Bioinspired Nanomaterials to Combat Microbial Biofilm and Pathogen Challenges: A Review

Abstract

The emergence of antibiotic-resistant biofilms poses a significant challenge in healthcare, as these complex microbial communities demonstrate an increased resistance to conventional treatment methods. Traditional antibiotics often fail against biofilms, resulting in persistent infections and treatment failures. To address this urgent issue, innovative strategies such as bioinspired nanomaterials, antimicrobial peptides, quorum sensing inhibitors, and combination therapies show promise in disrupting biofilm structures, enhancing antimicrobial activity, and overcoming resistance mechanisms. Bioinspired nanomaterials have emerged as a pivotal approach for tackling the challenges presented by biofilms and microbial pathogens across various sectors, including healthcare, industry, and environmental protection. Their advantages include enhanced biocompatibility, targeted delivery, and improved efficacy against biofilm formation and microbial threats. Recent advancements highlight the potential of innovative solutions, such as antimicrobial nanoparticles, smart nanocarriers, surface modifications, and nanozymes, in combating biofilm-related issues. Despite significant progress in bioinspired nanomaterial research, challenges remain. The intricate interactions within biofilms and the evolving nature of microbial pathogens necessitate multidisciplinary approaches. Furthermore, translating laboratory findings into practical applications faces obstacles related to scalability, stability, and regulatory compliance. Future advancements in bioinspired nanomaterials are expected to focus on multifunctional nanoparticles that disrupt biofilms, advanced surface modifications for better interaction, smart nanocarriers for targeted delivery, and innovative nanozymes to dismantle biofilm structures. This review focuses on the development and application of bioinspired nanoparticles to address microbial biofilm and pathogen challenges. It emphasizes the roles of antimicrobial nanoparticles, surface modifications, smart nanocarriers, and nanozymes in enhancing the efficacy and targeting capabilities. Additionally, the review explores the potential of bioinspired nanomaterials in formulating biofilm management practices, providing insights into the advantages, limitations, and future perspectives of these innovative approaches.