Browsing by Author "Kaya, Ayşe Demet"

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Clustering of Phentermine HCL Drug from Online Patient Medication Reviews
(Elsevier, 2019) Yildirim, Pinar; Kaya, Alkan
In this paper, a study to reveal hidden knowledge in the online patient medication reviews for phentermine HCL is presented. Phentermine HCL is used most frequently in the treatment of obesity. Obesity is a complex health disorder that affects huge amount of people. In recent years, the number of overweight people in industrialized countries has increased significantly and people who are obese are at a much higher risk for serious medical conditions such as high blood pressure, heart attack, stroke and diabetes. Considering the importance of the medication of obesity, knowledge discovery from online patient reviews is performed. Some information technologies and data mining techniques are used to discover some hidden knowledge between patient information and side effects in these reviews. Our results can give new ideas to medical researchers and pharmaceutical industry for drug safety. (C) 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) Peer-review under responsibility of the Conference Program Chairs.
Distribution and antifungal susceptibility profiles of candida species isolated from dermatomycosis patients
(2024) Kurç, Mine Aydın; Kaya, Ayşe Demet; Erfan, Gamze; Albayrak, Şule
Aims: Superficial mycoses are the most common dermatological diseases worldwide, and the causes are becoming increasingly resistant to antifungal agents used in treatment. The aim of our study was to identify the yeast species causing superficial mycoses and determine their susceptibilities to some antifungal agents. Methods: Skin and nail scraping samples obtained from 726 patients with suspected superficial fungal infection were collected and examined by direct microscopy and culture. Isolates were identified by conventional methods and API ID32 C (Biomeriux, France) commercial kits. The minimum inhibitory concentrations (MIC) of isolates against itraconazole, miconazole, nystatin, and terbinafine antifungals were determined by microdilution method. Results: A total of 59 yeasts were isolated from the samples. The most frequently isolated species were Candida glabrata (n=31, 52.54%), Candida guillermondii (n=9, 15.25%), and Candida albicans (n=7, 11.86%). In terms of infection sites, the most common involvement was observed in the foot (n=39, 66.1%) and nails (n=16, 27.1%). In terms of their antifungal susceptibilities, the highest resistance was detected against terbinafine (35.6%) and itraconazole (33.9%). Multidrug resistance was observed among strains of the Candida species (n=17, 28.8%). Conclusion: The most striking results of this study can be summarized as high rates of Candida glabrata isolation, increase in resistance rates, and a prevalence of 28.8% multidrug resistance. This data once again emphasize the importance of isolation, identification, and antifungal susceptibility testing in the diagnosis and effective treatment of superficial mycoses.
Does the Right or Left Hemisphere Involvement Affect Swallowing in Patients With Hemiplegia
(Ios Press, 2020) Sayaca, Cetind; Sapcioglu, Taha Yasin; Kaya, Defne
BACKGROUND: Stroke is one of the most important causes of swallowing difficulty. It is seen in one of every two patients with stroke. Although the swallowing function is controlled by both hemispheres, it is unknown which hemisphere is more dominant than another for controlling the swallowing function. However, the aspiration and pharyngeal phase dysfunction can be seen in right hemisphere involvement while oral phase dysfunction can be seen in left hemisphere involvement. OBJECTIVE: The aim of this study was to investigate whether water swallowing performance, deep cervical flexor muscle endurance, and maximum phonation time were affected in right handed patients with hemiplegia. STUDY DESIGN: The study was designed as a cross-sectional study. METHODS: Patients with unilateral strokes that damaged the right (Group I: n = 37) and left (Group II: n = 20) hemispheres were included. Swallowing difficulties were evaluated with the Turkish version of the Eating Assessment Tool. The water swallowing performance was measured with the 100 ml water swallow test. The muscle endurance (ME) of deep neck flexors was measured in the chin-tuck position. The laryngeal function was measured indirectly with maximum phonation time (MPT). RESULTS: The mean age of patients was 73.54 +/- 7.28 years in Group I and the mean age of patients was 73.15 +/- 6.94 years in Group II. There were no differences in maximum phonation time, water swallowing performance (swallow volume, capacity, and speed), and swallowing difficulty (p > 0.05). The neck flexor muscular endurance of patients with unilateral strokes that damaged the left hemisphere was better than the patients with unilateral strokes that damaged the right hemisphere (p < 0.05). There was a relationship between MPT and ME, MPT and swallowing difficulty, ME and swallowing difficulty (r:0.637, p:0.000; r:-0.465, p:0.004; r:-0.473, p:0.003 respectively) in the right hemisphere involvement patients. There was a relationship between swallowing difficulty to swallowing volume and swallowing capacity (respectively, r:-0.402 and p:0.014; r:-0.473 and p:0.003) in the patients with unilateral strokes that damaged the right hemisphere. There was no relationship between other parameters in Group I (p > 0.05). There was no relationship between all parameters in Group II (p > 0.05). CONCLUSIONS: This study is the first study to investigate whether water swallowing performance, deep cervical flexor muscle endurance, and maximum phonation time were affected in right handed patients with unilateral strokes that damaged the right or left hemispheres. In light of the findings of the study, it was thought that swallowing should be evaluated in detail especially in hemiplegic patients with right hemisphere involvement. There is a need for studies examining the results of swallowing rehabilitation on right or left hemisphere in hemiplegic individuals.
Evaluation of The Effect of Different Polyetheretherketone Materials on Biofilm Formation: An in vitro Study
(Galenos Publ House, 2024) Kayaalti-Yuksek, Sibel; Atalik, Kevser; Karademir, Beguem; Saridag, Serkan; Kaya, Ayse Demet; Degirmenci, Kuebra
Objective: The aim of this in vitro study was to investigate microorganism adhesion and biofilm formation between pure and ceramic-reinforced polyetheretherketone (PEEK) materials. Methods: A total of 72 rectangular (8 x 8 x 4 mm) samples were prepared from pure-PEEK without filler and PEEK (Ceramicreinforced PEEK - bio high-performance polymer) containing 20% nano-ceramic filler. A profilometer contact surface measurement device was used to assess the surface roughness of the samples. PEEK groups (36 pure PEEK, 36 Ceramic-reinforced PEEK) were divided into 4 sub-groups of 9 according to the microorganism strains. Staphylococcus aureus [American Type Culture Collection (ATCC 29213)], Acinetobacter baumannii (ATCC 19606), Enterococcus faecalis (ATCC 29212), and Candida albicans (ATCC 10231) standard strains were used for microbiological analysis. Blocks were added to 24-well microplates containing suspensions of microorganisms and were incubated at 37 degrees C for 72 hours. Microplates were read at a wavelength of 490 nm using crystal violet. Results: No significant difference was determined between the PEEK groups in terms of surface roughness. No significant differences in biofilm formation of S. aureus , A. baummanii , E. faecalis , and C. albicans strains were found between the PEEK groups (p>0.05). In the pure -PEEK, the highest adhesion was recorded in S. aureus (p<0.001), and the lowest adhesion in C. albicans (p<0.001). In the ceramic -reinforced PEEK group, S. aureus and A. baummanii adhesions were observed more than E. faecalis and C. Albicans (p<0.001). Conclusion: The results of this investigation demonstrated no significant differences in the biofilm formation of different strains between PEEK materials. This was a preliminary study to define the biological characteristics of ceramic -reinforced PEEK. There is a need for further comparative and clinical studies on this subject.
GÜVENLİ KAN İÇİN KİME GÜVENELİM? TEKİRDAĞ İLİNDE KIZILAY KAN BAĞIŞ MERKEZİ ÇALIŞMALARININ MİKROBİYOLOJİK AÇIDAN DEĞERLENDİRİLMESİ
(2017) Saraçoğlu, Gamze Varol; Kurç, Mine Aydın; Kaya, A. Demet; Saraçoğlu, Atilla
Amaç: Bu araştırmanın amacı, Tekirdağ İlinde Kızılay Kan Bağışı Merkezi'ne (KKBM) yapılan gönüllü kan bağışı başvurularını ve mikrobiyolojik test sonuçlarını değerlendirmektir.Gereç ve Yöntem: Kesitsel tipte olan araştırma KKBM' nin 2010 yılı kayıtlarının incelenmesini kapsamaktadır. Veriler rutin kayıt sistemindeki bilgilerden düzenlenerek elde edildi. Çalışmanın evrenini 2010 yılında KKBM'ne gönüllü kan bağışçısı olmak için başvuran 8451 kişi oluşturdu. Çalışmada tanımlayıcı istatistik yöntemleri kullanıldı. Karşılaştırmalı analizlerde Tek yönlü varyans analizi, Student t ve Chi-square testi uygulandı. Sonuçlar, %95 güven aralığında ve iki yönlü olarak değerlendirildi. Bulgular: 2010'da KKBM'ne 8451 gönüllü kan bağışı başvurusu yapıldı. Gönüllü kan bağışçısı olarak başvuran 8451 kişinin %82.3'ünün başvurusu kabul edildi (n=6952). Kabul edilmeyen kanların %17.6'sı (n=1489) geçici, %0.1'i (n=10) kesin ret tanısı aldı; alınan kanların % 0.3'ü (n=23) reaktif sonuç nedeniyle imha edildi. Kanların %1.11'inde (n=77) mikrobiyolojik tarama testleri pozitif bulundu. HBsAg pozitifliği %0.98, Anti-HCV pozitifliği %0.10 ve VDRL serolojik pozitifliği %0.03 bulundu. Anti-HIV pozitif kan saptanmadı. Sonuç: Çalışmamızda VDRL/RPR pozitifliği ülkemiz verileriyle benzer bulunurken, HBsAg ve Anti-HCV pozitifliğinin Türkiye geneline göre daha düşük olduğu belirlendi.
Hemşirelik Öğrencilerinde Nazal Staphylococcus aureus Taşıyıcılığının Araştırılması
(2022) Kevser ATALIK; Aydın AYDINLI; Birsen YÜRÜGEN; Ülken Tunga BABAOĞLU; Deniz SERTEL ŞELALE; Harika DİNÇ; Ayşe Demet KAYA
Amaç: Staphylococcus aureus ve Metisiline dirençli Staphylococcus aureus (MRSA) ile kolonize sağlık personeli ve sağlık alanında eğitim alan öğrenciler, hastane enfeksiyonları gelişimi açısından risk oluşturmaktadır.Nazal taşıyıcılığın belirlenmesi ve önlenmesi, enfeksiyon kontrolünde önem taşımaktadır. Bu çalışmada, hemşirelik öğrencilerinin klinik stajlara başlamadan ve staj döneminde aktif olarak sağlık kurumlarında çalışırken nazal S. aureus taşıyıcılık durumları araştırılmıştır. Gereç ve Yöntemler: Çalışmaya, 69’u birinci sınıfta, 60’ı ise üçüncü sınıfta eğitim görmekte olan toplam 129 hemşirelik öğrencisi dahil edilmiştir. Öğrencilerden alınan nazal sürüntü örnekleri koyun kanlı agar ve mannitol tuz agara ekilmiş ve bir gece inkübasyonu takiben, konvansiyonel yöntemler ile identifiye edilmiştir. Metisilin duyarlılığı disk difüzyon yöntemi ile belirlenmiştir. İstatistiki analizde Pearson Ki-Kare testi kullanılmış ve istatistiksel anlamlılık p
Investigating the usage possibility of metal mono carboxylates(metal naphthenates) as antibacterial agent in textile applications
(inst Natl Cercetare-dezvoltare Textile Pielarie-bucuresti, 2014) Yildiz, Aylin; Oztas, Merve; Dumrul, Gulen; Yesilyurt, Murat; Atav, Riza; Agirgan, A. Ozgur; Kaya, A. Demet; Tıbbi Mikrobiyoloji / Medical Microbiology
In this study, it was aimed to produce a substance, which could be used as an antibacterial agent in textiles, from petroleum sub-products in order to extend the use of petroleum and petroleum sub-products in textiles. For this aim, complex compounds with copper, cobalt, nickel, zinc, and sodium, were produced. Then, those compounds were applied onto cotton fabric by padding process, and their antibacterial activities were evaluated according to the AATCC 147 agar diffusion test method. As a result of the trials, it was determined that best results were obtained against both gram-positive and gram-negative bacteria with copper mono carboxylate. Its activity was still present against Staphylococcus aureus and Escherichia coli after 3 washings and against Bacillus subtilis and Klebsiella pneumoniae after 10 washings.
Investigation of therapeutic effect of Saccharomyces boulardii and translocation in immunosuppressed rats infected with Shigella sonnei
(2020) Ayşe Demet KAYA; Mustafa BEHÇET
Aim: To investigate the therapeutic effects of Saccharomyces boulardii (S. boulardii) and detectblood and tissue penetrations of S. boulardii and Shigella sonnei (S. sonnei) in immunosuppressedrats infected with S. sonnei.Methods: Forty rats were divided into four groups: Group A (immunosuppressed, not-treated); GroupB (immunosuppressed, treated with S. boulardii); Group C (immunosuppressed, infected with S.sonnei, treated with S. boulardii); Group D (immunosuppressed, infected with S. sonnei). After takingsamples for blood cultures, the rats were sacrificed. The large bowel, liver, spleen and mesentericlymph nodes (MLN) were removed for microbiological examination.Results: S. boulardii in group B and S. sonnei in group D were isolated from blood in some rats.Statistical analysis of our data, showed that the numbers of translocated colonies in the liver andspleen were relatively higher for S. boulardii in Group B and for S. sonnei in Group D, withoutreaching levels of statistical significance. For MLN, colony counts in Group B was higher than GroupC and A showing statistical significance.Conclusion: The administration of S. boulardii showed promising results for the therapy of S. sonneiinfection in immunosuppressed rats, but therapeutic usage of S. boulardii should be carefully assessedby taking into consideration the risk it poses versus potential benefits in risk groups.
Kinesiology of the hip
(Elsevier, 2020) Eyüboğlu,F.; Sayaca,Ç.; Çalik,M.; Korkem,D.; Tascilar,L.N.; Kaya,D.
This chapter introduces kinesiology of hip. It starts by anatomy (bones, static and dynamic stabilizers, veins and nerves) of hip. The chapter continues with biomechanics and osteokinematics of the hip. The relation between femur and pelvis is explained as kinesiology. Movements of the hip during walking and running are explained. At the end of the chapter, changes in the hips in neurological and orthopedic illness situations will be explained. © 2020 Elsevier Inc. All rights reserved.
Kinesiology of the pelvis
(Elsevier, 2020) Sayaca,Ç.; Eyüboğlu,F.; Tascilar,L.N.; Çalık,M.; Kaya,D.
This chapter introduces the pelvis and its relationship with the lumbosacral joints. It starts by explaining the importance of pelvis, explains the anatomy and biomechanics followed by pelvic pathomechanics in selected orthopedic conditions. Sacroiliac and lumbosacral joints are also discussed as they are structurally and functionally related to pelvis. © 2020 Elsevier Inc. All rights reserved.
Treatment Success with Tigecycline in Combination in a Critically Ill Brucellosis Patient: A Case Report
(Nobel Ilac, 2023) Yesilyurt, I. D. Murat; Kaya, Ayse Demet; Kurc, Mine Aydin; Tıbbi Mikrobiyoloji / Medical Microbiology
Neurobrucellosis is serious complication of Brucella infections and treatment options are quite controversial. Due to high relapse rates and treatment failure observed with monotherapy, a combined therapy is applied. In combination therapy, recently promising results are reported when tigecycline is combined with other antibacterial agents. Besides in-vitro studies, human case reports,-predominantly for severe and life-threatening infections-support treatment success. In this study, we are presenting a case of neurobrucellosis, who recieved a combination therapy including tigecycline, ceftriaxone and rifampicin and totally recovered with no sequela. Our case had the signs and symptoms suspecting of neurobrucellosis, but remained underdiagnosed and cardio/pulmonary arrest had occurred. After resuscitation the patient was hospitalized in the intensive care unit (ICU). Diagnosis of brucellosis was based on clinical features, culture and serological tests of blood and cerebrospinal fluid (CSF) samples, neuroimaging and confirmed by molecular methods. Tigecycline was used by intravenous (IV) route in combination with ceftriaxone and rifampicin, as the patient was mechanicaly ventilated and oral intake was by nasogastric (NG) tube. Risk of vomiting which would prevent doxycycline efficiency led us to apply this combination, to eliminate the risk in this critically ill patient. After observing significant improvement, the treatment was replaced with the oral treatment of rifampicin and doxycycline and terminated in six months. In conclusion, tigecycline seems to be a potential treatment option for brucellosis in combination with other drugs, particularly for specific patient groups, and severe and life threatening conditions related with brucellosis, who have limited alternative treatment options.
Vulvovajinal Kandidiyazis: Risk Faktörleri ve İnfeksiyon Etkenlerinin Dağılımı
(2024) Arzu MALAK; Mine AYDIN KURÇ; Dumrul GÜLEN; Ayşe Demet KAYA; Nicel TAŞDEMİR; Gamze VAROL
Amaç: Dünyada yaygın görülen, milyonlarca kadının hayatını etkileyen ve anormal vajinal akıntının sık nedenlerinden olan vulvovajinal kandidiyazis (VVC)’in en önemli etkeni günümüze kadar Candida albicans iken, son yıllarda Non-albicans Candida (NAC) türlerinin sıklığı artmıştır. VVC’ da, birçok risk faktörünün de infeksiyon gelişimi ve tekrarlamasını etkilediği belirlenmiştir. Bu çalışmada; anormal vajinal akıntı yakınması olan hastalarda VVC sıklığı ve etkenlerinin belirlenerek, infeksiyon ile ilişkili risk faktörlerinin araştırılması amaçlanmıştır. Gereç ve Yöntemler: Anormal vajinal akıntı şikayeti olan 87 hastaya, sosyo-demografik özellikleri ve risk faktörleri olarak tanımlanan bağımsız değişkenleri içeren 26 soruluk anket uygulanmıştır. Toplanan vajinal sürüntü örneklerinin kültür ve mikroskopik incelemesi yapılarak, izolatlar klasik ve biyokimyasal testle identifiye edilmiştir. Bulgular: Hastaların %18,4’ünde Candida cinsi mantar üremesi saptanırken, gebelerde bu oran %60 olarak bulunmuştur. İnfeksiyon etkeni olarak izole edilen Candida’lardan %43,7 C. albicans, %37,5 C. glabrata, %12,5 C. krusei ve %6,3 C. parapsilosis olarak tanımlanmıştır. Hastaların %68,7’i tekrarlayan infeksiyon geçirdiğini bildirmiştir. Çalışmada VVC üremesini etkileyen tek faktör gebelik olarak saptanmış (p=0,041); VVC’i etkilemesi beklenen diğer bağımsız faktörler arasında anlamlı fark saptanmamıştır (p>0,05). Sonuç: Çalışmamız; VVC etiyolojisinde NAC türlerinin öneminin arttığını ve saptanan yüksek rekürrens oranları ile ilişkili olabileceğini göstermektedir. Bu bulgu VVC hastalarında ve özellikle de çalışmamızda risk faktörü olarak saptanmış gebelik döneminde, etkenlerin tür düzeyinde tanımlanmasının ve olası risk faktörlerinin bilinerek, kontrol altında tutulmasının önemini ortaya koymaktadır.