Browsing by Author "Meral, Deniz Gökçe"

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Citation Count: 0
Ağız, Diş ve Çene Cerrahisi lisans ve öğretim üyesi kliniklerine başvuran hastaların dental anksiyete ve korku açısından değerlendirilmesi
(2022) Gül Merve Yalçın Ülker; Deniz Gökçe MERAL; Aleyna Kucur; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
Giriş ve Amaç: Dental korku ve anksiyete, hem diş hekimlerini dental tedaviler sırasında zorlamakta; hem de hastaların ağız ve diş sağlığını olumsuz yönde etkilemektedir. Bu çalışmada Ağız, Diş ve Çene Cerrahisi lisans ve öğretim üyesi kliniklerine başvuran hastaların sosyodemografik özellikleri, duygusal ce- vapları ve dental tecrübelerine göre dental anksiyete ve korku seviyelerindeki farklılıkların incelenmesi ve tedavilerini yapan hekiminin tecrübesinin bu parametrelere etkisinin incelenme- si amaçlanmıştır. Gereçler ve Yöntem: Çalışmada Ağız, Diş ve Çene Cerrahi- si Anabilim Dalı lisans ve öğretim üyesi kliniklerine diş çeki- mi için başvuran hastalara 10 adet demografik bilgilerini ve daha öncekileri dental tecrübelerini sorgulayan, 11 adet den- tal korkuyu sorgulayan, 5 adet de dental anksiyeteyi sorgu- layan sorular elektronik bir anket aracılığı ile tedavilerinden hemen önce yöneltilmiştir. Normal dağılıma uygunluk Kolmo- gorov-Smirnov ve Shapiro-Wilk testi ile incelenmiştir.Dental korku ve anksiyete puanlarının karşılaştırılmasında Mann-W- hitney-U ve Kruskal Wallis testi kullanılmıştır. Önem düzeyi p<0,05 olarak alınmıştır. Bulgular: Lisans ve öğretim üyesi kliniklerine başvuru tiple- rine göre hastaların dental korku düzeylerindeki farklılıklar is- tatistiksel olarak anlamlı bulunmuş ve lisans kliniğinde daha yüksek olduğu tespit edilmiştir (p=0,036).Hastalar cinsiyete göre dental korku ve anksiyete açısından karşılaştırıldığında, erkeklerde her iki değişkenin de istatistiksel olarak anlamlı derecede daha yüksek seviyelerde olduğu tespit edilmiştir (p=0,002;p<0,001).Yaş gruplarına göre dental korku düzeyi- nin en yüksek 45-54 yaş grubundaki, en düşük 18-29 yaş gru- bundaki hastalarda olduğu gözlenmiştir(p=0,009). Sonuç: Dental korku açısından tedavi olunan kliniğe göre bir fark gözlenirken, dental anksiyete açısından bir farklılık göz- lenmemiştir.Çalışmanın sonucuna göre erkek hastaların den- tal anksiyete ve korku düzeylerinin daha yüksek olduğu ve 45-54 yaş grubunun en yüksek dental korku seviyesine sahip olduğu gözlenmiştir. Bu farklılıkların geçmiş dental tecrübe- lerden kaynaklanabileceği sonucuna varılmıştır.
Citation Count: 4
Antibiotic prescribing habits of the clinicians dealing with dental implant surgery in Turkey: a questionnaire study
(Springer Japan Kk, 2020) Yalcin-Ulker, Gul Merve; Cakir, Merve; Meral, Deniz Gokce; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
Purpose Although various prophylactic and/or postoperative systemic antibiotic regimens have been suggested to minimize failure after dental implant placement and postoperative infection, the role of antibiotics in implant dentistry is still controversial. The purposes of this questionnaire study were to determine the current antibiotic prescribing habits of clinicians in conjunction with dental implant placement and to understand whether any consensus has been reached among implant surgery performing clinicians. Methods An electronic questionnaire was sent by electronic mail to all members of the Turkish Dental Society. The questions were related to whether antibiotics were routinely prescribed either pre- or/and postoperatively during routine dental implant placement. The respondents were also asked to specify their workplace and education. The results were analyzed using SPSS software. Descriptive and chi-square analyses were used to compare categorical data; Kruskal-Wallis test was used to compare the quantitative data by category. Results A total of 429 members responded to the questionnaire. The clinicians having more experience had a greater tendency to prescribe preoperative antibiotics (p< 0.001), but there was no statistically significant difference between the postoperative antibiotic prescription choice of the clinician according to the clinicians' experience (p> 0.05). A total of 175 of the clinicians preferred to prescribe preoperative antibiotics when there was systemic comorbidity; 99 of the clinicians preferred to prescribe antibiotics before every implant surgery. The aminopenicillins were the most commonly prescribed antibiotics by the clinicians. A total of 38.58% of the respondents (n= 130) who were prescribing preoperative antibiotics, 2000 mg aminopenicillin was given 1 h before the surgical procedure. Dentists and solo private practitioners were prescribing more preoperative antibiotics (p< 0,05). Conclusions There was no consensus among clinicians regarding the use of antibiotics in association with routine dental implant placement. Aminopenicillins were the most commonly prescribed antibiotics for both pre- and postoperatively. Furthermore, most of the antibiotic regimens being used are not in accordance with the current published data.
Citation Count: 3
Comparison of the effect of postoperative care agents on human gingival fibroblasts: a preliminary study
(Istanbul Univ Press, Istanbul Univ Rectorate, 2019) Mercan, Ugur; Gonen, Z. Burcin; Salkin, Hasan; Yalcin-Ulker, Gul Merve; Meral, Deniz Gokce; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
Purpose The aim of this study is to compare effects of postoperative care agents; chlorhexidine, octenidine dihydrochloride and hyaluronic acid on human gingival fibroblasts' viability, proliferation, apoptosis and migration. Material and Methods After cell culturing; chlorhexidine, octenidine dihydrochloride and hyaluronic acid solutions were applied on cells and nothing was applied for control group. The cells were monitored to investigate cytotoxicity; the percentage of apoptotic, living and dead cells at the time of 24, 48, and 72 hours (h). A scratch wound assay was performed to detect cell migration and cells were monitored at baseline, at 24 and 48h. Results At 24h, chlorhexidine showed statistically lower percentage of total apoptotic cells' than octenidine dihydrochloride (p=0.049), hyaluronic acid (p=0.049) and control (p=0.049). At 48h, hyaluronic acid showed statistically lower percentage than chlorhexidine (p=0.049), and control (p=0.049). All agents were found to have statistically and significantly more cytotoxic than control. However, there was no difference between experimental groups for proliferation rate. Octenidine dihydrochloride showed statistically negative effects on cell migration than chlorhexidine and hyaluronic acid at 24h. Chlorhexidine and hyaluronic acid maintained migration ability of cells than octenidine dihydrochloride at 48h. Conclusion All agents have similar effects on cell behavior such as viability, apoptosis and cell proliferation. However, octenidine dihydrochloride showed statistically negative effects on migration ability than chlorhexidine and hyaluronic acid.
Citation Count: 0
Effect of Residual Bone Height and Implant Macro-Design on Primary Stability in Sinus Floor Elevation: An Ex Vivo Study
(Allen Press inc, 2023) Tokuc, Berkay; Cakir, Merve; Ulker, Gul Merve Yalcin; Geckili, Onur; Meral, Deniz Gokce; Kan, Bahadir; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
The objective was to evaluate the influence of residual bone height (RBH) and implant macro -design on the primary stability (PS) of implants using a simultaneous sinus floor elevation (SFE) and implant insertion model. Fresh bovine rib samples that resembled type -IV density that were confirmed by computerized tomography were prepared to represent 4 groups of varying RBHs (3, 6, 9, 15 mm). To simulate simultaneous implant insertion with SFE, 120 implants in different macro -designs (group R: NobelReplace; group P: NobelParallel; group A: NobelActive, Nobel Biocare, Gothenburg, Sweden) were randomly inserted at RBHs of 3, 6, 9, and 15 mm in each rib. The implant stability quotient (ISQ) was measured immediately after implant insertion. RBH and implant macro -design have an impact on ISQ values (P < .001). ISQ values were the highest with RBH of 15 mm, followed by RBHs of 9, 6, and 3 mm. (P < .001). There was no statistically significant difference between different implant macro -designs at RBHs of 3 and 15 mm regarding ISQ values (P = .111, P = .551). ISQ values of group P were higher than those of group R and group A at an RBH of 6 mm (P = .049, P = .029). ISQ values were also higher in group P compared to group A at an RBH of 9 mm (P = .006). A higher PS may be expected in sites with higher RBH, regardless of the macro -design. In addition, cylindric implant design may enhance the PS at RBHs of 6 and 9 mm in simultaneous implant insertion with SFE.
Citation Count: 0
The effects of a single high-dose injection of vitamin-D on healing of condylar fractures in osteoporotic rats
(2019) Akif TÜRER; Uğur MERCAN; Osman KELAHMETOĞLU; Yonca Betil KABAK; Deniz Gokce MERAL; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
Aim: In this study we have tried to show the effects of a singlehigh-dose ınjection of vitamin d on healing of condylar fractures in osteoporotic rats.Materials and method: This study included sixteen femalewistar rats. All rats were overiectomized. Osteoporotic ratswere randomly divided into two groups of eight animals/group. Group D animals received a single high dose of vitamin D (50.000 IU/kg) intraperitoneally and group C (control)animals received saline (0.05 mL) intraperitoneally. All injections were given immediately after condylar fracture. All ratswere euthanized after 28 days, examined histopathologicaland immunohistochemical.Results: Histopathological and immunohistochemical evaluations were done. Histopathological scores between groupD and C were found statistically significant. TGFβ1 and osteopentin levels in group D were found higher than group C.Conclusion: We have determined that a single high-dose injection of vitamin D given immediately after surgery increasedTGFβ and osteopontin levels and enhanced new bone formation at condylar fractures of osteoporotic rats.
Citation Count: 5
Influence of the Localization of Frontal Bone Defects on Primary Stability Values of 2 Different Implant Designs: An In Vitro Study
(Lippincott Williams & Wilkins, 2017) Mercan, Ugur; Bilhan, Hakan; Meral, Deniz Gokce; Kazokoglu, Sehnaz; Aykol-Sahin, Gokce; Geckili, Onur; Periodontoloji / Periodontology; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
Objectives: The aim of this study was to determine the influence of different frontal bone defect localizations on primary stability values of 2 different implant designs. Materials and Methods: Eight cow rib segments were prepared before implant installation, as 2 segments with coronal, 2 with middle, and 2 with apical defects and 2 with control. Thirty-two cylindrical and 32 tapered implants were placed in the remaining 4 segments. Implant stability measurements were performed using electronic percussive testing and resonance frequency analysis. Results: No significance was detected between the stability values of the 2 implant designs except the implant stability quotient (ISQ) of control groups. The tapered implants control group showed significantly higher lateral ISQs compared with cylindrical implants (P = 0.033). For both implant types, stability values were significantly lower in coronal defects (P < 0.01). No significant differences were detected in other defect types. Conclusion: Within the limitations of this study, it may be concluded that coronal defects may influence primary stability negatively, compared with middle and apical defects. Although statistically not significant, coronal defects caused lower primary stability values with the tapered design compared with parallel design.
Citation Count: 3
Is there any predictive bone parameter for implant stability in 2-dimensional and 3-dimensional radiologic images?
(Elsevier Science inc, 2021) Arsan, Belde; Yalcin-Ulker, Gul Merve; Meral, Deniz Gokce; Erdem, Tamer Lutfi; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
Objectives. This ex vivo study aimed to compare radiomorphometric parameters between 2-dimensional (2-D) and 3-dimensional (3-D) radiographs and evaluate the influence of preoperative radiologic bone parameters on the clinical outcomes of implant stability. Study Design. Implant recipient sites in fresh bovine blocks were evaluated on panoramic radiographs for gray value (GV), fractal dimension (FD), number of connected trabeculae (Co), and density of connected trabeculae (CoD). Cone beam computed tomography (CBCT) scans were evaluated for trabecular thickness (TbTh), cortical thickness (CTh), degree of anisotropy (DA), FD, and Co. Insertion torque (IT) and implant stability quotient (ISQ) were measured. Results. GV was significantly correlated with all parameters in 2-D and 3-D images except FD in 2-D and Co in 3-D, and with all surgical parameters (P <= .029). Co and CoD values on panoramic radiographs had significant correlation with TbTh, CTh, and DA values on CBCT images (P < .001). All 2-D parameters and TbTh and CTh in the CBCT data were significantly correlated with IT only (P <= .047). Only GV was correlated with ISQ measurements (P <= .029). Conclusion. GV, Co, and CoD values on panoramic radiographs reflect the architecture of trabecular bone and the thickness of cortical bone, and might help predict implant stability in clinical situations.
Citation Count: 0
Osteoporoti̇k sıçanlarda hyaluroni̇k asi̇ti̇n denti̇n grefti̇yle korti̇kal kemi̇k defektleri̇nde kemi̇k i̇yi̇leşmesi̇ne etki̇si̇ni̇n değerlendi̇ri̇lmesi
(2020) Çakır, Merve; Meral, Deniz Gökçe; Mercan, Uğur; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
Amaç: Bu çalışmanın amacı, osteoporotik sıçanlarda kortikal kemik defektlerinde hyaluronik asit ve dentin greftinin kemik iyileşmesi üzerindeki etkisini değerlendirmektir.Yöntem: Çalışmada 24 adet erişkin dişi sıçan kullanılmıştır. Sıçanlara bilateral ovarektomi yapılmış, altı hafta sonunda osteoporotik olarak kabul edilen sıçanlar, üç gruba ayrılmıştır. Grup D, Grup D-HA ve Grup C. Her hayvanın kalvarium’unda 5 mm çapında kritik boyutta bir defekt oluşturulmuştur. Defektler D grubunda; dentin grefti ile, D-HA grubunda; dentin grefti ve hyaluronik asit ile doldurulmuş, kontrol grubunda (C grubu) ise boş bırakılmıştır. Bütün hayvanlar 28. günde sakrifiye edilmiştir. Her defekt bölgesinde yeni kemik oluşumu; hematoksilen ve eozin, BMP2,TGFβ ve osteopontin seviyelerine göre hem histolojik hem de immünohistokimyasal olarak değerlendirilmiştir.Bulgular: Histolojik olarak grup D ve grup D-HA, grup C’den anlamlı olarak daha fazla yeni kemik oluşumu göstermiştir. İmmünhistokimyasal olarak; TGFβ ve osteopontin seviyeleri Grup D-HA’da anlamlı olarak yüksek bulunmuştur. BMP2seviyeleri D grubu ve D-HA grubu arasında anlamlı farklılık göstermemiştir.Sonuç: Dentin grefti ve hyaluronik asitle birlikte dentin greftinin osteoporotik kemiklerde yeni kemik oluşumunu hızlandırdığı gözlenmiştir.
Citation Count: 2
Use of Leukocyte-rich and Platelet-rich Fibrin (L-PRF) Adjunct to Surgical Debridement in the Treatment of Stage 2 and 3 Medication-Related Osteonecrosis of the Jaw
(Lippincott Williams & Wilkins, 2023) Yalcin-Ulker, Gul Merve; Duygu, Gonca; Tanan, Gamze; Cakir, Merve; Meral, Deniz Gokce; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
Medication-related osteonecrosis of the jaw (MRONJ) is characterized by exposed necrotic bone persisting for more than 8 weeks in the maxillofacial region in patients using antiresorptive or antiangiogenetic drugs for several treatment options like bone metastasis or osteoporosis. There are several treatment options studied in scientific literature, and one of them with promising results is using platelet concentrates adjunct to surgical therapy. The aim of this study is to examine the therapeutic effect of leukocyte and platelet-rich fibrin (L-PRF) on patients with MRONJ. This 2-centered study investigated patients referred to oral and maxillofacial surgery departments of 2 university clinics between the years 2014 and 2020 with the diagnosis of MRONJ. Demographic data, the indication of the drug usage, drug type, duration, administration route, and systemic comorbidities of the patients were recorded. L-PRF was applied to 20 osteonecrotic lesions of 19 patients following surgical debridement. The male/female ratio was 5/14. Except 1 of the patients, all of the indications of medication were neoplasia-related. The mean follow-up period of patients was 27.9 & PLUSMN;9.2 months. Most common antirezorptive drug was zoledronate (84.2%). Complete resolution was observed in 16 necrosis sites (80%). It could be concluded that the use of L-PRF may represent an important adjunct in the surgical management of MRONJ.