Browsing by Author "Gürcan VURAL"

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Citation Count: 0
Dilde mikroinvaziv karsinom: Bir olgu sunumu
(2019) Belde ARSAN; Erdoğan FİŞEKÇİOĞLU; Gürcan VURAL; Gözde TURGUT
Dünya Sağlık Örgütü raporuna göre oral skuamöz hücrelikarsinom oral kavitenin en sık gö-rülen malignitesidir.Teşhis ve tedavideki ilerlemelere rağmen hastaların 5yıllık sağkalım oranları belirgin bir şekilde iyileştirilememiştir.Oral kanserlerin erken evrede teşhisi bu sebepleönemlidir.Kliniğimize başvuran 55 yaşında erkek hasta sistemikolarak sağlıklıdır ve sigara kullanmadığını belirtmiştir.Hastanın yapılan ağız içi muayenesinde dil lateralindeyüzeyden kabarık hiperkeratotik lökoplaki tespit edilmiştir.Hasta lezyonun varlığından haberdar değildir veherhangi bir klinik semptom yoktur. Eksizyonel biyopsisonrasında yapılan histopatolojik incelemede yüksekdereceli displazi görülmüştür. Mikroskopik bir odakta bazalmembran devamlılığının bozulduğu ve mikroinvazivpatern geliştiği gösterilmiştir. Histopatolojik olarak mikroinvazivkarsinom tanısı konulmuştur.Mikroinvaziv karsinom en erken evre malignitedir ve oralkanserlerin bu evrede teşhis edil-mesi, prognozun iyileştirilmesive sağkalım oranlarının arttırılması için önemlibir yere sahiptir.
Citation Count: 1
Human Papilloma Virus Frequency and Genotypes; Evaluation of the 4879 Screenings Made with Polymerase Chain Reaction and Chip Array Between 2001 and 2019 in Istanbul
(2021) Nedim POLAT; Gürcan VURAL
Objectives: The aim of this study is the documentation of human papilloma virus (HPV) frequency and types seen in the city of Istanbul, Turkey, as well as evaluation of the relationship between these subtypes and cytological and pathological diagnoses. Methods: 4879 cases were studied in our molecular pathology department between 2001 and 2019 in Istanbul. Between 2001 and 2010, 1692 cases were screened for HPV 6, 11, 16, 18, 31, and 33 by conventional hybridization and polymerase chain reaction (PCR). Since 2011, up to 49 HPV typing has been performed for 3187 cases with chip array. The cases were referred to the pathology center and the hospital pathology department by clinicians for screening before HPV vaccination and on the observation of precancerous changes and koilocyts in cytological-histopathological evaluations. Results: In this study, the frequency of HPV was found to be 10.8% (527 HPV-positive cases). Among these, 348 cases were highrisk groups, whether or not they were previously associated with a low-risk group. When we look at the distribution of the cases according to the high-risk HPV types, HPV 16 is the most common type. The frequencies of occurrence of other HPV types are as following: HPV–16: 41.7%, HPV–31: 11.7%, HPV–52: 7.9%, HPV–51: 7.1%, HPV–33: 6.9%, HPV–45: 6.5%, HPV–18: 6.3%, HPV–39: 6.1%, and HPV–58: 5.8%. It was further found that multiple infections were 28% of high grade squamous intraepithelial lesion cases. HPV frequency was 38% and 72%, respectively, in cases with cytologically or histopathological precancerous, low-grade squamous intraepithelial lesion, and HSIL changes. As a final note, HPV was detected in 9 of 10 cases with cervical cancer (90%). Only 1 adenocarcinoma case detected in the series was a double infection with HPV types 18 and 45. Conclusion: HPV 16 was the most common type found in this study. It is followed by types 31, 52, 51, 33, 45, 18, 39, and 58, respectively. The most common association observed in double infections was between HPV 16 and 58. It was also observed that the incidence of HPV in the city of Istanbul, Turkey, was similar to other developed countries. As a final note, in addition to screening tests, PCR and chip array studies should be conducted and the community should be informed about preventive medicine and the importance of condom use.