PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
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Article Examining the Burnout of Audiologists in Türkiye Relationships With Quality of Work Life and Psychological Well-Being(Amer Speech-Language-Hearing Assoc, 2025) Akbulut, Ahmet Alperen; Demirel, Aysenur Karaman; Sacli, Yeter; Satici, Sema; Ozcan, Ahsen Kartal; Ciprut, AycaPurpose: Although burnout among audiologists has been studied in various countries, there is no research yet that examines this issue in T & uuml;rkiye, where working conditions and sociodemographic factors may differ from those in other countries. Considering the unique working conditions and sociodemographic factors, this study aimed to investigate the burnout levels of Turkish audiologists. Additionally, this study will explore the impact of various sociodemographic variables on burnout, work-related quality of life, and depression to gain a deeper understanding of the specific challenges faced by audiologists in T & uuml;rkiye. Method: A total of 193 audiologists, with a median age of 27 (interquartile range: 25-29) years, working in different working areas, such as clinical practice, academic institutions, rehabilitation centers, and amplification services in T & uuml;rkiye, were included. Audiologists were invited to participate in this study via several online forums and hospital notice boards. All participants completed the sociodemographic data form and then the Maslach Burnout Inventory (MBI), Work- Related Quality of Life Scale (WRQoL), and Beck Depression Inventory (BDI). Results: Differences between MBI, WRQoL, and BDI scores were analyzed according to gender, level of education, area of work, and title of audiologist. There are significant differences in the subscale scores of the MBI and WRQoL scales and in the BDI scores between groups according to gender, education, and area of work. There are also significant differences in BDI scores according to title. There is a significant correlation between the MBI, WRQoL, and BDI scores of audiologists. Conclusions: This study represents the initial exploration of burnout, quality of work life, and depression levels among audiologists employed in T & uuml;rkiye. A low quality of work life can increase the risk of burnout and depression. Enhancements in the work environment can lessen burnout and depression while also improving employees' general quality of life.Letter Investigation of Trace Element and Toxic Metal Blood Levels in Obese Children(Aves, 2025) Kilic, SinanArticle Anatomical Relationship Between the Profunda Brachii Artery and the Radial Nerve at the Entrance and Within the Radial Groove(Springer France, 2025) Sanliturk, Yusra Nur; Gayretli, Ozcan; Zeybek, Nursen; Ozturk, AdnanPurposeIn this study, it was aimed to examine the relationship between the profunda brachii artery and the radial nerve at the entrance to and within the radial groove considering no comparable study was found in the literature.MethodDissection was performed in 44 upper extremities (21 right and 23 left) of 24 fixed cadavers used for medical education at Istanbul University, Istanbul Medical Faculty, Department of Anatomy.ResultsProfunda brachii artery was found to be a single artery in 39 extremities and a double artery in 5 extremities. In 27 cases with single PBA, the nerve was located superolateral to the PBA (Type A), and in 8 cases the nerve was located inferomedial to the PBA (Type B). In all 5 extremities with double profunda brachii artery, the proximal branch was superolateral (Type A) and the distal branch was inferomedial (Type B).ConclusionsThis research will support surgeons understanding how to better anatomically and radiologically treat humeral fractures and lateral arm flap applications.Article Choroidal Vascularity Index Findings in Patients Recovered From Mild Course Covid-19 Pneumonia(Springer, 2025) Toprak, Muge; Kesim, Enes; Karasu, Bugra; Celebi, Ali Riza CenkPurposeTo assess the choroidal vascularity index (CVI) in individuals who have recovered from moderate pneumonia caused by COVID-19, using enhanced depth imaging optical coherence tomography (EDI-OCT).MethodsThis study included 43 patients who had recovered from SARS-CoV-2 infection with mild pneumonia (Group 1-COVID group), as well as 45 healthy individuals (Group 2- healthy control group). The study comprised COVID-19 patients who fully recovered from COVID-19 pneumonia. These patients were assessed 6 months after their pneumonia had totally resolved. The measurements were acquired via EDI-OCT investigations of the choroidal structures. The primary measure of interest was the CVI, which is defined as the ratio of the luminal area (LA) to the total choroidal area (TCA).ResultsPatients from Group 1 (COVID group) who had totally recovered exhibited significantly higher mean TCA, stromal area (SA), and LA compared to patients from Group 2 (control or healthy group). The two groups did not show a significant difference in CVI (p = 0.080).ConclusionChoroidal vascularity index can reveal the choroidal vascular physiology in patients who have fully recovered from COVID-19 pneumonia. EDI-OCT can be utilized to evaluate choroidal vascular alterations, serving as a non-invasive indicator for early vascular impairment following SARS-CoV-2 infection.Article Smart Mxene-Based Microrobots for Targeted Drug Delivery and Synergistic Therapies(Royal Soc Chemistry, 2025) Iravani, Siavash; Zarepour, Atefeh; Khosravi, Arezoo; Varma, Rajender S.; Zarrabi, AliMXenes and their composites exhibit remarkable electrical conductivity, mechanical flexibility, and biocompatibility, making them ideal candidates for microrobot fabrication. Their tunable surface chemistry allows for easy functionalization, which enhances their interaction with biological environments, thereby facilitating targeted therapies. Such smart microrobots can be engineered to navigate through complex biological systems with precision via the integration of responsive elements, such as stimuli-sensitive polymers or magnetic components. MXene-based microrobots are able to actively seek out specific tissues or cells. This capability is crucial for applications in cancer treatment, where localized drug delivery minimizes side effects and enhances therapeutic efficacy. The primary advantage of MXene-based microrobots lies in their ability to deliver therapeutic agents directly to diseased cells. Utilizing ligand-receptor interactions, these microrobots can bind to target cells and release their payload in a controlled manner. This targeted delivery system not only improves the effectiveness of the drug but also reduces the required dosage, thus mitigating potential side effects. Moreover, smart MXene-based microrobots can facilitate synergistic therapies by co-delivering multiple therapeutic agents. For instance, combining chemotherapy drugs with immunotherapeutic agents could enhance treatment outcomes in cancer therapy. The ability to simultaneously deliver different types of drugs allows for more comprehensive treatment strategies that can tackle tumor heterogeneity. Significant advancements are anticipated in synergistic therapies, particularly in chemo-photothermal, chemodynamic, and photothermal/photodynamic therapies. These strategies leverage multiple therapeutic modalities to enhance cancer treatment outcomes. Despite their outstanding potential, several challenges remain in the development of MXene-based microrobots namely matters pertaining to scalability, stability in biological environments, and associated regulatory hurdles which ought to be addressed. Future research should focus on optimizing the design and functionality of these microrobots, including enhancing their navigation capabilities and ensuring their safety and effectiveness in vivo. By presenting the innovative capabilities of MXene-based microrobots, this perspective aims to inspire additional explorations in the field of advanced targeted drug delivery systems and synergistic therapies, ultimately contributing to the future of personalized medicine and oncology.Article Which Screening Tool Performs Best in Identifying Malnutrition Risk Among Hospitalized Older Adults With Cardiovascular Disease? a Diagnostic Accuracy Study Comparing Six Different Screening Tools With Glim Criteria(Springer, 2025) Selcuk, Kevser Tari; Arslan, Sedat; Aydin, Ayca; Durmaz, DuyguPurpose This study aimed to compare the performance of six different screening tools with the GLIM criteria in identifying malnutrition risk among older adults with cardiovascular diseases. Methods In this diagnostic accuracy study, data from 669 patients aged 65 and older, hospitalized at Band & imath;rma Training and Research Hospital diagnosed with cardiovascular disease, were evaluated. The data were obtained using a questionnaire that included a Demographic Information Form, Global Leadership Initiative on Malnutrition (GLIM) Criteria, Malnutrition Screening Tool (MST), Malnutrition Universal Screening Tool (MUST), Short Nutritional Assessment Questionnaire (SNAQ), Mini Nutritional Assessment-Short Form (MNA-SF), Nutritional Risk Screening-2002 (NRS-2002), and Graz Malnutrition Screening (GMS) tool. GLIM criteria were used as gold standard and six screening tools were used as index tests. Receiver Operating Characteristic (ROC) curve analysis was conducted to calculate the Area Under the Curve (AUC), and the sensitivity, specificity, accuracy, and Cohen's Kappa (kappa) coefficient of the index tests were assessed. Results The mean age of the patients was 75.5 +/- 7.7 years, 55.2% were female. According to the GLIM criteria, the prevalence of malnutrition was calculated as 22.0%. The AUC calculated by ROC indicated that MST (AUC: 0.905) had excellent predictive value, while MUST (AUC: 0.874), SNAQ (AUC: 0.851), MNA-SF (AUC: 0.842), and GMS (AUC: 0.820) demonstrated good predictive value. Among the screening tools, GMS had the highest sensitivity (92.5%), whereas MNA-SF exhibited the highest specificity (91.6%). MNA-SF also demonstrated the highest agreement with the GLIM criteria (Cohen's kappa: 66.8) and the highest accuracy (88.3%). Conclusion This study found that the MNA-SF tool outperformed other comprehensive screening tools when evaluating malnutrition risk in light of the GLIM criteria.Article Examining Men's Attitudes Toward Family Planning in Istanbul, Turkey(Bmc, 2025) Baglan, Derya; Esencan, Tugba YilmazBackground Family planning (FP) is a vital component of reproductive health and gender equality, particularly in developing countries. Despite the critical role of men in FP decision-making, their involvement remains limited due to sociocultural factors. This study aims to examine men's attitudes toward FP in Turkey and highlight the need for more inclusive FP strategies. Methods A descriptive study was conducted with 400 male participants residing in Istanbul, using the Family Planning Attitude Scale (FPAS), a validated and standardized questionnaire. Stratified sampling was employed to ensure diverse representation of educational backgrounds and sociodemographic factors. The statistical analyses employed descriptive statistics, an independent sample t-test, a one-way ANOVA, and a Pearson correlation analysis. Results The mean total score of the Family Planning Attitude Scale was found to be 74.5 +/- 30.4, with the mean of the sub-dimensions "attitude towards society" being 31.8 +/- 14.3, "attitude towards methods" being 24.8 +/- 11.2, and "attitude towards pregnancy" being 17.9 +/- 8.0. The total scale score and sub-dimension scores of the participants were found to be at a relatively low level. Significant differences were observed in participants' attitudes towards family planning according to educational level, spouses' educational status, age at early marriage, and having children (p < 0.05). The results indicated that individuals who did not utilize contraceptive methods exhibited more negative attitudes than those who did (M = 84.0 vs. M = 71.1). The criteria that men considered when selecting a family planning method were found to significantly influence their attitudes toward pregnancy (F = 7.02; p = 0.001). Conclusions The findings underscore the necessity of increasing men's FP knowledge and access to contraceptive methods. Targeted interventions should focus on improving men's understanding of FP methods to foster shared decision-making between spouses. Trial registration Clinical trial number: not applicable. The data that support the findings of this study are openly available in the National Thesis Center at tez.yok.gov.tr/UlusalTezMerkezi/tezSorguSonucYeni.jsp.Article Monomer Release, Cytotoxicity, and Surface Roughness of Temporary Fixed Prosthetic Materials Produced by Digital and Conventional Methods(Springer, 2025) Sahin, Zeynep; Ozkan Vardar, Deniz; Erdogmus, Ekin; Calamak, Semih; Gumusel, Belma KocerThis study compared surface roughness, monomer release, and, cytotoxicity of temporary fixed prosthetic materials manufactured using the conventional, CAD/CAM milling and 3D printing methods. Disc-shaped samples (2 mm height, 5 mm diameter) were prepared from four materials [polyethyl methacrylate/polymethyl methacrylate (Dentalon Plus-DP), bis-acrylic composite resin (Protemp 4-PT), polymethyl methacrylate CAD/CAM disc (On Dent), and methacrylate-based resin (QuraCROWN Temp)]. Surface roughness was measured with a profilometer; scanning electron microscopy (SEM) was used for surface characterization. Following 24, 72, and 120 h of artificial saliva incubation for the samples, the obtained extracts were evaluated for cytotoxicity by performing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test in the mouse fibroblast cell. Monomer release from the test samples was analyzed by High-Performance Liquid Chromatography. Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR) was performed to evaluate the chemical composition of artificial saliva extracts. Cell viability was assessed by one-way ANOVA, and surface roughness by Kruskal-Wallis and Mann-Whitney U tests. No monomer was detected in artificial saliva for any materials. The FTIR spectroscopy of the extracts did not show any peaks corresponding to these monomer or polymer structures, indicating that no residual monomer or polymer was released into the artificial saliva after exposure to artificial saliva. 3D-printed materials were significantly more cytotoxic than the other three test materials at all time points and dilutions (p < 0.05). The highest cell viability rates were detected in CAD/CAM milling (99.43 +/- 3.79) at 24 h and PT materials (100.47 +/- 5.31) at 72 h for 1:8 dilution. At 1:4 dilution, except for the DP-3D printing test groups, the other groups show similar cell viability rates with the control group (p > 0.05). Digitally manufactured materials had lower roughness than conventionally produced ones (p < 0.05). CAD/CAM milling and PT materials were the most biocompatible, while 3D-printed material was found to be cytotoxic. CAD/CAM milling and PT materials may offer safe and effective options for temporary prosthetic restorations. Although DP showed acceptable results, it was less effective than CAD/CAM milling and PT materials. Due to their cytotoxicity, 3D-printed materials require further investigation before clinical use.Article Serotypes Distribution and Antibiotic Susceptibility of Streptococcus Pneumoniae Strains: Five-Year Surveillance Results of Post-Pcv(Bmc, 2025) Atici, Serkan; Guneser, Deniz; Kepenekli, Eda; Soyletir, Guner; Soysal, AhmetBackgroundApproximately 100 capsular serotypes of S. pneumonia have been identified according to the composition of their capsular polysaccharides, currently available vaccines do not cover many of these. Pneumococcal vaccination serotype coverage is essential for preventing noninvasive and invasive illnesses as well as asymptomatic carriage. We aimed to determine the serotype distribution and antimicrobial susceptibility pattern of pneumococcal clinical isolates in this study. We also analyzed the serotype coverage rates of PCV13, which is applied in the NIP, and PCV-15 and PCV20, which have been introduced recently.MethodsThis study is a retrospective surveillance of pneumococcal infections including invasive pneumococcal isolates (IPIs) and non-invasive pneumococcal isolates (non-IPIs).ResultsA total of 420 isolates from 356 different patients aged 0-89 years were enrolled in the study. A total of 420 pneumococcal isolates were serotyped and 26 different serotypes were detected. Serotype 19 F was the most prevalent serotype (n = 96, 22.8%), followed by 6 A/B (n = 55, 13.1%), 23 F (n = 49, 11.6%), 3 (n = 22, 5.2%) and 19 A (n = 16, 3.8%).ConclusionsSurveillance studies of pneumococcal diseases are critical to investigating current serotype distributions, antibiotic resistance status, and frequency of IPD cases. Considering the increasing antibiotic resistance rates of S. pneumoniae, it is necessary to provide protective immunization by switching to more comprehensive PCV vaccines rather than treatment.Clinical trial numberNot applicable.Editorial Aso Visual Abstract: Breast Cancer Recurrence in Initially Clinically Node-Positive Patients Undergoing Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in the Neosentiturk-Trials Mf18-02/18-03(Springer, 2025) Cabioglu, Neslihan; Karanlik, Hasan; Igci, Abdullah; Muslumanoglu, Mahmut; Gulcelik, Mehmet Ali; Uras, Cihan; Ozmen, VahitArticle Search for Light Long-Lived Particles Decaying To Displaced Jets in Proton-Proton Collisions at √s=13.6 Tev(Iop Publishing Ltd, 2025) Hayrapetyan, A.; Tumasyan, A.; Adam, W.; Andrejkovic, W.; Bergauer, T.; Chatterjee, S.; Makarenko, V.A search for light long-lived particles (LLPs) decaying to displaced jets is presented, using a data sample of proton-proton collisions at a center-of-mass energy of 13.6 TeV, corresponding to an integrated luminosity of 34.7 fb(-1), collected with the CMS detector at the CERN LHC in 2022. Novel trigger, reconstruction, and machine-learning techniques were developed for and employed in this search. After all selections, the observations are consistent with the background predictions. Limits are presented on the branching fraction of the Higgs boson to LLPs that subsequently decay to quark pairs or tau lepton pairs. An improvement by up to a factor of 10 is achieved over previous limits for models with LLP masses smaller than 60 GeV and proper decay lengths smaller than 1 m. The first constraints are placed on the fraternal twin Higgs (FTH) and folded supersymmetry (FSUSY) models, where the lower bounds on the top quark partner mass reach up to 350 GeV for the FTH model and 250 GeV for the FSUSY model.Article Comparison of the Overall Fit of Three-Unit Posterior Fixed Dental Prostheses Fabricated With Laser Sintering and Conventional Casting Methods(Springer Heidelberg, 2025) Pekkan, Gurel; Degirmenci, Kubra; Tuna, Suleyman Hakan; Hekimoglu, Canan; Saridag, SerkanObjectives The aim of this study was to investigate the marginal, internal, and occlusal discrepancies of three-unit posterior cobalt-chromium (Co-Cr) fixed dental prostheses (FDPs) produced using five different fabrication techniques. Materials and methods Segmental maxillary models were prepared from polyamide material using a laser sintering method. The maxillary first premolar and first molar teeth were prepared to receive posterior FDPs. Direct metal laser sintering (DMLS) and selective laser melting (SLM) were used as two metal laser Co-Cr framework production systems. FDP specimen patterns were prepared by manual wax carving (Cast), 3D-printed polymer (3DP), and CAD/CAM wax and cast using the lost-wax technique as conventional methods. In total, 100 Co-Cr metal framework specimens were prepared for posterior FDPs (n = 20). The silicone replica technique was used to measure marginal, internal, and occlusal discrepancies of all frameworks. A stereomicroscope was employed to detect discrepancies at 100x magnification. The data were analyzed using two-way ANOVA (alpha = 0.05) and post hoc Bonferroni adjustment (alpha = 0.005) for pairwise comparisons. Results There were no significant differences between the occlusal discrepancy values of premolar abutments of FDPs when compared with different fabrication methods (P > 0.05). The highest marginal discrepancy value was detected as 116.22 mu m for molar abutment when the Cast method was used (P < 0.05). The highest occlusal discrepancy values were detected as 135.60 mu m and 141.49 mu m for molar abutments of posterior FDPs when the 3DP and Cast methods were used. The lowest marginal discrepancy value was detected as 38.94 mu m for molar abutments when the DMLS method was used (P < 0.05). Conclusions The DMLS method was more successful than other fabrication methods when fit values of abutment teeth for posterior frameworks were compared. Clinical relevance The morphology of the abutment teeth and the fabrication techniques of FDPs migth affect the discrepancy values of FDPs planned. It was seen that the discrepancy values were lowest with the DMLS and SLM methods. Considering the results of this in-vitro study, DMLS and SLM techniques may be more appropriate option than the 3DP method, which starts with digital design and ends conventionally casting technique for posterior three-unit FDPs.Article Isolation and Characterization of New Lytic Bacteriophage Psa-Kc1 Against Pseudomonas Aeruginosa Isolates From Cystic Fibrosis Patients(Nature Portfolio, 2025) Kurt, Kuebra Can; Kurt, Halil; Tokuc, Edip; Ozbey, Dogukan; Arabaci, Duygu Nur; Aydin, Sevcan; Tokman, Hrisi BaharA novel lytic bacteriophage, PSA-KC1, was isolated from wastewater. In this study, the whole genome of the bacteriophage PSA-KC1 was analyzed, and its lytic properties were assessed. PSA-KC1 has a linear double-stranded DNA genome with a total length of 43,237 base pairs and a GC content of 53.6%. In total, 65 genes were predicted, 46 of which were assigned functions as structural proteins involved in genome replication, packaging or phage lysis. PSA-KC1 belongs to the genus Septimatrevirus under the Caudoviricetes class. The aim of this study was to investigate the efficacy of the lytic bacteriophage PSA-KC1 and compare it with that of the Pyophage phage cocktail on 25 multi drug resistant (MDR) Pseudomonas aeruginosa strains isolated from sputum samples of cystic fibrosis patients. Seventeen of these strains were susceptible (68%) to the PSA-KC1 lytic phage we isolated, whereas eight clinical strains were resistant. However, 22 (88%) of the P. aeruginosa strains were susceptible to the Pyophage cocktail, and three (12%) were resistant to the Phage cocktail. At the end of our study, a new lytic phage active against multidrug-resistant P. aeruginosa strains from CF patients was isolated, and its genome was characterized. Since the PSA-KC1 phage does not contain virulence factors, toxins or integrase genes, it can be expected to be a therapeutic candidate with the potential to be used safely in phage therapy.Article Assessment of Stiffness-Dependent Autophagosome Formation and Apoptosis in Embryonal Rhabdomyosarcoma Tumor Cells(2025) Sezen, S.; Adiguzel, S.; Zarepour, A.; Khosravi, A.; Gordon, J.W.; Ghavami, S.; Zarrabi, A.Remodeling of the extracellular matrix (ECM) eventually causes the stiffening of tumors and changes to the microenvironment. The stiffening alters the biological processes in cancer cells due to altered signaling through cell surface receptors. Autophagy, a key catabolic process in normal and cancer cells, is thought to be involved in mechano-transduction and the level of autophagy is probably stiffness-dependent. Here, we provide a methodology to study the effect of matrix stiffness on autophagy in embryonal rhabdomyosarcoma cells. To mimic stiffness, we seeded cells on GelMA hydrogel matrices with defined stiffness and evaluated autophagy-related endpoints. We also evaluated autophagy-dependent pathways, apoptosis, and cell viability. Specifically, we utilized immunocytochemistry and confocal microscopy to track autophagosome formation through LC3 lipidation. This approach suggests that the use of GelMA hydrogels with defined stiffness represents a novel method to evaluate the role of autophagy in embryonal rhabdomyosarcoma and other cancer cells. © 2024. Springer Science+Business Media, LLC.Article Search for cp Violation in D0 → Ks0< Decays in Proton-Proton Collisions at √s=13tev(Springer, 2024) Hayrapetyan, A.; Tumasyan, A.; Adam, W.; Andrejkovic, J. W.; Bergauer, T.; Chatterjee, S.; Zhokin, A.A search is reported for charge-parity CP violation in D-0 -> (KSKS0)-K-0 decays, using data collected in proton-proton collisions at root s =13 TeV recorded by the CMS experiment in 2018. The analysis uses a dedicated data set that corresponds to an integrated luminosity of 41.6fb(-1), which consists of about 10 billion events containing a pair of b hadrons, nearly all of which decay to charm hadrons. The flavor of the neutral D meson is determined by the pion charge in the reconstructed decays D*(+) -> D-0 pi(+) and D*(-) -> (D) over bar (0)pi(-). The CP asymmetry in D-0 -> (KSKS0)-K-0 is measured to be A(CP)((KSKS0)-K-0) = (6.2 +/- 3.0 +/- 0.2 +/- 0.8)%, where the three uncertainties represent the statistical uncertainty, the systematic uncertainty, and the uncertainty in the measurement of the CP asymmetry in the D-0 -> K-S(0)pi(+)pi(-) decay. This is the first CP asymmetry measurement by CMS in the charm sector as well as the first to utilize a fully hadronic final state.Article Citation - Scopus: 0Effect of Surface Coatings on Endothelialization and Biofilm in Ptfe Vascular Grafts(Sage Publications Ltd, 2025) Erkan, Muhammet Huseyin; Boga, Mehmet; Salih, Hanife; Barbarus, Emin; Rahman, Omer Faruk; Sakarya, SarhanPolytetrafluoroethylene (PTFE) grafts are of great importance for vascular surgery and many methods have been developed to improve their biocompatibility. The most important of these methods is the coating of the inner surfaces of the grafts. In this study, the effects of surface coatings used in vascular grafts on endothelialization and bacterial biofilm formation were investigated. Three different PTFE graft types, heparin coated, carbon coated and uncoated, were compared. HUVEC cell culture was used for endothelialization experiments and Staphylococcus aureus strain was used for biofilm formation. Endothelialization was evaluated by inverted microscopy and scanning electron microscopy (SEM). Heparin-coated grafts showed more biofilm formation than other graft types (p < 0.01). Moderate biofilm formation was observed in carbon-coated grafts (p < 0.05). When evaluating endothelialization, heparin-coated grafts showed more cell adhesion in the first days, but lagged behind the other graft types in the following days. Carbon-coated grafts showed more endothelial cell proliferation in the long term. While biofilm formation was high in heparin-coated grafts, carbon-coated grafts provided better endothelialization. Our study showed that the coating of PTFE grafts significantly affects biocompatibility and infection risk.Editorial Citation - Scopus: 0Embryo Versus Endometrial Receptivity: Untangling a Complex Debate(Frontiers Media Sa, 2025) Mercan, Ramazan; Guzel, Yilmaz; Usta, Irem; Alper, EbruArticle Citation - WoS: 0Citation - Scopus: 0Thyroid Cancer in Childhood Cancer Survivors: Demographic, Clinical, Germline Genetic Characteristics, Treatment, and Outcome(Mdpi, 2025) Yildirim, Ulku Miray; Kebudi, Rejin; Celik, Ayca Iribas; Zulfikar, Buelent; Kebudi, AbutObjective: Childhood cancer survival rates have improved, but survivors face an increased risk of second malignant neoplasms (SMNs), particularly thyroid cancer. This study examines the demographic, clinical, genetic, and treatment characteristics of childhood cancer survivors who developed thyroid cancer as a second or third malignancy, emphasizing the importance of long-term surveillance. Methods: A retrospective review was conducted for childhood cancer survivors treated between 1990 and 2018 who later developed thyroid cancer as a second or third malignancy. Data on demographics, clinical characteristics, treatment, and outcomes were analyzed. Results: Among the 3204 childhood cancer survivors, 10 patients (6 female, 4 male) developed papillary thyroid carcinoma (PTC), a median of 9 years post-initial diagnosis. Radiation therapy, particularly to the head and neck, was commonly used. Genetic testing revealed mutations in the Cell Cycle CheckPoint Kinase 2 (CHEK2) and Adenomatous Polyposis Coli (APC) genes in four patients, possibly contributing to the increased risk. All were diagnosed through thyroid ultrasound and underwent total thyroidectomy, and three received radioactive iodine (RAI). No recurrences or deaths related to PTC occurred, with a median follow-up of 5.5 years after diagnosis. Conclusions: Radiation therapy, especially combined with chemotherapy, significantly increases the risk of thyroid cancer in childhood cancer survivors. Genetic predispositions also play a role. Lifelong thyroid cancer surveillance is essential, particularly for those who received radiation or chemotherapy. Further research is needed to refine surveillance strategies and better understand genetic factors that influence thyroid cancer risk. Early detection and ongoing monitoring are critical for improving long-term outcomes.Review Citation - WoS: 0Citation - Scopus: 0Anionic Polysaccharides as Delivery Carriers for Cancer Therapy and Theranostics: an Overview of Significance(Elsevier, 2025) Sivakumar, Ponnurengam Malliappan; Zarepour, Atefeh; Akhter, Sohail; Perumal, Govindaraj; Khosravi, Arezoo; Balasekar, Premkumar; Zarrabi, AliRecently, cancer therapy has witnessed remarkable advancements with a growing focus on precision medicine and targeted drug delivery strategies. The application of anionic polysaccharides has gained traction in various drug delivery systems. Anionic polysaccharides have emerged as promising delivery carriers in cancer therapy and theranostics, offering numerous advantages such as biocompatibility, low toxicity, and the ability to encapsulate and deliver therapeutic agents to tumor sites with high specificity. This review underscores the significance of anionic polysaccharides as essential components of the evolving landscape of cancer therapy and theranostics. These polymers can be tailored to carry a wide range of therapeutic cargo, including chemotherapeutic agents, nucleic acids, and imaging agents. Their negative charge enables electrostatic interactions with positively charged drugs and facilitates the formation of stable nanoparticles, liposomes, or hydrogels for controlled drug release. Additionally, their hydrophilic nature aids in prolonging circulation time, reducing drug degradation, and minimizing off-target effects. Besides, some of them could act as targeting agents or therapeutic compounds that lead to improved therapeutic performance. This review offers valuable information for researchers, clinicians, and biomedical engineers. It provides insights into the recent progress in the applications of anionic polysaccharide-based delivery platforms in cancer theranostics to transform patient outcomes.Article Citation - WoS: 0Citation - Scopus: 0Demographic Features, Clinical Characteristics, and Comorbid Relation in Hidradenitis Suppurativa: a Population-Based Study(Frontiers Media Sa, 2025) Kaya, Gokhan; Ozgen, Fatma Pelin; Kelahmetoglu, Osman; Kucuk, Ozlem Su; Onsun, NahideBackground/objective Hidradenitis suppurativa (HS) is a chronic inflammatory disease affecting apocrine gland areas, characterized by painful nodules and abscesses that may result in sinus tracts and scarring. The global prevalence of HS is increasing due to heightened awareness, improved diagnostic methods, rising obesity rates, and higher smoking prevalence. This study aimed to describe the epidemiological, clinical, and comorbid characteristics of HS patients.Methodology This retrospective descriptive cross-sectional study included 193 outpatients aged between 15 and 73 years who visited a tertiary HS clinic between 2017 and 2022. Demographic, clinical, and comorbid characteristics were recorded and analyzed using chi-square and ordinal regression methods.Results The mean age was 34.5 +/- 12.1 years, with a mean disease duration of 5.9 +/- 6.7 years. According to the Hurley classification, 61.1, 24.4, and 14.5% were stages I, II, and III, respectively. Comorbidities were present in 48.2% of patients, with psychiatric disorders (19.2%), diabetes mellitus (14%), and hypertension (9.3%) being most common. Disease duration, smoking, male gender, and atypical localization were associated with increased disease severity.Conclusion Geographic and cultural factors influence the prevalence, severity, and management of HS, necessitating tailored treatment. Effective management requires multidisciplinary screening for early detection and prevention of comorbidities, including psychiatric disorders, cardiovascular conditions, and metabolic syndrome.
