Biochemical, immunohistochemical and morphometrical investigation of the effect of thymoquinone on the rat testis following exposure to a 900-MHz electromagnetic field

dc.authorid Yahyazadeh, Ahmad/0000-0002-6093-3588
dc.authorscopusid 56521486700
dc.authorscopusid 15063935100
dc.authorscopusid 7403238396
dc.authorwosid Kaplan, Suleyman/A-5396-2008
dc.authorwosid Yahyazadeh, Ahmad/AED-6755-2022
dc.contributor.author Yahyazadeh, Ahmad
dc.contributor.author Altunkaynak, Berrin Zuhal
dc.contributor.author Kaplan, Suleyman
dc.date.accessioned 2024-05-25T11:39:55Z
dc.date.available 2024-05-25T11:39:55Z
dc.date.issued 2020
dc.department Okan University en_US
dc.department-temp [Yahyazadeh, Ahmad] Karabuk Univ, Fac Med, Dept Histol & Embryol, Karabuk, Turkey; [Altunkaynak, Berrin Zuhal] Okan Univ, Fac Med, Dept Histol & Embryol, Istanbul, Turkey; [Kaplan, Suleyman] Ondokuz Mayis Univ, Fac Med, Dept Histol & Embryol, Samsun, Turkey en_US
dc.description Yahyazadeh, Ahmad/0000-0002-6093-3588 en_US
dc.description.abstract Long-term use of cell phones emitting electromagnetic fields (EMFs) have raised concerns regarding public health in recent year. We aimed to investigate the possible effects of 900 MHz EMF exposure (60 min/day for 28 days) on the rat testis. Another objective was to determine whether the deleterious effect of EMF radiation would be reduced by the administration of thymoquinone (TQ) (10 mg/kg/day). Twenty-four male adult Wistar albino rats were randomly selected, then assigned into four groups as followControl, EMF, TQ and EMF + TQ. Testicular samples were analyzed using histological, stereological, biochemical and immunohistochemical techniques. Total numbers of primary spermatocytes and spermatids as well as Leydig cells were significantly decreased in the EMF group compared to the Control group (p < 0.05). In the EMF + TQ group, the total number of primary spermatocytes was significantly increased compared to the EMF group (p < 0.05). Superoxide dismutase (SOD) activity was significantly increased in the EMF group compared to the Control group (p< 0.05). Also, serum testosterone levels and wet weight of testes were significantly decreased in the EMF group compared to the Control group (p < 0.05). Our findings suggested that exposure to a 900 MHz EMF had adverse effects on rat testicular tissue and that the administration of TQ partially mitigated testicular oxidative damages caused by EMF radiation. en_US
dc.description.sponsorship Ondokuz Mayis University Project Management Office [TIP 1904.14.018] en_US
dc.description.sponsorship This research was supported by the Ondokuz Mayis University Project Management Office (TIP 1904.14.018). en_US
dc.identifier.citationcount 14
dc.identifier.doi 10.1016/j.acthis.2019.151467
dc.identifier.issn 0065-1281
dc.identifier.issn 1618-0372
dc.identifier.issue 1 en_US
dc.identifier.pmid 31784235
dc.identifier.scopus 2-s2.0-85075855939
dc.identifier.scopusquality Q3
dc.identifier.uri https://doi.org/10.1016/j.acthis.2019.151467
dc.identifier.uri https://hdl.handle.net/20.500.14517/1365
dc.identifier.volume 122 en_US
dc.identifier.wos WOS:000527877500015
dc.identifier.wosquality Q4
dc.language.iso en
dc.publisher Elsevier Gmbh en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 18
dc.subject Electromagnetic field en_US
dc.subject Immunohistochemistry en_US
dc.subject Superoxide dismutase en_US
dc.subject Thymoquinone en_US
dc.subject Rat en_US
dc.subject Testis en_US
dc.title Biochemical, immunohistochemical and morphometrical investigation of the effect of thymoquinone on the rat testis following exposure to a 900-MHz electromagnetic field en_US
dc.type Article en_US
dc.wos.citedbyCount 15
dspace.entity.type Publication

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