The effect of local application of thymoquinone,<i> Nigella</i><i> sativa?s</i> bioactive component, on bone healing in experimental bone defects infected with <i>Porphyromonas gingivalis</i>

dc.authoridÖzçakır Tomruk, Ceyda/0000-0003-1545-5588
dc.authoridGuzel, Elif/0000-0001-9072-3322
dc.authoridOZEN, FATMA/0000-0001-9587-8358
dc.authoridozdemir, ilkay/0000-0003-2715-6825
dc.authorwosidÖzçakır Tomruk, Ceyda/H-9931-2018
dc.authorwosidGuzel, Elif/D-6668-2019
dc.contributor.authorBastug, Ayse Yilmaz
dc.contributor.authorTomruk, Ceyda Ozcakir
dc.contributor.authorGuzel, Elif
dc.contributor.authorOzdemir, Ilkay
dc.contributor.authorDuygu, Gonca
dc.contributor.authorKutan, Esma
dc.contributor.authorArici, Fatma Ozen
dc.date.accessioned2024-05-25T11:25:19Z
dc.date.available2024-05-25T11:25:19Z
dc.date.issued2022
dc.departmentOkan Universityen_US
dc.department-temp[Tomruk, Ceyda Ozcakir] Yeditepe Univ, Dept Oral & Maxillofacial Surg, Fac Dent, Istanbul, Turkey; [Guzel, Elif] Istanbul Univ, Dept Histol & Embryol, Cerrahpasa Med Fac, Istanbul, Turkey; [Ozdemir, Ilkay] Istanbul Univ, Dept Histol & Embryol, Med Fac, Istanbul, Turkey; [Duygu, Gonca] Tekirdag Namik Kemal Univ, Dept Oral & Maxillofacial Surg, Fac Dent, Tekirdag, Turkey; [Ulker, Gul Merve Yalcin] Istanbul Okan Univ, Dept Oral & Maxillofacial Surg, Fac Dent, Istanbul, Turkey; [Arici, Fatma Ozen] Yeditepe Univ, Grad Sch Nat & Appl Sci, Biotechnol Program, Istanbul, Turkeyen_US
dc.descriptionÖzçakır Tomruk, Ceyda/0000-0003-1545-5588; Guzel, Elif/0000-0001-9072-3322; OZEN, FATMA/0000-0001-9587-8358; ozdemir, ilkay/0000-0003-2715-6825en_US
dc.description.abstractPurpose: This study was performed to evaluate the influence of local application of thymoquinone (TQ) on bone healing in experimental bone defects infected with Porphyromonas gingivalis (PG). Methods: Forty-two female rats were randomly divided into 6 groups. A bone defect was created on the right tibia of all animals. The PG, PG/collagen membrane (COL) and PG/ TQ/COL groups were infected with PG. In the COL and PG/COL groups, the defects were covered with a COL; in the TQ/COL and PG/TQ/COL groups, the defects were covered with a TQ-containing COL. After 28 days, all animals were sacrificed. Quantitative measurements of new bone formation and osteoblast lining, as well as semiquantitative measurements of capillary density and tissue response, were analyzed. Furthermore, the presence of bacterial infections in defect areas was evaluated. Results: The new bone formation, osteoblast number, and capillary density were significantly higher in the TQ groups than in the control groups (P<0.001, P<0.001, and P<0.01, respectively). In a comparison between the TQ/COL group, with a TQ-containing COL (TQ/COL), and the PG-infected TQ-containing COL (PG/TQ/COL) group, the newly formed bone and capillary density were higher in the TQ/COL group (P<0.01). When the control group was compared to the PG, PG/COL, and PG/TQ/COL groups in terms of tissue response, the differences were statistically significant (P<0.001, P=0.02, and P=0.041, respectively). The intensity of the inflammatory cell reaction was higher in the PG, PG/COL, and PG/TQ/COL groups (P<0.05). Conclusions: Within the limitations of this study, the local application of a TQ-containing COL positively affected bone healing even if the bone defects were infected. The results suggest that TQ increased angiogenesis and showed promise for accelerating bone defect healing. Further research is warranted to support these findings and reach more definitive conclusions.en_US
dc.identifier.citation3
dc.identifier.doi10.5051/jpis.2101360068
dc.identifier.endpage219en_US
dc.identifier.issn2093-2278
dc.identifier.issn2093-2286
dc.identifier.issue3en_US
dc.identifier.pmid35775696
dc.identifier.scopusqualityN/A
dc.identifier.startpage206en_US
dc.identifier.urihttps://doi.org/10.5051/jpis.2101360068
dc.identifier.urihttps://hdl.handle.net/20.500.14517/886
dc.identifier.volume52en_US
dc.identifier.wosWOS:000821953900004
dc.identifier.wosqualityN/A
dc.language.isoenen_US
dc.publisherKorean Acad Periodontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBoneen_US
dc.subjectNigella sativaen_US
dc.subjectPorphyromonas gingivalisen_US
dc.subjectRatsen_US
dc.subjectThymoquinoneen_US
dc.subjectTibiaen_US
dc.titleThe effect of local application of thymoquinone,<i> Nigella</i><i> sativa?s</i> bioactive component, on bone healing in experimental bone defects infected with <i>Porphyromonas gingivalis</i>en_US
dc.typeArticleen_US
dspace.entity.typePublication

Files