PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14517/21
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Article Citation Count: 0Search for the Formula Presented Boson Decay To Formula Presented in Proton-Proton Collisions at Formula Presented(American Physical Society, 2024) Hayrapetyan, A.; Tumasyan, A.; Adam, W.; Andrejkovic, J.W.; Bergauer, T.; Chatterjee, S.; Puerta Pelayo, J.The first search for the Formula Presented boson decay to Formula Presented at the CERN LHC is presented, based on data collected by the CMS experiment at the LHC in proton-proton collisions at a center-of-mass energy of 13 TeV and corresponding to an integrated luminosity of Formula Presented. The data are compatible with the predicted background. For the first time, an upper limit at the 95% confidence level of 6.9 times the standard model expectation is placed on the ratio of the Formula Presented to Formula Presented branching fractions. Limits are also placed on the six flavor-conserving four-lepton effective-field-theory operators involving two muons and two tau leptons, for the first time testing all such operators. © 2024 CERN, for the CMS Collaboration.Article Citation Count: 1Search for Soft Unclustered Energy Patterns in Proton-Proton Collisions at 13 Tev(American Physical Society, 2024) Hayrapetyan, A.; Tumasyan, A.; Adam, W.; Andrejkovic, J.W.; Bergauer, T.; Chatterjee, S.; Alvarez Gonzalez, B.The first search for soft unclustered energy patterns (SUEPs) is performed using an integrated luminosity of Formula Presented of proton-proton collision data at Formula Presented, collected in 2016-2018 by the CMS detector at the LHC. Such SUEPs are predicted by hidden valley models with a new, confining force with a large ’t Hooft coupling. In events with boosted topologies, selected by high-threshold hadronic triggers, the multiplicity and sphericity of clustered tracks are used to reject the background from standard model quantum chromodynamics. With no observed excess of events over the standard model expectation, limits are set on the cross section for production via gluon fusion of a scalar mediator with SUEP-like decays. © 2024 CERN, for the CMS Collaboration.Article Citation Count: 0Searches for Pair-Produced Multijet Resonances Using Data Scouting in Proton-Proton Collisions at Formula Presented(American Physical Society, 2024) Hayrapetyan, A.; Tumasyan, A.; Adam, W.; Andrejkovic, J.W.; Bergauer, T.; Chatterjee, S.; de Trocóniz, J.F.Searches for pair-produced multijet signatures using data corresponding to an integrated luminosity of Formula Presented of proton-proton collisions at Formula Presented are presented. A data scouting technique is employed to record events with low jet scalar transverse momentum sum values. The electroweak production of particles predicted in Formula Presented-parity violating supersymmetric models is probed for the first time with fully hadronic final states. This is the first search for prompt hadronically decaying mass-degenerate higgsinos, and extends current exclusions on Formula Presented-parity violating top squarks and gluinos. © 2024 CERN, for the CMS Collaboration.Article Citation Count: 6Search for Scalar Leptoquarks Produced Via Τ-Lepton–quark Scattering Ffiffi in Pp Collisions at Ps = 13 Tev(American Physical Society, 2024) Hayrapetyan, A.; Tumasyan, A.; Adam, W.; Andrejkovic, J.W.; Bergauer, T.; Chatterjee, S.; Bhowmik, S.The first search for scalar leptoquarks produced in τ-lepton–quark collisions is presented. It is based on a set of proton-proton collision data recorded with the CMS detector at the LHC at a center-of-mass energy of 13 TeV corresponding to an integrated luminosity of 138 fb−1. The reconstructed final state consists of a jet, significant missing transverse momentum, and a τ lepton reconstructed through its hadronic or leptonic decays. Limits are set on the product of the leptoquark production cross section and branching fraction and interpreted as exclusions in the plane of the leptoquark mass and the leptoquark-τ-quark coupling strength. © 2024 American Physical Society. All rights reserved.Article Citation Count: 0Impact of Blood Flow Restriction Intensity on Pain Perception and Muscle Recovery Post-Eccentric Exercise(Wiley, 2025) Sürenkök, Özgür; Aydın, Gamze; Kendal, Kübra; Atıcı, Emine; Atici, Emine; Fizyoterapi ve Rehabilitasyon / Physiotherapy and RehabilitationBackgroundDelayed onset muscle soreness (DOMS) is a well-established phenomenon characterized by ultrastructural muscle damage that typically develops following unfamiliar or high-intensity exercise. DOMS manifests with a constellation of symptoms, including muscle tenderness, stiffness, edema, mechanical hyperalgesia, and a reduced range of joint motion. In recent years, the application of blood flow restriction (BFR) has garnered attention for its potential impact on DOMS.ObjectiveThis study aimed to investigate the effects of different BFR intensities on biomechanical alterations induced by DOMS in healthy individuals.Design and MethodsThirty participants were split into two groups receiving either 80% or 20% BFR applied during low-intensity resistance exercise following DOMS induction. Pain perception, pressure pain threshold, muscle biometric characteristics, and strength were assessed before DOMS, after DOMS, and following BFR application at 24, 48, and 72 h.ResultsThe 80% BFR group experienced faster reductions in pain perception compared to the 20% BFR group. Muscle strength recovery was also statistically faster in the 80% BFR group. No significant differences were observed between groups in muscle stiffness, flexibility, or other mechanical properties.ConclusionsThese findings suggest that BFR, particularly at higher intensities, may alleviate DOMS symptoms and accelerate muscle strength recovery. However, the lack of a control group and limitations in muscle property assessment warrant further research to definitively determine BFR's efficacy in managing DOMS.Article Citation Count: 0Evaluation of Respiratory Function, Respiratory Muscle Strength, Physical Activity, and Functionality in Patients With Lower Extremity Lymphedema(Mary Ann Liebert, inc, 2024) Aydın, Gamze; Aydin, Gamze; Fizyoterapi ve Rehabilitasyon / Physiotherapy and RehabilitationBackground: Lymphedema is a chronic, progressive condition that has major physical and psychological consequences. It was aimed to examine the respiratory functions, respiratory muscle strength, physical activity level, and functionality of patients with lower extremity lymphedema and to compare them with healthy controls. Methods and Results: A total of 82 individuals (29.3% male, 70.7% female, with a mean age of 49.89 +/- 15.07 years) with lower extremity lymphedema (Group 1) and healthy individuals (Group 2) were included. Respiratory functions of the participants were evaluated by spirometry, respiratory muscle strength by maximum oral pressure measurements, physical activity levels using the International Physical Activity Questionnaire-Short Form (IPAQ-SF), functionality by Lower Extremity Functional Scale (LEFS) and Timed Up and Go test (TUG test). All respiratory function test measurements were lower in mean Group 1 than in Group 2 (p < 0.05). While inspiratory muscle strength did not differ between the groups (p > 0.05), expiratory muscle strength was lower in Group 1 than Group 2 (p < 0.05). Although spent time and energy for sitting were higher in Group 1 (p < 0.05), IPAQ vigorous-, moderate-, and light-intensity physical activity (MET-min/week) and IPAQ-total score did not differ between groups (p > 0.05). In Group 1, mean of LEFS score was lower and TUG test (seconds) in Group 1 was longer compared to Group 2 (p < 0.05). Conclusions: Respiratory functions, expiratory muscle strength, and functionality in patients with lower extremity lymphedema were adversely affected; however, inspiratory muscle strength and physical activity levels were similar to those of healthy controls.Article Citation Count: 0A Secure and Efficient Blockchain Enabled Federated Q-Learning Model for Vehicular Ad-Hoc Networks(Nature Portfolio, 2024) Ahmed, Huda A.; Jasim, Hend Muslim; Gatea, Ali Noori; Al-Asadi, Ali Amjed Ali; Al-Asadi, Hamid Ali AbedVehicular Ad-hoc Networks (VANETs) are growing into more desirable targets for malicious individuals due to the quick rise in the number of automated vehicles around the roadside. Secure data transfer is necessary for VANETs to preserve the integrity of the entire network. Federated learning (FL) is often suggested as a safe technique for exchanging data among VANETs, however, its capacity to protect private information is constrained. This research proposes an extra level of security to Federated Q-learning by merging Blockchain technology with VANETs. Initially, traffic data is encrypted utilizing the Extended Elliptic Curve Cryptography (EX-ECC) technique to enhance the security of data. Then, the Federated Q-learning model trains the data and ensures higher privacy protection. Moreover, interplanetary file system (IPFS) technology allows Blockchain storage to improve the security of VANETs information. Additionally, the validation process of the proposed Blockchain framework is performed by utilizing a Delegated Practical Byzantine Fault Tolerance (DPBFT) based consensus algorithm. The proposed approach to federated Q-learning offered by Blockchain technology has the potential to develop VANET safety and performance. Comprehensive simulation tests are performed with several assessment criteria considered for number of vehicles 100, Throughput (102465.8 KB/s), Communication overhead (360.57 Mb), Average Latency (864.425 ms), Communication Time (19.51 s), Encryption time (0.98 ms), Decryption time (1.97 ms), Consensus delay (50 ms) and Validation delay (1.68 ms), respectively. As a result, the proposed approach performs significantly better than the existing approaches.Article Citation Count: 0Muscle Tone and Stiffness Comparison in Ambulatory Children With Unilateral Spastic Cerebral Palsy: Implications for Postural Balance and Functional Mobility(Human Kinetics Publ inc, 2024) Akdikan, Melisa; Kara, Ike; Saldiran, Tillay cevikObjectives: To compare muscle tone and stiffness in ambulatory children with unilateral spastic cerebral palsy (UCP) with typically developing peers and explore their relationship with postural balance and functional mobility. Methods: Forty ambulatory children with UCP and age-matched typically developing peers were assessed for tone and stiffness of lumbar spinal extensors, gastrocnemius, and hamstring muscles using a myotonometer. Functional mobility was evaluated with the 2-Minute Walk Test, and the Timed Up and Go Test, while postural balance was evaluated using the Pediatric Balance Scale and the Trunk Control Measurement Scale (TCMS). Results: The gastrocnemius muscle tone and stiffness were higher on the affected side in UCP compared with the less affected side and typically developing peers (P < .05). Lumbar spinal extensor tone correlated with improved Trunk Control Measurement Scale scores (P = .003). The gastrocnemius and hamstring muscles' tone and stiffness did not significantly affect functional mobility measures in UCP (P> .05). Conclusions: Our study highlights the importance of achieving muscle symmetry, particularly in the plantar flexors, for functional mobility in UCP children. While differences in ankle and knee muscle biomechanics were observed, they didn't significantly impact functional mobility or postural balance. Symmetry in lumbar spinal extensor biomechanics correlated with better outcomes, emphasizing the crucial role of trunk control in rehabilitation strategies for ambulatory children with UCP.Article Citation Count: 0Exploring Drug Repurposing for Interstitial Cystitis/Bladder Pain Syndrome: Defining Novel Therapeutic Targets(Wiley, 2024) İnal Gültekin, Güldal; Cetin, Zeliha; Mangir, Naside; Fizyoloji / PhysiologyIntroduction: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating pain condition of unknown etiology. Effective therapies for this condition could not have been developed in the last century. Drug repurposing is a practical strategy for enhancing patient access to successful therapies. It is an approach for discovering novel applications for licensed or investigational pharmaceuticals that extend beyond the initial medical indication. This work aims to identify repurposable medications through bioinformatics to discover potential drugs or compounds that can reverse the IC/BPS disease signature. Methods and Material: The analysis involved examining the differentially expressed genes in IC/BPS patients with two distinct disease phenotypes (Hunner's lesion disease, non-Hunner's lesion disease) and controls using the datasets GSE11783, GSE28242, and GSE57560. The goal was to assess the reversal of the disease signature on the L1000CDS2 and cMAP platforms. Results: Twenty-one compounds were repurposed, consisting of 11 small molecules, 10 chemical compounds, 3 natural products, and 6 FDA-approved drugs, currently used for clinical indications such as cancer, myelofibrosis, and diabetes. Discussion: Bioinformatics can be useful for identifying therapeutic agents for IC/BPS by accessing and processing big data on molecular and cellular levels. Prospective in vivo experiments must validate repurposed drugs. The expansion of large-scale genome sequencing, gene expression studies, and clinical data for IC/BPS will improve successful drug selection.Review Citation Count: 0Regulating the Regulators: Long Non-Coding Rnas as Autophagic Controllers in Chronic Disease Management(Bmc, 2024) Kumar, Aviral; Yap, Kenneth Chun-Hong; Bharathwajchetty, Bandari; Lyu, Juncheng; Hegde, Mangala; Abbas, Mohamed; Kunnumakkara, Ajaikumar B.The increasing prevalence of chronic diseases and their associated morbidities demands a deeper understanding of underlying mechanism and causative factors, with the hope of developing novel therapeutic strategies. Autophagy, a conserved biological process, involves the degradation of damaged organelles or protein aggregates to maintain cellular homeostasis. Disruption of this crucial process leads to increased genomic instability, accumulation of reactive oxygen species (ROS), decreased mitochondrial functions, and suppression of ubiquitination, leading to overall decline in quality of intracellular components. Such deregulation has been implicated in a wide range of pathological conditions such as cancer, cardiovascular, inflammatory, and neurological disorders. This review explores the role of long non-coding RNAs (lncRNAs) as modulators of transcriptional and post-transcriptional gene expression, regulating diverse physiological process like proliferation, development, immunity, and metabolism. Moreover, lncRNAs are known to sequester autophagy related microRNAs by functioning as competing endogenous RNAs (ceRNAs), thereby regulating this vital process. In the present review, we delineate the multitiered regulation of lncRNAs in the autophagic dysfunction of various pathological diseases. Moreover, by highlighting recent findings on the modulation of lncRNAs in different stages of autophagy, and the emerging clinical landscape that recognizes lncRNAs in disease diagnosis and therapy, this review highlights the potential of lncRNAs as biomarkers and therapeutic targets in clinical settings of different stages of autophagic process by regulating ATG and its target genes. This focus on lncRNAs could lead to breakthroughs in personalized medicine, offering new avenues for diagnosis and treatment of complex diseases.Review Citation Count: 0Comparative Efficacy and Safety of Therapeutic Strategies for Mirror Aneurysms: a Systematic Review and Meta-Analysis(Springer, 2024) Sheıkhvatan, Mehrdad; Bahadori, Amir Reza; Naghavi, Erfan; Kashan, Azadeh Imeni; Davari, Afshan; Sheikhvatan, Mehrdad; Ranji, Sara; Tıbbi Biyoloji Anabilim Dalı / Department of Medical BiologyMirror aneurysms are rare and pose therapeutic challenges, with both endovascular and microsurgical options available. Single-stage and two-stage procedures are employed, but the optimal strategy remains unclear. This systematic review and meta-analysis evaluate the efficacy and safety of different therapeutic strategies for managing mirror aneurysms. The study adhered to PRISMA guidelines and comprehensively analyzed data from multiple databases, including Pubmed, Scopus, Embase, Web of Science, and the Cochrane Library, up to 30th September 2024. Statistical analysis utilized the Comprehensive Meta-analysis (CMA) software version 3.0. This systematic review encompasses 42 studies, with 11 studies undergoing meta-analysis. The meta-analysis included 629 participants. Both microsurgical clipping and endovascular interventions achieved high rates of complete occlusion (RROC 1) (ES = 0.896; 95% CI: 0.840 to 0.931; P < 0.001) with low to moderate heterogeneity (I-2 = 46.46%). Favorable neurological outcomes (mRS <= 2) were significantly achieved among all patients (ES = 0.924; 95% CI: 0.891 to 0.948; P < 0.001) with low heterogeneity (I-2 = 15.52%). Subgroup analysis revealed that microsurgical clipping demonstrated superior occlusion rates and more consistent neurological outcomes compared to endovascular treatment. Also, complications were reported in seven studies (n = 492) and included cerebral infarction, hydrocephalus, and vasospasm. As well, mortality and recurrence were rare. Both microsurgical clipping and endovascular interventions are effective and safe for treating mirror aneurysms, with clipping showing superior occlusion rates and consistent outcomes. Single-stage procedures and unilateral craniotomy are associated with better neurological outcomes when feasible.Review Citation Count: 0Environmental and Biomedical Applications of 2d Transition Metal Borides (mbenes): Recent Advancements(Royal Soc Chemistry, 2024) Khosravı, Arezoo; Zarepour, Atefeh; Khosravi, Arezoo; Zarrabi, Ali; Genetik ve Biyomühendislik / Genetic and Bio-EngineeringRecently, interest has surged in the environmental and biomedical applications of two-dimensional transition metal borides, commonly referred to as MBenes. These materials have emerged as promising candidates for energy storage devices, such as batteries and supercapacitors. Additionally, MBenes have shown remarkable catalytic activity due to their high surface area and tunable electronic properties. They exhibit significant promise in various catalytic applications, particularly in nitrogen reduction reactions (NRRs), electrocatalytic conversion of nitrogen oxides, and several electrochemical reactions such as the oxygen evolution reaction (OER), oxygen reduction reaction (ORR), and hydrogen evolution reaction (HER). Notably, MBenes have shown great potential in water treatment and pollutant removal applications, such as desalination and water purification. Their high water permeability, ion selectivity, and excellent stability make them suitable for efficient water treatment processes. On the other hand, MBenes are emerging as versatile materials with significant potential in various biomedical applications, particularly in biosensing, cancer therapy, and the treatment of neurodegenerative diseases. However, several challenges hinder their practical implementation in biomedical and environmental fields. One significant issue is the scalability of synthesis methods; producing MBenes in large quantities while maintaining high purity and uniformity is often complex and costly. Moreover, the stability of MBenes and their composites under different environmental and biological conditions raises concerns, as they may undergo degradation or lose their functional properties over time, which could limit their long-term effectiveness. Additionally, there is a need for comprehensive toxicity assessments to ensure the safety of MBenes in biomedical applications, particularly when interacting with human tissues or biological systems. This review aims to systematically investigate the environmental and biomedical applications of MBenes and their composites, emphasizing their unique characteristics and potential roles in addressing pressing global challenges. Furthermore, the review will identify and discuss the existing challenges and limitations in the operational performance of MBenes and their composites, providing a critical assessment of their current state in various applications.Article Citation Count: 1Breast Cancer Recurrence in Initially Clinically Node-Positive Patients Undergoing Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in the Neosentiturk-Trials Mf18-02/18-03(Springer, 2025) Cabioglu, Neslihan; Karanlik, Hasan; Igci, Abdullah; Muslumanoglu, Mahmut; Gulcelik, Mehmet Ali; Uras, Cihan; Ozmen, VahitBackground. This study aims to identify factors predicting recurrence and unfavorable prognosis in cN+ patients who have undergone sentinel lymph node biopsy (SLNB) following neoadjuvant chemotherapy (NAC). MethodsThe retrospective multi-centre "MF18-02" and the prospective multi-centre cohort registry trial "MF18-03" (NCT04250129) included patients with cT1-4N1-3M0 with SLNB+/- axillary lymph node dissection (ALND) post-NAC. Results. A total of 2407 cN+ patients, who later achieved cN0 status after NAC and subsequently underwent SLNB, were studied. The majority had cT1-2 (79.1%) and N1 (80.7%). After a median follow-up time of 41 months, the rates of locoregional recurrence and axillary recurrence (AR) were 1.83% and 0.37%, respectively. No significant difference in locoregional recurrence or AR rates was observed between the SLNB/targeted axillary dissection-only (n = 1470) and ALND (n = 937) groups. Factors significantly linked with AR included age younger than 45 years, nonpathological complete response (non-pCR) in the breast, and nonluminal pathology. Locoregional recurrences were associated with nonluminal or HER2(+) pathology, non-pCR in the breast, and ALND. Poor prognostic factors for disease-free survival (DFS) included having cT3-T4, no breast pCR (non-pCR), ypN(+), and nonluminal pathology. No significant difference was found in DFS or disease-specific survival (DSS) rates among ypN0, ypN-isolated tumour cells, ypNmic, and ypN1. However, significant decreases in DFS and DSS rates were observed when comparing ypN2 or ypN3 disease with ypN0. Conclusions. The present large registry data indicate that younger patients (<45), those with nonluminal pathology, and those who only partially respond in the breast are more susceptible to axillary and locoregional recurrences.Article Citation Count: 0Neurohormonal Activation Pattern in Patients With Atrial Septal Defect(Nature Portfolio, 2024) Guvenc, Rengin Cetin; Koc Ada, Saniye; Guvenc, Tolga Sinan; Celik, Fatma Betul; Ocakli, Ezgi Polat; Al Arfaj, Abdullah Ayar; Caliskan, MustafaAtrial septal defects (ASD) divert flow from systemic to pulmonary circulation, and some degree of plasma volume expansion and neurohormonal activation are necessary to maintain the effective circulatory volume. The aim of the present study was to understand the patterns of neurohormonal activation in ASD patients. 16 ASD patients and 10 controls were enrolled. Fasting blood samples were collected prior to procedure and 48 h after defect closure. At baseline, renin (185.0(79.0-437.0 vs. 79.4(60.8-110.0), p = 0.04), aldosterone (20.2 +/- 7.6 vs. 11.7 +/- 2.8, p < 0.001), copeptin (43.6 +/- 27.5 vs. 16.4 +/- 8.7, p = 0.002) and both natriuretic peptides were higher in ASD patients, while noradrenaline (113.0 +/- 61.3 vs. 178.0 +/- 49.4, p = 0.009) and endothelin-1 (2.93 +/- 2.00 vs. 5.06 +/- 1.25, p = 0.006) were higher in controls. After ASD closure, only NT-proBNP reduced significantly (p = 0.02). There were negative correlations between defect area with noradrenaline (r=-0.73, p = 0.002) and with endothelin-1 (r=-0.59, p = 0.02). Present findings suggest that in patients with an ASD, there is an increase in neurohormones that are related to regulation of plasma volume (aldosterone and arginine vasopressin) with simultaneous reductions in neurohormones related to vasoconstriction in systemic and pulmonary beds (noradrenaline and endothelin-1).Article Citation Count: 1Observation of Enhanced Long-Range Elliptic Anisotropies Inside High-Multiplicity Jets in pp Collisions at √s = 13 TeV(American Physical Society, 2024) Hayrapetyan, A.; Tumasyan, A.; Adam, W.; Andrejkovic, J.W.; Bergauer, T.; Chatterjee, S.; Garcia, J.M.V.A search for collective effects inside jets produced in proton-proton collisions is performed via correlation measurements of charged particles using the CMS detector at the CERN LHC. The analysis ffiffi uses data collected at a center-of-mass energy of √s = 13 TeV, corresponding to an integrated luminosity of 138 fb−1. Jets are reconstructed with the anti-kT algorithm with a distance parameter of 0.8 and are required to have transverse momentum greater than 550 GeV and pseudorapidity (equation presented). Two-particle correlations among the charged particles within the jets are studied as functions of the particles' azimuthal angle and pseudorapidity separations (Δϕ* and Δη*) in a jet coordinate basis, where particles' η*, ϕ* are defined relative to the direction of the jet. The correlation functions are studied in classes of in-jet charged-particle multiplicity up to Njch ≈ 100. Fourier harmonics are extracted from long-range azimuthal correlation functions to characterize azimuthal anisotropy for (equation presented). For low-Njch jets, the long-range elliptic anisotropic harmonic, v*2, is observed to decrease with Njch. This trend is well described by Monte Carlo event generators. However, a rising trend for v*2 emerges at (equation presented), hinting at a possible onset of collective behavior, which is not reproduced by the models tested. This observation yields new insights into the dynamics of jet evolution in the vacuum. © 2024 CERN, for the CMS Collaboration.Article Citation Count: 0The antidepressant-like effects of kisspeptin-10 are reversed by kisspeptin antagonist peptide 234 in male rats(Cellular and Molecular Biology Association, 2024) Keleştimur, Haluk; Kacar, E.; Yardimci, A.; Ertugrul, N.U.; Bulmus, O.; Ercan, Z.; Kelestimur, H.; Fizyoloji / PhysiologyKisspeptins are reported to be the most potent activators of the hypothalamus-pituitary-gonadal (HPG) axis known to date. Kisspeptin potently elicits gonadotropin-releasing hormone (GnRH) release and luteinizing hormone (LH) secretion, even in the pre-pubertal period. Beyond the hypothalamus, kisspeptin is also expressed in limbic and paralimbic brain regions, which are areas of the neurobiological network primarily implicated in emotional behaviors alongside sexual functions. Therefore, an increasing body of studies has implicated kisspeptin as having many influences on emotional behaviors. The study was set out to explore if the kisspeptin/GPR54 signaling system is required for the anti-depressant-like effect of kisspeptin-10 (KP-10), besides the regulation of the HPG axis. To test this concept, peptide 234 (P234), a kisspeptin antagonist, was given to the male rats, and its modulatory effect on the anti-depressant-like effects of kisspeptin was investigated by using a forced swimming test (FST). The study has also sought to know whether kisspeptin can exert its effects through adrenergic and serotonergic receptors. To investigate this, the agents yohimbine (Yoh), an alpha-2 adrenergic receptor antagonist, and cyproheptadine (Cry), a non-selective 5-HT2 serotonergic receptor antagonist, were administered in the experiments. Our results indicate that, in rats, the anti-depressant-like effects of KP-10 in a modified rat FST are mediated by GPR54 receptors since the kisspeptin antagonist peptide 234 reversed kisspeptin-induced anti-depressant-like effects. Our data also demonstrate that the antidepressant-like effects of kisspeptin, at least in part, are mediated by an interaction of the alpha-2 adrenergic and 5-HT2 serotonergic receptors. © 2024 Cellular and Molecular Biology Association. All rights reserved.Review Citation Count: 0Efficacy and safety of deep brain stimulation in drug resistance epilepsy: A systematic review and meta-analysis(Springer, 2024) Sheıkhvatan, Mehrdad; Javadnia, Parisa; Davari, Afshan; Sheikhvatan, Mehrdad; Ranji, Sara; Shafiee, Sajad; Tafakhori, Abbas; Tıbbi Biyoloji Anabilim Dalı / Department of Medical BiologyIn the context of drug-resistant epilepsy, deep brain stimulation (DBS) has received FDA approval. However, there have been reports of potential adverse effects, such as depression and memory impairment associated with DBS.This systematic review and meta-analysis aimed to investigate the impact of DBS on the quality of life (QoL), and seizure frequency of patients who had DRE, and assess its potential adverse events. The study followed PRISMA guidelines and thoroughly assessed databases, including Pubmed, Scopus, Embase, Web of Science, and the Cochrane Library, up to 31 July. Statistical analysis, fixed effect model analysis, performed by the Comprehensive Meta-analysis software (CMA) version 3.0. Additionally, Cochran's Q test was conducted to determine the statistical heterogeneity. The systematic review encompassed 54 studies, with 38 studies included in the subsequent meta-analysis. The total number of patients included in the studies was 999. The findings indicated a significant decrease in the mean seizure frequency of subjects following DBS (SMD: 0.609, 95% CI: 0.519 to 0.700, p-value < 0.001). Moreover, patients' QoL significantly improved after DBS (SMD: -0.442, 95% CI: -0.576 to -0.308, p-value < 0.001). The hippocampus displayed the most notable effect size among the different DBS targets. Subgroup analysis based on follow-up duration revealed increased DBS efficacy after two years. There are few reports of adverse events, such as insertional-related complications, infection, and neuropsychiatric complications, but the majority of these were temporary and non-fatal. DBS emerged as an effective and safe procedure for reducing seizure frequency and enhancing the quality of life in DRE patients, with minimal adverse events. Furthermore, the efficacy of DBS was observed to improve over time.Review Citation Count: 0Microneedle patches: a new vantage point for diabetic wound treatments(Royal Soc Chemistry, 2024) Khosravı, Arezoo; Zarepour, Atefeh; Khosravi, Arezoo; Iravani, Siavash; Zarrabi, Ali; Genetik ve Biyomühendislik / Genetic and Bio-EngineeringMicroneedle patches have emerged as a promising approach for diabetic wound healing by enabling the targeted delivery of therapeutic agents such as stem cells and their derived exosomes, as well as localized delivery of bioactive moieties. These patches offer a non-invasive and efficient method for administering therapeutic payloads directly to the site of the wound, bypassing systemic circulation and minimizing potential side effects. The targeted delivery of stem cells holds immense potential for promoting tissue regeneration and accelerating wound healing in diabetic patients. Similarly, the localized delivery of stem cell-derived exosomes, which are known for their regenerative and anti-inflammatory properties, can enhance the healing process. Furthermore, microneedle patches enable the precise and controlled release of bioactive moieties, such as growth factors and cytokines, directly to the wound site, creating a conducive microenvironment for tissue repair and regeneration. The challenges associated with microneedle patches for diabetic wound healing are multifaceted. Biocompatibility issues, variability in skin characteristics among diabetic patients, regulatory hurdles, scalability, cost considerations, long-term stability, and patient acceptance and compliance all present significant barriers to the widespread adoption and optimization of microneedle technology in clinical practice. Overcoming these challenges will require collaborative efforts from various stakeholders to advance the field and address critical gaps in research and development. Ongoing research focuses on enhancing the biocompatibility and mechanical properties of microneedle materials, developing customizable technologies for personalized treatment approaches, integrating advanced functionalities such as sensors for real-time monitoring, and improving patient engagement and adherence through education and support mechanisms. These advancements have the potential to improve diabetic wound management by providing tailored and precise therapies that promote faster healing and reduce complications. This review explores the current landscape of microneedle patches in the context of diabetic wound management, highlighting both the challenges that need to be addressed and future perspectives for this innovative treatment modality.Article Citation Count: 0Late-onset drug-resistant epilepsy in pyridoxamine 5′-phosphate oxidase deficiency: a case report(Bmc, 2024) Naghavi, Erfan; Davari, Afshan; Bahadori, Amir Reza; Razmafrooz, Mohammad; AmiriFard, Hamed; Sabzgolin, Iman; Ranji, SaraBackground Pyridoxamine 5 '-phosphate oxidase deficiency is a rare inborn error of vitamin B6 metabolism that presents with drug-resistant epileptic seizures. However, the condition is responsive to supplementation with the active vitamin B6 metabolite pyridoxal 5 '-phosphate and, in some cases, pyridoxine. Case presentation In this case report, a 10-year-old Iranian male of Fars ethnicity came to a regional hospital in Tehran, Iran with a chief complaint of tic-like movement. He had a history of unintentional, repetitive, and stereotypic movements of both arms since the age of 4 years. The physical examination depicted facial dimorphism. During admission, the patient experienced habitual hypermotor seizures and generalized tonic-clonic seizures. Ictal electroencephalography demonstrated a generalized background attenuation and bursts of generalized, predominantly left-sided, biphasic spike-wave complexes. Whole-genome sequencing revealed a pyridoxamine 5 '-phosphate oxidase deficiency as the underlying cause of the drug-resistant seizures, resulting in a low serum level of pyridoxal 5 '-phosphate. The patient underwent pyridoxine supplementation therapy, which ultimately resolved his seizures. At 6 months, he was seizure free. Conclusion Physicians ought to be aware of manifestations of vitamin B6 deficiency such as mimicking tic and consider it in the differential for drug-resistant epilepsy.Article Citation Count: 0Shoulder disarticulation after clavicle fracture: a case report(Turkish Assoc Trauma Emergency Surgery, 2024) Yilmaz, Bilge Kagan; Ali, Mohamed Salah; Butuner, Ibrahim Ethem; Maralcan, GoekhanIn this case report, we presented to a 90-year-old female with multiple comorbidities presented to the emergency department of our hospital three weeks following a fall from standing height. Upon arrival, the patient exhibited a Glasgow Coma Scale (GCS) 12, blood pressure of 100/60 mmHg, heart rate of 117 beats/min, respiratory rate of 24 breaths/min. Examination revealed atrophy, skin color change, sensory disturbance, or motor palsy in the left upper extremity. Chest X-ray showed a fractured left clavicle, with its free fragment dislocated toward the thorax. She was diagnosed with a displaced midshaft clavicle fracture, Arbeitsgemeinschaft f & uuml;r Osteosynthesefragen (AO) type 15.2B2. On doppler ultrasound examination, flow loss secondary to compression was observed in the proximal left subclavian artery (SA). No flow was observed in the axillary, brachial, radial and ulnar arteries. Due to the patient's high number of comorbid diseases and poor general condition, disarticulation was performed from the shoulder joint, which is the proximal region of arterial occlusion. No other symptoms of circulatory dysfunction were observed at the 3 months follow-up. This case report emphasizes that delayed clavicle fracture can lead to catastrophic consequences. Trauma surgeons should also consider surgical treatment of clavicle fractures, depending on the patient's condition.
