PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14517/21

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Autoimmune Encephalitis and Musicogenic Epilepsy: a Case of Gad65 Antibody-Associated Seizure
(Wiley, 2025) Mohammadi-Asl, Ali; Bahadori, Amir Reza; Sabzgolin, Iman; Davari, Afshan; Razmafrooz, Mohammad; Tafakhori, Abbas; Ranji, Sara
Musicogenic epilepsy (ME) is a rare form of reflex epilepsy with a prevalence of 1 in 10,000,000. Recent research suggests a potential link between ME and autoimmune encephalitis, particularly involving glutamic acid decarboxylase 65-isoform (GAD65) antibodies. A 48-year-old female presented with a one-year history of music-triggered seizures. Her episodes were characterized by an initial aura followed by unresponsiveness and oral automatisms. Electroencephalography revealed abnormalities in the left anterior temporal lobe and temporal leads. Laboratory studies showed positive anti-GAD65 antibodies. The patient was treated with a combination of antiepileptic medication (Lamotrigine) and corticosteroids and intravenous immunoglobulin. This case contributes to the growing evidence supporting an association between ME and autoimmune mechanisms, particularly GAD65 antibody-mediated autoimmunity. It highlights the importance of screening autoimmune factors in ME patients and highlights the need for further research into targeted treatment strategies.
Comparison of Posterior and Antero-Lateral Renal Tumors in Retroperitoneal Laparoscopic Partial Nephrectomy: a Propensity Score Matching Analysis
(Codon Publications, 2023) Anil, Hakan; Yildiz, Ali; Guzel, Ahmet; Akdemir, Serkan; Karamik, Kaan; Arslan, Murat
This study aimed to compare the antero-lateral and posterior localized renal masses in laparoscopic partial nephrectomy with the retroperitoneal approach in terms of operative, functional, and oncological outcomes. Patients who underwent retroperitoneal laparoscopic partial nephrec-tomy by a single surgeon between January 2013 and January 2021 were included in the study. A one-to-one propensity score matching (PSM) analysis was conducted to obtain two balanced groups. The patients were divided into two groups as posterior and antero-lateral according to the localization of the mass. A total of 239 patients were included in the PSM analysis, with 65 patients allocated to each group. The mean operative time was 79.2 & PLUSMN; 11.2 min in the posterior group, while it was 90.0 & PLUSMN; 11.6 min in the antero-lateral group (P < 0.001). Warm ischemia time was 15.9 & PLUSMN; 2.4 min in the posterior group and 18.6 & PLUSMN; 2.7 min in the antero-lateral group (P < 0.001). The median decrease in eGFR at 1 year was 4.8 (IQR, 2.9-6.9) mL/min in the posterior group and 5.0 (IQR, 2.8-11) mL/min in the antero-lateral group (P = 0.219). The warm isch-emia time and clamping technique were found to be significant factors for predicting eGFR change after surgery (13:0.693, 95% CI: 0.39-0.99, P < 0.001; 13:6.43, 95% CI: 1.1-11.7, P = 0.017, respectively). We report that retroperitoneal laparoscopic partial nephrectomy provided longer warm ischemia and operative time for antero-lateral renal masses than posterior masses. However, long-term oncological and functional results were similar for both localizations.
Human Papilloma Virus Frequency and Genotypes; Evaluation of the 4879 Screenings Made With Polymerase Chain Reaction and Chip Array Between 2001 and 2019 in Istanbul
(Kare Publ, 2021) Vural, Gurcan; Polat, Nedim
Objectives: The aim of this study is the documentation of human papilloma virus (HPV) frequency and types seen in the city of Istanbul, Turkey, as well as evaluation of the relationship between these subtypes and cytological and pathological diagnoses. Methods: 4879 cases were studied in our molecular pathology department between 2001 and 2019 in Istanbul. Between 2001 and 2010, 1692 cases were screened for HPV 6, 11, 16, 18, 31, and 33 by conventional hybridization and polymerase chain reaction (PCR). Since 2011, up to 49 HPV typing has been performed for 3187 cases with chip array. The cases were referred to the pathology center and the hospital pathology department by clinicians for screening before HPV vaccination and on the observation of precancerous changes and koilocyts in cytological-histopathological evaluations. Results: In this study, the frequency of HPV was found to be 10.8% (527 HPV-positive cases). Among these, 348 cases were high-risk groups, whether or not they were previously associated with a low-risk group. When we look at the distribution of the cases according to the high-risk HPV types, HPV 16 is the most common type. The frequencies of occurrence of other HPV types are as following: HPV-16: 41.7%, HPV-31: 11.7%, HPV-52: 7.9%, HPV-51: 7.1%, HPV-33: 6.9%, HPV-45: 6.5%, HPV-18: 6.3%, HPV-39: 6.1%, and HPV-58: 5.8%. It was further found that multiple infections were 28% of high grade squamous intraepithelial lesion cases. HPV frequency was 38% and 72%, respectively, in cases with cytologically or histopathological precancerous, low-grade squamous intraepithelial lesion, and HSIL changes. As a final note, HPV was detected in 9 of 10 cases with cervical cancer (90%). Only 1 adenocarcinoma case detected in the series was a double infection with HPV types 18 and 45. Conclusion: HPV 16 was the most common type found in this study. It is followed by types 31, 52, 51, 33, 45, 18, 39, and 58, respectively. The most common association observed in double infections was between HPV 16 and 58. It was also observed that the incidence of HPV in the city of Istanbul, Turkey, was similar to other developed countries. As a final note, in addition to screening tests, PCR and chip array studies should be conducted and the community should be informed about preventive medicine and the importance of condom use.
Sınır Kişilik Bozukluğunda Dürtüsellik ve Riskli Karar Verme Eğiliminin Sosyal Biliş Becerileriyle İlişkisi
(Turkish Neuropsychiatry Assoc-turk Noropsikiyatri dernegi, 2024) Vatansever, Büşra Kuzgun; Büyükgök, Deniz; Aypak, Oya Çelik; Şahin, Doğan; Ercis, Mete; Ercis, Mete
Amaç: Bu çalışma, Sınır Kişilik Bozukluğu (SKB) tanılı bireylerde karar verme süreçlerini nöropsikolojik testlerle değerlendirerek, SKB’ye özgü bilişsel özelliklerin karar verme süreçleriyle ilişkisini sağlıklı kontrollerle karşılaştırarak incelemeyi hedeflemektedir. Yöntem: Çalışmanın örneklemi SKB tanılı hasta grubu (n=27) ile psikiyatrik tanısı olmayan sağlıklı katılımcılardan (n=28) oluşmaktadır. Hastalık şiddetinin değerlendirilmesi için Borderline Kişilik Envanteri (BKE), nöropsikolojik değerlendirme için Iowa Kumar Testi (IKT), Stroop Testi, Benton Yüz Tanıma Testi, Gözlerden Zihin Okuma Testi, Dokuz Eylül Zihin Teorisi Ölçeği (DEZTÖ), WMS-R Sayı Menzili ve Mantıksal Bellek Alt Ölçeği uygulanmıştır. Bulgular: SKB grubu ile kontrol grubu arasında BKE puanlarında anlamlı düzeyde farklılık izlenmektedir (p=0,02). Stroop Testi’ndeki enterferans süresi ve hata sayıları açısından gruplar arası anlamlı bir fark izlenmezken, spontan düzeltme cevap sayılarının anlamlı düzeyde farklılık taşıdığı (p=0,02) gözlenmiştir. WMS-R Mantıksal Bellek alt testi A hikâyesinin anlık hatırlama puanlarında gruplar arasında fark olduğu (p<0,01) tespit edilmiştir. IKT’de ilk yarıda A destesinden (p=0,028) son yarıda ise B destesinden (p=0,03) seçme eğiliminde gruplar arasında fark izlenmektedir. Son olarak, DEZTÖ’de iki grup arasında toplam puanda (p<0,01) izlenen anlamlı farkın 2. derece yanlış inanç (p=0,024) ve empati (p=0,027) görevlerinde ortaya çıktığı görülmüştür. Sonuç: Çalışmamız örneklemini oluşturan SKB tanılı bireylerin uygunsuz cevabın inhibisyonunda minimal güçlüğe sahip oldukları, bu güçlüğün karar verme davranışında dezavantajlı seçimler yapmayla ilişkili olduğu sonucuna ulaşılmıştır. Ayrıca, SKB tanılı bireylerin dışsal ipuçlarından zihinsel durumları yordamada başarılı oldukları fakat sosyal bir örüntü dâhilinde ipuçlarını bütünleştirme ve uyumlu öyküleştirme yapmakta zorlandıkları görülmüştür.
The Test-Retest Reliability and Concurrent Validity of 360° Turn Test in Patients With Knee Osteoarthritis
(Taylor & Francis Ltd, 2024) Yarar, Haci Ahmet; Narin, Selnur; Erduran, Mehmet; Gurbanov, Iftikhar
PurposeThe aim of this study is to determine whether the 360 degrees turn test is a reliable and valid evaluator that can be used to assess dynamic balance in patients with early (radiographic grades I and II) and advanced (radiographic grades III and IV) knee osteoarthritis.Materials and MethodsThis study is a methodological research. For the test time and step count of 360 degrees turn test; test-retest reliability were determined by calculating the intraclass correlation coefficient and concurrent validity in patients with knee osteoarthritis was investigated by correlation with the timed up and go test time.ResultsThe final analysis was made on 117 participants. The intraclass correlation coefficient values for the test time and step count of 360 degrees turn test in patients with early knee osteoarthritis are 0.931 and 0.902, respectively, while they are 0.923 and 0.943 in patients with advanced knee osteoarthritis. The Pearson correlation coefficients between the time and step count of 360 degrees turn test and the test time of the timed up and go test in patients with early knee osteoarthritis, respectively; while they are 0.547 and 0.388, the correlation in patients with advanced knee osteoarthritis are 0.697 and 0.700, respectively (p < 0.01).ConclusionsThe 360 degrees turn test is a evaluator that has excellent test-retest reliability and moderate to strong concurrent validity in patients with both early and advanced knee osteoarthritis and can be used in the assessment of dynamic balance in this population.
Watt Matters: Safety and Efficacy of Using a 140-W High-Powered Holmium Laser for Enucleation of the Prostate (Holep)
(Aves, 2021) Yildiz, Ali; Akdemir, Serkan; Anil, Hakan; Arslan, Murat
Objective: This study aimed to assess the perioperative and the 12-month efficacy and safety of 140 W high-powered holmium laser for enucleation of the prostate (HP-HoLEP) for the treatment of benign prostatic obstruction. Material and methods: The data of 540 patients who underwent HoLEP by a single surgeon were analyzed retrospectively. Preoperative evaluation included a physical examination with a digital rectal examination, measurement of maximum urinary flow rate (Q(max)), postvoid residual volume (PVR) and prostate volume by transabdominal ultrasonography, serum prostate-specific antigen (PSA), international prostate symptom score (I-PSS) and international index of erectile function-5 (IIEF-5) questionnaires, and urine analysis. Morcellation, enucleation, and operation efficiencies were calculated with the resected weight divided by morcellation, enucleation, and operative times, respectively. The patients were reassessed at 1, 3, 6, and 12 months after surgery by I-PSS, IIEF-5, Q(max), PSA, and the occurrence of complications. Results: The mean operative time was 65.2 +/- 20.9 minutes. The mean enucleation time and efficiency were 53 +/- 15.1 minutes and 1.72 +/- 0.4 g/min, respectively. The mean morcellation time and efficiency were 12.3 +/- 15.1 minutes and 7.4 +/- 3.2 g/min respectively. Clavien grade 1 complications were observed in 102 (18.9%) patients, Clavien grade 2 complications in 20 (3.7%) patients, and Clavien grade 3b complications in 23 (5.4%) patients. I-PSS, Q(max), and IIEF-5 at postoperative 1, 3, 6, and 12 months were significantly better than baseline results. Conclusion: Our study demonstrated that 140 W HP-HoLEP can be performed with high enucleation efficiency, low perioperative and postoperative complication rates, and excellent functional results.

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