patients with a history of anaphylaxis induced by NSAID intake (p= 0.006). Conclusion: The diagnosis of COX-1-mediated multiple NSAID hypersensitivity can be often established with a detailed history. Although rare, severe hypersensitivity reactions may be observed in these patients. Undesired situations for both patients and physicians may be avoided by testing relatively safe paracetamol and COX-2 inhibitors in experienced centers.eninfo:eu-repo/semantics/openAccessCyclooxygenase-2 InhibitorsHypersensitivityNonnarcotic AnalgesicsNonsteroidal Anti-Inflammatory AgentsParacetamolArticleN/AQ3103WOS:00055701660000632789114