A Multicentered Study on Epidemiologic and Clinical Characteristics of 37 Neonates With Community-acquired COVID-19
No Thumbnail Available
Date
2020
Authors
Kanburoglu, Mehmet Kenan
Tayman, Cuneyt
Oncel, Mehmet Yekta
Akin, Ilke Mungan
Can, Emrah
Demir, Nihat
Koc, Esin
Journal Title
Journal ISSN
Volume Title
Publisher
Lippincott Williams & Wilkins
Open Access Color
OpenAIRE Downloads
OpenAIRE Views
Abstract
Background: Coronavirus disease 2019 (COVID-19) primarily affects adults and spares children, whereas very little is known about neonates. We tried to define the clinical characteristics, risk factors, laboratory, and imagining results of neonates with community-acquired COVID-19. Methods: This prospective multicentered cohort study included 24 neonatal intensive care units around Turkey, wherein outpatient neonates with COVID-19 were registered in an online national database. Full-term and premature neonates diagnosed with COVID-19 were included in the study, whether hospitalized or followed up as ambulatory patients. Neonates without severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) via reverse transcriptase-polymerase chain reaction testing or whose mothers had been diagnosed with COVID-19 during pregnancy were excluded. Results: Thirty-seven symptomatic neonates were included. The most frequent findings were fever, hypoxemia, and cough (49%, 41%, 27%, respectively). Oxygen administration (41%) and noninvasive ventilation (16%) were frequently required; however, mechanical ventilation (3%) was rarely needed. Median hospitalization was 11 days (1-35 days). One patient with Down syndrome and congenital cardiovascular disorders died in the study period. C-reactive protein (CRP) and prothrombin time (PT) levels were found to be higher in patients who needed supplemental oxygen (0.9 [0.1-8.6] vs. 5.8 [0.3-69.2]p= 0.002, 11.9 [10.1-17.2] vs. 15.2 [11.7-18.0]p= 0.01, respectively) or who were severe/critical (1.0 [0.01-8.6] vs. 4.5 [0.1-69.2]p= 0.01, 11.7 [10.1-13.9] vs. 15.0 [11.7-18.0]p= 0.001, respectively). Conclusions: Symptomatic neonates with COVID-19 had high rates of respiratory support requirements. High CRP levels or a greater PT should alert the physician to more severe disease.
Description
Uygun, Saime Sundus/0000-0002-6694-8115; Kanburoglu, Mehmet Kenan/0000-0001-6859-6689; MUNGAN AKIN, Ilke/0000-0002-3677-1582; Oncel, Mehmet Yekta/0000-0003-0760-0773; Can, Emrah/0000-0002-2163-6564; AKIN, Mustafa Ali/0000-0001-6102-2703; Hakyemez Toptan, Handan/0000-0002-6966-8514; CANER, İBRAHİM/0000-0002-6756-122X; Yalınbaş, E.Esin/0000-0003-3762-4418; Reis, AlessanRSS/0000-0001-8486-7469
Keywords
coronavirus infections, SARS-CoV-2, COVID-19, newborn, acute respiratory distress syndrome
Turkish CoHE Thesis Center URL
Fields of Science
Citation
31
WoS Q
Q1
Scopus Q
Q2
Source
Volume
39
Issue
10
Start Page
E297
End Page
E302