Assessment of IL-7RA T244I Polymorphism as a Risk Factor of MultipleSclerosis in Turkish Population

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dc.contributor.authorNihal IŞIK
dc.contributor.authorMiraç Aysen ÜNSAL
dc.contributor.authorNüket Yıldız MANUKYAN
dc.contributor.authorGüher SARUHAN DİRESKENELİ
dc.date.accessioned2024-05-25T12:20:29Z
dc.date.available2024-05-25T12:20:29Z
dc.date.issued2020
dc.departmentOkan Universityen_US
dc.department-tempOkan Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, İstanbul, Türkiye Sultan Abdülhamid Han Eğitim ve Araştırma Hastanesi, Nöroloji Bölümü, İstanbul, Türkiye Fatih Sultan Mehmet Eğitim ve Araştırma Hastanesi, Nöroloji Anabilim Dalı, İstanbul, Türkiye İstanbul Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, İstanbul, Türkiyeen_US
dc.description.abstractIntroduction: The T244I variant of the IL-7RA gene, rs6897932, is one of the first polymorphisms found to be associated with the development of multiple sclerosis (MS). Although several studies provided evidence for the association of MS and this variant, other studies could not confirm this result. These inconsistent results suggest that the role of this polymorphism in the development of disease is associated with ethnicity.Methods: We investigated rs6897932 polymorphisms in a large cohort of patients with MS and healthy controls in a turkish population.Results: In our study, there were no significant differences in genotype frequencies in the IL-7RA rs6897932 polymorphism and no significant difference between C and T alleles in patients with MS and controls.Conclusion: This study is the first to evaluate the risk of the rs6897932 polymorphism in turkish patients with MS.en_US
dc.identifier.citation0
dc.identifier.doihttps://doi.org/10.29399/npa.23437
dc.identifier.endpage282en_US
dc.identifier.issn1309-4866
dc.identifier.issue4en_US
dc.identifier.startpage280en_US
dc.identifier.trdizinid407363
dc.identifier.urihttps://doi.org/https://doi.org/10.29399/npa.23437
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/407363/assessment-of-il-7ra-t244i-polymorphism-as-a-risk-factor-of-multiplesclerosis-in-turkish-population
dc.identifier.urihttps://hdl.handle.net/20.500.14517/1915
dc.identifier.volume57en_US
dc.language.isoen
dc.relation.ispartofNöropsikiyatri Arşivien_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleAssessment of IL-7RA T244I Polymorphism as a Risk Factor of MultipleSclerosis in Turkish Populationen_US
dc.typeArticleen_US
dspace.entity.typePublication

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