A stereological study of the effects of antidepressants on postmenopausal rat kidney

Simple item page
dc.authoridkurtoglu, emel/0000-0002-2183-7227
dc.authoridozdes, emel kurtoglu/0000-0002-2183-7227
dc.authorscopusid55133866200
dc.authorscopusid15063935100
dc.authorscopusid26425788700
dc.authorscopusid24773142500
dc.authorscopusid55623179000
dc.authorscopusid6701466395
dc.authorwosidkurtoglu, emel/AAC-3010-2020
dc.authorwosidozdes, emel kurtoglu/AAQ-9916-2020
dc.contributor.authorOzdes, E.
dc.contributor.authorAltunkaynak, B. Z.
dc.contributor.authorDeniz, O. G.
dc.contributor.authorIlkaya, F.
dc.contributor.authorGuzel, H.
dc.contributor.authorKokcu, A.
dc.contributor.otherHistoloji ve Embriyoloji / Histology and Embriology
dc.date.accessioned2024-05-25T11:39:58Z
dc.date.available2024-05-25T11:39:58Z
dc.date.issued2020
dc.departmentOkan Universityen_US
dc.department-temp[Ozdes, E.] Mem Hizmet Hosp, Dept Gynaecol & Obstet, Istanbul, Turkey; [Altunkaynak, B. Z.] Istanbul Okan Univ, Med Fac, Dept Histol & Embryol, Istanbul, Turkey; [Deniz, O. G.] Ondokuz Mayis Univ, Med Fac, Dept Histol & Embryol, Samsun, Turkey; [Ilkaya, F.; Guzel, H.] Ondokuz Mayis Univ, Med Fac, Dept Pharmacol, Samsun, Turkey; [Kokcu, A.] Med Pk Hosp, Dept Gynaecol & Obstet, Samsun, Turkeyen_US
dc.descriptionkurtoglu, emel/0000-0002-2183-7227; ozdes, emel kurtoglu/0000-0002-2183-7227en_US
dc.description.abstractMany factors can cause depression including genes (DNA), brain chemistry or stress. Antidepressant drugs affect the brain, heart, liver and kidney. We investigated the effects of the antidepressant drugs, amitriptyline (AMI) and paroxetine (PARO) on kidney. We used 24 adult female rats that were ovariectomized bilaterally 7 days before the experiment. The ovariectomized (OVX) animals and healthy control rats were divided into four equal groups for 4 weeks: control group, OVX control group (sham), AMI group and PARO group. Following the experimental period, the Cavalieri method was applied to sections of the kidney. PARO produced adverse effects on distal and proximal tubule volume, but AMI had no effect on the volume of distal and proximal tubules. Both PARO and AMI decreased the volume of Bowman spaces. PARO also damaged the kidney tubules and cells.en_US
dc.identifier.citation2
dc.identifier.doi10.1080/10520295.2019.1680865
dc.identifier.endpage267en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue4en_US
dc.identifier.pmid31746664
dc.identifier.scopus2-s2.0-85084326928
dc.identifier.scopusqualityQ3
dc.identifier.startpage262en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2019.1680865
dc.identifier.urihttps://hdl.handle.net/20.500.14517/1381
dc.identifier.volume95en_US
dc.identifier.wosWOS:000498357400001
dc.identifier.wosqualityQ4
dc.institutionauthorAltunkaynak, Berrin Zühal
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectamitriptylineen_US
dc.subjectantidepressantsen_US
dc.subjectkidneyen_US
dc.subjectparoxetineen_US
dc.subjectserotonin re-uptake inhibitorsen_US
dc.subjectstereologyen_US
dc.subjecttricyclicsen_US
dc.titleA stereological study of the effects of antidepressants on postmenopausal rat kidneyen_US
dc.typeArticleen_US
dspace.entity.typePublication
relation.isAuthorOfPublication6322a75b-d2c9-4ab3-9e93-6d62d46b6331
relation.isAuthorOfPublication.latestForDiscovery6322a75b-d2c9-4ab3-9e93-6d62d46b6331
relation.isOrgUnitOfPublicationfd9bb63c-4930-43ba-b59a-984b3a14ea30
relation.isOrgUnitOfPublication.latestForDiscoveryfd9bb63c-4930-43ba-b59a-984b3a14ea30

Files

Collections

WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection