Akdeniz, Fatma TubaBarut, ZerrinNalbantoglu, Ahmet MertIsbir, Turgay2026-03-152026-03-1520262227-905910.3390/biomedicines140203462-s2.0-105031360701https://doi.org/10.3390/biomedicines14020346https://hdl.handle.net/20.500.14517/8906Background: Gingivitis and periodontitis are progressive inflammatory diseases affecting the tissues surrounding the teeth; gingivitis involves reversible gingival inflammation, whereas periodontitis is a more advanced condition characterized by irreversible tissue destruction, including clinical attachment and alveolar bone loss. Salusin-alpha and salusin-beta are inflammation-related polypeptides that may reflect periodontal inflammatory burden; however, salivary data in periodontal diseases are lacking. This study aimed to evaluate the salivary salusin-alpha and salusin-beta levels in individuals with gingivitis and periodontitis. Methods: Saliva samples were collected from a total of 80 systemically healthy non-smoker individuals classified into three groups: gingivitis (n = 27), stage III grade B periodontitis (n = 27), and healthy participant (n = 26) based on the 2017 Periodontal Classification criteria. Salusin-alpha and salusin-beta levels in saliva were quantified using enzyme-linked immunosorbent assays (ELISA). Statistical analysis utilized one-way ANOVA, Student's t-test, and Receiver Operating Characteristic (ROC) curve analysis. Results: Compared to the healthy group, salivary levels of salusin-alpha and salusin-beta were found to be significantly elevated in periodontitis groups (p < 0.05), not gingivitis (p > 0.05); moreover, the increase in both markers was significantly greater in the periodontitis group than in the gingivitis group (p < 0.05). Conclusions: Our finding suggests that salusins play a role in the inflammatory processes of periodontal diseases. The increase in salusin-alpha and salusin-beta levels in the periodontitis suggests that these parameters may serve as biomarkers.eninfo:eu-repo/semantics/openAccessGingivitisPeriodontitisSalusinsSalivaBiomarkersSalusin-AlphaSalusin-BetaSalusin-αSalusin-βArticle