WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14517/18

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Browsing WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection by Author "Akdeniz F.T."

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    Investigation of Mirna-223-3p Expression in Non-small Cell Lung Cancers
    (int inst Anticancer Research, 2024) Barut, Zerrin; Akdeniz, Fatma Tuba; Isbir, Turgay; Genetik ve Biyomühendislik / Genetic and Bio-Engineering
    Background/ Aim: Lung cancer remains a principal cause of cancer-related mortality worldwide. Non-small cell lung cancer (NSCLC), representing a significant 80-85% of lung cancer diagnoses, often presents at an advanced stage, with many patients demonstrating local growth or metastasis at the time of detection. Consequently, there exists a pressing need for augmented research into the molecular and genetic underpinnings of this malignancy to facilitate the development of innovative therapeutic and preventative strategies. MicroRNA's (miRNAs) are non-coding RNA molecules, consisting of 20-25 nucleotides. Their involvement in epigenetic processes holds a pivotal role in the elucidation of molecular mechanisms. This study examined the potential of miRNA-223-3p as a biomarker in the diagnosis of patients with NSCLC. Materials and Methods: The expression analysis of miRNA-223-3p was performed in serum samples obtained from 18 patients diagnosed with NSCLC and a control group comprising 15 healthy volunteers. Results: The miRNA-223-3p Delta CT values in the serum samples taken from the patient group exhibited statistically significant elevation compared to those of the control group (p=0.043). Conclusion: The present study corroborates previous literature indicating elevated levels of miRNA-223-3p in NSCLC cases and thereby suggesting its potential role as a biomarker in NSCLC cases.
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    Unraveling the Impact of miRNA-17 in Glial Tumors and Cerebral Metastases: A Step Towards Enhanced Diagnosis and Prognosis
    (int inst Anticancer Research, 2024) Turk, Okan; Demirel, Nail; Yaltirik, Cumhur Kaan; Kaya, Mustafa; Sahin, Omer Faruk; Yilmaz, Seda Guelec; Isbir, Turgay; Genetik ve Biyomühendislik / Genetic and Bio-Engineering
    Background/Aim: MicroRNAs (miRNAs) have been identified as key regulators in various cancer types, including brain tumors. This study aimed to investigate the differential expression of miRNA-17 in glial tumors, cerebral metastases, and normal glial tissues. Materials and Methods: A total of 42 patients were included in this cross-sectional study. Tissue samples were obtained from patients with glial tumors or cerebral metastases and from normal glial tissues. miRNA-17 expression levels were computed by using real-time polymerase chain reaction. Receiver operating characteristics analysis was used to determine the predictive potential of miRNA-17. Results: In this study, we demonstrated a statistically significant difference in miRNA-17 expression levels between glial tumors and the control group (p=0.001), with higher miRNA-17 expression observed in glial tumors. Similarly, there was statistically higher miRNA-17 expression in metastatic cases compared with the control group (p=0.007). Conclusion: These findings suggest miRNA-17 might be a potential biomarker for differentiating glial tumors and cerebral metastases from normal glial tissue, although further research is necessary to validate these findings and investigate the potential role of miRNA-17 in the pathogenesis of these brain tumors.