Investigation of the Relationship Between HMGB1 and Obesity in the Adrenal Gland

dc.contributor.authorAltunkaynak, Berrin Zühal
dc.contributor.authorIşınsu Aydın Alkan
dc.contributor.authorEmin Oztas
dc.contributor.authorBerrin Zuhal ALTUNKAYNAK
dc.contributor.authorAdem KOCAMAN
dc.contributor.otherHistoloji ve Embriyoloji / Histology and Embriology
dc.date.accessioned2024-05-25T12:21:26Z
dc.date.available2024-05-25T12:21:26Z
dc.date.issued2022
dc.departmentOkan Universityen_US
dc.department-tempGülhane Askeri Hastanesi, Histoloji ve Embriyoloji Anabilim Dalı, Ankara, Türkiye Nevşehir Hacı Bektaş Veli Üniversitesi, Diş Hekimliği Fakültesi, Temel Bilimler Bölümü, Nevşehir, Türkiye Gülhane Askeri Hastanesi, Histoloji ve Embriyoloji Anabilim Dalı, Ankara, Türkiye Okan Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, İstanbul, Türkiye Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Samsun, Türkiyeen_US
dc.description.abstractAim: The interaction between obesity and increased production of pro-inflammatory cytokines results the existence of inflammation HMGB1 secreted from the adrenal gland can play a role in inflammation pathways. The aim of this study is to explain the link between HMGB1 and obesity in the adrenal gland. Material and Methods: In this study; eighteen female Wistar Albino rats were divided into two groups: untreated control group (n=8) and obese group (n=10). The rats in obese group were fed with high fat diet for ten weeks. Morphometric parameters of adrenal gland were assessed by using stereological techniques. The expression of high mobility group box protein 1 (HMGB1) in adrenal gland was evaluated. Results: At the end of the analyses; mean volumes of zona fasciculate, zona reticularis, and medulla were significantly increased in obese group. Also, the number of HMGB1 stained cells was significantly increased in the obese group in comparison to control group.Conclusion: The results suggest that obesity may be one of the reasons of inflammation and hypertrophy in the adrenal gland. HMGB1 may provide a novel perspective into the anti-inflammatory therapeutic strategies in obese patients.en_US
dc.identifier.citation0
dc.identifier.doi10.37990/medr.1087598
dc.identifier.endpage250en_US
dc.identifier.issn2687-4555
dc.identifier.issue2en_US
dc.identifier.startpage242en_US
dc.identifier.trdizinid1124958
dc.identifier.urihttps://doi.org/10.37990/medr.1087598
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1124958/investigation-of-the-relationship-between-hmgb1-and-obesity-in-the-adrenal-gland
dc.identifier.urihttps://hdl.handle.net/20.500.14517/2021
dc.identifier.volume4en_US
dc.institutionauthorAltunkaynak, Berrin Zühal
dc.language.isoen
dc.relation.ispartofMedical records-international medical journal (Online)en_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleInvestigation of the Relationship Between HMGB1 and Obesity in the Adrenal Glanden_US
dc.typeArticleen_US
dspace.entity.typePublication
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