Comparison of the effectiveness of Ankaferd Blood Stopper(R) and Emdogain in periodontal regeneration

dc.authoridKURT BAYRAKDAR, Sevda/0000-0002-3711-6520
dc.authorscopusid56463728100
dc.authorscopusid13104882100
dc.authorscopusid57202306502
dc.authorscopusid8343091600
dc.authorscopusid55663819500
dc.authorwosidkurt bayrakdar, sevda/AFV-9029-2022
dc.contributor.authorGuler, Sevki
dc.contributor.authorCetinkaya, Burcu Ozkan
dc.contributor.authorKurt Bayrakdar, Sevda
dc.contributor.authorAyas, Bulent
dc.contributor.authorKeles, Gonca Cayir
dc.date.accessioned2024-05-25T12:29:38Z
dc.date.available2024-05-25T12:29:38Z
dc.date.issued2022
dc.departmentOkan Universityen_US
dc.department-temp[Guler, Sevki] Abant Izzet Baysal Univ, Fac Dent, Dept Periodontol, Bolu, Turkey; [Cetinkaya, Burcu Ozkan] Ondokuz Mayis Univ, Fac Dent, Dept Periodontol, Samsun, Turkey; [Kurt Bayrakdar, Sevda] Eskisehir Osmangazi Univ, Fac Dent, Dept Periodontol, TR-26240 Eskisehir, Turkey; [Ayas, Bulent] Ondokuz Mayis Univ, Fac Med, Dept Histol & Embriol, Samsun, Turkey; [Keles, Gonca Cayir] Istanbul Okan Univ, Fac Dent, Dept Periodontol, Istanbul, Turkeyen_US
dc.descriptionKURT BAYRAKDAR, Sevda/0000-0002-3711-6520en_US
dc.description.abstractObjectives The present study was performed to compare the effectiveness of Ankaferd Blood Stopper(R) (ABS) with enamel matrix derivatives (EMD) for treating fenestration defects in rats. Materials and Methods Forty-eight male Wistar rats were randomly divided into six groups (each n = 8). Fenestration defects were created in all rats, to which ABS, EMD, or saline (S) was then applied. The rats were grouped and sacrificed at one of two different time points, as follows: ABS-10-group, ABS-treatment/sacrifice on day 10; EMD-10-group, EMD-treatment/sacrifice on day 10; S-10-group, S-treatment/sacrifice on day 10; ABS-38-group, ABS-treatment/sacrifice on day 38; EMD-38-group, EMD-treatment/sacrifice on day 38; and S-38-group, S-treatment/sacrifice on day 38. Then, histomorphometric analysis including measurements of new bone area (NBA) and new bone ratio (NBR), and immunohistochemical analysis including the determination of osteopontin (OPN) and type-III-collagen (C-III) expression were performed. Results The NBA and NBR were significantly higher in the ABS-10-group and EMD-10-group compared to the S-10-group (p < .05), and in the EMD-38-group compared to the S-38-group (p < .05). The levels of C-III and OPN immunoreactivity were significantly higher in the ABS-10-group compared to the S-10-group (p < .017). Conclusions The results of this study suggested that ABS can promote early periodontal regeneration, although its efficacy seems to decrease over time.en_US
dc.description.sponsorshipOndokuz Mayis Research Fund [PYO.DIS.1904.14.002]en_US
dc.description.sponsorshipOndokuz Mayis Research Fund, Grant/Award Number: PYO.DIS.1904.14.002en_US
dc.identifier.citation0
dc.identifier.doi10.1111/odi.13852
dc.identifier.endpage1957en_US
dc.identifier.issn1354-523X
dc.identifier.issn1601-0825
dc.identifier.issue7en_US
dc.identifier.pmid33740823
dc.identifier.scopus2-s2.0-85103933341
dc.identifier.scopusqualityQ1
dc.identifier.startpage1947en_US
dc.identifier.urihttps://doi.org/10.1111/odi.13852
dc.identifier.urihttps://hdl.handle.net/20.500.14517/2114
dc.identifier.volume28en_US
dc.identifier.wosWOS:000635543900001
dc.identifier.wosqualityQ1
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnkaferd Blood Stopperen_US
dc.subjectEmdogainen_US
dc.subjecthistomorphometricen_US
dc.subjectosteopontinen_US
dc.subjecttype&#8208en_US
dc.subjectIII collagenen_US
dc.titleComparison of the effectiveness of Ankaferd Blood Stopper(R) and Emdogain in periodontal regenerationen_US
dc.typeArticleen_US
dspace.entity.typePublication

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