Changes in Antimicrobial Resistance of Urinary Tract Infections in Adult Patients over a 5-Year Period

dc.authoridVahaboglu, H/0000-0001-8217-1767
dc.authoridCulpan, Meftun/0000-0001-8573-1192
dc.authoridcaskurlu, hulya/0000-0002-6760-2052
dc.authorscopusid6507367274
dc.authorscopusid57192680827
dc.authorscopusid7004932286
dc.authorscopusid42162301800
dc.authorscopusid6603778078
dc.authorscopusid6602450251
dc.authorwosidVahaboglu, H/HHZ-1169-2022
dc.authorwosidÇulpan, Meftun/AAC-9624-2019
dc.authorwosidCulpan, Meftun/AAR-6117-2021
dc.authorwosidCulpan, Meftun/GPX-3240-2022
dc.authorwosidcaskurlu, hulya/ABI-3919-2020
dc.contributor.authorCaskurlu, Hulya
dc.contributor.authorCulpan, Meftun
dc.contributor.authorErol, Bulent
dc.contributor.authorTuran, Turgay
dc.contributor.authorVahaboglu, Haluk
dc.contributor.authorCaskurlu, Turhan
dc.date.accessioned2024-05-25T12:29:58Z
dc.date.available2024-05-25T12:29:58Z
dc.date.issued2020
dc.departmentOkan Universityen_US
dc.department-temp[Caskurlu, Hulya; Vahaboglu, Haluk] Istanbul Medeniyet Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey; [Culpan, Meftun] Istanbul Okan Univ, Fac Med, Dept Urol, Istanbul, Turkey; [Erol, Bulent; Caskurlu, Turhan] Istanbul Medeniyet Univ, Gortepe Training & Res Hosp, Fac Med, Dept Urol, Istanbul, Turkey; [Turan, Turgay] Turgutlu State Hosp, Dept Urol, Manisa, Turkeyen_US
dc.descriptionVahaboglu, H/0000-0001-8217-1767; Culpan, Meftun/0000-0001-8573-1192; caskurlu, hulya/0000-0002-6760-2052en_US
dc.description.abstractObjectives: We aimed to determine the most common bacteria that cause urinary tract infections (UTIs), the rate of antibiotic resistance of these uropathogens, and the changes in resistance rates over the years for adult patients diagnosed with UTIs. Methods: We retrospectively reviewed urine cultures and antibiotic susceptibility results of patients >17 years of age from our outpatient clinic between 2014 and 2018. The most common uropathogens and their antibiotic resistance rates were identified in different age groups (18-39, 40-59, and >= 60 years) and with respect to gender and date of admission. In addition, the change in antibiotic resistance of Escherichia coli between 2014 and 2018 was also examined. Results: A total of 9,556 positive urine cultures were included. The most common uropathogen was E. coli, and its prevalence was higher in females than males (70.6 vs. 53.4%, respectively). The majority of isolates were from patients >= 60 years of age. E. coli resistance was most pronounced for ampicillin (61.56%), followed by trimeth-oprim-sulfamethoxazole (49.80%), amoxicillin-clavulanic acid (34.69%), and cefazolin (30.72%). E. coli resistance to ampicillin, nitrofurantoin, cefepime, ciprofloxacin, fosfomycin, and amoxicillin-clavulanic acid increased significantly with time (all p = 0.001). For E. coli, resistance to ciprofloxacin, one of the most commonly used antibiotics for UTI, increased from 17 to 43% from 2014 to 2018. Conclusion: Most of the uropathogens displayed high resistance to ampicillin, tri-methoprim-sulfamethoxazole, and amoxicillin-clavulanic acid, and were susceptible to meropenem, ertapenem, and imipenem. Fosfomycin and cefepime were useful in the empirical treatment of community-acquired UTIs. A surprisingly high increase was observed in the resistance of E. coli to antimicrobial agents from 2014 to 2018.en_US
dc.identifier.citation11
dc.identifier.doi10.1159/000504415
dc.identifier.endpage292en_US
dc.identifier.issn0042-1138
dc.identifier.issn1423-0399
dc.identifier.issue3-4en_US
dc.identifier.pmid31940639
dc.identifier.scopus2-s2.0-85078290560
dc.identifier.scopusqualityQ2
dc.identifier.startpage287en_US
dc.identifier.urihttps://doi.org/10.1159/000504415
dc.identifier.urihttps://hdl.handle.net/20.500.14517/2165
dc.identifier.volume104en_US
dc.identifier.wosWOS:000533868200018
dc.identifier.wosqualityQ4
dc.language.isoen
dc.publisherKargeren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntimicrobial resistanceen_US
dc.subjectUrinary tract infectionsen_US
dc.subjectUropathogensen_US
dc.subjectOutpatient urine cultureen_US
dc.titleChanges in Antimicrobial Resistance of Urinary Tract Infections in Adult Patients over a 5-Year Perioden_US
dc.typeArticleen_US
dspace.entity.typePublication

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