Breast Cancer Recurrence in Initially Clinically Node-Positive Patients Undergoing Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in the Neosentiturk-Trials Mf18-02/18-03

dc.authorid kocer, belma/0000-0002-9888-0661
dc.authorid Celik, Burak/0000-0002-8626-7675
dc.authorscopusid 56037273500
dc.authorscopusid 6508305875
dc.authorscopusid 6603880221
dc.authorscopusid 15045176000
dc.authorscopusid 6602445051
dc.authorscopusid 6602733262
dc.authorscopusid 6507248798
dc.authorwosid Cabıoğlu, Neslihan/AAZ-1196-2020
dc.authorwosid Soyder, Aykut/AAE-1969-2022
dc.authorwosid Bademler, Süleyman/AAY-4675-2020
dc.authorwosid VELİDEDEOĞLU, MEHMET/AAY-9588-2020
dc.authorwosid Dag, Ahmet/AAV-5939-2020
dc.authorwosid Aydiner, Adnan/AAU-4591-2020
dc.authorwosid Karanlik, Hasan/AAU-3529-2020
dc.contributor.author Cabioglu, Neslihan
dc.contributor.author Karanlik, Hasan
dc.contributor.author Igci, Abdullah
dc.contributor.author Muslumanoglu, Mahmut
dc.contributor.author Gulcelik, Mehmet Ali
dc.contributor.author Uras, Cihan
dc.contributor.author Ozmen, Vahit
dc.date.accessioned 2025-01-15T21:48:14Z
dc.date.available 2025-01-15T21:48:14Z
dc.date.issued 2025
dc.department Okan University en_US
dc.department-temp [Cabioglu, Neslihan; Igci, Abdullah; Muslumanoglu, Mahmut; Tukenmez, Mustafa; Emiroglu, Selman; Kilic, Halime Gul; Ozcinar, Beyza; Ozmen, Vahit] Istanbul Univ, Istanbul Fac Med, Dept Gen Surg, Istanbul, Turkiye; [Karanlik, Hasan; Bademler, Suleyman; Kilic, Berkay] Istanbul Univ, Dept Surg Oncol, Inst Oncol, Istanbul, Turkiye; [Igci, Abdullah; Yildirim, Nilufer] Amer Hosp, Dept Surg, Istanbul, Turkiye; [Gulcelik, Mehmet Ali] Hlth Sci Univ, Gulhane Fac Med, Dept Surg Oncol, Ankara, Turkiye; [Uras, Cihan; Kara, Halil] Acibadem Mehmet Ali Aydinlar Univ, Sch Med, Dept Gen Surg, Istanbul, Turkiye; [Kocer, Havva Belma] Sakarya Univ, Fac Med, Dept Gen Surg, Sakarya, Turkiye; [Trabulus, Didem Can] Istanbul Samatya Training & Res Hosp, Dept Gen Surg, Istanbul, Turkiye; [Ozkurt, Enver; Ilgun, Serkan] Istanbul Demiroglu Bilim Univ, Sch Med, Sch Med, Istanbul, Turkiye; [Cakmak, Guldeniz Karadeniz] Zonguldak Bulent Ecevit Univ, Sch Med, Dept Gen Surg, Zonguldak, Turkiye; [Sen, Ebru] Hlth Sci Univ, Basaksehir Cam & Sakura City Hosp, Dept Gen Surg, Istanbul, Turkiye; [Senol, Kazim; Aljorani, Israa] Uludag Univ, Fac Med, Dept Gen Surg, Bursa, Turkiye; [Citgez, Bulent; Yigit, Banu; Baran, Elif] Univ Hlth Sci, Seyrantepe Hamidiye Etfal Training & Res Hosp, Dept Gen Surg, Istanbul, Turkiye; [Ersoy, Yeliz Emine] Bezmialem Vakif Univ, Fac Med, Dept Gen Surg, Istanbul, Turkiye; [Dag, Ahmet] Mersin Univ, Fac Med, Dept Gen Surg, Mersin, Turkiye; [Zengel, Baha] Izmir Bozyaka Training & Res Hosp, Dept Gen Surg, Izmir, Turkiye; [Basaran, Gul] Acibadem Mehmet Ali Aydinlar Univ, Dept Med Oncol, Sch Med, Istanbul, Turkiye; [Dilege, Ece; Celik, Burak; Agcaoglu, Orhan] Koc Univ, Sch Med, Dept Gen Surg, Istanbul, Turkiye; [Ugurlu, M. Umit] Marmara Univ, Sch Med, Dept Gen Surg, Istanbul, Turkiye; [Celik, Atilla; Yigit, Banu] Hlth Sci Univ, Dept Gen Surg, Bagcilar Training & Res Hosp, Istanbul, Turkiye; [Bolukbasi, Yasemin] Koc Univ, Sch Med, Dept Radiat Oncol, Istanbul, Turkiye; [Karaman, Niyazi; Dogan, Lutfi] Univ Hlth Sci, Ankara Oncol Training & Res Hosp, Dept Surg Oncol, TR-06200 Ankara, Turkiye; [Sakman, Guerhan] Cukurova Univ, Sch Med, Dept Surg, Adana, Turkiye; [Polat, Ayfer Kamali] Ondokuz Mayis Univ, Sch Med Samsun, Dept Gen Surg, Samsun, Turkiye; [Ozemir, Ibrahim Ali] Istanbul Medeniyet Univ, Goztepe State Hosp, Sch Med, Dept Gen Surg, Istanbul, Turkiye; [Altinok, Ayse] Altinbas Univ, Bahcelievler Med Pk Hosp, Dept Gastroenterol, Istanbul, Turkiye; [Varol, Ecenur; Utkan, Zafer] Kocaeli Univ, Fac Med, Dept Gen Surg, Kocaeli, Turkiye; [Akcan, Alper] Erciyes Univ, Sch Med, Dept Gen Surg, Kayseri, Turkiye; [Zer, Leyla] Atasehir Florence Nightingale, Dept Gen Surg, Istanbul, Turkiye; [Soyder, Aykut] Acibadem Mehmet Ali Aydinlar Univ, Altunizade Acibadem Hosp, Sch Med, Dept Gen Surg, Istanbul, Turkiye; [Velidedeoglu, Mehmet] Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Dept Gen Surg, Istanbul, Turkiye; [Erozgen, Fazilet] Hlth Sci Univ, Haseki Training & Res Hosp, Dept Gen Surg, Istanbul, Turkiye; [Goktepe, Berk] Ege Univ, Sch Med, Dept Gen Surg, Izmir, Turkiye; [Dogan, Mutlu] Hlth Sci Univ, Ankara Oncol Training & Res Hosp, Dept Med Oncol, Ankara, Turkiye; [Kebudi, Abut] Istanbul Okan Univ, Fac Med, Dept Gen Surg, Istanbul, Turkiye; [Yormaz, Serdar] Selcuk Univ, Fac Med, Dept Gen Surg, Konya, Turkiye; [Arici, Cumhur] Akdeniz Univ, Fac Med, Dept Gen Surg, Antalya, Turkiye; [Sevinc, Ali Ibrahim] Dokuz Eylul Univ, Sch Med, Dept Gen Surg, Izmir, Turkiye; [Atahan, M. Kemal] Izmir Katip Celebi Univ, Sch Med, Dept Gen Surg, Izmir, Turkiye; [Valiyeva, Vafa] Azerbaijan Med Univ, Dept Breast Surg, Oncol Clin, Baku, Azerbaijan; [Soran, Atilla] Univ Pittsburgh, Dept Surg Oncol, Med Ctr, Pittsburgh, PA USA; [Aydiner, Adnan] Istanbul Univ, Dept Med Oncol, Inst Oncol, Istanbul, Turkiye; [Ibis, Kamuran] Istanbul Univ, Dept Radiat Oncol, Inst Oncol, Istanbul, Turkiye; [Ozmen, Vahit] Istanbul Florence Nightingale Hosp, Breast Ctr, Istanbul, Turkiye; [Trabulus, Didem Can] Istanbul Bahcesehir Univ, Dept Gen Surg, Istanbul, Turkiye; [Citgez, Bulent] Uskudar Univ, Mem Atasehir Hosp, Dept Gen Surg, Istanbul, Turkiye; [Zengel, Baha] Izmir Univ Econ, Med Point Hosp, Sch Med, Dept Gen Surg, Izmir, Turkiye; [Ilgun, Serkan] Mater Dei Hosp, Dept Gen Surg, Msida, Malta en_US
dc.description kocer, belma/0000-0002-9888-0661; Celik, Burak/0000-0002-8626-7675 en_US
dc.description.abstract Background. This study aims to identify factors predicting recurrence and unfavorable prognosis in cN+ patients who have undergone sentinel lymph node biopsy (SLNB) following neoadjuvant chemotherapy (NAC). MethodsThe retrospective multi-centre "MF18-02" and the prospective multi-centre cohort registry trial "MF18-03" (NCT04250129) included patients with cT1-4N1-3M0 with SLNB+/- axillary lymph node dissection (ALND) post-NAC. Results. A total of 2407 cN+ patients, who later achieved cN0 status after NAC and subsequently underwent SLNB, were studied. The majority had cT1-2 (79.1%) and N1 (80.7%). After a median follow-up time of 41 months, the rates of locoregional recurrence and axillary recurrence (AR) were 1.83% and 0.37%, respectively. No significant difference in locoregional recurrence or AR rates was observed between the SLNB/targeted axillary dissection-only (n = 1470) and ALND (n = 937) groups. Factors significantly linked with AR included age younger than 45 years, nonpathological complete response (non-pCR) in the breast, and nonluminal pathology. Locoregional recurrences were associated with nonluminal or HER2(+) pathology, non-pCR in the breast, and ALND. Poor prognostic factors for disease-free survival (DFS) included having cT3-T4, no breast pCR (non-pCR), ypN(+), and nonluminal pathology. No significant difference was found in DFS or disease-specific survival (DSS) rates among ypN0, ypN-isolated tumour cells, ypNmic, and ypN1. However, significant decreases in DFS and DSS rates were observed when comparing ypN2 or ypN3 disease with ypN0. Conclusions. The present large registry data indicate that younger patients (<45), those with nonluminal pathology, and those who only partially respond in the breast are more susceptible to axillary and locoregional recurrences. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.citationcount 1
dc.identifier.doi 10.1245/s10434-024-16472-6
dc.identifier.endpage 966 en_US
dc.identifier.issn 1068-9265
dc.identifier.issn 1534-4681
dc.identifier.issue 2 en_US
dc.identifier.pmid 39623189
dc.identifier.scopus 2-s2.0-85211486057
dc.identifier.scopusquality Q2
dc.identifier.startpage 952 en_US
dc.identifier.uri https://doi.org/10.1245/s10434-024-16472-6
dc.identifier.uri https://hdl.handle.net/20.500.14517/7587
dc.identifier.volume 32 en_US
dc.identifier.wos WOS:001376815300001
dc.identifier.wosquality Q1
dc.language.iso en en_US
dc.publisher Springer en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 2
dc.subject Sentinel Lymph Node Biopsy en_US
dc.subject Axillary Dissection en_US
dc.subject Neoadjuvant Chemotherapy en_US
dc.subject Axillary Recurrence en_US
dc.subject Locoregional Recurrence en_US
dc.subject Regional Nodal Irradiation en_US
dc.subject Breast Cancer Recurrence en_US
dc.subject Survival en_US
dc.subject Young Age en_US
dc.subject Non-Luminal Pathology en_US
dc.title Breast Cancer Recurrence in Initially Clinically Node-Positive Patients Undergoing Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in the Neosentiturk-Trials Mf18-02/18-03 en_US
dc.type Article en_US
dc.wos.citedbyCount 2

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