Effects of Topical Timolol Maleate on Anterior Segment Structure, Pupil Dynamics and Retinal and Choroidal Thickness in Healthy Subjects

dc.contributor.author Veysel CANKURTARAN
dc.contributor.author Serdar OZATES
dc.date.accessioned 2024-05-25T12:20:19Z
dc.date.available 2024-05-25T12:20:19Z
dc.date.issued 2020
dc.department Okan University en_US
dc.department-temp Mustafa Kemal Üniversitesi, Tıp Fakültesi, Hatay, Türkiye Okan Üniversitesi, Tıp Fakültesi, İstanbul, Türkiye en_US
dc.description.abstract Purpose: To investigate the effect of a single dose of topical timolol maleate 0.5% on anterior segment structure, pupil dynamics, and retinal and choroidal thickness in healthy subjects. Materials and Methods: Thirty subjects were included in this prospective and observational study.One eye of the participants received a single dose of topical benzalkonium chloride (BAC) preserved Timolol maleate 0.5% (Timosol 0.5%, Bilim Ilac, Istanbul, Turkey) (treated eye). Contralateral eye received a single dose of sodium hyaluronate ophthalmic solution without preservative (control eye). Main outcome measures were central corneal thickness (CCT), aqueous depth, anterior chamber volume, iridocorneal angle, horizontal anterior chamber diameter, static and dynamic pupil functions, central macular thickness, and choroidal thickness. Results: Mean CCT was signifi cantly higher after timolol instillation in treated eyes (p=0.001). Timolol did not affect aqueous depth, anterior chamber volume, iridocorneal angle and horizontal anterior chamber diameter in treated eyes (p>0.05 for each). Mean pupil diameters were similar under scotopic, mesopic and photopic conditions before and after timolol instillation (p>0.05 for each); however, pupil dilation speed was signifi cantly lower after timolol instillation in the treated eyes (p<0.05). Mean central macular thickness was signifi cantly higher after timolol instillation in treated eyes (p=0.005); however, no signifi cant difference was observed in choroidal thickness (p>0.05). Pre- and post-instillation outcomes were similar in control eyes for all parameters (p>0.05 for each). Conclusion: Topical BAC-preserved timolol maleate reduces pupil dilation speed without any effect on static pupil functions and increases the CCT and central macular thickness. en_US
dc.identifier.citationcount 0
dc.identifier.doi 10.37844/glauc.cat.2020.15.31
dc.identifier.endpage 180 en_US
dc.identifier.issn 1305-9173
dc.identifier.issn 2717-7157
dc.identifier.issue 3 en_US
dc.identifier.startpage 174 en_US
dc.identifier.trdizinid 410617
dc.identifier.uri https://doi.org/10.37844/glauc.cat.2020.15.31
dc.identifier.uri https://search.trdizin.gov.tr/tr/yayin/detay/410617/effects-of-topical-timolol-maleate-on-anterior-segment-structure-pupil-dynamics-and-retinal-and-choroidal-thickness-in-healthy-subjects
dc.identifier.uri https://hdl.handle.net/20.500.14517/1887
dc.identifier.volume 15 en_US
dc.language.iso en
dc.relation.ispartof Glokom Katarakt en_US
dc.relation.publicationcategory Diğer en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.title Effects of Topical Timolol Maleate on Anterior Segment Structure, Pupil Dynamics and Retinal and Choroidal Thickness in Healthy Subjects en_US
dc.type Article en_US

Files