Khoshvaghti, HabibAltunkaynak, Berrin ZuhalHistoloji ve Embriyoloji / Histology and Embriology2024-05-252024-05-25201802008-38662008-387410.22038/IJBMS.2018.24756.6152https://doi.org/10.22038/IJBMS.2018.24756.6152https://hdl.handle.net/20.500.14517/404Objective(s): In this study, potential protective effects of Bortezomib (Bort), as a proteasome inhibitor, were investigated on the uterus of ovariectomized rats by histological, morphometric and immunohistochemical methods. Materials and Methods: In this study, 18 Sprague dawley strain female rats (12 weeks old, 250-300 g body weight) were used. Animals in the control group (Cont, n=6) were not exposed to any treatment. Ovariectomy was performed on the experimental groups. They (n=12) were divided into ovariectomy (Ovt, n=6) and Bortezomib (Bort, n=6) subgroups. Twelve weeks later, the rats were perfused. Then, uterine tissues were removed and examined by morphometrical, and light and electron microscopy methods. In addition, immunoreactivity of nuclear factor-kappa (NF-kappa B) was evaluated. Results: Morphometric and histopathological evaluations showed that Bort was effective in the uterus and protects the layer structures and the cells. Conclusion: In the light of these findings, we suggest that for proteasome inhibitor particularly Bort is thought to be useful through proteasome inhibition and NF-kappa B pathway.eninfo:eu-repo/semantics/closedAccessBortezomibMicroscopyOvariectomyRatStereologyUterusArticleQ3Q3211111181125WOS:00044592310000430483384