Browsing by Author "Alkan,I."

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Peripheral nerve system development, diclofenac sodium toxicity, and melatonin protection
(Nova Science Publishers, Inc., 2021) Keskin,I˙.; Alkan,I.; Keskin,M.; Kaplan,S.
Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently employed for the treatment of pain, fever, and inflammation. Diclofenac sodium (DS) exhibits potent anti-inflammatory, analgesic, and antipyretic effects. Studies have investigated DS neurotoxicity, especially in the first trimester of pregnancy. Studies of the impacts of prenatal DS exposure on the nervous system show that DS exhibits neurotoxic effects in the pyramidal and granular cells of the hippocampus and in the Purkinje cells of the cerebellum. Although some information is available concerning the teratogenic effects of DS on the nervous system, less is known regarding the effect of DS use on the development of the peripheral nervous system. Oxidative stress generated by DS through the enzyme cyclooxygenase can disrupt the integrity of the nervous system, including its myelin and axon content, and thus cause developmental problems in embryonic life. Melatonin may be used as a neuroprotective agent to reduce the neurotoxic effect of DS on nervous system development. However, the mechanism involved in the neuroprotective activity of melatonin in the development of the nervous system has not been entirely elucidated. This chapter describes the neuroprotective effect and mechanism of melatonin against DS toxicity. © 2021 by Nova Science Publishers, Inc. All rights reserved.
Citation Count: 0
Prenatal diclofenac sodium exposure and newborn testis: Histomorphometric, light and electron microscopic evaluation
(Nova Science Publishers, Inc., 2021) Ulkay,M.B.; Aktaş,A.; Alkan,I.; Kaplan,A.A.; Deniz,Ö.G.; Kaplan,S.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used as analgesic with anti-inflammatory and antioxidant effects. Their widespread used and because of its toxic effects led to many studies to be done on it. Diclofenac sodium (DS) is the most commonly used a NSAID and it is used orally or topically. Many studies on the effects of DS on the reproductive system have shown that DS can cause infertility by means of various reasons. The effects of DS on the male reproductive system can be explained as impairment in secretion of the male endocrine system and formation of new spermatogonium, Sertoli and Leydig cells in the testicle. While DS causes a decrease in gonadotropin releasing hormone (GnRH) and testosterone levels, it may create a significant increase in prolactin level. However, several studies have shown that weights of the testes, epididymis, ventral prostate, and seminal vesicles, sperm count, sperm density, sperm motility, and testicular cell populations were seriously decreased by DS exposure. In this chapter, morphological and endocrinological effects of prenatal/postnatal DS exposure on the male reproductive system and fixation methods that can be used for toxicological studies of the male reproductive system will be evaluated. © 2021 by Nova Science Publishers, Inc. All rights reserved.