Chitosan Nanoplatforms as Carriers for Photodynamic and Photothermal Therapies in Cancer, Wound Healing, and Antimicrobial Applications

Abstract

Chitosan (CS)-based nanoplatforms have emerged as transformative tools in photodynamic (PDT) and photothermal (PTT) therapies, offering targeted, biocompatible solutions for cancer treatment, wound healing, and antimicrobial applications. Recent advancements include the design of multifunctional CS nanocomposites that enhance photosensitizer delivery, improve light-triggered efficacy, and enable synergistic therapies with reduced side effects. These developments address critical challenges in precision medicine, such as drug resistance and tissue regeneration, making this area of significant interdisciplinary interest. The tunable physicochemical properties of CS, combined with its biodegradability and antimicrobial activity, position it as a key material for next-generation therapeutic platforms. The future of this field depends on optimizing nanoplatform specificity, scalability, and clinical translation, with insights from this review guiding the rational design of advanced biomaterials. This review aims to provide a comprehensive overview of the recent advancements in CS-based nanomaterials specifically for PTT and PDT, while also addressing the associated challenges that hinder their clinical application. Moreover, it aims to highlight future perspectives that could enhance the effectiveness and applicability of chitosan-based therapies in cancer treatment. © 2025 Elsevier Ltd.