Aspirin, low molecular weight heparin, or both in preventing pregnancy complications in women with recurrent pregnancy loss and factor V Leiden mutation

dc.authorscopusid 57188755301
dc.authorscopusid 56439873300
dc.authorscopusid 54393007500
dc.authorscopusid 57203396053
dc.authorscopusid 57211453477
dc.authorscopusid 6701507807
dc.authorwosid Caliskan, Eray/HTR-8541-2023
dc.authorwosid Aslancan, Reyhan/JMR-1028-2023
dc.contributor.author Karadag, Cihan
dc.contributor.author Akar, Bertan
dc.contributor.author Gonenc, Gokcenur
dc.contributor.author Aslancan, Reyhan
dc.contributor.author Yilmaz, Nagihan
dc.contributor.author Caliskan, Eray
dc.date.accessioned 2024-05-25T11:39:57Z
dc.date.available 2024-05-25T11:39:57Z
dc.date.issued 2020
dc.department Okan University en_US
dc.department-temp [Karadag, Cihan; Gonenc, Gokcenur; Caliskan, Eray] Okan Univ, Sch Med, Dept Obstet & Gynecol, Istanbul, Turkey; [Akar, Bertan] Istinye Univ, Sch Med, Dept Obstet & Gynecol, Istanbul, Turkey; [Aslancan, Reyhan] Bahcesehir Univ, Sch Med, Dept Obstet & Gynecol, Istanbul, Turkey; [Yilmaz, Nagihan] Istanbul Aydin Univ, Sch Med, Dept Obstet & Gynecol, Istanbul, Turkey en_US
dc.description.abstract Objective: The aim of this study was to compare the effects of low molecular weight heparin (LMWH), LMWH plus low dose aspirin, or low dose aspirin only on pregnancy outcomes in recurrent pregnancy loss (RPL) patients with factor V Leiden mutation (FVLM). Materials and methods: A total of 2764 RPL patients were evaluated in for the etiology of RPL. Mutations in factor V Leiden homozygous and heterozygous were determined. Subsequently, 196 of these patients were diagnosed with FVLM and included in the study; of these 174 completed the study. At the sixth week of gestation of subsequent pregnancy participants were randomly distributed into three groups. Group A (n?=?61) was composed of patients with an oral dose of 100?mg aspirin daily, Group B (n?=?59) consisted of patients using 40?mg enoxaparin and 100?mg orally aspirin daily, and Group C (n?=?54) included patients using 40?mg enoxaparin daily during pregnancy. Results: Among the 174 patients who completed the study, the live birth and miscarriage rates were similar for the three groups (p?=?.843 and p?=?.694, respectively). There was no significant difference among the groups in rates of eclampsia, placental abruption, intrauterine fetal growth restriction and gestational diabetes mellitus. The number of preeclamptic patients was significantly higher in Group A than Groups B and C. The levels of preterm birth was significantly higher in Group A than Groups B and C. Conclusion: Using low dose aspirin, LMWH plus aspirin, or LMWH alone yielded comparable live birth rates in RPL patients with FVLM. However, LMWH decreased the risk of preeclampsia in this group of patients. LMWH might therefore have a preventive role regarding preeclampsia. en_US
dc.identifier.citationcount 17
dc.identifier.doi 10.1080/14767058.2019.1671348
dc.identifier.endpage 1939 en_US
dc.identifier.issn 1476-7058
dc.identifier.issn 1476-4954
dc.identifier.issue 11 en_US
dc.identifier.pmid 31550962
dc.identifier.scopus 2-s2.0-85074050727
dc.identifier.scopusquality Q2
dc.identifier.startpage 1934 en_US
dc.identifier.uri https://doi.org/10.1080/14767058.2019.1671348
dc.identifier.uri https://hdl.handle.net/20.500.14517/1379
dc.identifier.volume 33 en_US
dc.identifier.wos WOS:000488409300001
dc.identifier.wosquality Q4
dc.language.iso en
dc.publisher Taylor & Francis Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 19
dc.subject Aspirin en_US
dc.subject factor V Leiden mutation en_US
dc.subject live birth en_US
dc.subject low molecular weight heparin en_US
dc.subject recurrent pregnancy loss en_US
dc.title Aspirin, low molecular weight heparin, or both in preventing pregnancy complications in women with recurrent pregnancy loss and factor V Leiden mutation en_US
dc.type Article en_US
dc.wos.citedbyCount 18

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