The Histological Effects of Ozone Therapy on Sciatic Nerve Crush Injury in Rats

dc.authoridHakan, Tayfun/0000-0003-1444-7076
dc.authoridHakan, Tayfun/0000-0003-1444-7076
dc.authoridOrakdogen, Metin/0000-0002-9395-2902
dc.authorscopusid12753757000
dc.authorscopusid54966854500
dc.authorscopusid6603773561
dc.authorscopusid55968913100
dc.authorscopusid57191982399
dc.authorscopusid6602786070
dc.authorscopusid6602786070
dc.authorwosidHakan, Tayfun/O-9979-2019
dc.authorwosidHakan, Tayfun/P-8626-2015
dc.authorwosidUSLU, SERAP/AAG-5479-2019
dc.authorwosidince, ümit/T-8783-2017
dc.contributor.authorSomay, Hakan
dc.contributor.authorEmon, Selin Tural
dc.contributor.authorUslu, Serap
dc.contributor.authorOrakdogen, Metin
dc.contributor.authorMeric, Zeynep Cingu
dc.contributor.authorInce, Umit
dc.contributor.authorHakan, Tayfun
dc.date.accessioned2024-05-25T11:20:37Z
dc.date.available2024-05-25T11:20:37Z
dc.date.issued2017
dc.departmentOkan Universityen_US
dc.department-temp[Somay, Hakan; Emon, Selin Tural; Orakdogen, Metin] Haydarpasa Numune Training & Res Hosp, Dept Neurosurg, Istanbul, Turkey; [Uslu, Serap] Medeniyet Univ, Sch Med, Dept Histol & Embryol, Istanbul, Turkey; [Meric, Zeynep Cingu] Private Ozone Ctr, Istanbul, Turkey; [Ince, Umit] Acibadem Univ, Sch Med, Dept Pathol, Istanbul, Turkey; [Hakan, Tayfun] Okan Univ, Vocat Sch Hlth Serv, Istanbul, Turkeyen_US
dc.descriptionHakan, Tayfun/0000-0003-1444-7076; Hakan, Tayfun/0000-0003-1444-7076; Orakdogen, Metin/0000-0002-9395-2902en_US
dc.description.abstractOBJECTIVE: Peripheral nerve injury is a common, important problem that lacks a definitive, effective treatment. It can cause neurologic deficits ranging from paresthesia to paralysis. This study evaluated the effect of ozone therapy on sciatic nerve crush injury in rats. MATERIALS AND METHODS: Twenty-four male rats were divided into control sham surgery, sciatic nerve injury, and sciatic nerve injury with ozone groups (each n = 8). The sciatic nerve injury was inflicted via De Koning's crush-force method. The sciatic nerve injury group received medical air and the sciatic nerve injury ozone group received 0.7 mg/kg ozone. Sciatic nerve samples were obtained 4 weeks after injury. Vascular congestion, vacuolization, edema formation, S100 expression, and the thicknesses of the perineurium and endoneurium and diameter of the injured sciatic nerves were evaluated. RESULTS: The diameter of the sciatic nerve and thicknesses of the perineurium and epineurium were significantly greater in the sciatic nerve injury group (P < 0.05) and significantly less in the sciatic nerve injury with ozone group (P < 0.001). High S100 immunoreactivity was seen in the sciatic nerve injury group compared with the other 2 groups (P < 0.05). The distributions of vascular congestion and vacuolization were significantly less in the sciatic nerve injury with ozone group (P < 0.05). CONCLUSIONS: Ozone therapy improved sciatic nerve injury recovery without causing an increase in fibrotic tissue. Ozone reduced fibrosis, vascular congestion, vacuolization, and edema in rodents. Ozone treatment might be used to assist in sciatic nerve injury.en_US
dc.identifier.citation17
dc.identifier.doi10.1016/j.wneu.2017.05.161
dc.identifier.endpage708en_US
dc.identifier.issn1878-8750
dc.identifier.issn1878-8769
dc.identifier.pmid28587982
dc.identifier.scopus2-s2.0-85021766264
dc.identifier.scopusqualityQ2
dc.identifier.startpage702en_US
dc.identifier.urihttps://doi.org/10.1016/j.wneu.2017.05.161
dc.identifier.urihttps://hdl.handle.net/20.500.14517/518
dc.identifier.volume105en_US
dc.identifier.wosWOS:000411027600089
dc.identifier.wosqualityQ3
dc.language.isoen
dc.publisherElsevier Science incen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFibrosisen_US
dc.subjectInjuryen_US
dc.subjectOzoneen_US
dc.subjectS100en_US
dc.subjectSciatic nerveen_US
dc.titleThe Histological Effects of Ozone Therapy on Sciatic Nerve Crush Injury in Ratsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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