Effects of polyamine synthesis enzymes on angiogenesis and apoptosis during endometriosis
No Thumbnail Available
Date
2023
Journal Title
Journal ISSN
Volume Title
Publisher
Via Medica
Open Access Color
OpenAIRE Downloads
OpenAIRE Views
Abstract
Objectives: Since we assumed that endometriosis is a benign cell division disorder, our study was conducted to investi-gate the effects of the relationships between polyamine synthesis and angiogenesis in the formation of endometriosis. Material and methods: Thirty-five patients with endometriosis and 35 healthy female women were included in the study. The patient and the control groups were compared regarding the blood levels of agmatine, argininecarboxylase (ADC), ornithinecarboxylase (ODC), agmatinase, arginase, ornithine, and the vascular endothelial growth factor (VEGF). Results: There is a statistically significant difference between the patient and the control groups regarding the agmatinase, arginase and VEGF levels (higher in the patient group) (p < 0.05). There is no statistically significant difference between the patient and the control groups regarding the ODC, ornithine and the ADC levels (p > 0.05). There is a statistically significant difference between the patient and the control groups regarding the agmatine levels (higher in the control group) (p < 0.05). Conclusions: The increase in the serum levels of polyamine synthesis enzymes may contribute to the formation of endometriosis. It is anticipated that the study of the relationship between enzymes and molecules in the polyamine synthesis pathway and angiogenesis in patients with endometriosis will contribute to the literature.
Description
KURT, BEGUM/0000-0002-7166-3130
ORCID
Keywords
angiogenesis, apoptosis, endometriosis, polyamine
Turkish CoHE Thesis Center URL
Fields of Science
Citation
0
WoS Q
Q4
Scopus Q
Q3
Source
Volume
94
Issue
2
Start Page
89
End Page
94