VOLTAMMETRIC DETERMINATION OF VARDENAFIL ON MODIFIED ELECTRODES CONSTRUCTED BY GRAPHITE, METAL OXIDES AND FUNCTIONALIZED MULTI-WALLED CARBON NANOTUBES

dc.authorid Demir, Ersin/0000-0001-9180-0609
dc.authorid BOZAL-PALABIYIK, BURCIN/0000-0002-2525-4192
dc.authorid Uslu, Bengi/0000-0002-7327-4913
dc.authorscopusid 55910480000
dc.authorscopusid 55544573600
dc.authorscopusid 7004051343
dc.authorscopusid 6602858808
dc.authorwosid Uslu, Bengi/B-7488-2012
dc.authorwosid Demir, Ersin/V-6633-2019
dc.authorwosid BOZAL-PALABIYIK, BURCIN/AAH-6176-2020
dc.contributor.author Demir, Ersin
dc.contributor.author Bozal-Palabiyik, Burcin
dc.contributor.author Uslu, Bengi
dc.contributor.author Inam, Recai
dc.date.accessioned 2024-05-25T11:41:06Z
dc.date.available 2024-05-25T11:41:06Z
dc.date.issued 2019
dc.department Okan University en_US
dc.department-temp [Demir, Ersin] Okan Univ, Fac Engn, Dept Food Engn, TR-34959 Istanbul, Turkey; [Demir, Ersin; Inam, Recai] Gazi Univ, Fac Sci, Dept Chem, TR-06500 Ankara, Turkey; [Bozal-Palabiyik, Burcin; Uslu, Bengi] Ankara Univ, Fac Pharm, Dept Analyt Chem, TR-06100 Ankara, Turkey en_US
dc.description Demir, Ersin/0000-0001-9180-0609; BOZAL-PALABIYIK, BURCIN/0000-0002-2525-4192; Uslu, Bengi/0000-0002-7327-4913 en_US
dc.description.abstract The voltammetric behavior of the vardenafil was investigated by means of square wave stripping voltammetry (SWSV), differential pulse stripping voltammetry (DPSV) and cyclic voltammetry (CV) on the modified electrodes constructed by graphite, metal oxide and functionalized multi-walled carbon nanotubes (MWCNT).Different experimental conditions were optimized such as pH and electrolyte type, accumulation potential and accumulation time for both techniques and step potential, pulse amplitude and frequency for SWSV. In the optimum conditions a linear relationship has been constructed in the concentration range of 0.02 to 1.0 mg/L and 0.01 to 0.5 mg/L for SWSV and DPSV in pH 3.0 phosphate buffer solution, respectively. Limit of detection (LOD) values for vardenafil determinations were13.6 mu g/L and 4.38 mu g/L for SWSV and DPSV, respectively. Quantifications were performed on commercial pharmaceutical tablets and synthetic blood serum using both techniques. The relative errors were +5.0% and -3.0% for SWSV and DPSV, respectively in the determination of vardenafil active ingredient in Levitra (R) tablet. SWS and DPS voltammetric determination of synthetic blood serum spiked with 50.0 mu g/L vardenafil exhibited 100.8% and 104.4% recovery, respectively. Interference effects of some organic species such as ascorbic acid, uric acid, dopamine, glucose have also been investigated. en_US
dc.description.sponsorship Ankara University Scientific Research Project Foundation [16H0237007] en_US
dc.description.sponsorship This work was supported by a grant from Ankara University Scientific Research Project Foundation (No: 16H0237007), Turkey. en_US
dc.identifier.citationcount 6
dc.identifier.doi 10.33224/rrch.2019.64.1.04
dc.identifier.endpage 54 en_US
dc.identifier.issn 0035-3930
dc.identifier.issue 1 en_US
dc.identifier.scopus 2-s2.0-85069639214
dc.identifier.scopusquality Q4
dc.identifier.startpage 45 en_US
dc.identifier.uri https://doi.org/10.33224/rrch.2019.64.1.04
dc.identifier.uri https://hdl.handle.net/20.500.14517/1478
dc.identifier.volume 64 en_US
dc.identifier.wos WOS:000472724000004
dc.identifier.wosquality Q4
dc.language.iso en
dc.publisher Editura Acad Romane en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 6
dc.subject Vardenafil en_US
dc.subject voltammetry en_US
dc.subject determination en_US
dc.subject graphite en_US
dc.subject metal oxide en_US
dc.subject functionalized multi-walled carbon nanotubes en_US
dc.title VOLTAMMETRIC DETERMINATION OF VARDENAFIL ON MODIFIED ELECTRODES CONSTRUCTED BY GRAPHITE, METAL OXIDES AND FUNCTIONALIZED MULTI-WALLED CARBON NANOTUBES en_US
dc.type Article en_US
dc.wos.citedbyCount 5

Files