PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14517/21
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Article Citation Count: 0Investigation of miRNA-199a-5p Expression and its Clinical Association With LDL Cholesterol Levels in Atherosclerosis(2024) Barut, Z.; Akdeniz, F.T.; Avsar, O.; Cabbar, A.T.BACKGROUND/AIM: Atherosclerosis is a chronic and progressive pathological condition marked by the accumulation of lipids, fibrous materials, and inflammatory cells, within the arterial walls. MicroRNAs (miRNAs) are single-stranded, evolutionarily conserved, non-coding small RNAs, that play a pivotal role in controlling various pathophysiological cellular functions and molecular signalling cascades associated with the development of atherosclerosis. Additionally, dysregulation in cholesterol and lipid metabolism is known to increase susceptibility to atherosclerosis. In this study, we aimed to determine the changes in serum levels of miRNA-199a-5p, examine its relationship with LDL cholesterol, and investigate its diagnostic value in patients diagnosed with atherosclerosis. MATERIALS AND METHODS: MiRNA-199a-5p expression analysis was conducted using PCR on serum samples from 20 patients diagnosed with atherosclerosis and 26 completely healthy, voluntary control subjects. The blood biochemical analysis values for all groups participating in the study were obtained from their records. RESULTS: The data analysis revealed significant up-regulation of miRNA-199a-5p in the serum of the patient group. Additionally, miRNA-199a-5p expression levels positively correlated with LDL cholesterol levels. CONCLUSION: miRNA-199a-5p can be considered a reliable biomarker in patients with atherosclerosis, potentially informing and guiding future therapeutic approaches. Additionally, a significant relationship was found between lipid metabolism and miRNA-199a-5p in atherosclerosis. Copyright © 2024, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.Article Citation Count: 0Investigation of Predisposing Risk Factors in Adolescent Male Water Polo Players(Sage Publications inc, 2024) Yeral, Asli; Subasi, Feryal; Tekin, Ata; Cil, Elif Tugce; Mumcu, Gonca; Yay, Meral; Sayli, UgurBackground: Shoulder injuries are prevalent in adolescent water polo (WP) players. Study aimed to determine whether preseason shoulder characteristics (range of motion [ROM], flexibility, and strength) and core endurance can identify athletes at risk of future shoulder injuries. Hypothesis: Shoulder characteristics, including changes in ROM (internal rotation [IR], external rotation [ER], and total), strength (IR and ER), pectoralis minor flexibility, shoulder capsule flexibility, and core endurance, would be risk factors for shoulder reinjury in athletes with previous overuse injuries compared with noninjured athletes. Study Design: Prospective cohort study. Level of Evidence: Level 3. Methods: At baseline, 53 male youth WP players (mean age, 16.6 +/- 3.5 years) were assigned to Group 1 (with previous shoulder injuries [G1, n = 26]) and Group 2 (without previous shoulder injuries [G2, n = 27]). ROM, flexibility, strength, and core muscle endurance were assessed preseason. After a 12-month follow-up, players were again divided into those who developed new shoulder injuries (G3, n = 27) and those who remained healthy (G4, n = 26). Results: Total of 26 players (49%) had previous shoulder injuries at baseline. At baseline, decreased pectoralis minor flexibility, IR, total ROM, and core endurance were found in players with a previous shoulder injury compared with players without a previous shoulder injury (P < 0.05). Conclusion: At baseline, a significant difference was present in proposed risk factors (shoulder and core endurance parameters) between players with and without a previous shoulder injury. Shoulder IR ROM and years of experience were significant predictors of shoulder injury. Early detection of modifiable proposed risk factors may help prevent reinjury in young athletes. Clinical Relevance: Screening at an early age can help identify and address pre-existing injuries, support youth athletes' return to sport after a shoulder injury, prevent new injuries, and improve performance.Article Citation Count: 0Comparative Histopathological Analysis of Nasal Osteotomy Techniques in a Rabbit Model(Sage Publications inc, 2024) Hanci, Deniz; Gurpinar, Berk; Altun, Huseyin; Onaran, Oyku Izel; Uygan, Ugur; Kumas, Omer; Uyar, YavuzObjective: Nasal osteotomy is a crucial step in rhinoplasty, explicitly addressing the open roof deformity in nasal bones. This study aimed to assess and compare the recovery patterns associated with 4 distinct osteotomy techniques in a rabbit model. Materials and Methods: Twenty white New Zealand rabbits weighing 2.5 to 3.0 kg were included in the study. Median osteotomies were performed on the left side using piezosurgery and on the right side using an oscillating micro-saw. Additionally, internal osteotomy was executed on the right side and external osteotomy on the left side, both performed with a chisel across all rabbits. Ten rabbits were sacrificed on the 7th day, while the remaining 10 were sacrificed on the 15th day for subsequent histological examination. The granulation tissue formation (GTF), vascularization, inflammation, collagen fibril content, osteotomy gap width, and new bone formation were evaluated in hematoxylin and eosin and Masson's trichrome-stained sections. Results: On the 7th day, piezosurgery demonstrated statistically-significant advantages in terms of GTF, neovascularization, and collagen fibril quantity when compared to the oscillating micro-saw (P < .05). Furthermore, a statistically-significant difference was observed among the groups concerning the distribution of connective tissue organization between the 7th and 15th days (P < .05). Conclusions: This study's findings unequivocally establish that bone healing after osteotomy with piezosurgery surpasses that achieved with an oscillating micro-saw in this rabbit model.Article Citation Count: 0Psychological resilience in patients with primary Sjögren's syndrome: effect of involvement of major salivary and lacrimal glands(Wiley, 2024) Sevimli, Esra; Gunay, Seda; Aliyeva, Alida; Aksoy, Burcu; Fortune, Farida; Inanc, Nevsun; Mumcu, GoncaThe aim of this study was to assess whether the involvement of major salivary and lacrimal glands in primary Sj & ouml;gren's syndrome (pSS) affected the psychological resilience of patients. This cross-sectional study included 116 patients with pSS. Data were collected through clinical examinations, measurement of salivary flow rates (SFRs), and from Schirmer's test, as well as from patient-reported outcome measures (PROMs), such as the European League Against Rheumatism (EULAR) Sj & ouml;gren's Syndrome Patient Reported Index (ESSPRI), Brief Resilience Scale (BRS), Work Productivity and Activity Impairment (WPAI), Oral Health Impact Profile-14 (OHIP-14), and the Hospital Anxiety and Depression Scale (HADS). Hyposalivation was defined as an unstimulated SFR of <= 0.1 mL/min. The BRS score (mean +/- SD = 2.60 +/- 0.69) was lower in patients with recurrent parotitis (2.11 +/- 0.37) than in those without recurrent parotitis (2.67 +/- 0.86), in the whole group. In patients with an unacceptable symptom state (ESSPRI score >= 5 points), a lower BRS score was observed in patients with both hyposalivation and ocular dryness (2.59 +/- 0.69) than in patients with isolated hyposalivation (2.84 +/- 0.84). The BRS score was also negatively associated with the WPAI-Daily Impairment and OHIP-14 scores in patients with hyposalivation as well as with HADS-A (the seven items of HADS relating to the anxiety dimension) and HADS-D (the seven items of HADS relating to the depression dimension) in the whole group. The results suggest that psychological resilience in pSS may be affected by recurrent parotitis, the levels of anxiety and depression, as well as hyposalivation with ocular dryness.Article Citation Count: 0Effectiveness of different types of toothbrushes on periodontal health in orthodontic patients with gingivitis: A randomized controlled study(Bmc, 2024) Aykol-Sahin, Gokce; Ay-Kocabas, Busranur; Mert, Banu; Usta, Hande; Ortodonti / Orthodontics; Periodontoloji / PeriodontologyBackground The aim of the study is to evaluate the effectiveness of different toothbrushes in reducing gingival inflammation and dental biofilm removal in gingivitis patients with fixed orthodontic appliances. Methods Following baseline clinical assessments, including the Turesky modification of the Quigley-Hein plaque index (TQHI), gingival index (GI), bleeding on probing (BOP), and probing pocket depth (PPD), all patients received nonsurgical periodontal therapy. Patients were then randomly assigned to one of three groups: conventional toothbrush (C-TB), orthodontic toothbrush (O-TB), or single-tufted toothbrush (ST-TB). Each group received tailored oral hygiene instructions based on their assigned toothbrush type. Clinical assessments were repeated and recorded in the first week, sixth week, and third month. Results Thirty-six patients with a mean age of 23.14 +/- 3.86 (18-32 years) participated in the study. All groups with twelve patients each demonstrated significant improvements in clinical parameters compared to baseline. In the sixth week, the O-TB and ST-TB groups showed significantly greater improvements in TQHI and BOP scores compared to the C-TB group (p < 0.05). By the third month, the ST-TB group maintained significantly lower TQHI and BOP scores, while the O-TB group's scores became similar to those of the C-TB group. ST-TB and C-TB groups had significantly lower GI scores than the O-TB group in all time points. Although the effectiveness of ST-TB was significantly higher than that of other toothbrushes, all toothbrushes demonstrated lower efficacy in the posterior region. Conclusions The ST-TB was shown to be more effective in reducing gingival inflammation over three months, while it demonstrated similar efficacy to the O-TB in dental biofilm removal. Further research is necessary to substantiate these findings and to demonstrate the efficacy of this approach in promoting periodontal tissue health in patients with fixed orthodontic appliances.Article Citation Count: 0An appropriate artificial intelligence technique for plastic materials recycling using bipolar dual hesitant fuzzy set(Nature Portfolio, 2024) Ramya, Lakshmanaraj; Thilagasree, Chakkarapani Sumathi; Jayakumar, Thippan; Peter, Antony Kishore; Akhir, Emelia Akashah P.; Ferrara, Massimiliano; Ahmadian, AliPlastic recycling has become more important than ever as the globe struggles with growing environmental issues. This research explores the significant environmental impact of recycling plastic and its growing relevance. The pervasive material known as plastic presents a complex risk to both human health and ecosystems in contemporary life. It exacerbates problems including marine pollution, habitat damage, and wildlife entanglement because of its persistence in landfills and seas, which leads to serious ecological deterioration. In addition, producing plastic uses a lot of energy and produces a lot of greenhouse gas emissions, which exacerbate climate change. Through the use of multi-criteria decision making (MCDM), this study emphasizes how vital it is to support recycling activities in order to protect the environment and promote a sustainable future. The elimination and choice ex-pressing reality (ELECTRE) approach is used to rank the alternatives in this proposed research study that employs bipolar dual hesitant fuzzy sets (BDHFs). The most efficient and versatile outranking method for making decisions is the BDHF-ELECTRE approach. The weights of environment, economic, social, technical, and finally safety is computed using the entropy distance metric. The economic factor received the highest score of 0.2945 among the other factors since economic considerations are crucial in choosing the most efficient plastic recycling method, as they ensure sustainability, cost-effectiveness, resource allocation, and overall feasibility in managing plastic waste. The decision-makers determined that the mechanical recycling approach ought to be prioritized over all others for the efficient recycling of plastic waste. The robustness of the system is examined in the sensitive and comparative analyses. The proposed MCDM technique thus presents a viable solution, mitigating the adverse effects of plastic waste by conserving resources, reducing energy consumption, and curbing pollution.Article Citation Count: 0Turkish validity and reliability of the universal mental health literacy scale for adolescents (10-14 years): A methodological study(Wiley, 2024) Uysal, Guelzade; Semerci, Remziye; Sengun, Rukiye; Duzkaya, Duygu SonmezRationaleMental health literacy enables adolescents to acquire information that will accompany them in their future lives and to define their attitudes and behaviors.Aims and ObjectivesThis study evaluated the Turkish validity and reliability of the Universal Mental Health Literacy Scale for Adolescents (10-14 years).MethodsThis is a methodological, correlational, cross-sectional, and descriptive study. The study was conducted with 223 adolescents. Data were collected by 'Information Form' and 'Universal Mental Health Literacy Scale for Adolescents.' Exploratory Factor Analysis, Confirmatory Factor Analysis, and Pearson Correlation analysis were used to assess the validity and reliability of the UMHL-A.ResultsItem Content Validity Index (I-CVI) scores ranged from 0.94 to 0.96, while the Scale Content Validity Index (S-CVI) was 0.95. For 'Help-seeking and Stigma dimensions' chi 2/df = 3.347, NFI = 0.804, IFI = 0.854, TLI = 0.778, CFI = 0.849, RMSEA = 0.103. For 'Knowledge of Mental Health and Knowledge of Mental Illnesses dimensions' chi 2/df = 1.959, NFI = 0.731, IFI = 0.847, TLI = 0.774, CFI = 0.837, RMSEA = 0.066. The internal consistency and time stability were affirmed by a Hotelling T-square value of 15.241 and an F-test result of 27.793.ConclusionsThis study reveals that the Turkish validity and reliability of the Universal Mental Health Literacy Scale for Adolescents is a valid and reliable tool for assessing mental health literacy among adolescents. The UMHL-A scale is a valid tool to evaluate critical aspects of mental health literacy in adolescent populations and can be used in both research and clinical practice in mental health education and intervention. It is recommended that the Turkish version of the Universal Mental Health Literacy Scale should be used to determine resilience in adolescents.Article Citation Count: 1Extracting the speed of sound in quark-gluon plasma with ultrarelativistic lead-lead collisions at the LHC(Iop Publishing Ltd, 2024) Hayrapetyan, A.; Tumasyan, A.; Adam, W.; Andrejkovic, J. W.; Bergauer, T.; Chatterjee, S.; Zhokin, A.Ultrarelativistic nuclear collisions create a strongly interacting state of hot and dense quark-gluon matter that exhibits a remarkable collective flow behavior with minimal viscous dissipation. To gain deeper insights into its intrinsic nature and fundamental degrees of freedom, we determine the speed of sound in an extended volume of quark-gluon plasma using lead-lead (PbPb) collisions at a center-of-mass energy per nucleon pair of 5.02 TeV. The data were recorded by the CMS experiment at the CERN LHC and correspond to an integrated luminosity of 0.607 nb(-1). The measurement is performed by studying the multiplicity dependence of the average transverse momentum of charged particles emitted in head-on PbPb collisions. Our findings reveal that the speed of sound in this matter is nearly half the speed of light, with a squared value of 0.241 +/- 0.002 (stat) +/- 0.016 9(syst) in natural units. The effective medium temperature, estimated using the mean transverse momentum, is 219 +/- 8 The measured squared speed of sound at this temperature aligns precisely with predictions from lattice quantum chromodynamic (QCD) calculations. This result provides a stringent constraint on the equation of state of the created medium and direct evidence for a deconfined QCD phase being attained in relativistic nuclear collisions.Article Citation Count: 0Evaluation of the Effects of Orthopedic Treatment on the Dentofacial Structure and Upper Airway of Subjects with Skeletal Class III Malocclusion(Galenos Publ House, 2024) Kan, Hilal; Sozen, Tevfik; Ogretmenoglu, Oguz; Ciger, SemraObjective: The present study aimed to evaluate the effect of rapid maxillary expansion (RME) and face mask treatment on the upper airway in patients with maxillary retrusion in two dimensions using digital cephalograms and volumetric evaluation using acoustic rhinometric measurements. Methods:A A total of 22 individuals with a concave profile and skeletal and dental Class III malocclusion during growth and development with a mean age of 9.9 +/- 1.38 years were included in the study. A bonded RME appliance and a petit face mask were adapted for the patients. Before treatment (T0) and after maxillary protraction (T1), lateral cephalometric films and acoustic rhinometric recordings were obtained. The dependent sample t-test was used for statistical evaluation. Results: Cephalometric analysis revealed forward movement of the maxilla and backward downward rotation of the mandible. A significant increase was observed in the nasopharyngeal and oropharyngeal regions of the upper airway. Three-dimensional evaluation of the upper airway by acoustic rhinometry revealed only an increase in the volumes of the left nasal cavity after decongestant administration. A statistically significant increase in acoustic rhinometric measurements in nasal valves. When the correlation of the cephalometric findings of the nasopharyngeal region with the acoustic rhinometry findings was examined, no statistically significant relationship was found. Conclusion: As a result of this study, we observed an increase in the cephalometric measurements of the nasopharyngeal and oropharyngeal areas. A significant increase was observed in the minimal cross-sectional area measured by acoustic rhinometry.Review Citation Count: 0Nanosystems for targeted drug Delivery: Innovations and challenges in overcoming the Blood-Brain barrier for neurodegenerative disease and cancer therapy(Elsevier, 2024) Rafati, Nesa; Zarepour, Atefeh; Bigham, Ashkan; Khosravi, Arezoo; Naderi-Manesh, Hossein; Iravani, Siavash; Zarrabi, Ali; Genetik ve Biyomühendislik / Genetic and Bio-EngineeringThe evolution of sophisticated nanosystems has revolutionized biomedicine, notably in treating neurodegenerative diseases and cancer. These systems show potential in delivering medication precisely to affected tissues, improving treatment effectiveness while minimizing side effects. Nevertheless, a major hurdle in targeted drug delivery is breaching the blood-brain barrier (BBB), a selective shield separating the bloodstream from the brain and spinal cord. The tight junctions between endothelial cells in brain capillaries create a formidable physical barrier, alongside efflux transporters that expel harmful molecules. This presents a notable challenge for brain drug delivery. Nanosystems present distinct advantages in overcoming BBB challenges, offering enhanced drug efficacy, reduced side effects, improved stability, and controlled release. Despite their promise, challenges persist, such as the BBB's regional variability hindering uniform drug distribution. Efflux transporters can also limit therapeutic agent efficacy, while nanosystem toxicity necessitates rigorous safety evaluations. Understanding the long-term impact of nanomaterials on the brain remains crucial. Additionally, addressing nanosystem scalability, cost-effectiveness, and safety profiles is vital for widespread clinical implementation. This review delves into the advancements and obstacles of advanced nanosystems in targeted drug delivery for neurodegenerative diseases and cancer therapy, with a focus on overcoming the BBB.Review Citation Count: 0Biohybrid Micro/Nanorobots: Pioneering the Next Generation of Medical Technology(Wiley, 2024) Zarepour, Atefeh; Khosravi, Arezoo; Iravani, Siavash; Zarrabi, Ali; Genetik ve Biyomühendislik / Genetic and Bio-EngineeringBiohybrid micro/nanorobots hold a great potential for advancing biomedical research. These tiny structures, designed to mimic biological organisms, offer a promising method for targeted drug delivery, tissue engineering, biosensing/imaging, and cancer therapy, among other applications. The integration of biology and robotics opens new possibilities for minimally invasive surgeries and personalized healthcare solutions. The key challenges in the development of biohybrid micro/nanorobots include ensuring biocompatibility, addressing manufacturing scalability, enhancing navigation and localization capabilities, maintaining stability in dynamic biological environments, navigating regulatory hurdles, and successfully translating these innovative technologies into clinical applications. Herein, the recent advancements, challenges, and future perspectives related to the biomedical applications of biohybrid micro/nanorobots are described. Indeed, this review sheds light on the cutting-edge developments in this field, providing researchers with an updated overview of the current potential of biohybrid micro/nanorobots in the realm of biomedical applications, and offering insights into their practical applications. Furthermore, it delves into recent advancements in the field of biohybrid micro/nanorobotics, providing a comprehensive analysis of the current state-of-the-art technologies and their future applications in the biomedical field. This review is about biohybrid micro/nanorobots, a class of micro/nanorobotics composed of a biological part and an artificial sector. It also explores recent advancements in biomedical applications of biohybrid micro/nanorobots by focusing on their potential usage in targeted drug delivery, tissue engineering, cancer therapy, and imaging-guided therapy. imageReview Citation Count: 1A comprehensive review on the potential of coumarin and related derivatives as multi-target therapeutic agents in the management of gynecological cancers(Frontiers Media Sa, 2024) Karatoprak, Gokce Seker; Dumlupinar, Berrak; Celep, Engin; Celep, Inci Kurt; Akkol, Esra Kupeli; Sobarzo-Sanchez, Eduardo; Beslenme ve Diyetetik / Nutrition and DieteticsCurrent treatments for gynecological cancers include surgery, radiotherapy, and chemotherapy. However, these treatments often have significant side effects. Phytochemicals, natural compounds derived from plants, offer promising anticancer properties. Coumarins, a class of benzopyrone compounds found in various plants like tonka beans, exhibit notable antitumor effects. These compounds induce cell apoptosis, target PI3K/Akt/mTOR signaling pathways, inhibit carbonic anhydrase, and disrupt microtubules. Additionally, they inhibit tumor multidrug resistance and angiogenesis and regulate reactive oxygen species. Specific coumarin derivatives, such as auraptene, praeruptorin, osthole, and scopoletin, show anti-invasive, anti-migratory, and antiproliferative activities by arresting the cell cycle and inducing apoptosis. They also inhibit metalloproteinases-2 and -9, reducing tumor cell migration, invasion, and metastasis. These compounds can sensitize tumor cells to radiotherapy and chemotherapy. Synthetic coumarin derivatives also demonstrate potent antitumor and anticancer activities with minimal side effects. Given their diverse mechanisms of action and minimal side effects, coumarin-class phytochemicals hold significant potential as therapeutic agents in gynecological cancers, potentially improving treatment outcomes and reducing side effects. This review will aid in the synthesis and development of novel coumarin-based drugs for these cancers.Article Citation Count: 0Effect of scanning strategies on trueness and time efficiency of digital impression on paediatric models(Wiley, 2024) Alpkilic-Issever, Dilara Seyma; Tokuc, Muege; Pedodonti / PedodonticBackgroundVarious scanning methods aim to reduce intraoral scanner errors, yet no specific approach targets paediatric patients. AimEvaluate continuous (C) and noncontinuous (NC) scanning patterns' impact on the trueness and duration of paediatric digital impressions. DesignA standard pedodontic typodont model was scanned with a Trios 4 Move+ IOS using four scanning strategies. C1 and C2 followed continuous scanning from the right molars, with different directions. NC1 scanned noncontinuously from the right molar, with breaks every four teeth. NC2 began at the right primary incisor, with breaks after every three teeth. Each scan, performed five times by one researcher, was timed. Industrial scanning provided reference data. Deviations were analyzed using the MIXED procedure. ResultsNC1 had higher deviations in the lower jaw, whereas C1 and NC1 showed higher deviations in the upper jaw (p < .001). C1 had significantly higher deviations in the upper jaw than the lower jaw (p = .041). NC2 had the longest scanning time in both upper and lower jaws (p = .002). ConclusionPaediatric digital impressions benefit from starting at the anterior and incorporating breaks, although this increases scanning time.Review Citation Count: 0Effect of deep brain stimulation on sexual dysfunction among patients who had Parkinson's disease: a systematic review and meta-analysis(Taylor & Francis Ltd, 2024) Bahadori, Amir Reza; Zafari, Rasa; Fathollahi, Mohammad Amin; Davari, Afshan; Sheikhvatan, Mehrdad; Ranji, Sara; Tafakhori, Abbas; Tıbbi Biyoloji Anabilim Dalı / Department of Medical BiologyBackground: Patients who have Parkinson's disease (PD) present several non-motor issues, such as sexual dysfunction. Deep brain stimulation (DBS) is a great treatment for PD and could affect both motor and non-motor symptoms of patients. Aim: The main goal of the current study is to evaluate the impact of DBS on the sexual dysfunction among patients with PD. Methods: Five databases (PubMed, Scopus, Embase, Web of Science, and Cochrane Library) were searched for records. Studies that measured the effect of DBS sexual function were included. The risk of bias assessment tool of non-randomized studies of interventions (ROBINS-I) was used to assess the quality of the included studies. The before and after data extraction and statistical analysis were performed using the Comprehensive Meta-analysis software (CMA) version 3.0. Result: Ten studies were included in the systematic review; six of them were eligible to perform a meta-analysis with a total sample size of 532 participants and a mean age of 62.21 +/- 1.59 years. All participants performed STN-DBS. The sexual function of participants after STN-DBS implantation significantly increased (SMD = -0.124, 95% CI: -0.209 to -0.038, P-value = 0.005). It also did not have any publication bias. Additionally, their quality of life mounts significantly (SMD = -0.712, 95% CI: -1.002 to -0.422, p-value <0.001). Conclusion: Our systematic review highlights the potential effect of STN-DBS on reducing the sexual dysfunction of patients with PD and boosting their quality of life.Article Citation Count: 1Effect of Ramadan Fasting on Intestinal Microbiota and Fatty Acid Binding Protein 4 in Overweight and Obese Individuals(Medical Univ Press, 2024) Selen, Halime; Seylam-Kusumler, Aylin; Karakan, Tarkan; Moral, Kenan; Beslenme ve Diyetetik / Nutrition and DieteticsBackground and aims: Intermittent fasting is a nutritional strategy that focuses on when to eat, rather than what to eat. Although the effectiveness of intermittent fasting practices in many metabolic diseases is known, its effect on microbiota and its underlying mechanism has not yet been clarified. This study aimed to investigate the effect of Ramadan fasting, one of the intermittent fasting practices, on gut microbiota and fatty acid binding protein 4 (FABP4). Methods: The study involved 10 male volunteers, 6 of whom were overweight and 4 were obese. They fasted for an average of 14-15 hours daily from dawn to sunset during the 29-day Ramadan month between 23 March - 20 April 2023 and met the inclusion criteria. The participants' nutritional and physical activity status before and during Ramadan, as well as their anthropometric measurements before and after Ramadan, intestinal microbiota, transaminases, gamma-glutamyl transferase, C reactive protein, total cholesterol (C), high-density lipoprotein (HDL) C, low-density lipoprotein C, triglycerides (TG), and FABP4 levels, were evaluated within the scope of the study. Results: The study found a statistically significant increase in both alpha and beta diversity in the intestinal microbiota following Ramadan fasting (p<0.05). The F/B ratio, Firmicutes phylum, Clostridia class, Clostridiales order, and Ruminococcaceae family exhibited statistically significant decreases, while the Bacteroidetes and Proteobacteria phyla, Bacteroidia, Alphaproteobacteria, and Erysipelotrichi classes, Bacteroidales, Erysipelotrichales, and Actinomycetales orders, Erysipelotrichaceae family and Prevotella genus, demonstrated statistically significant increases (p<0.05). Participants who achieved an average weight loss of 2.3 +/- 0.99 kg at the end of Ramadan showed a significant increase in HDL-C and a significant decrease in TG levels (p<0.05). Although FABP4 levels decreased after fasting, this difference was not statistically significant (p>0.05). Conclusion: Ramadan fasting induces weight loss, modifies gut microbiota, and improves blood lipid profile and FABP4 levels, suggesting the need for more extensive studies.Article Citation Count: 4Laser Therapy Induces Increased Viability and Proliferation in Isolated Fibroblast Cells(Cliggott Publishing Co., 2020) Kara,N.; Selamet,H.; Benkli,Y.A.; Beldüz,M.; Gökmenoğlu,C.; Kara,C.Introduction. Laser therapy (LT), which stimulates natural biological processes in the application region, is frequently used in dental treatments. Objective. The aim of this study is to evaluate the effects of LT that could increase wound healing on fibroblast cells in vitro. Methods. Twenty-four hours after preparing the fibroblast cell culture plates, laser irradiation was performed 1, 2, and 3 times according to the test groups using an Nd:YAG (neodymium-doped yttrium aluminum garnet) laser with a power output of 0.5 W, 1 W, 2 W, and 3 W. Cell proliferation analysis was performed by MTT (methylthiazole diphenyl tetrazolium) assay at the twenty-fourth hour following the last laser application. Results. In terms of the laser irradiation power level, the most proliferation was observed in 1 W and 2 W application groups. Although a statistically significant increase was observed, particularly at 0.5 W, the increase at 1 W was greater than at a power output of 0.5 W. In terms of the number of laser irradiation applications, the most proliferation was observed in 2 and 3 application groups. The highest proliferation value was obtained with 1 W of power for 2 applications, and the lowest was with 3 W of power for 3 applications. Conclusions. The findings of this study show LT increased fibroblast cell proliferation, depending on the power output level of the laser and number of applications. In addition to the proliferation and mitotic activity of the fibroblast cells, the results demonstrate that LT could increase wound healing after oral surgery and periodontal treatments. © 2020 HMP Communications. All rights reserved.Article Citation Count: 4Evaluation of plantar foot sensation, balance, physical performance, and fear of movement in substance use disorders(American Podiatric Medical Association, 2020) Erdoğanoğlu,Y.; Sayaca,Ç.; Çalık,M.; Noyan,C.O.; Çetin,A.; Yertutanol,D.K.; Kaya,D.Background: Neuropathologic changes may occur in the nervous system due to long-term substance use, leading to functional disability with altering of balance. We know little about substance-related mechanisms that can cause movement disorders. This study investigated the effects of plantar foot sensation and balance on physical performance as an effect of substance use in detoxified patients. Methods: Twenty-three users of cannabis, volatile agents, or narcotic/stimulant agents alone or in combination for at least 1 year (mean age, 27.6 years) and 20 healthy volunteers (mean age, 24.6 years) were included. Participant evaluations were implemented immediately after the detoxification process with psychiatrist approval. Depression, state-trait anxiety, and fear of movement levels were evaluated with the Beck Depression Inventory, State-Trait Anxiety Inventory, and Tampa Scale for Kinesiophobia, respectively. Plantar foot sensations were evaluated with light touch, two-point discrimination, and vibration examinations. Balance was assessed with balance software and a balance board and force platform. Balance path, balance path distance, and center of pressure were recorded. Physical performance was evaluated with the Timed Up and Go (TUG) test in the final step. Results: There was a significant difference in two-point discrimination of patients versus controls (P <05). Significant differences were also found in balance values, particularly in the sagittal direction (P <05). TUG test results of patients compared with controls showed a negative influence on physical function (P <05). Conclusions: Detailed examination should be performed to understand movement disorders in substance users. Herein, substance users had impaired two-point discrimination and sagittal balance reciprocally. Thus, customized physiotherapy approaches to substance users should be considered to improve their movement disorders. © 2020, American Podiatric Medical Association. All rights reserved.Article Citation Count: 5The Effects of Motivational Methods Applied During Toothbrushing on Children's Oral Hygiene and Periodontal Health(NLM (Medline), 2020) Yıldırım,S.; Kayaaltı-Yüksek,S.; Periodontoloji / PeriodontologyPurpose: The purpose of this study was to evaluate the effect of different motivational methods on children's oral hygiene and periodontal health. Methods: A prospective, controlled, single-blinded, randomized clinical trial was conducted with 60 six- to 12-year-olds who were randomly assigned to toothbrushing with an hourglass timer, music video, or control group. All three groups were divided into two equal subgroups: those using a manual toothbrush and those using a powered toothbrush. The plaque index (PI) and gingival index (GI) were measured in each group. The data obtained were analyzed using three-factor variance analysis. Results: A statistically significant decrease was observed in PI and GI values in all groups (P<0.05). The highest decrease in PI values was observed in the group brushing with a music video and a powered toothbrush (51.8 percent), whereas the least decrease was observed in the control group using a powered toothbrush (26.1 percent). The differences were not statistically significant among the groups. Conclusions: A significant decrease in plaque index and gingival index values was obtained in all groups compared to baseline values. Although the additional motivational methods used during toothbrushing contributed to improved plaque removal and toothbrushing efficiency, no statistically significant differences were found among the groups.Article Citation Count: 4Effects of bathing habits on postoperative wound complications following sacrococcygeal pilonidal sinus surgery: A retrospective analysis of 67 adolescent patients(HMP Communications, 2019) Ferhatoglu,M.F.; Kartal,A.; Ekici,U.; Kebudi,A.Introduction. Sacrococcygeal pilonidal sinus disease generally affects young people and impacts their quality of life. Few published studies assessing the characteristics of the disease in the adolescent population exist. Objective. In this paper, the authors aim to evaluate the effects of bathing habits on wound complications in adolescent patients following Karydakis flap surgery for sacrococcygeal pilonidal sinus. Materials and Methods. The medical records of 79 adolescent patients who underwent sacrococcygeal pilonidal sinus surgery between January 2014 and December 2017 at the Surgery Clinic of Malatya State Hospital (Malatya, Turkey) were evaluated retrospectively. Following exclusion, 67 patients were evaluated for demographics, body mass index (BMI), previous abscess formation, bathing frequency, number of sinus pits, and postoperative wound infection and dehiscence. The total follow-up time for the 67 patients was 90 days. Results. The BMIs of patients with previous abscess formation were significantly higher (P = .029). In the cases with abscess, the number of pilonidal sinus pits was significantly higher (P = .039) There was a statistically significant difference between postoperative complication rates according to the number of baths per week. Wound infection rates were found to be higher in patients who bathed more than twice weekly during the 28 days after surgery (P = .005). No statistical significance was observed in complication rates from days 28 to 90 after the surgery between those who bathed twice weekly and more than twice weekly (P > .05). Conclusions. Postoperative wound complications in adolescent patients treated with Karydakis flap surgery for sacrococcygeal pilonidal sinus are more frequent in those who bathe more than twice weekly during the first 28 days postoperatively. © 2019 HMP Communications. All rights reserved.Article Citation Count: 1The first described case of bizarre leiomyoma of the portal vein(College of Physicians and Surgeons Pakistan, 2019) Ferhatoglu,M.F.Vascular leiomyomas with bizarre nuclei are rare. Differentiation of these tumors from malignant lesions is essential to avoid unnecessary dissection and organ loss in surgery. Herein, we present a 39-year Kosovo woman with a bizarre leiomyoma arising from the portal vein. The patient presented to the general surgery clinic with a one-year history of abdominal pain, vomiting and back ache. No abnormality was observed on physical examination. On computed tomography, a 42x35 mm, cystic-solid mass in the pancreatic neck, wrapping the superior mesenteric vein for 360-degrees and the superior mesenteric artery for 180-degrees, was found. In contrast to preoperative findings, a 5x4 cm mass located behind the portal vein and reaching portal vein-superior mesenteric vein junction posteriorly was seen perioperatively. There was no relationship between the mass and the superior mesenteric artery. The tumor was excised with the posterior wall of the junction of the portal vein and the superior mesenteric vein. The end-to-end vascular anastomosis was performed between the portal vein and the superior mesenteric vein. After finishing distal pancreatectomy, the operation was accomplished without any complication. The patient was discharged on 10th day of the operation without any problem. In conclusion, vascular bizarre leiomyomas are rare tumors. It is impossible to diagnose these correctly before surgery. Perioperative use of pathological examination as a frozen section can be helpful to avoid unnecessary surgical procedures. © 2019 Informatics Publishing Limited. All rights reserved.
