Kanlioz, MuratEkici, UgurFerhatoglu, Murat Ferhat2024-05-252024-05-25202242168-818410.7759/cureus.31071https://doi.org/10.7759/cureus.31071https://hdl.handle.net/20.500.14517/960Introduction The aim of this work was to treat patients with leaky gut syndrome (LGS) and gastrointestinal flora loss in a simple, inexpensive, permanent and effective way without the need for further treatment. Methods A total gastrointestinal flora transplantation (TGFT) procedure is performed by simultaneously transferring the "flora" taken from approximately 30 different anatomical sites, from the mouth to the anus, of healthy donors to the corresponding anatomical site of the patient using the endoscopic lavage method. Results Of the patients, 25 (44.6%) were female and 31 (55.4%) were male, totaling 56 (100%). The mean age was 32.88 +/- 15.78 years. Among the 56 patients enrolled in the study, TGFT had no efficacy in one patient, five patients underwent repeat TGFT during a mean follow-up period of 23.73 +/- 16.74 months, and the treatment was permanent in 50 patients; our success rate during the follow-up period was 89.3%. Conclusion In LGS, TGFT should be the gold standard treatment.eninfo:eu-repo/semantics/openAccessceliac diseasefecal microbiota transplantation (fmt)intestinal flora disorderfood allergy quality of lifetotal gastrointestinal flora transplantationleaky gut syndromeArticle1411WOS:00097854420003336475195