On knowledge discovery in open medical data on the example of the FDA drug adverse event reporting system for alendronate (Fosamax)

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2013

Authors

Yildirim,P.
Ekmekci,I.O.
Holzinger,A.

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Open Access Color

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Abstract

In this paper, we present a study to discover hidden patterns in the reports of the public release of the Food and Drug Administration (FDA)'s Adverse Event Reporting System (AERS) for alendronate (fosamax) drug. Alendronate (fosamax) is a widely used medication for the treatment of osteoporosis disease. Osteoporosis is recognised as an important public health problem because of the significant morbidity, mortality and costs of treatment. We consider the importance of alendronate (fosamax) for medical research and explore the relationship between patient demographics information, the adverse event outcomes and drug's adverse events. We analyze the FDA's AERS which cover the period from the third quarter of 2005 through the second quarter of 2012 and create a dataset for association analysis. Both Apriori and Predictive Apriori algorithms are used for implementation which generates rules and the results are interpreted and evaluated. According to the results, some interesting rules and associations are obtained from the dataset. We believe that our results can be useful for medical researchers and decision making at pharmaceutical companies. © 2013 Springer-Verlag.

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Keywords

alendronate (fosamax), apriori algorithm, biomedical data mining, cooccurrence analysis, drug adverse event, knowledge discovery, Open medical data, osteoporosis

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14

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Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) -- 3rd International Workshop on Human-Computer Interaction and Knowledge Discovery in Complex, Unstructured, Big Data, HCI-KDD 2013, Held at SouthCHI 2013 -- 1 July 2013 through 3 July 2013 -- Maribor -- 97742

Volume

7947 LNCS

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Start Page

195

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206