PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14517/21

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Abnormal Right Ventricular to Pulmonary Artery Coupling in Patients with End-Stage Kidney Disease and Normalization After Renal Transplantation: A Observational Study
(Karger, 2025) Cetin Guvenc, Rengin; Guvenc, Tolga Sinan; Karakaya, Ezgi Sude; Acik, Hasan; Korkmaz, Aysu; Salem, Abdul Fattah; Gurkan, Alp
Introduction: Pulmonary hypertension and right ventricular (RV) dysfunction are associated with an increase in mortality and worse prognosis in patients with end-stage kidney disease (ESKD), but pathophysiologic mechanisms underlying the progression of RV dysfunction remain incompletely understood. The present study aimed to understand right ventricular to pulmonary artery (RV-PA) coupling, which is an early indicator of transition to RV dysfunction, to better characterize adaptive RV response to increased afterload in ESKD patients and changes in RV-PA coupling following renal transplantation. Methods: One hundred eleven patients with ESKD, including 49 patients scheduled for renal transplantation, underwent a detailed echocardiographic examination and measurement of tricuspid annular plane excursion to pulmonary artery systolic pressure (TAPSE/PASP) ratio, and a repeat examination was performed 6 months after the baseline examination. Results: Patients with ESKD had significantly lower TAPSE/PASP ratio at baseline (1.02 [0.71-1.63] vs. 1.29 [1.09-1.96], p < 0.001). In 40 patients that underwent transplantation, TAPSE/PASP ratio increased significantly from (0.97 [0.72-1.42] to 1.30 [1.01-1.82], p = 0.03), while in 27 patients remained on dialysis, there was a nonsignificant reduction in TAPSE/PASP ratio (1.21 [0.71-1.62] vs. 0.84 [0.61-1.38], p = 0.44). The change in TAPSE/PASP ratio correlated significantly with the change in pulmonary vascular resistance (OR: 0.61, 95% CI: 0.51-0.72, p < 0.001) and left ventricular mass index (OR: 0.97, 95% CI: 0.96-0.99, p = 0.001) after adjustment. Conclusions: Patients with ESKD had abnormal RV-PA coupling, as indicated by a reduced TAPSE/PASP ratio, which normalizes 6 months after renal transplantation.
Autoimmune Encephalitis and Musicogenic Epilepsy: a Case of Gad65 Antibody-Associated Seizure
(Wiley, 2025) Mohammadi-Asl, Ali; Bahadori, Amir Reza; Sabzgolin, Iman; Davari, Afshan; Razmafrooz, Mohammad; Tafakhori, Abbas; Ranji, Sara
Musicogenic epilepsy (ME) is a rare form of reflex epilepsy with a prevalence of 1 in 10,000,000. Recent research suggests a potential link between ME and autoimmune encephalitis, particularly involving glutamic acid decarboxylase 65-isoform (GAD65) antibodies. A 48-year-old female presented with a one-year history of music-triggered seizures. Her episodes were characterized by an initial aura followed by unresponsiveness and oral automatisms. Electroencephalography revealed abnormalities in the left anterior temporal lobe and temporal leads. Laboratory studies showed positive anti-GAD65 antibodies. The patient was treated with a combination of antiepileptic medication (Lamotrigine) and corticosteroids and intravenous immunoglobulin. This case contributes to the growing evidence supporting an association between ME and autoimmune mechanisms, particularly GAD65 antibody-mediated autoimmunity. It highlights the importance of screening autoimmune factors in ME patients and highlights the need for further research into targeted treatment strategies.
Can Super Resolution via Deep Learning Improve Classification Accuracy in Dental Radiography
(Oxford University Press, 2025) Celik, Berrin; Mikaeili, Mahsa; Genç, Mehmet Zahid; Çelik, Mahmut Emin
Objectives Deep learning-driven super resolution (SR) aims to enhance the quality and resolution of images, offering potential benefits in dental imaging. Although extensive research has focused on deep learning based dental classification tasks, the impact of applying SR techniques on classification remains underexplored. This study seeks to address this gap by evaluating and comparing the performance of deep learning classification models on dental images with and without SR enhancement. Methods An open-source dental image dataset was utilized to investigate the impact of SR on image classification performance. SR was applied by 2 models with a scaling ratio of 2 and 4, while classification was performed by 4 deep learning models. Performances were evaluated by well-accepted metrics like structural similarity index (SSIM), peak signal-to-noise ratio (PSNR), accuracy, recall, precision, and F1 score. The effect of SR on classification performance is interpreted through 2 different approaches. Results Two SR models yielded average SSIM and PSNR values of 0.904 and 36.71 for increasing resolution with 2 scaling ratios. Average accuracy and F-1 score for the classification trained and tested with 2 SR-generated images were 0.859 and 0.873. In the first of the comparisons carried out with 2 different approaches, it was observed that the accuracy increased in at least half of the cases (8 out of 16) when different models and scaling ratios were considered, while in the second approach, SR showed a significantly higher performance for almost all cases (12 out of 16). Conclusion This study demonstrated that the classification with SR-generated images significantly improved outcomes. Advances in knowledge For the first time, the classification performance of dental radiographs with improved resolution by SR has been investigated. Significant performance improvement was observed compared to the case without SR. © 2025 Elsevier B.V., All rights reserved.
Comparison of Posterior and Antero-Lateral Renal Tumors in Retroperitoneal Laparoscopic Partial Nephrectomy: a Propensity Score Matching Analysis
(Codon Publications, 2023) Anil, Hakan; Yildiz, Ali; Guzel, Ahmet; Akdemir, Serkan; Karamik, Kaan; Arslan, Murat
This study aimed to compare the antero-lateral and posterior localized renal masses in laparoscopic partial nephrectomy with the retroperitoneal approach in terms of operative, functional, and oncological outcomes. Patients who underwent retroperitoneal laparoscopic partial nephrec-tomy by a single surgeon between January 2013 and January 2021 were included in the study. A one-to-one propensity score matching (PSM) analysis was conducted to obtain two balanced groups. The patients were divided into two groups as posterior and antero-lateral according to the localization of the mass. A total of 239 patients were included in the PSM analysis, with 65 patients allocated to each group. The mean operative time was 79.2 & PLUSMN; 11.2 min in the posterior group, while it was 90.0 & PLUSMN; 11.6 min in the antero-lateral group (P < 0.001). Warm ischemia time was 15.9 & PLUSMN; 2.4 min in the posterior group and 18.6 & PLUSMN; 2.7 min in the antero-lateral group (P < 0.001). The median decrease in eGFR at 1 year was 4.8 (IQR, 2.9-6.9) mL/min in the posterior group and 5.0 (IQR, 2.8-11) mL/min in the antero-lateral group (P = 0.219). The warm isch-emia time and clamping technique were found to be significant factors for predicting eGFR change after surgery (13:0.693, 95% CI: 0.39-0.99, P < 0.001; 13:6.43, 95% CI: 1.1-11.7, P = 0.017, respectively). We report that retroperitoneal laparoscopic partial nephrectomy provided longer warm ischemia and operative time for antero-lateral renal masses than posterior masses. However, long-term oncological and functional results were similar for both localizations.
Correction to: Modeling Dysentery Spread and the Impact of Public Awareness on Control Dynamics (Scientific Reports, (2025), 15, 1, (40602), 10.1038/S41598-025-24286-z)
(Nature Research, 2025) Ahmed, K.K.; Yusuf, J.S.; Isa Aliyu, A.I.; Agaie, B.G.; Yusuf, A.S.; Ozsahin, I.; Sulaıman, T.A.
Correction to: Scientific Reportshttps://doi.org/10.1038/s41598-025-24286-z, published online 18 November 2025 The original version of this Article contained an error in the spelling of the author Ilker Ozsahin which was incorrectly given as Ilker Ozşahin. The original Article has been corrected. © The Author(s) 2025.
Factors Affecting the Level of Reflective Thinking and Clinical Decision-Making Skills in Medical Faculty Students
(Kare Publ, 2023) Senturk, Erol; Sarıkaya, Ozlem; Hafız, Aysenur Meric; Teker, Cenk
Objectives: The aim of this study is to evaluate the reflection skills of students at the Faculty of Medicine and the factors influenc- ing these skills, as well as to measure the impact of students' reflection skills on their clinical decision-making. Methods: This study is an educational research project conducted on fifth-year Ear Nose Throat (ENT) interns at Vakif University's Faculty of Medicine. The \"Reflective Thinking Level Determination Scale\" and the \"Clinical Decision-Making Scale,\" which are valid and reliable, were used to assess the reflection skills and clinical decision-making abilities of the 125 students participating in the study. Results: In our study, the mean score of the sub-dimensions of the Groningen Reflection Skills Scale was 77.04±5.14 for the fifth- year student population surveyed. Scores from the \"Self-Reflection\" and \"Reflective Communication\" sub-dimensions of the Gron- ingen Reflection Skills Scale were compared based on gender, participation in summer internships, receipt of scholarships, mem- bership in social sciences clubs, place of residence, school attended, diary-keeping habits, study styles, and cities of residence. Although there were some differences between the groups, these differences were not statistically significant. The total scores of the students on the Clinical Decision-Making Scale sub-dimensions ranged from 98 to 169, with a mean score of 146.18±10.97. A statistically positive and moderate correlation was found between the total scores of the participants on the Groningen Reflection Skills Scale and the total scores they obtained on the Clinical Decision-Making Scale (r=0.403; p=0.001). Conclusion: Consequently, an increase in the reflection skills of participants is associated with higher clinical decision-making scores. Reflection is the primary means of transitioning students from novices to experts, enhancing both comprehensive learning and learning experiences. Therefore, every medical school should develop a training program for student reflection, along with a feedback and assessment system integrated into the curriculum.
Human Papilloma Virus Frequency and Genotypes; Evaluation of the 4879 Screenings Made With Polymerase Chain Reaction and Chip Array Between 2001 and 2019 in Istanbul
(Kare Publ, 2021) Vural, Gurcan; Polat, Nedim
Objectives: The aim of this study is the documentation of human papilloma virus (HPV) frequency and types seen in the city of Istanbul, Turkey, as well as evaluation of the relationship between these subtypes and cytological and pathological diagnoses. Methods: 4879 cases were studied in our molecular pathology department between 2001 and 2019 in Istanbul. Between 2001 and 2010, 1692 cases were screened for HPV 6, 11, 16, 18, 31, and 33 by conventional hybridization and polymerase chain reaction (PCR). Since 2011, up to 49 HPV typing has been performed for 3187 cases with chip array. The cases were referred to the pathology center and the hospital pathology department by clinicians for screening before HPV vaccination and on the observation of precancerous changes and koilocyts in cytological-histopathological evaluations. Results: In this study, the frequency of HPV was found to be 10.8% (527 HPV-positive cases). Among these, 348 cases were high-risk groups, whether or not they were previously associated with a low-risk group. When we look at the distribution of the cases according to the high-risk HPV types, HPV 16 is the most common type. The frequencies of occurrence of other HPV types are as following: HPV-16: 41.7%, HPV-31: 11.7%, HPV-52: 7.9%, HPV-51: 7.1%, HPV-33: 6.9%, HPV-45: 6.5%, HPV-18: 6.3%, HPV-39: 6.1%, and HPV-58: 5.8%. It was further found that multiple infections were 28% of high grade squamous intraepithelial lesion cases. HPV frequency was 38% and 72%, respectively, in cases with cytologically or histopathological precancerous, low-grade squamous intraepithelial lesion, and HSIL changes. As a final note, HPV was detected in 9 of 10 cases with cervical cancer (90%). Only 1 adenocarcinoma case detected in the series was a double infection with HPV types 18 and 45. Conclusion: HPV 16 was the most common type found in this study. It is followed by types 31, 52, 51, 33, 45, 18, 39, and 58, respectively. The most common association observed in double infections was between HPV 16 and 58. It was also observed that the incidence of HPV in the city of Istanbul, Turkey, was similar to other developed countries. As a final note, in addition to screening tests, PCR and chip array studies should be conducted and the community should be informed about preventive medicine and the importance of condom use.
The Influence of Clinician Experience on the Primary Stability of Tri-Oval Versus Standard Parallel-Walled Implants Placed Using Different Surgical Protocols: An Ex Vivo Study
(Quintessence Publishing Co Inc, 2025) Cakir, Merve; Ulker, Gul Merve Yalcin; Saygili, Sina; Durgun, Mehmet Akif; Dayan, Suleyman Cagatay; Kan, Bahadir; Geckili, Onur
Purpose: To investigate the effect that clinical experience has on implant primary stability using insertion torque (IT) and resonance frequency analysis (RFA) from two different drilling protocols: (1) implant-specific osteotomy protocol and (2) conventional drilling. Materials and Methods: A total of 60 tri-oval and 60 parallel-walled implants were placed in fresh bovine ribs by three clinicians (B.K., M.& Ccedil;., and M.A.D), who were classified according to the total number of implants they had previously placed. Tri-oval implants were placed with an implant-specific osteotomy protocol, and parallel implants were placed with conventional drilling. The ITs of the implants were measured by the same clinician who performed the operation. An independent examiner (O.G.) measured the RFA of all implants after placement via a resonance frequency analyzer. Results: In the IT evaluation, no statistical significance was observed between the clinicians and both tri-oval implants and parallel implants (P = .293 and P = .98, respectively); in all experience levels, the ITs were significantly lower in parallel implants. Additionally, across all experience levels, tri-oval implants demonstrated greater RFA values than parallel implants (P = .001). Within-group comparisons of RFA by experience level for the tri-oval implants did not show a statistically significant difference (P = .950). However, in parallel implants, there was a significant difference between the moderately experienced and inexperienced groups (P = .019). Conclusions: The implant-specific osteotomy procedure with tri-oval implants offers greater primary stability compared to conventional osteotomy with parallel-walled implants, regardless of the clinician's experience.
Promoting Patients’ Empowerment in Rheumatic Diseases: The Perspective of the International Society of Behçet’s Disease Working Group on Patient Empowerment, Adherence to Therapy and Patients’ Education
(Clinical and Experimental Rheumatology S.A.S., 2025) Di Cianni, F.; Marinello, D.; Altenburg, A.; Karaçayli, U.; Emmi, G.; Schirmer, M.; Mumcu, G.
Behçet’s disease (BD) is a rare multisystemic vasculitis that significantly impacts patients’ quality of life. Effective management of BD requires a patientcentred approach that empowers individuals to actively participate in their care. This work explores the importance of patient empowerment, adherence to treatment, and patient education in BD. The impact of BD on quality of life (QOL) is significant, affecting both physical and psychological well-being. QOL measures are essential in capturing the full burden of the disease from the patient’s perspective, helping guide interventions that can improve disease management. Moreover, treatment adherence remains a major challenge due to various factors, including medication complexity, fear of side effects, and patient perceptions of their health status. Empowerment strategies, including education and emotional support, are crucial to improving adherence and reducing healthcare costs. Empowering BD patients involves fostering a collaborative relationship between healthcare providers and patients, promoting shared decision-making and enhancing patients’ knowledge and skills to manage their condition. Patient education plays a crucial role in empowering patients by providing them with accurate information about the disease, treatment options, and self-management strategies. The International Society for Behçet’s Disease Working Group on Patient Empowerment, Adherence to Therapy, and Patient Education aims to address these issues by developing global strategies to empower BD patients, caregivers and healthcare providers. This initiative promotes collaboration across the BD community, ultimately leading to better patient outcomes and serving as a model for similar efforts in other disease areas. © 2025 Elsevier B.V., All rights reserved.
Rheb1 Signaling and the Fate of Pancreatic Β Cells: Toward a New Frontier in Diabetes Therapy
(Baishideng Publishing Group Inc, 2025) Karimkhani, Hadi
A recent study in the World Journal of Diabetes by Yang et al explored how Rheb1 signaling influenced pancreatic beta cell fate and its potential as a therapeutic target. This invited commentary by a senior diabetes researcher discussed the findings of Yang et al in the context of current knowledge on beta cell biology, providing critical insight into the role of Rheb1 in beta cell survival and function and the prospects for diabetes treatment. Key outcomes of the study were interpreted alongside established literature on Rheb1- mechanistic target of rapamycin signaling in islet cells. Rheb1 emerges as a pivotal regulator of beta cell growth and insulin secretory function, aligning with evidence that beta cell-specific Rheb1 deletion impairs beta cell mass and glucose-stimulated insulin secretion. The commentary highlighted how modulating this pathway could preserve or restore the beta cell population in diabetes while cautioning about potential off-target effects (e.g. in alpha cells). Targeting Rheb1 signaling represents a promising new frontier in diabetes therapy to enhance beta cell resilience; however, a balanced approach addressing both its benefits and risks is essential. This letter discussed the scientific implications and future research directions needed to translate Rheb1 modulation into clinical application for diabetes.
Search for a Neutral Gauge Boson With Nonuniversal Fermion Couplings in Vector Boson Fusion Processes in Proton-Proton Collisions at (Formula Presented)
(American Physical Society, 2025) Hayrapetyan, A.; Tumasyan, A.; Adam, W.; Andrejkovic, J.W.; Benato, L.; Bergauer, T.; Chatterjee, S.
The first search for a heavy neutral spin-1 gauge boson ((Formula presented)) with nonuniversal fermion couplings produced via vector boson fusion processes and decaying to tau leptons or (Formula presented) bosons is presented. The analysis is performed using LHC data at (Formula presented), collected from 2016 to 2018 with the CMS experiment and corresponding to an integrated luminosity of (Formula presented). The data are consistent with the standard model predictions. Upper limits are set on the product of the cross section for production of the (Formula presented) boson and its branching fraction to (Formula presented) or (Formula presented). The presence of a (Formula presented) boson decaying to (Formula presented) ((Formula presented)) is excluded for masses up to 2.45(1.60) TeV, depending on the (Formula presented) boson coupling to standard model weak bosons, and assuming a (Formula presented) ((Formula presented)) branching fraction of 50%. © 2025 CERN, for the CMS Collaboration.
Search for New Physics in Jet Multiplicity Patterns of Multilepton Events at (Formula Presented)
(American Physical Society, 2025) Hayrapetyan, A.; Tumasyan, A.; Adam, W.; Andrejkovic, J.W.; Bergauer, T.; Chatterjee, S.; Damanakis, K.
A first search for beyond the standard model physics in jet multiplicity patterns of multilepton events is presented, using a data sample corresponding to an integrated luminosity of (Formula presented) of 13 TeV proton-proton collisions recorded by the CMS detector at the LHC. The search uses observed jet multiplicity distributions in one-, two-, and four-lepton events to explore possible enhancements in jet production rate in three-lepton events with and without bottom quarks. The data are found to be consistent with the standard model expectation. The results are interpreted in terms of supersymmetric production of electroweak chargino-neutralino superpartners with cascade decays terminating in prompt hadronic (Formula presented)-parity violating interactions. © 2025 CERN, for the CMS Collaboration.
Search for the Rare Decay (Formula Presented) in Proton-Proton Collisions at (Formula Presented)
(American Physical Society, 2025) Tchekhovski, V.; Hayrapetyan, A.; Makarenko, V.; Tumasyan, A.; Adam, W.; Andrejkovic, J.W.; Benato, L.
A search for the rare decay (Formula presented) is reported using proton-proton collision events at (Formula presented) collected by the CMS detector in 2022-2023, corresponding to an integrated luminosity of (Formula presented). This is the first analysis to use a newly developed inclusive dimuon trigger, expanding the scope of the CMS flavor physics program. The search uses (Formula presented) mesons obtained from (Formula presented) decays. No significant excess is observed. A limit on the branching fraction of (Formula presented) at 95% confidence level is set. This is the most stringent upper limit set on any flavor changing neutral current decay in the charm sector. © 2025 CERN, for the CMS Collaboration.
The Test-Retest Reliability and Concurrent Validity of 360° Turn Test in Patients With Knee Osteoarthritis
(Taylor & Francis Ltd, 2024) Yarar, Haci Ahmet; Narin, Selnur; Erduran, Mehmet; Gurbanov, Iftikhar
PurposeThe aim of this study is to determine whether the 360 degrees turn test is a reliable and valid evaluator that can be used to assess dynamic balance in patients with early (radiographic grades I and II) and advanced (radiographic grades III and IV) knee osteoarthritis.Materials and MethodsThis study is a methodological research. For the test time and step count of 360 degrees turn test; test-retest reliability were determined by calculating the intraclass correlation coefficient and concurrent validity in patients with knee osteoarthritis was investigated by correlation with the timed up and go test time.ResultsThe final analysis was made on 117 participants. The intraclass correlation coefficient values for the test time and step count of 360 degrees turn test in patients with early knee osteoarthritis are 0.931 and 0.902, respectively, while they are 0.923 and 0.943 in patients with advanced knee osteoarthritis. The Pearson correlation coefficients between the time and step count of 360 degrees turn test and the test time of the timed up and go test in patients with early knee osteoarthritis, respectively; while they are 0.547 and 0.388, the correlation in patients with advanced knee osteoarthritis are 0.697 and 0.700, respectively (p < 0.01).ConclusionsThe 360 degrees turn test is a evaluator that has excellent test-retest reliability and moderate to strong concurrent validity in patients with both early and advanced knee osteoarthritis and can be used in the assessment of dynamic balance in this population.
Watt Matters: Safety and Efficacy of Using a 140-W High-Powered Holmium Laser for Enucleation of the Prostate (Holep)
(Aves, 2021) Yildiz, Ali; Akdemir, Serkan; Anil, Hakan; Arslan, Murat
Objective: This study aimed to assess the perioperative and the 12-month efficacy and safety of 140 W high-powered holmium laser for enucleation of the prostate (HP-HoLEP) for the treatment of benign prostatic obstruction. Material and methods: The data of 540 patients who underwent HoLEP by a single surgeon were analyzed retrospectively. Preoperative evaluation included a physical examination with a digital rectal examination, measurement of maximum urinary flow rate (Q(max)), postvoid residual volume (PVR) and prostate volume by transabdominal ultrasonography, serum prostate-specific antigen (PSA), international prostate symptom score (I-PSS) and international index of erectile function-5 (IIEF-5) questionnaires, and urine analysis. Morcellation, enucleation, and operation efficiencies were calculated with the resected weight divided by morcellation, enucleation, and operative times, respectively. The patients were reassessed at 1, 3, 6, and 12 months after surgery by I-PSS, IIEF-5, Q(max), PSA, and the occurrence of complications. Results: The mean operative time was 65.2 +/- 20.9 minutes. The mean enucleation time and efficiency were 53 +/- 15.1 minutes and 1.72 +/- 0.4 g/min, respectively. The mean morcellation time and efficiency were 12.3 +/- 15.1 minutes and 7.4 +/- 3.2 g/min respectively. Clavien grade 1 complications were observed in 102 (18.9%) patients, Clavien grade 2 complications in 20 (3.7%) patients, and Clavien grade 3b complications in 23 (5.4%) patients. I-PSS, Q(max), and IIEF-5 at postoperative 1, 3, 6, and 12 months were significantly better than baseline results. Conclusion: Our study demonstrated that 140 W HP-HoLEP can be performed with high enucleation efficiency, low perioperative and postoperative complication rates, and excellent functional results.

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