Okan Üniversitesi / Okan University

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ABD Askeri Sağlık Sistemi Reformunun İncelenmesi ve Uluslararası Güvenlik Çerçevesinde Türkiye Açısından Değerlendirilmesi
(2025) Özmen, Oğuzhan; Özkut, Uğur Tarık; Özmen, Pelin
Bu çalışmanın amacı; ABD askeri sağlık sistemindeki (ABD-ASS) reform ihtiyacının zamanlaması, nedenleri ve reform faaliyetlerinin analiz edilmesi, buradan elde edilen sonuçların, Türkiye’nin savunma ve güvenliği açısından değerlendirilmesidir. ASS, ulusal kongre raporları, ikincil kaynaklar, dönüşüm ve reformla ilgili veriler, uzman görüşleri ve açık kaynaklardan elde edilen bilgilerle kavramsal ve fonksiyonel olarak değerlendirilmiştir. Çalışma sağlık yönetimi, entegre sağlık hizmetleri, inovasyon ve muharebe hazırlığı temalarının elde edilmesine yönelik, tümevarımsal kodlamanın kullanıldığı, nitel bir araştırma olarak planlanmış ve gerçekleştirilmiştir. Çalışmanın temel bulgusu; muharebe ortamında karmaşıklık arttıkça askeri sağlık organizasyonunda küçük, hızlı, mobil ve deneyim sahibi sağlık birlik ve personeline ihtiyacın artacağıdır. Ayrıca askeri sağlığın uluslararası siyasetteki insancıl gücünün de politikaya hareket sahası kazandırmakta etkili olacağı görülmektedir. ABD’nin reform zamanlamasının, büyük bölgesel savaşların emaresi olarak değerlendirilebileceği ve Türkiye’nin savunma sanayii ile paralel olarak milli askeri sağlık sistemini de en geç 2030 yılına kadar reforme etmesi gerektiği sonucuna varılmıştır. İnovasyon, operasyonel tıp, reorganizasyon ve entegre kayıt sistemleri askeri sağlık sistemlerinin odaklanması gereken, temel reform konuları olarak tespit edilmiştir.
Accelerated Alkali-Silica Reaction After a Seven-Year Asr-Dormancy Period
(Kare Publishing, 2024) Beglarigale, Ahsanollah
The ongoing alkali-silica reaction (ASR) in concrete can be halted by dryness, which is im- portant for repairing ASR-suffered concrete structures. Drying of the concrete establishes an ASR-dormancy period until the end of the dryness. The residual expansion of such concrete after the ingress of water—the end of the dormancy period—is a significant risk, especially for repair works. In this experimental study, the post-dormancy expansion of various mixtures prepared by eight different Portland cement and three different supplementary cementitious materials (SCM) were tested using an accelerated mortar bar test. After accelerated ASR ex- pansions, an ASR-dormancy period was established by keeping the specimens dry for seven years; the residual ASR expansions of the specimens were tested by the same accelerated meth- od. The effect of pre-dormancy reactions on the residual expansions was discussed through two perspectives. The post-dormancy expansion behavior of mixtures without or with insuffi- cient SCM indicated that expansions were primarily driven by the swelling of old gel, whereas in specimens with sufficient SCM, the dominant mechanism was new gel formation, a result of lower pre-dormancy expansions due to the ASR-mitigating effect of SCMs.
Adolesan kadın basketbol oyuncularında anaerobık yorgunluğun proprıosepsıyon üzerıne etkısı
(Turkey AsSoc Physiotherapists, 2025) Kilic, Sefa; Alpay, Kubra; Atici, Emine; Soyal, Mehmet; Inal-Gultekin, Guldal
Proproseptif duyudaki eksiklikler yaralanma riskini artırmakta ve sporcunun performansını olumsuz yönde etkilemektedir. Kadın basketbol oyuncularında anaerobik yorgunluğun ve toparlanma sürecinin propriosepsiyon üzerine etkisi üzerinde sınırlı sayıda çalışma bulunmaktadır. Bu amaçla adolesan kadın basketbol oyuncularında anaerobik yorgunluğun alt ekstremite propriosepsiyonu üzerine etkisini değerlendirilmiştir. Çalışmaya 12–16 yaş aralığında 30 lisanslı kadın basketbol oyuncusu dahil edildi. Katılımcıların demografik bilgilerine takiben, istirahat, yorgunluk ve toparlanma olmak üzere üç durumda kalp atım sayıları, 30° ve 60° aktif ve pasif diz eklemi pozisyon hissi ölçümleri yapıldı. Diz eklemi pozisyon hissi ölçümleri için dominant bacakları değerlendirmeye alındı. Anaerobik yorgunluk için bisiklet ergometresinde Wingate anaerobik test protokolü uygulandı ve hemen sonrasındaki yorgunluk durumu verileri alındı. Toparlanma sonrası verilerin alınması için katılımcılar 10 dakika istirahate alındılar. Katılımcıların elde edilen yorgunluk nabızları ortalama 171,6±4,2 atım/dakika olarak tespit edildi ve karvonen formülüne göre hesaplanan iş yoğunluğu %72,7±2,9 olarak belirlendi. Anaerobik yorgunluk sonrası 30° ve 60° diz fleksiyonu aktif eklem pozisyon hissinde istirahat değelerine göre anlamlı azalma saptandı (p>0,017). Yorgunluk sonrası 10 dakikalık toparlanma ile 30° ve 60° diz fleksiyonu aktif eklem pozisyon hissinde tekrar istirahat seviyelerine dönüş olduğu belirlendi. Diz fleksiyonu 30° ve 60° pasif eklem pozisyon hissinde anaerobik yorgunluk sonrası anlamlı farklılık tespit edilmedi. Sonuç olarak, adolesan kadın basketbolcularında anaerobik yorgunluğun diz propripsepsiyonunu azalttağı saptanmış ve çalışmanın literatürdeki benzer bulgularla örtüştüğü görülmüştür. Bunula birlikte, 10 dakika kadar kısa bir toparlanma süresi ile propriyoseptif duyarlılığın başlangıç seviyelerine geri döndüğü görülmüştür.
Advancing Ovarian Cancer Care: Recent Innovations and Challenges in the Use of MXenes and Their Composites for Diagnostic and Therapeutic Applications
(Royal Soc Chemistry, 2025) Farzizadeh, Neda; Zarepour, Atefeh; Khosravi, Arezoo; Iravani, Siavash; Zarrabi, Ali
Ovarian cancer remains the deadliest form of gynecologic malignancy, largely owing to the absence of reliable early diagnostic tools and the limited effectiveness of current therapeutic strategies. Recent advances in nanotechnology-particularly the emergence of two-dimensional materials known as MXenes-offer promising avenues to address these challenges. This review highlights the emerging role of MXenes and their composites in the management of ovarian cancer, focusing on their potential in biomarker detection and targeted treatment strategies. We provide a comprehensive analysis of the latest studies examining the physicochemical features of MXenes, their synthesis and surface functionalization approaches, and their application in ovarian cancer, including biosensing, drug delivery, and combinatorial therapeutic systems. MXene-based biosensors have shown remarkable detection limits in detecting ovarian cancer biomarkers, such as cancer antigen 125 (CA125), human epididymis protein 4 (HE4), lipolysis-stimulated lipoprotein receptor (LSR), and carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5). However, several challenges remain, including issues of biocompatibility, structural stability, and clinical scalability. Continued interdisciplinary research is essential to address these limitations, optimize MXene functionalization, and translate their laboratory success into clinical settings. With appropriate advancements, MXenes hold significant promise for enabling more precise, efficient, and patient-specific approaches to ovarian cancer diagnosis and therapy.
Ag and Al2o3/Water Two-Phase Transient Flow Analysis in a Double-Pipe Heat Exchanger Equipped With Baffles and Rotating Inner Tube
(Elsevier Ltd, 2025) Al-Saad, M.; Ali, A.B.M.; Al-Mosallam, M.; Fares, M.N.; Fazilati, M.A.; Salahshour, S.; Sabetvand, R.
Considering the wide application of double-pipe heat exchanger made their performance improvement very important. Employing aqueous nanofluid (NF) of Ag and Al2O3 as the working fluid inside the inner tube of the heat exchanger and its rotation as the respective passive and active enhancing methods are investigated numerically using the two-phase mixture method. The sensitivity analysis was performed to reveal the effect of Reynolds (Re) number, NF concentration and tube rotational speeds on heat transfer coefficient, heat transfer effectiveness, and efficiency ratio. The Re number, NF concentration, and rotation speed lie in 1000-3000, 0–4 %, and 300–500 rpm, respectively. The results show the higher improving effect of Ag rather than Al2O3 nanoparticle; for Re = 1000, 1500 and 2000 the efficiency ratio averaged between different concentrations are 39 %, 30 %, 20 % for Al2O3/water and 62 %, 65 % and 26 % for Ag/water NFs, respectively. By increasing the Re number, the enhancing effect of velocity increment on heat transfer rate prevails and hinders that of employing NF. Also, in rotating mode, the enhancement made by increasing the Re number is higher in the rotation speed of 500 rather than 300 rpm. The overall change of efficiency ratio versus the Re number increment is decreasing and the greatest improving effect of using NF is for the lowest Re numbers. Also, the enhancement due to increasing the Re number increment is higher at a rotational speed of 500 rather than 300 rpm. © 2025 The Authors
Alternative Treatment for Refractory Jacquet Dermatitis After Hirschsprung Disease Surgery: a Case Report
(Elsevier, 2025) Kilic, Sinan; Guven, Ahmet; Isik, Sakine
Introduction: Jacquet's erosive diaper dermatitis (JDD) is a severe form of diaper dermatitis, characterized by papuloerythematous erosions with crater-like borders in the genital and perianal regions. Case presentation: A 2-year-old male patient was diagnosed with Hirschsprung disease (HD) during the neonatal period. A transition zone was detected in the rectosigmoid region on a contrast enema. Full-thickness rectal biopsy confirmed aganglionosis, and a colostomy was created from the transverse colon. At 18 months of age, the patient underwent the Swenson procedure, and the colostomy was closed during the same session. Following the operation, spontaneous stool passage was achieved. Approximately six months after surgery, ulcerative lesions characteristic of Jacquet dermatitis developed in the perianal region. Despite six months of treatment with moisturizers, regenerative, epithelializing, and barrier therapies (e.g., zinc oxide, madecassoside, shea butter, glycerin, oatmeal, hyaluronic acid), the lesions did not improve. However, after initiating treatment with pure Aloe Vera gel, including a 10 % diluted natural extract applied four times daily, plus a dairy-free diet for three weeks, a rapid clinical response was observed, with visible improvement within the same period. Conclusion: The combination of Aloe Vera-based ointment plus dairy-free diet seems to be an effective management strategy for children with post pull-through Jacquet's dermatitis.
Analysis and Implementation of Sensorless Pmsm Drive With Reduced Dc-Link Capacitance Under Parameter Variations
(Ieee, 2024) Sumsek, Reha Ozgur; Calik, Ramazan; Yavuz, Fikri Serkan; Kivanc, Omer Cihan
In AC drives used in heating, ventilation and air-conditioning applications, film capacitors are becoming widespread instead of electrolytic capacitors in DC-link. These drives with reduced capacitor value provide cost and volume advantages. However, dc-link oscillation increases due to the reduced capacity value. These oscillations cause instability, overvoltage and an increase in total harmonic distortion (THD). On the other hand, the winding temperatures of these motors, which operate continuously under rated operating conditions, reach 80 degrees C. The stator resistance and rotor flux value, which change with the increase in temperature, cause these drives, controlled without sensors, to operate even more unstable. In this study, a hybrid approach is proposed to improve the performance of the inverter using a 16 mu F film capacitor at the dc-link and to reduce the THD. The active damping method regulates the inverter output voltage for DC-link voltage stabilization. A permanent magnet synchronous machine (PMSM) sensorless speed control based on stator feedforward voltage estimation and a model reference adaptive system (MRAS) based on a multiparameter estimation algorithm is performed to minimize the effects of parameter variations. As a result of the experimental studies, it is observed that the grid input current complies with the IEC61000-3-2 standard, even under severe parameter variations.
Analyzing the Cooperation Between Azerbaijan Naval Forces and Türkiye: Strategic, Operational, and Diplomatic Aspects
(2024) Çora, Hakan; Gürson, Alı Poyraz; Mikail, Elnur Hasan; Çora, Ali Nazmi
This study investigates the historical context and strategic evolution of the naval cooperation between Azerbaijan and Türkiye, highlighting its roots in the early years of Azerbaijan's independence following the dissolution of the Soviet Union. As both nations embarked on building and modernizing their naval capabilities, their partnership became a cornerstone of regional security in the Caspian and Black Seas. The study emphasizes how this cooperation has grown from initial diplomatic ties into a robust military alliance, driven by shared strategic interests and mutual security concerns. The analysis delves into the strategic significance of this partnership, focusing on its role in enhancing the stability of a geopolitically sensitive region. The Caspian Sea, with its vast energy resources, and the Black Sea, a critical maritime zone, both play pivotal roles in regional dynamics. By fostering cooperation in these areas, Azerbaijan and Türkiye not only strengthen their own defense capabilities but also contribute to broader regional security frameworks. Operationally, the collaboration between the two nations' naval forces is characterized by joint exercises, training programs, and the establishment of information-sharing mechanisms. These efforts are designed to improve the interoperability of their naval forces, allowing them to respond more effectively to potential security threats. The study also outlines key areas for future collaboration, including maritime domain awareness, counterterrorism operations, and humanitarian assistance, which could further enhance the strategic partnership. By providing a nuanced and multidimensional analysis, this study aims to offer a comprehensive understanding of the Azerbaijan-Türkiye naval cooperation. It explores the implications of this partnership for regional stability, security, and the balance of power, as well as its potential to influence future maritime and geopolitical developments in the wider region.
Anaplastic Thyroid Carcinoma
(Springer Science+Business Media, 2018) Kebudi, A.; Deveci, U.; Çitgez, B.
Anaplastic thyroid carcinoma (ATC) is a relatively uncommon highly malignant tumor originating from the follicular cells of the thyroid gland having a poor prognosis. It accounts for 2-5% of all thyroid carcinomas, and patients typically present with a rapidly growing anterior neck mass with aggressive symptoms. A 66-year-old male presented with dyspnea, neck pain, and voice changes. Ultrasonographic neck examination demonstrated an enlarged thyroid gland and substernal extension of the right thyroid lobe. Fine needle aspiration (FNA) from the thyroid nodule biopsy showed benign cytology. Because of symptomatic disease and radiologic malignancy doubt, operation has been done. Histopathologic examination with frozen section demonstrated anaplastic thyroid carcinoma. After total thyroidectomy, the patient is discharged. The patient died 20 days after the start of systemic treatment because of septic multiorgan failure derived from bronchopneumonic lung infection. In the evaluation of sudden growing neck masses in elderly patients, anaplastic thyroid cancer should be considered as a differential diagnosis, even if the needle biopsy is normal. © Springer International Publishing AG, part of Springer Nature 2019.
Antihypertensive Drug Box Sales Between January 2019 - June 2024 in Turkish Drug Market: Investigating the Drug Group and Fix-Dose Combination Sales
(Society of Pharmaceutical Sciences of Ankara (FABAD), 2025) Vural, E.H.; Gümüşel, B.
The financial and emotional burden of chronic diseases, including hypertension, has been rising. The objective of this study was to assess the trends in box sales of antihypertensive medications in Türkiye and to compare these trends across the antihypertensive medicine subgroups. This study analyzed retail and hospital box sales of antihypertensive drug groups recommended by guidelines between January 2019 and June 2024. The data used in this study were obtained from IQVIA. While antihypertensive drugs sold a total of 176,453,254 boxes in 2019, they were sold 203,690,099 boxes in 2023, a 15.44% increase. The best-selling drug group is the Renin-Angiotensin System (RAS) antagonists. Angiotensin Receptor Blocker-Diuretic fixed-dose combination (FDC) is the best-selling subgroup in the RAS antagonists. FDCs of RAS antagonists are more often used than their mono forms, and in 2022 and 2023, FDCs of calcium channel blockers have begun to outsell their combined formulations. Triple FDCs of the RAS antagonists with calcium channel blockers and diuretics have been increasing regularly. In Türkiye, drug groups that have had the highest share in the antihypertensive drug market in recent years are the groups recommended in the guidelines. Increasing the triple FDC consumption is valuable for the rational treatment of hypertension. © 2025 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.
Antioxidant Activity, Chemical Composition, and Therapeutic Activity of Essential Oils from Certain Lamiaceae Species in Türkiye
(Marmara Univ, Fac Pharmacy, 2025) Goksu Surucu, Canan; Dumlupinar, Berrak; Gurbuz, Burcak; Seker Karatoprak, Gokce; Bahtiyarca, Reyhan; Ilgun, Selen
The study examined the antioxidant, antimicrobial, and potential anticancer properties of lavandin (Lavandula x intermedia 'Grosso'), oregano (Origanum vulgare 'Ulu & gbreve; Bey'), and sage (Salvia officinalis 'Beyhekim') essential oils (EOs). Chemical analysis revealed that oregano is rich in carvacrol (81.23%), cymene (5.51%), and 18-cineole (2.13%). Sage contains notable quantities of alpha-thujone (17.47%), camphor (13.59%), and borneol (12.14%). Lavandin is predominantly composed of linalool (41.10%), linalyl acetate (16.66%), and camphor (10.01%). The antimicrobial tests demonstrated that lavandin EOs exhibited a high inhibition rate of 90.77% at 1000 pg/mL, which subsequently decreased with lower concentrations. The oregano essential oils demonstrated robust antimicrobial activity across all concentrations, with a 10.97% inhibition rate observed even at the lowest concentration. The sage EOs exhibited a rapid decline in antimicrobial activity, reaching 4.97% at the lowest concentration. Both the DPPH and ABTS assays demonstrated that the antioxidant capacity of the essential oils was concentration-dependent. The cytotoxicity values of oregano essential oil were 35.58 at 50 pg/mL, 32.39 at 25 pg/mL, and 30.92 at 12.5 pg/mL. Similar cytotoxicity results were observed for sage and lavandin essential oils. These findings indicate that plant essential oils exert a dose-dependent cytotoxic effect on cell growth, significantly inhibiting cells at high concentrations. The research indicates that essential oils derived from Lamiaceae plants exhibit robust antimicrobial effects against a range of pathogens, suggesting potential applications as alternative therapies for specific microbial infections, comparable to ciprofloxacin at certain concentrations.
Applying different machine learning algorithms to predict the viscosity behavior of MWCNT–alumina/water–ethylene glycol (80:20) hybrid antifreeze
(Elsevier B.V., 2024) Hussein, S.A.; Omar, I.; Saddam, A.B.; Baghoolizadeh, M.; Salahshour, S.; Pirmoradian, M.
While machine learning has become the new way of analyzing data, neutral networks form the basis of this revolutionary technology. In this work, we shall employ the power of neural networks to analyze and demystify the processes in nanofluids. By combining the precision of neural networks with the optimization capabilities of genetic algorithms, we aim to create a more accurate and efficient prediction model for MWCNT-alumina/water-ethylene glycol (80:20) hybrid antifreeze. Our approach entails using an MLP neural network and several training functions (LM, GD, BFGS, BN) with an adjustable number of neurons. The inputs of the network are φ (solid volume fraction or ϕ), temperature (T), and shear rate (γ), and the output is μnf of MWCNT-alumina/water-ethylene glycol (80:20) hybrid anti-freeze. To improve the accuracy of the final model, we use genetic optimization to make final adjustments to the parameters of the neural network. Utilizing the detailed analysis of the primary characteristics of these algorithms, we conclude that the BFGS function is the best to obtain neural network training. Steady performance achieved by this function—0.99828 of the R-value and RMSE value significantly equal to 0.213—illustrates good stability and accuracy of the suggested model. This work contributes to progressing the existing knowledge about the behavior of nanofluids and can stimulate further improvement in heat transfer and energy utilization. © 2024 The Author(s)
Artificial Intelligence Anxiety Levels of Faculty of Health Sciences Students and Affecting Factors
(AVES, 2025) Çoban, N.; Kar, D.; Berk, Ş.N.
Objective: Artificial intelligence (AI) technology advancements are poised to bring significant changes to the healthcare field. As the adoption of AI systems in healthcare continues to grow, there is an increasing need to equip future healthcare professionals with the necessary knowledge and skills to work effectively with these technologies. This study explores the level of anxiety related to AI and examines the factors influencing this anxiety among university students enrolled in health sciences programs. Methods: This cross-sectional study was descriptive and correlational. The study was carried out with 450 students at the İstanbul Gedik University, Faculty of Health Sciences (Department of Nursing, Physiotherapy and Rehabilitation, Child Development, Nutrition and Diet, Occupational Health and Safety). A descriptive questionnaire and an AI anxiety scale were used to obtain the research data, which were analyzed using numerical data, descriptive statistics, analysis of variance, independent groups t-test, and post-hoc analysis. Results: The mean total score on the Artificial Intelligence Anxiety Scale (AIAS) was 109.642 ± 30.452 (min = 42; max = 147). Among the sub-dimensions of the AIAS, the mean of the Learning sub-dimension was 41.096 ± 12.083 (min = 16; max = 56), the mean of the Job Change sub-dimension was 31.118 ± 9.022 (min = 12; max = 42), the mean of the Sociotechnical Blindness sub-dimension was 21.558 ± 5.892 (min = 8; max = 28), and the mean of the AI Configuration sub-dimension was 15.871 ± 4.831 (min = 6; max = 21). Conclusion: According to this study, students from the Faculty of Health Sciences had a high level of AI anxiety. Significant differences were found between students’ AI anxiety levels according to gender, their thoughts about AI, their trust in AI-based devices, their desire to change their profession because of AI, and their use of AI in patient care. © 2025 AVES. All rights reserved.
Artificial Neural Networks; Definition, Properties and Misuses
(Nova Science Publishers, Inc., 2011) Guresen, E.; Kayakutlu, G.
There are no such clear and good definitions of ANNs in the literature. Many of the definitions refer to the figures instead of well explaining the ANNs. That is why many weighted graphs (as in shortest path problem networks) fit the definition of ANN. This study aims to give a clear definition that will differentiate ANN and graphs (or networks) by referring to biological neural networks. Although there is no input choice limitation or prior assumption in ANN, sometimes researchers compare ANN achievements with the results of other methods using different input data and make comments on these results. This study also gives examples from literature to misuses, unfair comparisons and evaluates the underlying reasons which will guide researchers. © 2011 Nova Science Publishers, Inc. All rights reserved.
Assessing Parents Perception of Environmental Awareness
(Stef92 Technology Ltd, 2013) Ozyaral, O.; Ayra, F.; Kaya, E.
It is inevitable to avoid from the influences of some adversities to arise in the ecosystem as "environmental risks" on our lives. The present study aims to determine the level of perception of parents on environmental awareness and environmental protection and to raise awareness on the environmental value and protection. In the present study, the questionnaires were administered to the parents of two private kindergarten students in Ki{dotless}zi{dotless}ltoprak-Erenköy districts on the Asian side of Istanbul as well as the parents of first and second grade students of a private primary school in Umraniye district on the Asian side of Istanbul. The parents of these first and second grade students and the kindergarten students were asked to fill in these questionnaires. A questionnaire prepared by the researchers and consisting of 76 questions was administered to the parents of the kindergarten students in order to measure their parents' environmental perception, 12 of which were prepared to measure the demographic characteristics and 64 of which were prepared for the perception measurement. In the study, the relations between the socio-economic and demographic characteristics of the parents and their environmental perceptions were tried to be found out. Moreover, to what extent the parents put into practice what they know was analyzed so that it can be shown how the information acquired affects the behavior acquisition. In line with the findings obtained, the fact that the awareness of the parents themselves on environment and ecosystem should be improved so that they can transfer the proper actions and approaches they have internalized to their children was found out. Emphasizing the environmental education in every part of the life and providing this education through non-governmental organizations and the experts and the efficiency of the media in this regard were among the results. In addition, the environmental awareness studies should begin during childhood for the sustainability of the environmental awareness education and the media studies should be heavily focused on so that the socio-cultural behavior changes could be ensured in the society and the social media studies should be made. © SGEM2013 All Rights Reserved by the International Multidisciplinary Scientific GeoConference SGEM.
Assessment of 5-6 Years Old Children's Perception of Environmental Awareness & Environmental Protection
(2013) Ozyaral, O.; Karakaya, M.; Kaya, E.
The aim of this study was to identify and assess the perception of environmental awareness and protection among preschool children (4-5-6 years old), and develop education programs accordingly. To that end, we carried out a survey that consisted of 46 questions by means of face to face question-answer method. To create environmental consciousness and raise awareness of environmental protection at an early age, it is very important to make a proper assessment of answers given to the questions about the role of education in the creation of environmental awareness and environmental protection, when and how such education should take place, and from where such education should be received to achieve higher efficiency. In this context, the answers to the aforementioned questions will help us develop healthy methods to create environmental consciousness, raise realistic, permanent awareness of environmental protection, and instill good habits. The subjects of the study were 37 children, who were attending research-based preschool institutions resident in the districts of Ki{dotless}zi{dotless}ltoprak-Erenköy on the Anatolian Side of Istanbul. The children were at the same time attending regular preschool institutions. Within the scope of the study, we identified the parents' level of education as well as the children's perception levels about environment and environmental pollution (air pollution, water pollution, noise pollution, soil, and recycling), information sources, lifestyles, and habits. The study revealed that, along with the parents' educational background, the education received from preschool institutions and mass media play a significant, efficient role in the creation of environmental consciousness and awareness of environmental protection among children, and that we need to develop more efficient means of education. © SGEM2013 All Rights Reserved by the International Multidisciplinary Scientific GeoConference SGEM.
Assessment of Stiffness-Dependent Autophagosome Formation and Apoptosis in Embryonal Rhabdomyosarcoma Tumor Cells
(2025) Sezen, S.; Adiguzel, S.; Zarepour, A.; Khosravi, A.; Gordon, J.W.; Ghavami, S.; Zarrabi, A.
Remodeling of the extracellular matrix (ECM) eventually causes the stiffening of tumors and changes to the microenvironment. The stiffening alters the biological processes in cancer cells due to altered signaling through cell surface receptors. Autophagy, a key catabolic process in normal and cancer cells, is thought to be involved in mechano-transduction and the level of autophagy is probably stiffness-dependent. Here, we provide a methodology to study the effect of matrix stiffness on autophagy in embryonal rhabdomyosarcoma cells. To mimic stiffness, we seeded cells on GelMA hydrogel matrices with defined stiffness and evaluated autophagy-related endpoints. We also evaluated autophagy-dependent pathways, apoptosis, and cell viability. Specifically, we utilized immunocytochemistry and confocal microscopy to track autophagosome formation through LC3 lipidation. This approach suggests that the use of GelMA hydrogels with defined stiffness represents a novel method to evaluate the role of autophagy in embryonal rhabdomyosarcoma and other cancer cells. © 2024. Springer Science+Business Media, LLC.
The AsSociation Between Monocyte/HDL-C Ratio and Heart Failure
(Marmara Univ, Fac Pharmacy, 2025) Cattik, Busra Nur; Aksoy, Nilay; Berk, Barkin; Gungor, Baris
The monocyte/HDL-cholesterol ratio (MHR) was shown to be a marker of inflammation. This study investigated the utilization of this ratio as a measure of severity for heart failure which is a condition asSociated with inflammation. The MHR was calculated for 323 ambulatory patients with chronic heart failure and compared to other variables asSociated with the severity of the condition. Additionally, the impact of MHR on the Seattle Heart Failure Model (SHFM) score was investigated. MHR correlated positively with C-reactive protein (r: 0.312, p<0.001) and neutrophil-to-lymphocyte ratio (r: 0.242, p<0.001), but not with platelet-to-lymphocyte ratio. In addition, a correlation was found between the SHFM score and MHR (r:-0.267, p<0.001). The SHFM score exhibited a significant result for proB-type natriuretic peptide (pro-BNP) (p<0.001), neutrophil (p<0.001), hematocrit (p=0.001), and serum creatinine (p=0.001) in the ordinal logistic regression analysis, but not for MHR. MHR showed a negative correlation with left ventricular ejection fraction (r:-0.151, p: 0.007), exhibited a positive asSociation with pro-BNP (r: 0.184, p<0.001), and no correlation with New York Heart AsSociation classes. There is a significant correlation between the MHR value and the factors asSociated with the severity of heart failure. The prognosis and management of this condition may be assessed by utilizing the MHR value in conjunction with existing biomarkers.
Asthmatic Patients: Is Homocysteine an Issue
(Galenos Publ House, 2024) Keskinel, İlkay; Eryilmaz, Müzeyyen; Güntürk, Arzu
Objective: Understanding the causes of asthma is crucial for developing new therapeutic modalities. Homocysteine (HCY) is an intermediate in methionine metabolism. Elevated HCY levels may indicate folate and vitamin B12 deficiencies, which are cofactors for the methylation of HCY to methionine. The relationship between hyperHCY mia and atherosclerosis is well-documented, and it is considered a cause of cardiovascular, neurodegenerative, and ocular diseases. HyperHCY mia may also cause atopy and, consequently, asthma. We aimed to evaluate the levels of HCY, vitamin B12, and folic acid in asthmatic patients and healthy adults, as well as to determine whether correlations exist between these levels and lung function, eosinophil counts, total immunoglobulin E (IgE), and eosinophilic cationic protein (ECP) levels in asthmatic subjects. Methods: A total of 142 asthmatic patients and 36 healthy controls were enrolled in the study. Folic acid, vitamin B12, total IgE, ECP, eosinophil percentage, eosinophil counts, and HCY levels were evaluated in both groups. Results: HCY, vitamin B12, and folic acid levels did not significantly differ between patients with asthma and controls. There was a statistically significant positive correlation (at the 0.95 confidence level) between HCY values and forced vital capacity, peak expiratory flow (PEF), and eosinophil counts in patients with asthma. Folic acid levels correlated positively only with PEF%, whereas vitamin B12 levels did not correlate with any functional parameters or atopic markers like IgE and ECP. Conclusion: Should large-scale randomized controlled trials conclusively establish HCY as a causative factor of asthma, metabolic interventions to lower HCY levels using methyl donors could be considered alongside conventional asthma treatments.
The Atomic and Thermal Performance of CuO Nanoparticles/Paraffin as Phase Change Materials in a Circular Tube: Molecular Dynamics Simulation Approach
(Elsevier B.V., 2025) Al-Timimy, S.Q.; Hassan, W.H.; Singh, N.S.S.; Naser, G.F.; Salahshour, S.; Sajadi, S.M.; Hekmatifar, M.
Background: Using molecular dynamics simulation, this study investigates the effect of CuO nanoparticle addition on the thermodynamic and atomic properties of an octadecane that was being utilized as a phase change material within a circular tube. Methods: The results indicate that the density (D) was greatest in the vicinity of the tube walls. At its peak, D was 0.0300 atoms per square centimeter. This behavior is due to the increased attractive force that is between the structure's boundaries and its particles. Particle velocity (V) values reached their utmost attainable values in the intermediate regions of the tube, where movement was greatest. At its peak, V was 0.0078 Å/fs. The tube exhibits a maximum temperature (Max T) value of 754.43 K at its midpoint. Significant Findings: Due to the increased particle motion in the intermediate regions, the investigated structure experienced a greater number of collisions in those areas. After 10 ns, the sample's heat flux, thermal conductivity, and thermal stability converged to values of 3.94 W/m2, 1.38 W/mK, and 1821 K, respectively. The structure showed charging and discharging times of 6.41 and 7.15 ns, respectively. © 2025 Elsevier B.V.

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