Altunkaynak, Berrin Zühal
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Name Variants
Berrin Z. Altunkaynak
Berrin Zühal, Altunkaynak
Altunkaynak, Berrin
ALTUNKAYNAK Berrin Zühal
Altunkaynak, Berrin Zühal
Berrin Zühal ALTUNKAYNAK
Altunkaynak, Zuhal
Altunkaynak Berrin Zuhal
Altunkaynak, B.
Altunkaynak Berrin Zühal
B. Zühal Altunkaynak
B. Z. ALTUNKAYNAK
ALTUNKAYNAK Berrin Zuhal
Berrin Zühal Altunkaynak
Zuhal Altunkaynak B.
Berrin Zuhal Altunkaynak
B. Zuhal Altunkaynak
Altunkaynak B.
Altunkaynak, Zühal
B. Z. Altunkaynak
Berrin Zuhal ALTUNKAYNAK
Altunkaynak, Z.
Altunkaynak, B. Z.
Altunkaynak, Berrin Zuhal
Altunkaynak,B.Z.
Berrin Zühal, Altunkaynak
Altunkaynak, Berrin
ALTUNKAYNAK Berrin Zühal
Altunkaynak, Berrin Zühal
Berrin Zühal ALTUNKAYNAK
Altunkaynak, Zuhal
Altunkaynak Berrin Zuhal
Altunkaynak, B.
Altunkaynak Berrin Zühal
B. Zühal Altunkaynak
B. Z. ALTUNKAYNAK
ALTUNKAYNAK Berrin Zuhal
Berrin Zühal Altunkaynak
Zuhal Altunkaynak B.
Berrin Zuhal Altunkaynak
B. Zuhal Altunkaynak
Altunkaynak B.
Altunkaynak, Zühal
B. Z. Altunkaynak
Berrin Zuhal ALTUNKAYNAK
Altunkaynak, Z.
Altunkaynak, B. Z.
Altunkaynak, Berrin Zuhal
Altunkaynak,B.Z.
Job Title
Prof.Dr.
Email Address
zuhal.altunkaynak@okan.edu.tr
Main Affiliation
Histoloji ve Embriyoloji / Histology and Embriology
Status
Website
ORCID ID
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
Scholarly Output
31
Articles
28
Citation Count
0
Supervised Theses
0
4 results
Scholarly Output Search Results
Now showing 1 - 4 of 4
Article Citation - WoS: 12Citation - Scopus: 13Hippocampal neural cell loss in high-fat diet-induced obese rats-exploring the protein networks, ultrastructure, biochemical and bioinformatical markers(Elsevier, 2021) Alkan, Isinsu; Altunkaynak, Berrin Zuhal; Gultekin, Guldal Inal; Baycu, Cengiz; Histoloji ve Embriyoloji / Histology and Embriology; Fizyoloji / PhysiologyObjective: Obesity, which has become one of the main health problems, results from irregular and unhealthy nutrition. In particular, an increase in the intake of high-fat foods leads to obesity and associated disorders. It is noteworthy to specify that obese individuals have memory problems. This study aims to examine the effects of high-fat diet on hippocampus, with stereological, histopathological methods and STRING bioinformatic tool. Methods: Female Adult Sprague Dawley rats (n = 20) were equally divided into control (CONT) and high-fat diet (HFD) groups. The control group was given standard rat pellet feed, while the high-fat diet group was fed with a 40 % fat content for 2 months. Following the feeding program, rats were sacrificed. The collected blood samples were analyzed biochemically to determine the level of oxidative stress while performing a stereological and histopathological examination of the brain tissues. Functional protein-protein networks for BDNF, C-Fos, CAT, LPO, SOD and MPO by gene ontology (GO) enrichment analysis were evaluated. Findings: The number of neurons decreased in the HFD group compared to the CONT group. Damage to the histological structure of the hippocampus region; such as degenerate neurons, damaged mitochondria and extended cisterns of the endoplasmic reticulum was observed. Although C-Fos level and oxidative stress parameters increased in HFD group, BDNF level decreased. While BDNF and C-Fos were observed in pathways related to neuron death, oxidative stress and memory, BDNF was pronounced in the mitochondria, and C-Fos in the endoplasmic reticulum. Discussion: This study shows that changes in both BDNF and C-Fos levels in obesity due to high-fat diet increase oxidative stress and cause neuron damage in the hippocampus.Article Citation - WoS: 1Citation - Scopus: 1The effects of myricitrin and chebulinic acid on the rat hippocampus exposed to gamma radiation: A stereological, histochemical and biochemical study(Elsevier, 2023) Uzun, Sumeyye Gumus; Altunkaynak, Berrin Zuhal; Alkan, Isinsu; Histoloji ve Embriyoloji / Histology and EmbriologyAim: Gamma radiation, a form of ionizing radiation, is used in many different areas, especially in the health field and in the treatment of cancer. However, gamma radiation used for therapeutic purposes also has numerous harmful effects on human health. This study was planned to investigate the impacts of exposure to gamma ra-diation on the hippocampal area and the preventive effects of myricitrin and chebulinic acid against that damage.Material and method: Thirty-six male Wistar albino rats were randomly divided into six groups. The control group was exposed to no treatment. The chebulinic acid and myricitrin groups were injected with the relevant drug at a dosage of 0.033 mg/kg) (vehicle; normal saline) per day. The gamma groups were placed in a plexiglass test setup with their heads positioned close to the source. The subjects were exposed to radiation with a mixed source containing radioactive Cs-137 and Co-60 isotopes obtained from Ondokuz Mayis University Physics Department Nuclear Physics Laboratory for 1 h. Gamma radiation was applied 16 mGy for one hour per day for 10 days. The gamma radiation+chebulinic acid and the gamma radiation myricitrin groups also received 0.033 mg/kg per day of these drugs via injection. Immediately after the experimental procedure, all animals were subjected to behavioural tests, and perfused brain tissues were analyzed using stereological methods.Results: Stereological analysis showed that gamma radiation caused a decrease in the numbers of neurons in the hippocampal area (p < 0.01; One-way ANOVA) and that chebulinic acid and myricitrin reduced this decrease (p < 0.01; One-way ANOVA). Decreases in learning and memory capacity were detected in behavioural tests in rats from the Gamma group.Conclusion: The study findings showed that that the adverse health effects of Gamma radiation can be amelio-rated using myricitrin and chebulinic acid. Myricitrin was more effective in terms of cell proliferation and defence against oxidative stress than chebulinic acid, and exhibited a more neuroprotective effect. However, more detailed analyses should be performed before using either antioxidant for therapeutic purposes.Article Citation - WoS: 0Citation - Scopus: 1Is vagal stimulation or inhibition benefit on the regulation of the stomach brain axis in obesity?(Taylor & Francis Ltd, 2022) Alkan, Isinsu; Altunkaynak, Berrin Zuhal; Kivrak, Elfide Gizem; Kaplan, Arife Ahsen; Arslan, Gulay; Histoloji ve Embriyoloji / Histology and EmbriologyObjective:Possible effects of the vagus inhibition and stimulation on the hypothalamic nuclei, myenteric plexes and the vagus nerve were investigated. Methods:The female rats divided to the inhibition (INH), stimulation (STI) and, sham (SHAM) groups were fed with high fat diet (including 40% of energy from animal fat). After nine weeks, the rats were allowed to recover for 4 weeks in INH group. In STI group, the left vagus nerve stimulated (30 Hz/500 msn/30 sec.) starting 2nd post operative day for 5 minutes during 4 weeks. Healthy female rats used as control (CONT). Then, tissue samples were analyzed by biochemical, histological and stereological methods. Results:The mean number of the neurons in the arcuate nucleus of the INH group was significantly less; but, that is significantly more in the STI group compared to the other groups. The neuronal density of ventromedial nucleus in the STI group was higher; while the density in the INH group was lower than the other groups. In the dorsomedial nucleus, neuron density of the INH group was lower than the other groups. In terms of the myenteric plexus volumes, that of the INH group was lowest. The myelinated axon number in the INH group was significantly highest. The myelin sheath thickness and axon area of the INH group was significantly lower than the other groups. Discussion:The results of the study show that the vagal inhibition is more effective than the vagal stimulation on the weight loss in the obesity.Article Citation - WoS: 1Citation - Scopus: 1Potential Effects of Stem Cells Derived from the Peripheral Nerve and Adipose Tissue after the Nerve Crush Injury in Control and Obese Rats(Taylor & Francis inc, 2022) Kustepe, Elif Kayhan; Altunkaynak, Berrin Zuhal; Alkan, Isinsu; Kivrak, Elfide Gizem; Yildiran, Alisan; Geuna, Stefano; Histoloji ve Embriyoloji / Histology and EmbriologyAim of this study is to investigate effects of stem cells derived from the peripheral nerve and adipose tissues following the nerve crush injury in control and obese rats. For this aim, 41 Wistar Albino female rats were separated into eight equal groups; non-obese control (NOC) obese control (OC), non-obese injury (NOH), obese injury (OH), non-obese adipose (NOY), obese adipose (OY), non-obese nerve (NOPS), obese nerve (OPS). At the end of 8 weeks, all experimental animals without control groups were subjected to nerve crush procedure and sciatic nerve or fat stem cell homogenates were injected on the treatment group rats, and then, recovery process has been observed and histopathological, stereological, electrophysiological analyses and bioinformatic evaluation were made on removed sciatic nerves. Stereological results showed that adipose homogenate gave more successful results than peripheral nerve homogenates in the NOY group in comparison to the NOPS group in terms of myelinated axon number. Peripheral nerve homogenate has shown more successful results in the OPS group in comparison to the OY group. The number of unmyelinated axons was increased following treatment with adipose tissue homogenate in NOY and OY groups. In terms of myelin sheath thickness; we detected that treatments by peripheral nerve and especially adipose tissue homogenates lead to increase in the thickness of the axons of the peripheral nerves belong to the control and obese injury groups. All results showed that mesenchymal stem cell treatment by fresh tissue homogenates is successful in peripheral nerve regeneration and fat tissue is a considerable source of the stem cells for clinical applications.
