Rhabdomyosarcoma: Current Therapy, Challenges, and Future Approaches to Treatment Strategies

dc.authoridGhavami, Saeid/0000-0001-5948-508X
dc.authoridZarepour, Atefeh/0000-0002-0347-5840
dc.authoridZarrabi, Ali/0000-0003-0391-1769
dc.authoridPecic, Stevan/0000-0002-3706-8768
dc.authoridMadrakian, Tayyebeh/0000-0002-6876-7633
dc.authoridMehrbod, Parvaneh/0000-0002-8391-9228
dc.authoridFallah, Ali/0000-0002-7744-4246
dc.authorscopusid23483174100
dc.authorscopusid57204019259
dc.authorscopusid57210580873
dc.authorscopusid57224116272
dc.authorscopusid57305831500
dc.authorscopusid35088483300
dc.authorscopusid7404625308
dc.authorwosidGhavami, Saeid/GLT-0606-2022
dc.authorwosidZarepour, Atefeh/AAH-9225-2020
dc.authorwosidZarrabi, Ali/U-2602-2019
dc.authorwosidPecic, Stevan/E-3578-2018
dc.authorwosidMadrakian, Tayyebeh/C-2780-2018
dc.authorwosidMehrbod, Parvaneh/I-4444-2017
dc.authorwosidRosik, Jakub/P-6960-2018
dc.contributor.authorZarrabi, Ali
dc.contributor.authorPerrin, David
dc.contributor.authorKavoosi, Mahboubeh
dc.contributor.authorSommer, Micah
dc.contributor.authorSezen, Serap
dc.contributor.authorMehrbod, Parvaneh
dc.contributor.authorGhavami, Saeid
dc.date.accessioned2024-05-25T11:38:49Z
dc.date.available2024-05-25T11:38:49Z
dc.date.issued2023
dc.departmentOkan Universityen_US
dc.department-temp[Zarrabi, Ali; Zarepour, Atefeh] Istinye Univ, Dept Biomed Engn, Fac Engn & Nat Sci, TR-34396 Istanbul, Turkiye; [Perrin, David; Sommer, Micah] Univ Manitoba, Dept Surg, Sect Orthopaed Surg, Winnipeg, MB R3E 0V9, Canada; [Kavoosi, Mahboubeh; Bhushan, Bhavya; Machaj, Filip; Rosik, Jakub; Kawalec, Philip; Afifi, Saba; Bolandi, Seyed Mohammadreza; Koleini, Peiman; Lindsey, Benjamin; Logue, Susan; Gordon, Joseph W.; Ghavami, Saeid] Univ Manitoba, Dept Human Anat & Cell Sci, Coll Med, Winnipeg, MB R3E 0V9, Canada; [Kavoosi, Mahboubeh; Los, Marek J.] Silesian Tech Univ, Biotechnol Ctr, 8 Krzywousty St, PL-44100 Gliwice, Poland; [Sommer, Micah] Univ Manitoba, Dept Internal Med, Sect Phys Med & Rehabil, Winnipeg, MB R3E 0V9, Canada; [Sezen, Serap; Cakir, Nilufer; Koc, Bahattin] Sabanci Univ, Fac Engn & Nat Sci, TR-34956 Istanbul, Turkiye; [Mehrbod, Parvaneh] Pasteur Inst Iran, Dept Influenza & Resp Viruses, Tehran 1316943551, Iran; [Bhushan, Bhavya] McGill Univ, Fac Sci, Sch Biomed Sci, Dept Anat & Cell Biol, Montreal, PQ H3A 0C7, Canada; [Machaj, Filip; Rosik, Jakub] Pomeranian Med Univ, Dept Physiol, PL-70111 Szczecin, Poland; [Machaj, Filip] Univ Chicago, Dept Biochem & Mol Biol, Chicago, IL 60637 USA; [Rosik, Jakub] Univ Chicago, Dept Chem, Chicago, IL 60637 USA; [Kawalec, Philip] Univ Manitoba, Hlth Sci Ctr, Dept Surg, Sect Neurosurg, Winnipeg, MB R3A 1R9, Canada; [Taheri, Mohsen] Zahedan Univ Med Sci, Genet Noncommunicable Dis Res Ctr, Zahedan 9816743463, Iran; [Madrakian, Tayyebeh; Ahmadi, Mazaher] Bu Ali Sina Univ, Fac Chem, Dept Analyt Chem, Hamadan 6517838695, Iran; [Hushmandi, Kiavash] Univ Tehran, Fac Vet Med, Dept Food Hyg & Qual Control, Div Epidemiol, Tehran 1419963114, Iran; [Fallah, Ali; Koc, Bahattin] Sabanci Univ, Integrated Mfg Technol Res & Applicat Ctr, TR-34956 Istanbul, Turkiye; [Koc, Bahattin] Sabanci Univ, Nanotechnol Res & Applicat Ctr SUNUM, TR-34956 Istanbul, Turkiye; [Khosravi, Arezoo] Istanbul Okan Univ, Fac Engn & Nat Sci, Dept Genet & Bioengn, TR-34959 Istanbul, Turkiye; [Orive, Gorka] Univ Basque Country UPV EHU, Sch Pharm, NanoBioCel Res Grp, Vitoria 01007, Spain; [Orive, Gorka] Univ Basque Country, Univ Inst Regenerat Med & Oral Implantol UIRMI, Fdn Eduardo Anitua, Vitoria 01007, Spain; [Orive, Gorka] NanoBioCel Res Grp, Bioaraba, Vitoria 01006, Spain; [Pecic, Stevan] Calif State Univ Fullerton, Dept Chem & Biochem, Fullerton, CA 92831 USA; [Gordon, Joseph W.] Univ Manitoba, Coll Nursing, Rady Fac Hlth Sci, Winnipeg, MB R3E 0V9, Canada; [Ghavami, Saeid] Univ Manitoba, Children Hosp Res Inst Manitoba, Biol Breathing Theme, Winnipeg, MB R3E 0V9, Canada; [Ghavami, Saeid] Shiraz Univ Med Sci, Autophagy Res Ctr, Shiraz 7134845794, Iran; [Ghavami, Saeid] Acad Silesia, Fac Med, Rolna 43, PL-40555 Katowice, Poland; [Ghavami, Saeid] Univ Manitoba, Res Inst Oncol, Canc Care Manitoba, Winnipeg, MB R3E 0V9, Canada; [Ghavami, Saeid] Univ Manitoba, Canc Care Manitoba, Res Inst Hematol, Winnipeg, MB R3E 0V9, Canadaen_US
dc.descriptionGhavami, Saeid/0000-0001-5948-508X; Zarepour, Atefeh/0000-0002-0347-5840; Zarrabi, Ali/0000-0003-0391-1769; Pecic, Stevan/0000-0002-3706-8768; Madrakian, Tayyebeh/0000-0002-6876-7633; Mehrbod, Parvaneh/0000-0002-8391-9228; ORIVE, GORKA/0000-0002-0773-300X; Ahmadi, Mazaher/0000-0001-9969-170X; SEZEN, Serap/0000-0003-3382-6020; Koc, Bahattin/0000-0001-9073-8516; Rosik, Jakub/0000-0001-7377-4566; Cakir, Nilufer/0000-0001-5447-527X; Los, Marek/0000-0001-9518-1411; Fallah, Ali/0000-0002-7744-4246en_US
dc.description.abstractSimple Summary Rhabdomyosarcoma (RMS) is a rare pediatric sarcoma affecting skeletal muscle in children and young adults. It is responsible for 3% of all childhood malignant tumors and is the third most prevalent pediatric extracranial solid tumor. Despite advances in diagnostic and treatment methods and clinical trials to improve pediatric RMS survival rates, children with high-risk RMS and recurrent disease have 5-year survival rates of less than 30% and 17%, respectively. The cure rate remains low and the current RMS therapies continue to pose potential life-threatening toxicities, which can lead to lifelong morbidity. The treatment strategies for RMS include multi-agent chemotherapies after surgical resection with or without radiotherapy. Here, we focus on chemotherapy strategies and discuss the impact of apoptosis, autophagy, and the UPR that are involved in the chemotherapy response. Then, to screen future therapeutic approaches and promote muscle regeneration, we discuss in vivo mouse and zebrafish models and in vitro three-dimensional bioengineering models.Abstract Rhabdomyosarcoma is a rare cancer arising in skeletal muscle that typically impacts children and young adults. It is a worldwide challenge in child health as treatment outcomes for metastatic and recurrent disease still pose a major concern for both basic and clinical scientists. The treatment strategies for rhabdomyosarcoma include multi-agent chemotherapies after surgical resection with or without ionization radiotherapy. In this comprehensive review, we first provide a detailed clinical understanding of rhabdomyosarcoma including its classification and subtypes, diagnosis, and treatment strategies. Later, we focus on chemotherapy strategies for this childhood sarcoma and discuss the impact of three mechanisms that are involved in the chemotherapy response including apoptosis, macro-autophagy, and the unfolded protein response. Finally, we discuss in vivo mouse and zebrafish models and in vitro three-dimensional bioengineering models of rhabdomyosarcoma to screen future therapeutic approaches and promote muscle regeneration.en_US
dc.description.sponsorshipURGP [56977]; CHRIM [OG2023-24-05]en_US
dc.description.sponsorshipS.G. was supported by the URGP (56977) and CHRIM (OG2023-24-05) operating grant.en_US
dc.identifier.citationcount6
dc.identifier.doi10.3390/cancers15215269
dc.identifier.issn2072-6694
dc.identifier.issue21en_US
dc.identifier.pmid37958442
dc.identifier.scopus2-s2.0-85176726499
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/cancers15215269
dc.identifier.urihttps://hdl.handle.net/20.500.14517/1294
dc.identifier.volume15en_US
dc.identifier.wosWOS:001103177700001
dc.identifier.wosqualityQ2
dc.institutionauthorKoc B.
dc.institutionauthorKoç, Şirin
dc.language.isoen
dc.publisherMdpien_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.scopus.citedbyCount22
dc.subjectalveolar rhabdomyosarcomaen_US
dc.subjectapoptosisen_US
dc.subjectautophagyen_US
dc.subjectunfolded protein responseen_US
dc.subjectbioengineeringen_US
dc.subjecttumor stiffnessen_US
dc.titleRhabdomyosarcoma: Current Therapy, Challenges, and Future Approaches to Treatment Strategiesen_US
dc.typeReviewen_US
dc.wos.citedbyCount23
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscoveryfc8d7d33-b73d-4dc3-9cef-b7e6bda58193

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