WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14517/18
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Article Citation Count: 0Measurements of Polarization and Spin Correlation and Observation of Entanglement in Top Quark Pairs Using Lepton Plus Jets Events From Proton-Proton Collisions at √s=13 Tev(Amer Physical Soc, 2024) Hayrapetyan, A.; Tumasyan, A.; Adam, W.; Andrejkovic, J. W.; Benato, L.; Bergauer, T.; Druzhkin, D.Measurements of the polarization and spin correlation in top quark pairs (t (t) over bar) are presented using events with a single electron or muon and jets in the final state. The measurements are based on proton-proton collision data from the LHC at root s = 13 TeV collected by the CMS experiment, corresponding to an integrated luminosity of 138 fb(-1). All coefficients of the polarization vectors and the spin correlation matrix are extracted simultaneously by performing a binned likelihood fit to the data. The measurement is performed inclusively and in bins of additional observables, such as the mass of the t (t) over bar system and the top quark scattering angle in the t (t) over bar rest frame. The measured polarization and spin correlation are in agreement with the standard model. From the measured spin correlation, conclusions on the t (t) over bar spin entanglement are drawn by applying the Peres-Horodecki criterion. The standard model predicts entangled spins for t (t) over bar states at the production threshold and at high masses of the t (t) over bar system. Entanglement is observed for the first time in events at high t (t) over bar mass, where a large fraction of the t (t) over tilde decays are spacelike separated, with an expected and observed significance of above 5 standard deviations.Article Citation Count: 0A Fractional-Order Improved Fitzhugh-Nagumo Neuron Model(Iop Publishing Ltd, 2025) Kumar, Pushpendra; Erturk, Vedat SuatWe propose a fractional-order improved FitzHugh-Nagumo (FHN) neuron model in terms of a generalized Caputo fractional derivative. Following the existence of a unique solution for the proposed model, we derive the numerical solution using a recently proposed L1 predictor-corrector method. The given method is based on the L1-type discretization algorithm and the spline interpolation scheme. We perform the error and stability analyses for the given method. We perform graphical simulations demonstrating that the proposed FHN neuron model generates rich electrical activities of periodic spiking patterns, chaotic patterns, and quasi-periodic patterns. The motivation behind proposing a fractional-order improved FHN neuron model is that such a system can provide a more nuanced description of the process with better understanding and simulation of the neuronal responses by incorporating memory effects and non-local dynamics, which are inherent to many biological systems.Article Citation Count: 0Advances in Phototheranostic Agents: From Imaging To Targeted Therapy(Elsevier Sci Ltd, 2025) Samadzadeh, Meisam; Khosravi, Arezoo; Zarepour, Atefeh; Noei, Hadi; Sivakumar, Ponnurengam Malliappan; Iravani, Siavash; Zarrabi, AliThe recent evolution of phototheranostic agents represents a groundbreaking intersection of diagnostic imaging and targeted therapy, particularly in oncology. This review aims to elucidate the recent advances in phototheranostic agents, highlighting their dual functionality in imaging and targeted therapy. Despite significant progress, several challenges persist, including the optimization of agent specificity, light penetration in tissues, and the potential for off-target effects. The variability in tumor microenvironments presents a significant obstacle, complicating the development of universal phototheranostic agents. Moreover, concerns regarding the long-term stability, potential toxicity, and biocompatibility of these agents necessitate thorough evaluation and optimization. Notably, the complexity of designing nanoparticles that can effectively deliver both imaging and therapeutic modalities poses additional hurdles. Future perspectives in this field emphasize the need for innovative strategies to enhance agent stability, biocompatibility, and targeted delivery. Furthermore, ongoing research focuses on the development of novel light-based techniques and the exploration of combination therapies to improve treatment efficacy. By addressing these challenges, the potential of phototheranostic agents to transform personalized cancer therapy becomes increasingly promising. This review serves as a comprehensive overview of the current landscape, challenges, and future directions in phototheranostic research, ultimately aiming to inform and inspire further investigation in this dynamic field.Article Citation Count: 0Thyroid Cancer in Childhood Cancer Survivors: Demographic, Clinical, Germline Genetic Characteristics, Treatment, and Outcome(Mdpi, 2025) Yildirim, Ulku Miray; Kebudi, Rejin; Celik, Ayca Iribas; Zulfikar, Buelent; Kebudi, AbutObjective: Childhood cancer survival rates have improved, but survivors face an increased risk of second malignant neoplasms (SMNs), particularly thyroid cancer. This study examines the demographic, clinical, genetic, and treatment characteristics of childhood cancer survivors who developed thyroid cancer as a second or third malignancy, emphasizing the importance of long-term surveillance. Methods: A retrospective review was conducted for childhood cancer survivors treated between 1990 and 2018 who later developed thyroid cancer as a second or third malignancy. Data on demographics, clinical characteristics, treatment, and outcomes were analyzed. Results: Among the 3204 childhood cancer survivors, 10 patients (6 female, 4 male) developed papillary thyroid carcinoma (PTC), a median of 9 years post-initial diagnosis. Radiation therapy, particularly to the head and neck, was commonly used. Genetic testing revealed mutations in the Cell Cycle CheckPoint Kinase 2 (CHEK2) and Adenomatous Polyposis Coli (APC) genes in four patients, possibly contributing to the increased risk. All were diagnosed through thyroid ultrasound and underwent total thyroidectomy, and three received radioactive iodine (RAI). No recurrences or deaths related to PTC occurred, with a median follow-up of 5.5 years after diagnosis. Conclusions: Radiation therapy, especially combined with chemotherapy, significantly increases the risk of thyroid cancer in childhood cancer survivors. Genetic predispositions also play a role. Lifelong thyroid cancer surveillance is essential, particularly for those who received radiation or chemotherapy. Further research is needed to refine surveillance strategies and better understand genetic factors that influence thyroid cancer risk. Early detection and ongoing monitoring are critical for improving long-term outcomes.Article Citation Count: 0Work-Domain Goal Orientation: a Theoretical Framework for the Construct and Turkish Adaptation of a Work-Domain Goal Orientation Instrument(Mdpi, 2025) Gurol, Aysun; Findikoglu, Dilek Ilhan; Gurol, Mehmet; Findikoglu, Fuat; Yesilkaya, MehmetThis study brings a novel perspective to the relationship between higher education and work life by examining work-domain goal orientation as a critical factor in preparing students for professional environments. Through an extensive literature review, it highlights the role of work-domain goal orientation in aligning higher education curricula with the demands of the modern workplace, emphasizing how students' goal orientation influences their future professional success. Additionally, this study adapts and validates a work-domain goal orientation instrument into Turkish, offering a reliable tool for use in Turkish contexts. A sample of 729 undergraduate students from various academic disciplines participated in the study. Exploratory and confirmatory factor analyses confirmed a three-factor structure (learning, proving, avoiding), accounting for 68.4% of the variance. The internal consistency was reliable, with Cronbach's alpha values ranging from 0.84 to 0.86 across subscales. The study provides a dual contribution by offering theoretical insights into work-domain goal orientation and delivering a psychometrically validated tool for assessing students' readiness for professional life in a non-Western context. These findings address gaps in the literature on goal orientation and its application in diverse cultural settings, advancing both academic understanding and practical applications for educational institutions and employers. This study contributes to bridging the gap between higher education and work life, offering both theoretical perspectives and a practical tool to improve workforce preparedness.Article Citation Count: 0Search for Bottom Quark Associated Production of the Standard Model Higgs Boson in Final States With Leptons in Proton-Proton Collisions at √s=13 Tev(Elsevier, 2025) Hayrapetyan, A.; Tumasyan, A.; Adam, W.; Andrejkovic, J. W.; Bergauer, T.; Chatterjee, S.; Makarenko, V.This Letter presents the first search for bottom quark associated production of the standard model Higgs boson, in final states with leptons. Higgs boson decays to pairs of tau leptons and pairs of leptonically decaying W bosons are considered. The search is performed using data collected from 2016 to 2018 by the CMS experiment in proton-proton collisions at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 138 fb(-1). Upper limits at the 95% confidence level are placed on the signal strength for Higgs boson production in association with bottom quarks; the observed (expected) upper limit is 3.7 (6.1) times the standard model prediction.Article Citation Count: 0Does Time Perspective Affect the Association Between Childhood Traumas and Post-Traumatic Growth?(Springer, 2025) Gokkaya, Fuesun; Yurdalan, Fatih; Civgin, UmutTime perspective is a concept that elucidates the manner in which individuals assess the present, past, and future. In the relevant literature, trauma and trauma-related issues have been matched to time perspective. In particular, there are conflicting findings regarding post-traumatic growth. The objective of the research is to investigate the mediator role of time perspective in the relationship between childhood traumas and post-traumatic growth. Based on this, it is predicted that early traumas and post-traumatic growth will be related to time perspective and proposed relationship will have important consequences for literature and clinicians. For this purpose, 676 participants were included, and the survey set was presented to the participants. Pearson correlation and mediation were performed. Results showed that there is a only significant relationship between emotional neglect and post-traumatic growth, while there is no relationship between the other sub-dimensions of childhood traumas and post-traumatic growth. As a result of the mediation analysis conducted, it was seen that time perspectives played a mediator role between emotional neglect and post-traumatic growth. The results obtained were discussed within the framework of the related literature and suggestions for future studies were presented.Review Citation Count: 0Anionic Polysaccharides as Delivery Carriers for Cancer Therapy and Theranostics: an Overview of Significance(Elsevier, 2025) Sivakumar, Ponnurengam Malliappan; Zarepour, Atefeh; Akhter, Sohail; Perumal, Govindaraj; Khosravi, Arezoo; Balasekar, Premkumar; Zarrabi, AliRecently, cancer therapy has witnessed remarkable advancements with a growing focus on precision medicine and targeted drug delivery strategies. The application of anionic polysaccharides has gained traction in various drug delivery systems. Anionic polysaccharides have emerged as promising delivery carriers in cancer therapy and theranostics, offering numerous advantages such as biocompatibility, low toxicity, and the ability to encapsulate and deliver therapeutic agents to tumor sites with high specificity. This review underscores the significance of anionic polysaccharides as essential components of the evolving landscape of cancer therapy and theranostics. These polymers can be tailored to carry a wide range of therapeutic cargo, including chemotherapeutic agents, nucleic acids, and imaging agents. Their negative charge enables electrostatic interactions with positively charged drugs and facilitates the formation of stable nanoparticles, liposomes, or hydrogels for controlled drug release. Additionally, their hydrophilic nature aids in prolonging circulation time, reducing drug degradation, and minimizing off-target effects. Besides, some of them could act as targeting agents or therapeutic compounds that lead to improved therapeutic performance. This review offers valuable information for researchers, clinicians, and biomedical engineers. It provides insights into the recent progress in the applications of anionic polysaccharide-based delivery platforms in cancer theranostics to transform patient outcomes.Article Citation Count: 0Framing of Syrian Refugees in Turkish Politics: an Analysis of Turkish Grand National Assembly Debates(Routledge Journals, Taylor & Francis Ltd, 2025) Kentmen-Cin, Cigdem; Sunay, Selcuk; Baltepe, Nazli EceThis study examines how Turkish political parties framed the Syrian refugee issue in floor speeches in the Turkish parliament leading up to the 2023 general election. Building upon research that explores how political party ideologies, issue ownership, and issue salience shape party approaches to immigration and refugee issues, we analyzed the incumbent AKP's response to opposition criticisms of its open-border policy. Additionally, we examined whether the CHP, MHP, & Idot;Y & Idot;P, and HDP increased their standing on the issue by addressing it in speeches and whether they framed the issue from social, demographic, economic, humanitarian, or security threat perspectives.Review Citation Count: 0The Safety and Efficacy of Robotic Radiosurgery and Radiotherapy in the Management of Skull Base Tumors: a Systematic Review and Meta-Analysis(Springer, 2025) Javadnia, Parisa; Bahadori, Amir Reza; Ghanaatpisheh, Aref; Dahaghin, Saba; Rajabi, Mohammad; Davari, Afshan; Tafakhori, AbbasStereotactic radiosurgery (SRS) and radiotherapy (SRT) have gained prominence as both adjuvant and primary treatment options for patients with skull base tumors that are either inoperable or present as residual or recurrent lesions post-surgery. The object of the current study is to evaluate the safety and efficacy of robotic-assisted SRS and SRT across various skull base pathologies. The study was conducted under PRISMA guidelines and involved a comprehensive evaluation of databases, including PubMed, Scopus, Embase, Web-of-Science, and the Cochrane Library. The data collection period was extended up to 30 September. Statistical analyses were executed using Comprehensive Meta-Analysis software. Furthermore, Cochran's Q test assessed statistical heterogeneity within the findings. From an initial pool of 1,792 articles, 69 studies were included in the systematic review, with 60 qualifying for meta-analysis, encompassing 3,046 participants. Meta-analysis revealed tumor control rates were significantly enhanced with the use of CyberKnife (95% CI: 0.901-0.928, p < 0.001) and robotic Gamma Knife radiosurgery (GKRS) (95% CI: 0.897-0.959, p < 0.001). Meningiomas and schwannomas exhibited higher treatment responsiveness (ES: 0.960 and 0.949, respectively), whereas chordomas displayed lower responsiveness (ES: 0.743). The overall major adverse event rate was between 5.6% and 8.3% (95% CI: 0.056-0.083, p < 0.001). Adverse events exhibited a higher incidence in patients with adenomas (95% CI: 0.122-0.217, p < 0.001), while they were least prevalent in those with schwannomas (95% CI: 0.019-0.041, p < 0.001). Robotic SRS and SRT, employing both gamma-knife and cyber-knife, have demonstrated promising outcomes characterized by high efficacy and safety in managing various skull base tumors.Article Citation Count: 0Demographic Features, Clinical Characteristics, and Comorbid Relation in Hidradenitis Suppurativa: a Population-Based Study(Frontiers Media Sa, 2025) Kaya, Gokhan; Ozgen, Fatma Pelin; Kelahmetoglu, Osman; Kucuk, Ozlem Su; Onsun, NahideBackground/objective Hidradenitis suppurativa (HS) is a chronic inflammatory disease affecting apocrine gland areas, characterized by painful nodules and abscesses that may result in sinus tracts and scarring. The global prevalence of HS is increasing due to heightened awareness, improved diagnostic methods, rising obesity rates, and higher smoking prevalence. This study aimed to describe the epidemiological, clinical, and comorbid characteristics of HS patients.Methodology This retrospective descriptive cross-sectional study included 193 outpatients aged between 15 and 73 years who visited a tertiary HS clinic between 2017 and 2022. Demographic, clinical, and comorbid characteristics were recorded and analyzed using chi-square and ordinal regression methods.Results The mean age was 34.5 +/- 12.1 years, with a mean disease duration of 5.9 +/- 6.7 years. According to the Hurley classification, 61.1, 24.4, and 14.5% were stages I, II, and III, respectively. Comorbidities were present in 48.2% of patients, with psychiatric disorders (19.2%), diabetes mellitus (14%), and hypertension (9.3%) being most common. Disease duration, smoking, male gender, and atypical localization were associated with increased disease severity.Conclusion Geographic and cultural factors influence the prevalence, severity, and management of HS, necessitating tailored treatment. Effective management requires multidisciplinary screening for early detection and prevention of comorbidities, including psychiatric disorders, cardiovascular conditions, and metabolic syndrome.Article Citation Count: 0Degradation of Preformed Gram-Positive and Gram-Negative Bacterial Biofilms Using Disintegrated and Intact Phages(Mary Ann Liebert, inc, 2025) Ali, Sahd; Karaynir, Abdulkerim; Dogan, Hanife Salih; Nachimuthu, Ramesh; Badu, Kingsley; Bozdogan, BulentIntroduction: Biofilm is a major challenge across several sectors and contributes to serious risks to public health. This study aimed to evaluate the antibiofilm efficacy of disintegrated phages, whose lytic activities have been eliminated, against bacterial biofilms.Methods: A total of seven lytic phages were disintegrated by sonication and confirmed to have completely lost their lytic activities by the spot test. Subsequently, both the disintegrated and intact phages were tested on the biofilms produced by five different biofilm-producing bacteria. The effects of heat and proteinase K on the ability of disintegrated phages to disrupt biofilms were determined. Moreover, the structural proteins released after the disintegration of phages were screened for their presence of lipase, amylase, protease, and DNase activities. Genome analysis of all the seven phages were screened for the presence of genes encoding proteins with enzymatic activities.Results: The disintegrated phages showed more effectiveness in degrading the bacterial biofilm when compared with intact phages. The amylase test results were positive for all the seven disintegrated phages tested, confirming the presence of starch-degrading enzymes. Genomic analysis of five phages revealed the presence of genes encoding transglycosylases, amidases, and glycosaminidases, which could contribute to biofilm degradation. However, only four of these proteins were also structural proteins of phages.Conclusions: Our study demonstrated that disintegrated phages without lytic effects can still possess biofilm degrading ability, probably associated with the enzymatic activities of their structural proteins. This study showed that phages may have activities beyond lytic phage activities exhibited by their structural enzymes.Article Citation Count: 0Dentoalveolar and Skeletal Effects of an Anterior Open Bite Treatment Protocol Using Zygomatic Anchorage(Wiley, 2025) Acar, Yasemin Bahar; Ozbilen, Elvan Onem; Yildirim, Gamze; Kahraman, Dilara; Tozlu, Murat; Erverdi, Ahmet NejatObjectivePrimary aim was to analyse dentoalveolar and skeletal effects induced by an anterior open bite (AOB) treatment protocol for intrusion of maxillary buccal segment. Secondary aim was to investigate whether a subsequent change occurred in hyoid position.Materials and MethodsStudy group included 28 non-growing subjects treated in academic setting for correction of AOB. All patients received same appliance that included bilateral acrylic bite-blocks covering posterior dentition. Intrusive force was applied between buccal bars of appliance and zygomatic multipurpose implants. Lateral cephalograms taken at pre-treatment (T0) and after intrusion (T1) were analysed using NemoCeph software. Eight skeletal, 9 dental, 6 soft tissue and 5 hyoid parameters were measured and evaluated statistically.ResultsMean open bite was -3.2 +/- 2.1 mm at T0. T1-T0 duration was 9.6 +/- 1.9 months. Increase in SNB (1.1 degrees +/- 2.1 degrees) and the decrease in ANB (-1.1 degrees +/- 1.3 degrees), Y-axis (-0.5 degrees +/- 3.5 degrees), SN-GoGn (-2.0 degrees +/- -2.5 degrees) and lower facial height (-1.4 +/- 2.1 mm) were significant, indicating mandibular counter-clockwise rotation. Overjet and open bite decreased significantly (-1.8 +/- 2.3 mm and 4.2 +/- 2.1 mm, respectively). Maxillary molars intruded (U6-PP: -3.1 +/- 1.3 mm) and distalised (Delta U6-TVL: -1.5 +/- 2.7 mm) significantly. Mean change in L6-MP was significant (0.9 +/- 1.4 mm) showing mandibular molar eruption. Lower lip-true vertical line (TVL) showed significant forward movement of lower lip (-1.8 +/- 2.3 mm). Mean changes in hyoid parameters were not significant.ConclusionSignificant maxillary buccal segment intrusion was achieved in a relatively short period. AOB was corrected while facial profile and smile aesthetics were improved. Distalisation of maxillary molar suggests that intrusive force vector can be modified to achieve simultaneous intrusion and distalisation.Article Citation Count: 0Prepubertal Phthalate Exposure Can Cause Histopathological Alterations, Dna Methylation and Histone Acetylation Changes in Rat Brain(Sage Publications inc, 2025) Koc, Seyda; Erdogmus, Ekin; Bozdemir, Ozlem; Ozkan-Vardar, Deniz; Yaman, Unzile; Erkekoglu, Pinar; Kocer-Gumusel, BelmaDi-2-(ethylhexyl)phthalate (DEHP) is a phthalate derivative used extensively in a wide range of materials, such as medical devices, toys, cosmetics, and personal care products. Many mechanisms, including epigenetics, may be involved in the effects of phthalates on brain development. In this study, Sprague-Dawley male rats were obtained 21-23 days after their birth (post-weaning) and were exposed to DEHP during the prepubertal period with low-dose DEHP (DEHP-L, 30 mg/kg/day) and high-dose DEHP (DEHP-H, 60 mg/kg/day, 37 days) until the end of adolescence (PND 60). The rats in the study groups were sacrificed during adulthood, and histopathological changes, epigenetic changes, and oxidative stress parameters were evaluated in brain tissues. Histopathological findings indicating the presence of deterioration in brain tissue morphology were obtained, more prominently in the DEHP-H group. Examining the hippocampus under the light microscope, pyramidal neuron loss was detected only in CA1 of the DEHP-L group, while in DEHP-H rats, pyramidal neuron losses were detected in the CA1, CA2, and CA3 regions. No significant change was observed in brain lipid peroxidation levels with DEHP compared to control. Significant increases in total glutathione (GSH) in both dose groups were considered to be an adaptive response to DEHP-induced oxidative stress. The decrease in DNA methylation in the brain, although not statistically significant, and the increase in histone modification showed that exposure to DEHP may cause epigenetic changes in the brain and these epigenetic changes may also take place as one of the mechanisms underlying the damage observed in the brain. The results suggest that DEHP exposure during early development may have a significant effect on brain development.Review Citation Count: 0The State of the Art in Anti-Aging: Plant-Based Phytochemicals for Skin Care(Bmc, 2025) Tomas, Merve; Gunal-Koroglu, Deniz; Kamiloglu, Senem; Ozdal, Tugba; Capanoglu, EsraPhytochemicals help mitigate skin aging by scavenging free radicals, modulating key enzymatic pathways, and promoting the skin's structural integrity. Carotenoids, vitamins, essential fatty acids, and phenolic compounds work by acting as antioxidants, inhibiting enzymes like hyaluronidase, collagenase, and elastase, which degrade skin structure, and reducing levels of inflammatory markers (IL-6, IL-8, etc.) and matrix metalloproteinases (MMP-1, MMP-2) linked to aging. Recent research highlights that plant-based phytochemicals can improve skin elasticity, reduce hyperpigmentation, prevent the breakdown of important skin proteins, and support wound healing, making them valuable components for skin care and treatments. This review explores the multifaceted roles of phytochemicals in maintaining and improving skin health, highlighting their mechanisms of action and potential in skin anti-aging innovations.Letter Citation Count: 0Gut Microbiota in Crohn's Disease Pathogenesis(Baishideng Publishing Group inc, 2025) Ozbey, Dogukan; Saribas, Suat; Kocazeybek, BekirInflammatory bowel diseases (IBDs) are classified into two distinct types based on the area and severity of inflammation: Crohn's disease (CD) and ulcerative colitis. In CD, gut bacteria can infiltrate mesenteric fat, causing expansion known as creeping fat, which may limit bacterial spread and inflammation but can promote fibrosis. The gut bacteria composition varies depending on whether the colon or ileum is affected. Fecal microbiota transplantation (FMT) transfers feces from a healthy donor to restore gut microbiota balance, often used in IBD patients to reduce inflammation and promote mucosal repair. The use of FMT for CD remains uncertain, with insufficient evidence to fully endorse it as a definitive treatment. While some studies suggest it may improve symptoms, questions about the duration of these improvements and the need for repeated treatments persist. There is a pressing need for methods that provide long-term benefits, as highlighted by Wu et al's research.Article Citation Count: 0A Critical Point Approach To Non-Local Complex Systems of Fractional Discrete Equations(Taylor & Francis Ltd, 2025) Ferrara, Massimiliano; Heidarkhani, Shapour; Moradi, ShahinDiscrete fractional equations have emerged across various fields such as science, engineering, economics, and finance to better capture the characteristics of non-local complex systems. In this discussion, we explore the existence of at least three unique solutions for discrete fractional boundary value problems featuring a p-Laplacian operator, provided suitable hypotheses on nonlinear terms are met. Our approach primarily relies on variational methods and critical points theorems. Additionally, we present an example to demonstrate the implications of our findings.Review Citation Count: 0Heat Transfer Enhancement of Phase Change Materials Using Tree Shaped Fins: a Comprehensive Review(Pergamon-elsevier Science Ltd, 2025) Rashid, Farhan Lafta; Dhaidan, Nabeel S.; Mahdi, Ali Jafer; Kadhim, Saif Ali; Hammoodi, Karrar A.; Al-Obaidi, Mudhar A.; Agyekum, Ephraim BonahThe efficiency of thermal energy storage is essential in phase change material (PCM) systems. Many traditional configurations of fins, such as radial, rectangular, and pin fins, have yet to be found lacking in how they facilitate heat transfer at charging and discharging processes, causing more extended phase change periods and decreasing the entire system's efficiency. This review seeks to fill the gap in thermal performance improvement and categorizes the existing literature related to melting, solidification, and a combination of both melting and solidification processes. Scientific research carried out in the melting section shows that tree-shaped fins have the potential to cut down melting time by 60 % compared to conventional fins and thereby significantly improve the ability to store energy. The solidification section highlights that such revolutionary fin configurations can reduce solidification time by 30 to 50 %, thus improving the system's performance. Additionally, the synchronized analysis of the trees proves that while the tree fins enhance the distribution of heat all over the trees, they also enhance the natural convection, improving the uniformity of temperatures and the effectiveness of phase change. The outcomes reveal that even though tree-shaped fins are capital-intensive, their low operating costs and higher efficiency leverage initial costs. Incorporating tree-shaped fins in the PCM system is a novel step in enhancing thermal energy storage systems with significant enhancement of solidification and melting in thermal management applications, which are crucial challenges to energy efficiency and sustainability.Review Citation Count: 0C-flip/Ku70 Complex; a Potential Molecular Target for Apoptosis Induction in Hepatocellular Carcinoma(Elsevier Science inc, 2025) Haghir-Sharif-Zamini, Yasamin; Khosravi, Arezoo; Hassan, Moustapha; Zarrabi, Ali; Vosough, MassoudHepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide and the most common form of liver cancer. Despite global efforts toward early diagnosis and effective treatments, HCC is often diagnosed at advanced stages, where conventional therapies frequently lead to resistance and/or high recurrence rates. Therefore, novel biomarkers and promising medications are urgently required. Epi-drugs, or epigenetic-based medicines, have recently emerged as a promising therapeutic modality. Since the epigenome of the cancer cells is always dysregulated and this is followed by apoptosis-resistance, reprogramming the epigenome of cancer cells by epi-drugs (such as HDAC inhibitors (HDACis), and DNMT inhibitors (DNMTis)) could be an alternative approach to use in concert with established treatment protocols. C-FLIP, an anti-apoptotic protein, and Ku70, a member of the DNA repair system, bind together and make a cytoplasmic complex in certain cancers and induce resistance to apoptosis. Many epi-drugs, such as HDACis, can dissociate this complex through Ku70 acetylation and activate cellular apoptosis. The novel compounds for dissociating this complex could provide an innovative insight into molecular targeted HCC treatments. In this review, we address the innovative therapeutic potential of targeting c-FLIP/Ku70 complex by epi-drugs, particularly HDACis, to overcome apoptosis resistance of HCC cells. This review will cover the mechanisms by which the c-FLIP/Ku70 complex facilitates cancer cell survival, the impact of epigenetic alterations on the complex dissociation, and highlight HDACis potential in combination therapies, biomarker developments and mechanistic overviews. This review highlights c-FLIP ubiquitination and Ku70 acetylation levels as diagnostic and prognostic tools in HCC management.Article Citation Count: 0Effects of Thermal Shock on the Performance of Welded Metallic Compounds: a Molecular Dynamics Approach(Pergamon-elsevier Science Ltd, 2025) Wang, Entong; Basem, Ali; Hussein, Zahraa Abed; Singh, Narinderjit Singh Sawaran; Al Rawi, Orabi; Abdullaeva, Barno; Baghaei, Sh.Welded metals exhibit various mechanical properties influenced by multiple factors, with temperature playing a crucial role. Although research exists on the mechanical behavior of welded materials, gaps remain in understanding how thermal shock affects the performance of Cu-Ag metallic compounds. This study used molecular dynamics simulations to investigate these effects comprehensively. In the present study, mechanical testing conditions were applied to assess key mechanical constants, including Young's modulus and ultimate strength. The findings show that thermal stress significantly affected the mechanical strength of atomic samples, with ultimate strength increasing from 1389.074 MPa at 350 K to 1426.61 MPa at 450 K. However, increasing the temperature to 500 K caused a decrease in ultimate strength to 1412.74 MPa and in Young's modulus to 93.499 GPa. This behavior illustrated how thermal effects can both enhance particle movement and introduce potential weaknesses at higher temperatures. Additionally, interaction energy decreased from -6657.4512 eV to -6613.2486 eV, indicating increased atomic mobility without disrupting atomic arrangements. The mean square displacement results showed a notable increase after reaching 450 K, reflecting improved atomic mobility. Overall, this study provided valuable insights for optimizing mechanical structures through controlled thermal applications in various industrial contexts.
