Browsing by Author "Khosravi, Arezoo"

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3D and 4D printing of MXene-based composites: from fundamentals to emerging applications
(Royal Soc Chemistry, 2024) Khosravı, Arezoo; Zarepour, Atefeh; Khosravi, Arezoo; Iravani, Siavash; Zarrabi, Ali; Genetik ve Biyomühendislik / Genetic and Bio-Engineering
The advent of three-dimensional (3D) and four-dimensional (4D) printing technologies has significantly improved the fabrication of advanced materials, with MXene-based composites emerging as a particularly promising class due to their exceptional electrical, mechanical, and chemical properties. This review explores the fundamentals of MXenes and their composites, examining their unique characteristics and the underlying principles of their synthesis and processing. We highlight the transformative potential of 3D and 4D printing techniques in tailoring MXene-based materials for a wide array of applications. In the field of tissue regeneration, MXene composites offer enhanced biocompatibility and mechanical strength, making them ideal for scaffolds and implants. For drug delivery, the high surface area and tunable surface chemistry of MXenes enable precise control over drug release profiles. In energy storage, MXene-based electrodes exhibit superior conductivity and capacity, paving the way for next-generation batteries and supercapacitors. Additionally, the sensitivity and selectivity of MXene composites make them excellent candidates for various (bio)sensing applications, from environmental monitoring to biomedical diagnostics. By integrating the dynamic capabilities of 4D printing, which introduces time-dependent shape transformations, MXene-based composites can further adapt to complex and evolving functional requirements. This review provides a comprehensive overview of the current state of research, identifies key challenges, and discusses future directions for the development and application of 3D and 4D printed MXene-based composites. Through this exploration, we aim to underscore the significant impact of these advanced materials and technologies on diverse scientific and industrial fields. This review highlights the developments in the 3D/4D printing of MXene-based composites, focusing on their application in tissue regeneration, drug delivery, sensing, and energy storage.
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Advancing paper-based sensors with MXenes and MOFs: exploring cutting-edge innovations
(Royal Soc Chemistry, 2024) Larijani, Sepehr; Zarepour, Atefeh; Khosravi, Arezoo; Iravani, Siavash; Eskandari, Mahnaz; Zarrabi, Ali
MXenes and metal-organic frameworks (MOFs) are emerging as promising materials for integration into paper-based sensors (PSs), offering unique properties that can enhance sensor performance in various applications. MXenes, with their high conductivity and large surface area, and MOFs, known for their tunable porosity and chemical functionalities, provide distinct advantages to PSs. By leveraging the exceptional properties of MXenes and MOFs, researchers can develop PSs with improved sensitivity, selectivity, and stability, paving the way for advanced sensing platforms with diverse capabilities in environmental monitoring, healthcare diagnostics, and beyond. However, challenges still exist for incorporating MXenes and MOFs into PSs, including sensitivity, stability, interference, and scalability. Addressing these challenges is crucial for optimizing sensor performance and reliability. Herein, recent developments pertaining to the applications of MXenes and MOFs in PSs are discussed, focusing on challenges and future perspectives. By examining the unique properties of these materials, exploring innovative sensor designs, and discussing potential solutions to current challenges, this review seeks to pave the way for the development of next-generation PSs with enhanced sensitivity, selectivity, and reliability.
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Advancing personalized medicine: Integrating statistical algorithms with omics and nano-omics for enhanced diagnostic accuracy and treatment efficacy
(Elsevier, 2024) Coskun, Abdurrahman; Khosravı, Arezoo; Pusparum, Murih; Van Hoof, Rebekka; Kaya, Zelal Zuhal; Khosravi, Arezoo; Zarrabi, Ali; Genetik ve Biyomühendislik / Genetic and Bio-Engineering
Medical laboratory services enable precise measurement of thousands of biomolecules and have become an inseparable part of high-quality healthcare services, exerting a profound influence on global health outcomes. The integration of omics technologies into laboratory medicine has transformed healthcare, enabling personalized treatments and interventions based on individuals' distinct genetic and metabolic profiles. Interpreting laboratory data relies on reliable reference values. Presently, population-derived references are used for individuals, risking misinterpretation due to population heterogeneity, and leading to medical errors. Thus, personalized references are crucial for precise interpretation of individual laboratory results, and the interpretation of omics data should be based on individualized reference values. We reviewed recent advancements in personalized laboratory medicine, focusing on personalized omics, and discussed strategies for implementing personalized statistical approaches in omics technologies to improve global health and concluded that personalized statistical algorithms for interpretation of omics data have great potential to enhance global health. Finally, we demonstrated that the convergence of nanotechnology and omics sciences is transforming personalized laboratory medicine by providing unparalleled diagnostic precision and innovative therapeutic strategies.
Citation Count: 1
Amine-functionalized mesoporous silica nanoparticles decorated by silver nanoparticles for delivery of doxorubicin in breast and cervical cancer cells
(Elsevier, 2024) Ghobadi, Melika; Khosravı, Arezoo; Ardestani, Mohammad Taha Salmanifard; Mousavi-Khattat, Mohammad; Shakeran, Zahra; Khosravi, Arezoo; Zarrabi, Ali; Genetik ve Biyomühendislik / Genetic and Bio-Engineering
Nanocarriers have demonstrated promising potential in the delivery of various anticancer drugs and in improving the efficiency of the treatment. In this study, silver nanoparticles (AgNPs) were green-synthesized using the extracts of different parts of the pomegranate plant, including the peel, flower petals, and calyx. To obtain the most efficient extract used for the green synthesis of AgNPs, all three types of synthesized nanoparticles were characterized. Then, (3-Aminopropyl) triethoxysilane-functionalized mesoporous silica nanoparticles (MSNs-APTES) decorated with AgNPs were fabricated via a one-pot green-synthesis method. AgNPs were directly coated on the surface of MSNs-APTES by adding pomegranate extract enriched with a source of reducing agent leading to converting the silver ion to AgNPs. The MSN-APTES-AgNPs (MSNs-AgNPs) have been thoroughly characterized using nanoparticle characterization techniques. In addition, DNA cleavage and hemolysis activities of the synthesized nanoparticles were analyzed, confirming the biocompatibility of synthesized nanoparticles. The Doxorubicin (DOX, as a breast/cervical anti-cancer drug) loading (42.8%) and release profiles were investigated via UV-visible spectroscopy. The fibroblast, breast cancer, and cervical cancer cells' viability against DOX-loaded nanoparticles were also studied. The results of this high drug loading, uniform shape, and small functionalized nanoparticles demonstrated its great potential for breast and cervical cancer management.
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Application of 3D, 4D, 5D, and 6D bioprinting in cancer research: what does the future look like?
(Royal Soc Chemistry, 2024) Khorsandi, Danial; Khosravı, Arezoo; Sezen, Serap; Ferrao, Rafaela; Khosravi, Arezoo; Zarepour, Atefeh; Zarrabi, Ali; Genetik ve Biyomühendislik / Genetic and Bio-Engineering
The application of three- and four-dimensional (3D/4D) printing in cancer research represents a significant advancement in understanding and addressing the complexities of cancer biology. 3D/4D materials provide more physiologically relevant environments compared to traditional two-dimensional models, allowing for a more accurate representation of the tumor microenvironment that enables researchers to study tumor progression, drug responses, and interactions with surrounding tissues under conditions similar to in vivo conditions. The dynamic nature of 4D materials introduces the element of time, allowing for the observation of temporal changes in cancer behavior and response to therapeutic interventions. The use of 3D/4D printing in cancer research holds great promise for advancing our understanding of the disease and improving the translation of preclinical findings to clinical applications. Accordingly, this review aims to briefly discuss 3D and 4D printing and their advantages and limitations in the field of cancer. Moreover, new techniques such as 5D/6D printing and artificial intelligence (AI) are also introduced as methods that could be used to overcome the limitations of 3D/4D printing and opened promising ways for the fast and precise diagnosis and treatment of cancer. Recent advancements pertaining to the application of 3D, 4D, 5D, and 6D bioprinting in cancer research are discussed, focusing on important challenges and future perspectives.
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Bacterial nanocelluloses as sustainable biomaterials for advanced wound healing and dressings
(Royal Soc Chemistry, 2024) Zarepour, Atefeh; Gok, Bahar; Budama-Kilinc, Yasemin; Khosravi, Arezoo; Iravani, Siavash; Zarrabi, Ali
Wound healing remains a significant clinical challenge, calling for innovative approaches to expedite the recovery process and improve patient outcomes. Bacterial nanocelluloses (BNCs) have emerged as a promising solution in the field of wound healing and dressings due to their unique properties such as high crystallinity, mechanical strength, high purity, porosity, high water absorption capacity, biodegradability, biocompatibility, sustainability, and flexibility. BNC-based materials can be applied for the treatment of different types of wounds, from second-degree burns to skin tears, biopsy sites, and diabetic and ischemic wounds. BNC-based dressings have exceptional mechanical properties such as flexibility and strength, which ensure proper wound coverage and protection. The renewable nature, eco-friendly production process, longer lifespan, and potential for biodegradability of BNCs make them a more sustainable alternative to conventional wound care materials. This review aims to provide a detailed overview on the application of BNC-based composites for wound healing and dressings via highlighting their ability as a carrier for delivery of different types of antimicrobial compounds as well as their direct effect on the healing process. Besides, it mentions some of the in vivo and clinical studies using BNC-based dressings and describes challenges related to the application of these materials as well as their future directions.
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Biohybrid Micro/Nanorobots: Pioneering the Next Generation of Medical Technology
(Wiley, 2024) Khosravı, Arezoo; Khosravi, Arezoo; Iravani, Siavash; Zarrabi, Ali; Genetik ve Biyomühendislik / Genetic and Bio-Engineering
Biohybrid micro/nanorobots hold a great potential for advancing biomedical research. These tiny structures, designed to mimic biological organisms, offer a promising method for targeted drug delivery, tissue engineering, biosensing/imaging, and cancer therapy, among other applications. The integration of biology and robotics opens new possibilities for minimally invasive surgeries and personalized healthcare solutions. The key challenges in the development of biohybrid micro/nanorobots include ensuring biocompatibility, addressing manufacturing scalability, enhancing navigation and localization capabilities, maintaining stability in dynamic biological environments, navigating regulatory hurdles, and successfully translating these innovative technologies into clinical applications. Herein, the recent advancements, challenges, and future perspectives related to the biomedical applications of biohybrid micro/nanorobots are described. Indeed, this review sheds light on the cutting-edge developments in this field, providing researchers with an updated overview of the current potential of biohybrid micro/nanorobots in the realm of biomedical applications, and offering insights into their practical applications. Furthermore, it delves into recent advancements in the field of biohybrid micro/nanorobotics, providing a comprehensive analysis of the current state-of-the-art technologies and their future applications in the biomedical field. This review is about biohybrid micro/nanorobots, a class of micro/nanorobotics composed of a biological part and an artificial sector. It also explores recent advancements in biomedical applications of biohybrid micro/nanorobots by focusing on their potential usage in targeted drug delivery, tissue engineering, cancer therapy, and imaging-guided therapy. image
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Bioinspired Nanomaterials to Combat Microbial Biofilm and Pathogen Challenges: A Review
(Amer Chemical Soc, 2024) Zarepour, Atefeh; Venkateswaran, Meenakshi R.; Khosravi, Arezoo; Iravani, Siavash; Zarrabi, Ali
The emergence of antibiotic-resistant biofilms poses a significant challenge in healthcare, as these complex microbial communities demonstrate an increased resistance to conventional treatment methods. Traditional antibiotics often fail against biofilms, resulting in persistent infections and treatment failures. To address this urgent issue, innovative strategies such as bioinspired nanomaterials, antimicrobial peptides, quorum sensing inhibitors, and combination therapies show promise in disrupting biofilm structures, enhancing antimicrobial activity, and overcoming resistance mechanisms. Bioinspired nanomaterials have emerged as a pivotal approach for tackling the challenges presented by biofilms and microbial pathogens across various sectors, including healthcare, industry, and environmental protection. Their advantages include enhanced biocompatibility, targeted delivery, and improved efficacy against biofilm formation and microbial threats. Recent advancements highlight the potential of innovative solutions, such as antimicrobial nanoparticles, smart nanocarriers, surface modifications, and nanozymes, in combating biofilm-related issues. Despite significant progress in bioinspired nanomaterial research, challenges remain. The intricate interactions within biofilms and the evolving nature of microbial pathogens necessitate multidisciplinary approaches. Furthermore, translating laboratory findings into practical applications faces obstacles related to scalability, stability, and regulatory compliance. Future advancements in bioinspired nanomaterials are expected to focus on multifunctional nanoparticles that disrupt biofilms, advanced surface modifications for better interaction, smart nanocarriers for targeted delivery, and innovative nanozymes to dismantle biofilm structures. This review focuses on the development and application of bioinspired nanoparticles to address microbial biofilm and pathogen challenges. It emphasizes the roles of antimicrobial nanoparticles, surface modifications, smart nanocarriers, and nanozymes in enhancing the efficacy and targeting capabilities. Additionally, the review explores the potential of bioinspired nanomaterials in formulating biofilm management practices, providing insights into the advantages, limitations, and future perspectives of these innovative approaches.
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Catalytic and biomedical applications of nanocelluloses: A review of recent developments
(Elsevier, 2024) Khorsandi, Danial; Khosravı, Arezoo; Zarepour, Atefeh; Khosravi, Arezoo; Rabiee, Navid; Iravani, Siavash; Zarrabi, Ali; Genetik ve Biyomühendislik / Genetic and Bio-Engineering
Nanocelluloses exhibit immense potential in catalytic and biomedical applications. Their unique properties, biocompatibility, and versatility make them valuable in various industries, contributing to advancements in environmental sustainability, catalysis, energy conversion, drug delivery, tissue engineering, biosensing/imaging, and wound healing/dressings. Nanocellulose-based catalysts can efficiently remove pollutants from contaminated environments, contributing to sustainable and cleaner ecosystems. These materials can also be utilized as drug carriers, enabling targeted and controlled drug release. Their high surface area allows for efficient loading of therapeutic agents, while their biodegradability ensures safer and gradual release within the body. These targeted drug delivery systems enhance the efficacy of treatments and minimizes side effects. Moreover, nanocelluloses can serve as scaffolds in tissue engineering due to their structural integrity and biocompatibility. They provide a three-dimensional framework for cell growth and tissue regeneration, promoting the development of functional and biologically relevant tissues. Nanocellulose-based dressings have shown great promise in wound healing and dressings. Their ability to absorb exudates, maintain a moist environment, and promote cell proliferation and migration accelerates the wound healing process. Herein, the recent advancements pertaining to the catalytic and biomedical applications of nanocelluloses and their composites are deliberated, focusing on important challenges, advantages, limitations, and future prospects.
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Contribution of Autophagy to Epithelial Mesenchymal Transition Induction during Cancer Progression
(Mdpi, 2024) Strippoli, Raffaele; Khosravı, Arezoo; Adelipour, Maryam; Khosravi, Arezoo; Cordani, Marco; Zarrabi, Ali; Allameh, Abdolamir; Genetik ve Biyomühendislik / Genetic and Bio-Engineering
Simple Summary This manuscript focuses on the complex relationships between autophagy and epithelial mesenchymal transition (EMT) in cancer. Autophagy, a cellular degradation process, and EMT, a mechanism where epithelial cells acquire mesenchymal features, both play significant roles in cancer development. This review aims to explore how these processes interact, particularly how autophagy impacts cancer cell fate during EMT. The findings from this study are expected to contribute to a better understanding of cancer biology and could potentially impact cancer treatment strategies, as both autophagy and EMT are considered targets for therapy.Abstract Epithelial Mesenchymal Transition (EMT) is a dedifferentiation process implicated in many physio-pathological conditions including tumor transformation. EMT is regulated by several extracellular mediators and under certain conditions it can be reversible. Autophagy is a conserved catabolic process in which intracellular components such as protein/DNA aggregates and abnormal organelles are degraded in specific lysosomes. In cancer, autophagy plays a controversial role, acting in different conditions as both a tumor suppressor and a tumor-promoting mechanism. Experimental evidence shows that deep interrelations exist between EMT and autophagy-related pathways. Although this interplay has already been analyzed in previous studies, understanding mechanisms and the translational implications of autophagy/EMT need further study. The role of autophagy in EMT is not limited to morphological changes, but activation of autophagy could be important to DNA repair/damage system, cell adhesion molecules, and cell proliferation and differentiation processes. Based on this, both autophagy and EMT and related pathways are now considered as targets for cancer therapy. In this review article, the contribution of autophagy to EMT and progression of cancer is discussed. This article also describes the multiple connections between EMT and autophagy and their implication in cancer treatment.
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Electrogenic bacteria in microbial fuel cells: innovative approaches to sustainable wastewater treatment and bioelectricity production
(Springernature, 2024) Khosravı, Arezoo; Khaleghi, Moj; Miroliaei, Mohammad Reza; Naghibi, Negin; Tehranian, Aref; Khosravi, Arezoo; Zarrabi, Ali; Genetik ve Biyomühendislik / Genetic and Bio-Engineering
Microbial fuel cells (MFCs) offer a promising solution to address contemporary issues such as water scarcity, pollution, high electricity costs, and reliance on fossil fuels. By utilizing exoelectrogenic bacteria, MFCs can simultaneously purify water and generate electricity. This study investigated the potential for electricity production and wastewater treatment using exoelectrogenic bacteria isolated from urban wastewater in Kerman City. A two-chamber MFC with a 500 ml volume and a KCl salt bridge for proton transfer was employed. The microbial community effectively reduced chemical oxygen demand (COD) and biological oxygen demand (BOD) by 99% and 63%, respectively, and removed heavy metals from the wastewater. The highest voltage and current generated from the effluent were 330 mV and 1.825 mA, respectively. Among the 28 identified bacterial strains, five (Shewanella sp., Lysinibacillus sp., Bacillus sp., Enterobacter sp., and Acinetobacter sp.) were selected for further study. Shewanella sp. produced the highest voltage and current, reaching 230 mV and 0.016 mA, respectively. These findings underscore the significant potential of exoelectrogenic bacteria in advancing MFC technology for sustainable wastewater treatment and energy production.
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Innovative approaches for cancer treatment: graphene quantum dots for photodynamic and photothermal therapies
(Royal Soc Chemistry, 2024) Zarepour, Atefeh; Khosravı, Arezoo; Yuecel Ayten, Necla; cakir Hatir, Pinar; Iravani, Siavash; Zarrabi, Ali; Genetik ve Biyomühendislik / Genetic and Bio-Engineering
Graphene quantum dots (GQDs) hold great promise for photodynamic and photothermal cancer therapies. Their unique properties, such as exceptional photoluminescence, photothermal conversion efficiency, and surface functionalization capabilities, make them attractive candidates for targeted cancer treatment. GQDs have a high photothermal conversion efficiency, meaning they can efficiently convert light energy into heat, leading to localized hyperthermia in tumors. By targeting the tumor site with laser irradiation, GQD-based nanosystems can induce selective cancer cell destruction while sparing healthy tissues. In photodynamic therapy, light-sensitive compounds known as photosensitizers are activated by light of specific wavelengths, generating reactive oxygen species that induce cancer cell death. GQD-based nanosystems can act as excellent photosensitizers due to their ability to absorb light across a broad spectrum; their nanoscale size allows for deeper tissue penetration, enhancing the therapeutic effect. The combination of photothermal and photodynamic therapies using GQDs holds immense potential in cancer treatment. By integrating GQDs into this combination therapy approach, researchers aim to achieve enhanced therapeutic efficacy through synergistic effects. However, biodistribution and biodegradation of GQDs within the body present a significant hurdle to overcome, as ensuring their effective delivery to the tumor site and stability during treatment is crucial for therapeutic efficacy. In addition, achieving precise targeting specificity of GQDs to cancer cells is a challenging task that requires further exploration. Moreover, improving the photothermal conversion efficiency of GQDs, controlling reactive oxygen species generation for photodynamic therapy, and evaluating their long-term biocompatibility are all areas that demand attention. Scalability and cost-effectiveness of GQD synthesis methods, as well as obtaining regulatory approval for clinical applications, are also hurdles that need to be addressed. Further exploration of GQDs in photothermal and photodynamic cancer therapies holds promise for advancements in targeted drug delivery, personalized medicine approaches, and the development of innovative combination therapies. The purpose of this review is to critically examine the current trends and advancements in the application of GQDs in photothermal and photodynamic cancer therapies, highlighting their potential benefits, advantages, and future perspectives as well as addressing the crucial challenges that need to be overcome for their practical application in targeted cancer therapy. Recent advancements pertaining to the application of GQD-based nanosystems in photothermal and photodynamic cancer therapies are discussed, highlighting crucial challenges, advantages, and future perspectives.
Citation Count: 1
Innovative approaches in skin therapy: bionanocomposites for skin tissue repair and regeneration
(Royal Soc Chemistry, 2024) Bal-Ozturk, Ayca; Khosravı, Arezoo; Yasayan, Gokcen; Avci-Adali, Meltem; Khosravi, Arezoo; Zarepour, Atefeh; Zarrabi, Ali; Genetik ve Biyomühendislik / Genetic and Bio-Engineering
Bionanocomposites (BNCs) have gained significant attention in the field of biomaterials, particularly for their potential applications in skin tissue repair and regeneration. Advantages of these biomaterials in skin care and wound healing/dressings include their ability to provide a suitable environment for tissue regeneration. They can mimic the extracellular matrix, supporting cellular interactions and promoting the formation of new tissue. They can also be engineered to have controlled release properties, allowing for the localized and sustained delivery of bioactive molecules, growth factors, or antimicrobial agents to the wound site. BNCs can be used as scaffolds or matrices for bioprinting, enabling the fabrication of complex structures that closely resemble native tissue. BNC-based films, hydrogels, and dressings can serve as protective barriers, promoting an optimal wound healing environment and preventing infection. These materials can also be incorporated into advanced wound care products, such as smart dressings, which can monitor wound healing progress and provide real-time feedback to healthcare professionals. This review aims to provide a comprehensive overview of the current trends, advantages, challenges, and future directions in this rapidly evolving field. The current trends in the field are deliberated, including the incorporation of natural polymers, such as silk fibroin, hyaluronic acid, collagen, gelatin, chitosan/chitin, alginate, starch, bacterial cellulose, among others. These BNCs offer biocompatibility/biodegradability, enhanced mechanical strength, and the ability to promote cell adhesion and proliferation. However, crucial challenges such as biocompatibility optimization, mechanical property tuning, and regulatory approval need to be addressed. Furthermore, the future directions and emerging research areas are deliberated, including the development of biomimetic BNCs that mimic the native tissue microenvironment in terms of composition, structure, and bioactive cues. Furthermore, the integration of advanced fabrication techniques, such as 3D bioprinting and electrospinning, and the incorporation of nanoparticles and bioactive molecules hold promise for enhancing the therapeutic efficacy of BNCs in skin tissue repair and regeneration. This review aims to provide a comprehensive overview of the current trends, advantages, challenges, and future directions in the field of bionanocomposites for skin tissue repair and regeneration.
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Intersecting pathways: The role of hybrid E/M cells and circulating tumor cells in cancer metastasis and drug resistance
(Churchill Livingstone, 2024) Hariri, Amirali; Khosravı, Arezoo; Khosravi, Arezoo; Zarepour, Atefeh; Iravani, Siavash; Zarrabi, Ali; Genetik ve Biyomühendislik / Genetic and Bio-Engineering
Cancer metastasis and therapy resistance are intricately linked with the dynamics of Epithelial-Mesenchymal Transition (EMT) and Circulating Tumor Cells (CTCs). EMT hybrid cells, characterized by a blend of epithelial and mesenchymal traits, have emerged as pivotal in metastasis and demonstrate remarkable plasticity, enabling transitions across cellular states crucial for intravasation, survival in circulation, and extravasation at distal sites. Concurrently, CTCs, which are detached from primary tumors and travel through the bloodstream, are crucial as potential biomarkers for cancer prognosis and therapeutic response. There is a significant interplay between EMT hybrid cells and CTCs, revealing a complex, bidirectional relationship that significantly influences metastatic progression and has a critical role in cancer drug resistance. This resistance is further influenced by the tumor microenvironment, with factors such as tumor-associated macrophages, cancer-associated fibroblasts, and hypoxic conditions driving EMT and contributing to therapeutic resistance. It is important to understand the molecular mechanisms of EMT, characteristics of EMT hybrid cells and CTCs, and their roles in both metastasis and drug resistance. This comprehensive understanding sheds light on the complexities of cancer metastasis and opens avenues for novel diagnostic approaches and targeted therapies and has significant advancements in combating cancer metastasis and overcoming drug resistance.
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Light-responsive liposome as a smart vehicle for the delivery of anticancer herbal medicine to skin
(Springernature, 2024) Zarepour, Atefeh; Ulker, Zeynep; Khosravi, Arezoo; Coskun, Abdurrahman; Ertas, Yavuz Nuri; Yildiz, Mehmet; Zarrabi, Ali
Sunlight is composed of various wavelengths, including visible light, ultraviolet (UV) rays, and infrared radiation that serves as a double-edged sword for humans via providing the energy for sustaining life on Earth and also acting as a source of hazardous UV radiation. The skin, as the largest protective part of the body, is exposed to sunlight daily, making it critical to protect this organ from its harmful effects. Accordingly, this research aims to fabricate a new type of light-responsive liposome to deliver herbal medicine as protective compounds with antioxidant and anticancer properties. The light-responsive part of this liposome has the capability of cleavage after exposure to UV-A light (the main UV-parts of sunlight) and improves drug release pattern. In detail, a light-responsive compound was fabricated at first and then was used along with phospholipids and curcumin (a type of herbal drug)-loaded cyclodextrin for the fabrication of liposomes using the thin-film hydration method. The physicochemical analysis confirmed the fabrication of spherical liposomes approximately 145 nm in size, which released around 62% of the therapeutic cargo over 120 h when exposed to UV irradiation. Besides, it showed anticancer ability (against melanoma cancer cells) while having a protecting effect for the normal cell line. Therefore, it could be a candidate for further application in skin-protecting products like wound healing compounds or anticancer usage.
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Microneedle patches: a new vantage point for diabetic wound treatments
(Royal Soc Chemistry, 2024) Bigham, Ashkan; Zarepour, Atefeh; Khosravi, Arezoo; Iravani, Siavash; Zarrabi, Ali
Microneedle patches have emerged as a promising approach for diabetic wound healing by enabling the targeted delivery of therapeutic agents such as stem cells and their derived exosomes, as well as localized delivery of bioactive moieties. These patches offer a non-invasive and efficient method for administering therapeutic payloads directly to the site of the wound, bypassing systemic circulation and minimizing potential side effects. The targeted delivery of stem cells holds immense potential for promoting tissue regeneration and accelerating wound healing in diabetic patients. Similarly, the localized delivery of stem cell-derived exosomes, which are known for their regenerative and anti-inflammatory properties, can enhance the healing process. Furthermore, microneedle patches enable the precise and controlled release of bioactive moieties, such as growth factors and cytokines, directly to the wound site, creating a conducive microenvironment for tissue repair and regeneration. The challenges associated with microneedle patches for diabetic wound healing are multifaceted. Biocompatibility issues, variability in skin characteristics among diabetic patients, regulatory hurdles, scalability, cost considerations, long-term stability, and patient acceptance and compliance all present significant barriers to the widespread adoption and optimization of microneedle technology in clinical practice. Overcoming these challenges will require collaborative efforts from various stakeholders to advance the field and address critical gaps in research and development. Ongoing research focuses on enhancing the biocompatibility and mechanical properties of microneedle materials, developing customizable technologies for personalized treatment approaches, integrating advanced functionalities such as sensors for real-time monitoring, and improving patient engagement and adherence through education and support mechanisms. These advancements have the potential to improve diabetic wound management by providing tailored and precise therapies that promote faster healing and reduce complications. This review explores the current landscape of microneedle patches in the context of diabetic wound management, highlighting both the challenges that need to be addressed and future perspectives for this innovative treatment modality.
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MOFs and MOF-Based Composites as Next-Generation Materials for Wound Healing and Dressings
(Wiley-v C H verlag Gmbh, 2024) Bigham, Ashkan; Khosravı, Arezoo; Khosravi, Arezoo; Zarepour, Atefeh; Iravani, Siavash; Zarrabi, Ali; Genetik ve Biyomühendislik / Genetic and Bio-Engineering
In recent years, there has been growing interest in developing innovative materials and therapeutic strategies to enhance wound healing outcomes, especially for chronic wounds and antimicrobial resistance. Metal-organic frameworks (MOFs) represent a promising class of materials for next-generation wound healing and dressings. Their high surface area, pore structures, stimuli-responsiveness, antibacterial properties, biocompatibility, and potential for combination therapies make them suitable for complex wound care challenges. MOF-based composites promote cell proliferation, angiogenesis, and matrix synthesis, acting as carriers for bioactive molecules and promoting tissue regeneration. They also have stimuli-responsivity, enabling photothermal therapies for skin cancer and infections. Herein, a critical analysis of the current state of research on MOFs and MOF-based composites for wound healing and dressings is provided, offering valuable insights into the potential applications, challenges, and future directions in this field. This literature review has targeted the multifunctionality nature of MOFs in wound-disease therapy and healing from different aspects and discussed the most recent advancements made in the field. In this context, the potential reader will find how the MOFs contributed to this field to yield more effective, functional, and innovative dressings and how they lead to the next generation of biomaterials for skin therapy and regeneration. Recent advancements pertaining to the applications of MOFs and their composites for wound healing and dressings are deliberated, with the purpose of identifying knowledge gaps, evaluating challenges, and guiding future directions in the field. image
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MXene-based composites in smart wound healing and dressings
(Royal Soc Chemistry, 2024) Zarepour, Atefeh; Khosravı, Arezoo; Khosravi, Arezoo; Rabiee, Navid; Iravani, Siavash; Zarrabi, Ali; Genetik ve Biyomühendislik / Genetic and Bio-Engineering
MXenes, a class of two-dimensional materials, exhibit considerable potential in wound healing and dressing applications due to their distinctive attributes, including biocompatibility, expansive specific surface area, hydrophilicity, excellent electrical conductivity, unique mechanical properties, facile surface functionalization, and tunable band gaps. These materials serve as a foundation for the development of advanced wound healing materials, offering multifunctional nanoplatforms with theranostic capabilities. Key advantages of MXene-based materials in wound healing and dressings encompass potent antibacterial properties, hemostatic potential, pro-proliferative attributes, photothermal effects, and facilitation of cell growth. So far, different types of MXene-based materials have been introduced with improved features for wound healing and dressing applications. This review covers the recent advancements in MXene-based wound healing and dressings, with a focus on their contributions to tissue regeneration, infection control, anti-inflammation, photothermal effects, and targeted therapeutic delivery. We also discussed the constraints and prospects for the future application of these nanocomposites in the context of wound healing/dressings. Recent advancements in MXene-based wound dressings are discussed, focusing on their contributions to tissue regeneration, infection control, anti-inflammation and photothermal effects, and targeted therapeutic delivery.
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MXene-based nano(bio)sensors for the detection of biomarkers: A move towards intelligent sensors
(Elsevier, 2024) Khorsandi, Danial; Khosravı, Arezoo; Ulker, Zeynep; Bayraktaroglu, Kenz; Zarepour, Atefeh; Iravani, Siavash; Khosravi, Arezoo; Genetik ve Biyomühendislik / Genetic and Bio-Engineering
MXene-based nano(bio)sensors have emerged as promising tools for detecting different biomarkers. These sensors utilize MXene materials, a class of two-dimensional transition metal carbides, nitrides, and carbonitrides, to enable highly sensitive and selective detection. One of the key advantages of MXene-based materials is their high surface area, allowing for efficient immobilization of biomolecules. They also exhibit excellent electrical conductivity, enabling rapid and sensitive detection of biomarkers. The combination of high surface area and conductivity makes MXene-based sensors ideal for detecting biomarkers at low concentrations. Furthermore, MXene-based materials possess unique mechanical properties, ensuring the durability of the sensors. This durability enables repeated use without compromising the sensor performance, making MXene-based sensors suitable for continuous monitoring applications. Despite their advantages, MXene-based nano(bio)sensors face certain challenges for practical biomedical and clinical applications. One challenge lies in the synthesis of MXene materials, which can be complex and time-consuming. Developing scalable synthesis methods is crucial to enable large-scale production and widespread use of MXene-based sensors. In addition, ensuring the stability of MXene layers under various environmental conditions remains a challenge for their practical application. Another limitation is the specificity of MXene-based sensors towards targeted biomarkers. Interfering substances or crossreactivity with similar biomolecules can lead to false-positive or false-negative results. Enhancing the selectivity of MXene-based sensors through optimization and functionalization is essential to improve their reliability and accuracy. The integration of these sensors with emerging technologies, such as artificial intelligence (AI) and internet of things, opens up new possibilities in biomarker detection. The combination of MXene sensors with AI algorithms can enable real-time monitoring, remote data analysis, and personalized healthcare solutions. Herein, the significant challenges and future prospects of MXene-based nano(bio)sensors for the detection of biomarkers are deliberated. The key obstacles have been highlighted, such as ensuring the stability and biocompatibility of MXene-based sensors, as well as addressing scalability issues. The promising future prospects of these sensors have also been explored, including their potential for high sensitivity, selectivity, and rapid response.
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MXene/zeolitic imidazolate framework (ZIF) composites: A perspective on their emerging applications
(Elsevier, 2024) Iravani, Siavash; Khosravı, Arezoo; Zarrabi, Ali; Khosravi, Arezoo; Makvandi, Pooyan; Genetik ve Biyomühendislik / Genetic and Bio-Engineering
MXene/zeolitic imidazolate framework (ZIF) composites represent a rapidly growing area of research in the field of energy storage, catalysis, sensing, flexible electronics, microwave/electromagnetic wave absorption, biomedicine, and environmental remediation/water treatment. The integration of MXene and ZIFs in composite materials has led to develop highly sensitive and selective (bio)sensing platforms, enabling advances in biomedicine/healthcare, environmental monitoring, and industrial safety. MXene/ZIF composites showcase exceptional catalytic activity for a wide range of chemical transformations. Their exceptional adsorption capacity, selectivity, membrane integration, regeneration capabilities, and antibacterial properties make them invaluable assets in tackling water treatment challenges. The combination of MXene's conductivity and ZIF's dielectric properties, along with their unique morphological features, results in enhanced microwave absorption capabilities. Furthermore, while the biomedical applications of MXene/ZIF composites are still in the early stages of exploration, the combination of their unique properties provides a platform for innovative solutions in drug delivery, cancer nanotheranostics, bioimaging, tissue engineering, and biosensing. This article aims to present a comprehensive overview of the research progress in MXene/ZIF composites, focusing on current trends, important challenges, and future perspectives.