Increased frequency of class I and II anti-human leukocyte antigen antibodies in systemic lupus erythematosus and scleroderma and associated factors: a comparative study
dc.authorid | Yazar, Metin/0000-0002-2657-3072 | |
dc.authorid | Gürkan, Hakan/0000-0002-8967-6124 | |
dc.authorid | SARI, Gulce/0000-0002-8585-5889 | |
dc.authorscopusid | 6504396778 | |
dc.authorscopusid | 7003635356 | |
dc.authorscopusid | 56418402500 | |
dc.authorscopusid | 54887131700 | |
dc.authorscopusid | 56417822000 | |
dc.authorscopusid | 6507263173 | |
dc.authorscopusid | 56418533400 | |
dc.authorwosid | Yazar, Metin/ABA-3934-2020 | |
dc.authorwosid | Gürkan, Hakan/AAF-2866-2020 | |
dc.contributor.author | Tozkir, Hilmi | |
dc.contributor.author | Yazar, Metin | |
dc.contributor.author | Duymaz, Julide | |
dc.contributor.author | Gurkan, Hakan | |
dc.contributor.author | Yazar, Metin | |
dc.contributor.author | Sari, Gulce | |
dc.contributor.author | Pamuk, Gulsum Emel | |
dc.contributor.other | Genetik ve Biyomühendislik / Genetic and Bio-Engineering | |
dc.date.accessioned | 2024-05-25T11:17:01Z | |
dc.date.available | 2024-05-25T11:17:01Z | |
dc.date.issued | 2016 | |
dc.department | Okan University | en_US |
dc.department-temp | [Tozkir, Hilmi; Gurkan, Hakan; Yazar, Metin] Trakya Univ, Dept Med Genet, Fac Med, Edirne, Turkey; [Pamuk, Omer Nuri] Trakya Univ, Dept Rheumatol, Fac Med, Edirne, Turkey; [Duymaz, Julide] Trakya Univ, Hlth Serv Vocat Coll, Edirne, Turkey; [Sari, Gulce] Okan Univ, Dept Genet & Bioengn, Istanbul, Turkey; [Tanrikulu, Hazel] Trakya Univ, Fac Med, Edirne, Turkey; [Pamuk, Gulsum Emel] Trakya Univ, Dept Hematol, Fac Med, Edirne, Turkey | en_US |
dc.description | Yazar, Metin/0000-0002-2657-3072; Gürkan, Hakan/0000-0002-8967-6124; SARI, Gulce/0000-0002-8585-5889 | en_US |
dc.description.abstract | Aim: There is significant autoantibody production in systemic lupus erythematosus (SLE) and scleroderma (SSc); microchimerism is also thought to play a role in pathogenesis. We determined the frequency of anti-HLA antibodies in SLE and SSc patients and evaluated associated clinical factors. Methods: We included 77 SLE patients, 46 SSc patients and 53 healthy controls into the study. Clinical data about the patients were obtained from hospital records. Anti-human leukocyte (anti-HLA) antigen antibody analysis of sera was performed by applying Lifecodes anti-HLA Class I and Class II Screening kits based on xMAP technology. Results: The frequencies of class I and II anti-HLA antibodies were significantly higher in SLE (27.3% and 41.6%) and SSc (26.1% and 41.3%) groups than in healthy controls (1.9% and 5.7%) (all P < 0.001). Frequencies of thrombocytopenia (P = 0.021), anti-ribonucleoprotein (P = 0.037) and anti-Ro (P = 0.027) were significantly higher in the class I antibody-positive SLE group; however, pericarditis was less frequent (P = 0.05). On the other hand, the class II antibody-positive SLE group had more frequent anti-ribosomal P antibody (P = 0.038), but less frequent active disease (P = 0.038). In the SSc group, class I antibody-positive patients had more frequent digital ulcers (P = 0.048) and anti-centromere antibodies (P = 0.01). There was no association of anti-HLA antibodies with pulmonary hypertension and interstitial fibrosis in SSc patients. Conclusions: Both class I and class II antibodies were found to be significantly increased in SLE and SSc. Rather than major organ involvement, anti-HLA antibodies were associated with the presence of other antibodies in both diseases. | en_US |
dc.description.sponsorship | Trakya University Scientific Research Fund (TUBAP), Edirne, Turkey | en_US |
dc.description.sponsorship | This study was supported by a grant from the Trakya University Scientific Research Fund (TUBAP), Edirne, Turkey. | en_US |
dc.identifier.citation | 7 | |
dc.identifier.doi | 10.1111/1756-185X.12484 | |
dc.identifier.endpage | 1309 | en_US |
dc.identifier.issn | 1756-1841 | |
dc.identifier.issn | 1756-185X | |
dc.identifier.issue | 12 | en_US |
dc.identifier.pmid | 25292400 | |
dc.identifier.scopus | 2-s2.0-84910604305 | |
dc.identifier.scopusquality | Q3 | |
dc.identifier.startpage | 1304 | en_US |
dc.identifier.uri | https://doi.org/10.1111/1756-185X.12484 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14517/209 | |
dc.identifier.volume | 19 | en_US |
dc.identifier.wos | WOS:000398230800012 | |
dc.identifier.wosquality | Q3 | |
dc.institutionauthor | Yazar M. | |
dc.language.iso | en | |
dc.publisher | Wiley | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | anti-HLA class I antibody | en_US |
dc.subject | anti-HLA class II antibody | en_US |
dc.subject | scleroderma | en_US |
dc.subject | systemic lupus erythematosus | en_US |
dc.title | Increased frequency of class I and II anti-human leukocyte antigen antibodies in systemic lupus erythematosus and scleroderma and associated factors: a comparative study | en_US |
dc.type | Article | en_US |
dspace.entity.type | Publication | |
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