PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14517/21

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Peas, Natural Resources for a Sustainable Future: A Multifaceted Review of Nutritional, Health, Environmental, and Market Perspectives
(Frontiers Media SA, 2026) Nikolic, Nada Cujic; Mutavski, Zorana; Savikin, Katarina; Zivkovic, Jelena; Pavlovic, Suzana; Jones, Petra; Knez, Marija
The pea (Pisum sativum L.) is an emerging pillar in plant-based nutrition and sustainable food systems due to its high-quality proteins, diverse bioactive compounds, and agroecological benefits. This review provides an updated synthesis of the nutritional composition, health-promoting properties, and environmental relevance of peas, emphasizing recent scientific findings. Pea seeds typically contain 20%-40% protein, 45%-55% starch, and 10%-15% dietary fiber, alongside essential micronutrients such as vitamin C (40-60 mg/100 g), folate (60-70 mu g/100 g), vitamin K (30-45 mu g/100 g), iron (1.5-2.0 mg/100 g), and manganese (0.4-0.6 mg/100 g). Their storage proteins, primarily legumin and vicilin, offer high digestibility and amino acid profiles compatible with human requirements, supporting their rapidly growing use in protein isolates and meat- and dairy-alternative products. Peas represent a valuable source of phenolic acids, flavonoids, and saponins, which contribute to notable antioxidant (50-120 mu mol Trolox/g) and anti-inflammatory activities demonstrated in preclinical studies. Compared with other legumes, peas exhibit a lower glycemic index (35-45), making them suitable for metabolic health applications. Agronomically, pea cultivation enhances soil fertility through biological nitrogen fixation (up to 150 kg N/ha), supporting reduced fertilizer inputs and improved crop rotation performance, aligning with circular economy and climate-resilience strategies. Despite these advantages, global consumption and breeding innovation remain insufficient to meet the rising demand for alternative proteins. Future opportunities include improving protein extraction technologies, valorizing processing side-streams, and exploring underutilized phytochemicals to strengthen the nutritional and sustainability profile of pea-based food systems.
The Impact of Organizational Blindness on Nurses' Commitment in Healthcare Settings
(Emerald Group Publishing Ltd, 2026) Berkay, Seda; Mat, Seda Tugba Baykara
Purpose-This study investigates the relationship between organizational blindness and organizational commitment among nurses, exploring how demographic and professional factors shape affective, normative and continuance commitment. By emphasizing workforce well-being, organizational transparency and sustainable healthcare management, the study supports the United Nations Sustainable Development Goals of Decent Work and Economic Growth. Design/methodology/approach-A cross-sectional design was used with 269 nurses employed in a private hospital in T & uuml;rkiye. Data were collected using a Demographic Information Form, the Organizational Commitment Scale and the Organizational Blindness Scale. Descriptive statistics, t-tests, ANOVA, Pearson correlation, linear regression and logistic regression were conducted. Assumptions of normality, homoscedasticity, autocorrelation, and outlier independence were confirmed. Findings-Nurses reported moderate levels of organizational blindness and commitment. Blindness was significantly and negatively but low correlated with commitment (r = -0.266, p < 0.001), explaining 7.1% of the variance (R-2 = 0.071). Being married (OR = 2.05, p = 0.031) and having longer professional experience (p = 0.045) predicted higher commitment, whereas male gender and rotating shifts were linked to greater blindness. Research limitations/implications-The single-site, cross-sectional design limits causal inference and generalizability. Future multi-center and longitudinal studies are recommended. Practical implications-Healthcare leaders should promote open communication, fair scheduling, mentorship and professional development to enhance commitment and reduce blindness. Social implications-Addressing organizational blindness and strengthening commitment can improve nurse retention, organizational culture and patient care quality. Originality/value-A focused literature search (PubMed, Scopus and Web of Science; 2000-2025) revealed no prior Turkish empirical study on this link.
Investigation of Antioxidant Properties of Propolis Products Collected From Different Regions
(MDPI, 2026) Cetin, Aynur; Bakir, Sena; Ozdal, Tugba; Capanoglu, Esra
Propolis, a sticky bee hive product collected from resinous plant sources by Apis mellifera bees, exhibits a wide range of biological and pharmacological properties, primarily attributed to its rich composition of bioactive constituents, including phenolic acids, esters, and flavonoids. In this study, the antioxidant properties of 76 liquid propolis solutions from 18 different countries were investigated based on their dry matter, total phenolic and total flavonoid contents, antioxidant capacities, and phenolic profiles. The antioxidant activities of propolis from various geographic regions, including Latvia, Croatia, New Zealand, San Marino, Russia, France, Romania, Italy, Estonia, Brazil, Belgium, Germany, Slovenia, Japan, the United States of America (USA), the United Arab Emirates (UAE), Spain, and Korea, were compared. Total phenolic and flavonoid contents, as well as total antioxidant capacity (Cupric Reducing Antioxidant Capacity-CUPRAC method), were analyzed by spectrophotometry, and the major constituents were investigated by liquid chromatography-mass spectrometry (LC-MS/MS). Antioxidant test results indicated that 29 products scored below 10 mg Trolox equivalent (TE)/mL, and only 14 were scored above 100 mg TE/mL. The results showed that the total phenolic content of the samples ranged from 0.1 to 107.5 mg Gallic acid equivalent (GAE)/mL, while total flavonoid content varied between 0.1 and 174.5 mg Catechin equivalent (CE)/mL. Based on the CUPRAC assay, total antioxidant capacity values ranged from 0.1 to 492.3 mg TE/mL. Among the 76 analyzed samples, nine products exhibited antioxidant capacity values exceeding 150 mg TE/mL. In all of these samples, phenolic profiling confirmed the presence of propolis, and the analytical results were consistent with the information declared on the product labels. Hence, this study provides a comprehensive, real-market evaluation of commercial propolis products by integrating spectrophotometric assays with LC-MS-based targeted metabolomics profiling, highlighting formulation- and product type-driven differences in phenolic composition and antioxidant capacity beyond geographical origin.
Diagnostic Value of Serum SST2 and MicroRNA-29a in Ovarian Cancer: A Dual-Biomarker Pilot Study
(MDPI, 2026) Akdeniz, Fatma Tuba; Barut, Zerrin; Avsar, Orcun; Bakirezer, Selvi Duman; Attar, Rukset; Isbir, Turgay
Ovarian cancer is frequently diagnosed at an advanced stage due to non-specific symptoms, contributing to high mortality. The limited diagnostic performance of current serum assays in early disease underscores the need for complementary circulating biomarkers. Circulating microRNAs and inflammation-related markers are promising candidates. Although miRNAs are implicated in cancer diagnostics, the role of miRNA-29a in ovarian cancer remains underexplored. Given that sST2 is elevated in several malignancies and is a direct target of miRNA-29a, concurrent evaluation may be informative. This pilot study compared serum miRNA-29a and sST2 levels in 23 ovarian cancer patients and 22 healthy female controls. miRNA-29a expression was quantified by real-time PCR (2(-Delta Delta Ct)), and sST2 was measured by ELISA; diagnostic performance was assessed using ROC analysis. miRNA-29a levels were significantly reduced (p < 0.05), whereas sST2 concentrations were significantly increased (p < 0.001) in patients versus controls. ROC analysis showed modest discrimination for miRNA-29a (AUC 0.678) and higher performance for sST2 (AUC 0.825). No significant correlation was observed between the two markers. These findings suggest that circulating miRNA-29a and sST2 may have biomarker potential in ovarian cancer; larger, well-designed studies are required to confirm clinical utility.
Pelvic Floor Dysfunction Following Gynecologic Cancer Surgery and Adjuvant Therapy: Epidemiology, Mechanisms, and Management-A Systematic Review
(Springer London Ltd, 2026) Kurtulus, Duygu; Arkan, Kevser; Suceken, Ferhat Yakup; Akgol, Sedat; Can, Behzat; Behram, Mustafa
Introduction and HypothesisThis systematic review synthesizes current evidence on the prevalence, risk factors, pathophysiology, clinical manifestations, and management of pelvic floor disorders (PFD) following gynecologic cancer surgery and adjuvant therapy, with an emphasis on rehabilitation, multidisciplinary care, and quality of life.MethodsFollowing PRISMA 2020 guidelines, PubMed, Embase, Scopus, and Web of Science were searched for English-language studies published between January 2000 and May 2025. Eligible studies included adult women with gynecologic malignancies reporting outcomes related to urinary or fecal incontinence, pelvic organ prolapse, chronic pelvic pain, or sexual dysfunction. Data were extracted using a standardized form, qualitatively synthesized, and the risk of bias was assessed using the Newcastle-Ottawa Scale.ResultsThirty studies met the inclusion criteria. PFD were highly prevalent, particularly after radical surgery and adjuvant therapies. Stress urinary incontinence and prolapse were more frequent after radical surgery, while urgency incontinence, vaginal stenosis, and chronic pelvic pain were linked to radiotherapy. Chemotherapy was associated with neurogenic bladder and bowel dysfunction. Independent risk factors included advanced age, obesity, and postmenopausal status. PFD significantly impaired physical, psychological, sexual, and social quality of life. Nerve-sparing and minimally invasive techniques showed promise in reducing dysfunction. Conservative measures-pelvic floor muscle training, biofeedback, vaginal dilators, and lifestyle modification-were effective for many patients, while surgical procedures such as slings and sacrocolpopexy were reserved for severe cases. Emerging options include local estrogen or DHEA after radiotherapy and onabotulinumtoxinA for refractory urge incontinence.ConclusionsPFD are underrecognized yet common and disabling complications in women treated for gynecologic cancers. Multidisciplinary management integrating pelvic floor rehabilitation and individualized survivorship care is essential to improve outcomes and quality of life. Further research should establish standardized screening, preventive strategies, and evidence-based rehabilitation protocols for this high-risk population.
Scoping Review on Motorcycle Crashes Patterns, Risk Factors, and Potential in Setting Policy Priorities in the Gulf Cooperation Council Countries (GCC)
(Elsevier Sci Ltd, 2026) Joseph, Simple Sibi; Al-Jarrah, Layth; Ahmed, Mohamed H.; El-Menyar, Ayman; Khan, Naushad Ahmad; Abdelrahman, Husham; Al-Thani, Hassan
Background: Although road traffic injuries (RTIs) pose a significant public health burden in the Gulf Cooperation Council countries (GCC), the true extent of motorcycle crash injuries (MCCIs) remains unclear because of limited published data from this region. Emerging evidence suggests that MCCIs are on the rise because of the growing use of motorcycles for transport and delivery services, even though road safety overall has improved. We sought to review regional evidence on MCCIs' patterns, key risk factors, and temporal trends to inform policy interventions and research priorities for effective prevention. Methods: A scoping review was conducted in accordance with the PRISMA-ScR guidelines. Articles on GCC MCCIs published from July 2008 to October 2025, examining injury patterns, mortality, and safety practices, were included in the review. Search was conducted across PubMed, Scopus, Google Scholar, and grey literature sources. The GCC consists of six countries: Saudi Arabia (KSA), Qatar, Kuwait, the United Arab Emirates (UAE), Bahrain, and Oman. Results: Of 1344 studies identified, 9 met the inclusion criteria and were analyzed. The GCC has seen an increase in the number of motorcycles registered, resulting in higher MCC rates over time. During the COVID-19 pandemic, these rates surged again as the delivery sector grew. MCCI victims were mainly young males (mean age of 29 years). Extremity injuries were the most frequent (two-thirds), followed by head injuries (20-41%), often associated with poor helmet use compliance (range 13-17%). Delivery riders represented a high-risk subgroup, reflecting occupational exposure, fatigue, and time pressure. Despite advances in trauma care, geographic gaps persist. Helmet use non-compliance, alcohol use, and inadequate documentation remain significant risk factors. Extremity injuries were the most common in the GCC. Conclusion: MCCIs in the GCC are on the rise with high rates of extremity and head trauma. Poor helmet use compliance is a significant factor. Therefore, we suggest strengthening helmet use laws and safety standards, increasing community efforts, and establishing motorcycle lanes with lower speed limits. Protection for riders at work should be enhanced. Road infrastructure and robust data systems also need improvement.
Female Sexual Function Before and After Labiaplasty
(Springer, 2026) Ceylan, Yasin; Sarac, Omer Dogukan; Kole, Emre; Akar, Bertan; Caliskan, Eray
Background Labiaplasty, a surgical procedure aimed at reducing the size of the labia minora, represents the most frequently performed female genital cosmetic surgery. This study aimed to systematically investigate the factors motivating women to undergo labiaplasty and to assess the surgery's impact on body image, genital self-image, sexual satisfaction, and body confidence, both pre- and postoperatively. Methods This prospective study included 88 patients who underwent labiaplasty, all performed by the same surgical team. Postoperative follow-up assessments were carried out during the first week, first month, and third month. All patients were allowed to practice sexual intercourse one month after the surgery. Any complications or cases requiring revision surgery were documented. All patients completed the 19-item Female Sexual Function Index (FSFI) and the 7-item Female Genital Self-Image Scale (FGSIS) questionnaires before the surgery and at the third month postoperatively. Results When comparing the preoperative and postoperative total scores of the Female Genital Self-Image Scale (FGSIS), the postoperative score indicated a statistically significant improvement. The total score of the Female Sexual Function Index (FSFI) increased from 15.8 +/- 2.6 preoperatively to 28.2 +/- 2.7 postoperatively, also showing statistical significance (p < 0.001). Conclusions In our study, both total FSFI and total FGSIS scores were significantly higher post-surgery. This improvement can be attributed to the psychological recovery and confidence gained by the patients, leading to greater sexual and social fulfillment.
Cryotherapy and Muscle Function in Immediate Return-to Scenarios
(Georg Thieme Verlag Kg, 2026) Surenkok, Ozgur; Balkisli, Berna Cagla; Yucel Karacan, Yildiz; Kendal, Kubra; Atici, Emine; Aydin, Gamze
Purpose This study aimed to investigate the effects of cold spray and cold pack applications on the biomechanical properties, muscle strength, and activity of the quadriceps femoris muscle. Methods Fifty-three male participants aged 18 to 25 were included in this randomised controlled study. Participants were randomly assigned to two groups: cold spray (n=27) and cold pack (n=26). The cold spray group received a 10-second application to the quadriceps, whereas the cold pack group received a 5-minute application. Measurements included skin surface temperature, muscle mechanical properties (MyotonPRO), isometric muscle strength (Lafayette dynamometer), and muscle activity (surface EMG). These measurements were conducted at three time points: before the intervention (baseline), immediately after the application, and five minutes post-application. Results Participant characteristics were similar between groups (p>0.05). Both groups showed time-dependent changes in muscle properties. Myoton-F, -S, and -D increased following the application, while Myoton-R decreased. Strength increased only in the cold spray group (p<0.05). The mean EMG workload was higher at baseline in the cold spray group (p<0.05), but no time-related change was observed in either group. EMG onset time decreased over time in the cold pack group (p<0.05). Skin temperature dropped significantly in both groups after the application (p<0.05), with a greater and more prolonged effect in the cold spray group (p<0.05). Conclusion These findings suggest that both cold spray and cold pack can induce short-term changes in quadriceps muscle function by altering the muscle's mechanical properties. Cold spray appears to improve muscle strength, while cold pack may influence the timing of muscle activation.
Cumulative Summation Test for Learning Curve in Vaginal Tightening
(Springer London Ltd, 2026) Ceylan, Yasin; Bayram, Reyhan Aslancan; Akar, Bertan; Aybek, Ozlem Yuksel; Caliskan, Eray
Introduction and HypothesisThe objective was to evaluate the learning curve of vaginoplasty procedures performed by two trainees with different levels of experience using the Learning Curve Cumulative Summation (LC-CUSUM) method.MethodsThis prospective study included 80 consecutive vaginoplasty cases performed by two trainees after structured theoretical and hands-on training. Trainee 1 was a senior resident in the third year of the Obstetrics and Gynecology specialty training program, with no prior experience in urogynecological surgery, whereas Trainee 2 was a certified specialist with a relevant surgical background. Both trainees were evaluated using LC-CUSUM parameters based on predefined acceptable (10%) and unacceptable (17.5%) failure rates. The number of procedures required to reach competency was recorded.ResultsTrainee 1 reached the predefined performance level after 27 procedures, whereas Trainee 2 achieved it after 14. No major complications occurred. The LC-CUSUM curves confirmed gradual and safe skill acquisition in both cases. Patient satisfaction scores were high in both groups, with no statistically significant differences in complication rates.ConclusionThe LC-CUSUM method provides an objective and individualized tool to assess surgical competence in vaginoplasty. It enables dynamic monitoring of learning curves and may contribute to safer surgical training, especially in procedures where experience heavily influences outcomes.
Status of a Lipid Accumulation Product, Triglycerides/Glucose Index and Visceral Adiposity Index on Cardiometabolic Risk Factors in Young Polycystic Ovary Syndrome Patients
(Nakladatelske Stredisko CLSJE Purkyne, 2025) Arslan, G.; Karakelleoglu, G.; Karadag, C.
Objective: To determine whether the triglycerides/glucose index (TyG-index), lipid accumulation product (LAP), and visceral adiposity index (VAI) would differ in young polycystic ovary syndrome (PCOS) patients when compared to the non-PCOS group, and to investigate the relationship between these markers and cardiovascular disease (CVD) risk in PCOS patients. Materials and methods: One hundred and ninety two women with PCOS, and 148 age and body mass index (BMI) matched healthy women without PCOS were enrolled. Levels of serum androgens, sex hormones, lipids, fasting glucose, fasting insulin, and N-terminal pro-brain natriuretic peptide (Nt-probnp) were determined. The 75 g oral glucose tolerance test was performed. The Homeostatic Model Assessment-Insulin Resistance Index (HOMA-IR) and Matsuda insulin sensitivity index were calculated. Levels of TyG-index, LAP, and VAI were determined. Results: TyG, LAP, and VAI were significantly higher in PCOS patients than in the control group (P = 0.001 vs. P = 0.001 vs. P = 0.001, resp.). HOMA-IR was significantly higher in PCOS patients and Matsuda ISI was significantly lower in PCOS patients (P = 0.001 vs. P = 0.001, resp.). Levels of Nt-probnp were significantly higher in PCOS patients (P = 0.001). Serum total testosterone and androstenedione levels had significant correlations with TyG, LAP, and VAI. Nt-probnp was significantly correlated with TyG, LAP, and VAI. LDL was positively correlated and HDL was negatively correlated with TyG-index, LAP, and VAI. Conclusion: PCOS patients have increased values of TyG-index, LAP, and VAI. TyG index, LAP, and VAI may indicate an increased risk of CVD and hyperandrogenism in PCOS patients.
Women's Perspectives on Integrating Artificial Intelligence in Breast Cancer Screening Services in Abu Dhabi, United Arab Emirates
(Nature Portfolio, 2025) Elhadi, Yasir Ahmed Mohammed; Abdullahi, Aminu S.; Al Shamsi, Alreem; Althehli, Aysha; Alzaabi, Hamda; Al Ali, Hind; Rahma, Azhar T.
Artificial intelligence (AI) offers opportunities to enhance breast cancer screening by improving diagnostic accuracy and reducing radiologist workload, yet its successful adoption depends on public trust and acceptability. This cross-sectional survey of 562 Emirati women aged 18 years and older in Abu Dhabi explored knowledge, perceptions, and willingness to participate in AI-supported screening. Using a structured, culturally adapted questionnaire, descriptive statistics summarized attitudes and concerns, and logistic regression identified predictors of AI-related knowledge. Most participants (69%) believed AI could improve diagnostic accuracy, although only 11% fully trusted AI without human oversight. Human clinicians remained central to decision-making, with 86% of women preferring physician judgment in cases of conflict between AI and radiologist findings. Willingness to undergo AI-supported screening was high (74%), though concerns about false results (59%) and data misuse (36%) were prevalent. Being a health professional (aOR = 2.76, 95% CI: 1.23-6.43) and having higher knowledge of breast screening methods (aOR = 8.29, 95% CI: 3.98-18.6) were significantly associated with awareness of AI use in breast cancer screening. These findings indicate that while Emirati women show cautious support for AI in breast cancer screening, trust, cultural values, and baseline knowledge are key determinants of acceptance. Public health strategies that emphasize transparent communication, robust data protection, and education on both conventional and AI-assisted screening are essential to promote equitable and ethical integration of AI technologies into cancer control programs.
Elective Cesarean Preserves Maternal-Fetal Redox Homeostasis, Whereas Emergency Cesarean Disrupts It: A Prospective Observational Study Delivery Mode and Oxidative Stress
(Taylor & Francis Ltd, 2026) Karakelleoglu, Gokcenur; Arslan, Gaye; Kirimli Yanik, Elif Ceren Nur
Introduction: Oxidative stress is a key component of maternal-fetal physiology and varies with the mode of delivery. Labor induces hypoxia-reoxygenation cycles that elevate reactive oxygen species, whereas elective cesarean section (CS) occurs in a controlled metabolic environment. Emergency CS combines labor-related hypoxia with acute surgical stress. Comprehensive comparisons of maternal and cord oxidative profiles across all delivery modes remain limited. Methods: This prospective observational study included 126 term singleton pregnancies categorized as elective CS (n = 46), emergency CS (n = 39), or vaginal delivery (n = 41). Maternal blood was collected immediately before delivery and cord blood after birth. Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), and paraoxonase-1 (PON-1) activity were measured using automated RelAssay methods; OSI was calculated as (TOS/TAS)x100. Neonatal outcomes included Apgar scores and NICU admission. Group comparisons used ANOVA, Kruskal-Wallis, and chi-square tests, with ANCOVA adjusting for gestational age, maternal weight, diabetes, hypothyroidism, preeclampsia, and ASA use. Results: Baseline characteristics were comparable. Emergency CS had lower Apgar-1 scores and higher NICU admission. Maternal OSI (p = 0.002) and PON-1 (p = 0.004) differed significantly, with elective CS showing the most favorable profile. Cord TOS (p < 0.001), OSI (p < 0.001), and PON-1 (p = 0.001) were also highest in emergency CS. Delivery mode independently predicted maternal OSI and PON-1, and cord TOS, OSI, and PON-1 (all p < 0.01). Discussion: The pronounced oxidative shifts observed in emergency CS likely reflect the cumulative impact of prolonged labor, fetal distress, and abrupt surgical intervention. Elective CS, by avoiding labor-induced hypoxia and metabolic exhaustion, preserves a more balanced maternal-fetal redox environment. The parallel maternal and cord responses underscore the sensitivity of the fetoplacental unit to intrapartum oxidative changes. These findings clarify mechanistic differences between delivery modes and highlight redox status as a potential peripartum biomarker. Conclusion: Elective CS preserves maternal-fetal redox homeostasis, whereas emergency CS results in significant oxidative disruption and poorer neonatal adaptation. These findings support the potential use of oxidative stress markers as adjunct indicators of acute intrapartum stress when interpreted alongside established clinical parameters.
The Association Between miRNA-223 Levels and Pain Severity in Fibromyalgia Syndrome: A Molecular Approach
(MDPI, 2025) Barut, Zerrin; Karatas, Ozlem; Akdeniz, Fatma Tuba; Circirli, Burke; Demir, Serpil; Isbir, Turgay
Fibromyalgia Syndrome (FMS) is a chronic syndrome commonly characterized by widespread musculoskeletal pain and fatigue. Current evidence suggests that FMS diagnosis relies on clinical evaluation and patient-reported symptoms. MicroRNAs, which serve as key regulators of gene expression, have been proposed to play a role in the pathogenesis of FMS and other chronic pain syndromes. In this pilot study, miRNA-223-3p expression levels were examined in patients with FMS, and their relationship with pain intensity-assessed using the Visual Analog Scale (VAS)was evaluated. To obtain a broader understanding of the inflammatory response, serum interleukin-1 beta (IL-1 beta) levels were also measured. miRNA-223-3p expression levels were significantly reduced in the FMS group compared with healthy controls (p < 0.05), whereas IL-1 beta levels did not differ significantly between the groups (p = 0.1135). The negative correlation between miRNA-223-3p and VAS scores indicates that lower miRNA levels are associated with increased pain severity. Overall, these results suggest that reduced miRNA-223-3p expression levels may be linked to neuroimmune processes and heightened pain perception in FMS. The findings provide valuable preliminary insights that may guide future studies with larger sample sizes.
Immune Cell-Based Therapies for Solid Tumors, Current Challenges and Therapeutic Advances
(BMC, 2025) Torabi, Shukoofeh; Yekzaman, Elham; Taherkhani, Soroush; Talachi, Negin; Khoshravesh, Roya; Khosravi, Arezoo; Vosough, Massoud
Solid tumors remain difficult to treat due to antigen heterogeneity, physical barriers that limit immune-cell trafficking, and a profoundly immunosuppressive tumor microenvironment (TME). Over the past decade, cancer immunotherapy advanced considerably through innovative strategies, including macrophage reprogramming and CAR-macrophages, dendritic-cell (DC) vaccines, natural killer (NK) and natural killer T (NKT) cell approaches, tumor-infiltrating lymphocyte (TIL) therapy, TCR-engineered and CAR-T cells, emerging B-cell engineering, and cell-derived extracellular vesicles (EVs). Here we summarize how each modality interacts with the TME, highlight key clinical milestones (e.g., FDA approval of a TIL product for melanoma in 2024), and outline bioengineering strategies-multi-antigen targeting, cytokine armoring, trafficking cues, and safety switches-that aim to overcome resistance and toxicity. We also review EV-based, cell-free strategies that retain tumor specificity with potentially improved safety and manufacturability. Finally, we discuss remaining barriers-standardized manufacturing, on-target/off-tumor effects, limited persistence-and propose rational combinations with checkpoint blockade, radiotherapy, and targeted agents. This overview positions immune cell-based therapy as a rapidly maturing, transformative approach for solid tumors.
Exercise Addiction in Older Adults: Health Preservation or Fear of Death
(Wiley, 2026) Surenkok, Ozgur; Kendal, Kubra; Aydin, Gamze; Atici, Emine
Objectives The aim of the study is to explore exercise addiction in older adults and the psychological, social and biological factors underlying the exercise addiction. Subjects and Methods This study employed a cross-sectional design. 254 participants aged 65 and above were divided into exercise addicted and non-exercise addicted groups in the study. The exercise addiction of participants was assessed using the Exercise Addiction Inventory (EAI). Health-preserving behaviours were evaluated with the Health Protection Behaviour Scale (HPBS). Anxiety related to health was measured using the Health Anxiety Inventory (HAI), while death anxiety was assessed using the Death Anxiety Scale (DAS). Results In intergroup analyses, the EAI, HPBS and TDAS scores were higher in the Exercise Addicted Group compared to the Non-Exercise Addicted Group (p < 0.001, p < 0.001, p = 0.009, respectively). However, the HAI score was lower in the Exercise Addicted Group (p = 0.021). In addition, a positive correlation was observed between HPBS and EAI scores (r = 0.454, p < 0.001). No correlation was found between EAI scores and age (r = 0.028, p = 0.654) or HAI (r = -0.088, p = 0.162). Conclusions This study found that individuals with exercise addiction had lower BMI, a lower proportion of women and higher education levels. Additionally, while positive relationships were observed between exercise addiction and both health-protective behaviours and death anxiety, a negative relationship was found with health anxiety. Correlation and regression analyses indicated that BMI and higher education level serve as protective factors against exercise addiction, whereas health-protective behaviours and death anxiety function as risk factors.
Correction to: Modeling Dysentery Spread and the Impact of Public Awareness on Control Dynamics (Scientific Reports, (2025), 15, 1, (40602), 10.1038/S41598-025-24286-z)
(Nature Research, 2025) Ahmed, K.K.; Yusuf, J.S.; Isa Aliyu, A.I.; Agaie, B.G.; Yusuf, A.S.; Ozsahin, I.; Sulaıman, T.A.
Correction to: Scientific Reportshttps://doi.org/10.1038/s41598-025-24286-z, published online 18 November 2025 The original version of this Article contained an error in the spelling of the author Ilker Ozsahin which was incorrectly given as Ilker Ozşahin. The original Article has been corrected. © The Author(s) 2025.
Search for New Physics in Jet Multiplicity Patterns of Multilepton Events at (Formula Presented)
(American Physical Society, 2025) Hayrapetyan, A.; Tumasyan, A.; Adam, W.; Andrejkovic, J.W.; Bergauer, T.; Chatterjee, S.; Damanakis, K.
A first search for beyond the standard model physics in jet multiplicity patterns of multilepton events is presented, using a data sample corresponding to an integrated luminosity of (Formula presented) of 13 TeV proton-proton collisions recorded by the CMS detector at the LHC. The search uses observed jet multiplicity distributions in one-, two-, and four-lepton events to explore possible enhancements in jet production rate in three-lepton events with and without bottom quarks. The data are found to be consistent with the standard model expectation. The results are interpreted in terms of supersymmetric production of electroweak chargino-neutralino superpartners with cascade decays terminating in prompt hadronic (Formula presented)-parity violating interactions. © 2025 CERN, for the CMS Collaboration.
The Effect of Passive Music Listening in Addition to Conventional Physiotherapy on Pain, Anxiety, and Quality of Life in Patients with Chronic Neck Pain
(Assoc. Medica Brasileira, 2025) Torlak, Mustafa Savas; Atici, Emine; Tufekci, Osman; Karaca, Osman; Dursun, Burcu; Tunc, Elif
OBJECTIVE: The aim of this study was to investigate the effect of passive music listening in addition to conventional physiotherapy on pain, anxiety, and quality of life in patients with chronic neck pain. METHODS: The study included 40 people aged 30-50 years with chronic neck pain, who volunteered to participate in it. The participants were randomized into a control group (n=20) and a music group (n=20). Participants in the control group received a classical physiotherapy programme, 5 days a week for 4 weeks. Participants in the music group listened to music through headphones throughout the treatment. RESULTS: At the end of treatment, there was a statistical difference in the Beck Anxiety Inventory, visual analog scale, Neck Disability Index, and SF-36 physical scores in intragroup comparisons in both groups (p<0.05), When comparing the differences between the groups before and after treatment, it was found that the decrease in visual analog scale score of the participants in the music group was statistically significant compared to the decrease in visual analog scale score of the participants in the control group (p<0.01). CONCLUSION: Passive listening to music has been shown to have a positive effect on chronic neck pain when used in addition to conventional physiotherapy.
Search for a Neutral Gauge Boson With Nonuniversal Fermion Couplings in Vector Boson Fusion Processes in Proton-Proton Collisions at (Formula Presented)
(American Physical Society, 2025) Hayrapetyan, A.; Tumasyan, A.; Adam, W.; Andrejkovic, J.W.; Benato, L.; Bergauer, T.; Chatterjee, S.
The first search for a heavy neutral spin-1 gauge boson ((Formula presented)) with nonuniversal fermion couplings produced via vector boson fusion processes and decaying to tau leptons or (Formula presented) bosons is presented. The analysis is performed using LHC data at (Formula presented), collected from 2016 to 2018 with the CMS experiment and corresponding to an integrated luminosity of (Formula presented). The data are consistent with the standard model predictions. Upper limits are set on the product of the cross section for production of the (Formula presented) boson and its branching fraction to (Formula presented) or (Formula presented). The presence of a (Formula presented) boson decaying to (Formula presented) ((Formula presented)) is excluded for masses up to 2.45(1.60) TeV, depending on the (Formula presented) boson coupling to standard model weak bosons, and assuming a (Formula presented) ((Formula presented)) branching fraction of 50%. © 2025 CERN, for the CMS Collaboration.
Abnormal Right Ventricular To Pulmonary Artery Coupling in Patients With End-Stage Kidney Disease and Normalization After Renal Transplantation: An Observational Study
(S. Karger AG, 2025) Çetin Güvenç, R.; Güvenç, T.S.; Karakaya, E.S.; Acik, H.; Korkmaz, A.; Salem, A.F.; Gürkan, A.
Abstract – Introduction: Pulmonary hypertension and right ventricular (RV) dysfunction are associated with an increase in mortality and worse prognosis in patients with end-stage kidney disease (ESKD), but pathophysiologic mechanisms underlying the progression of RV dysfunction remain incompletely understood. The present study aimed to understand right ventricular to pulmonary artery (RV-PA) coupling, which is an early indicator of transition to RV dysfunction, to better characterize adaptive RV response to increased afterload in ESKD patients and changes in RV-PA coupling following renal transplantation. Methods: One hundred eleven patients with ESKD, including 49 patients scheduled for renal transplantation, underwent a detailed echocardiographic examination and measurement of tricuspid annular plane excursion to pulmonary artery systolic pressure (TAPSE/PASP) ratio, and a repeat examination was performed 6 months after the baseline examination. Results: Patients with ESKD had significantly lower TAPSE/PASP ratio at baseline (1.02 [0.71–1.63] vs. 1.29 [1.09–1.96], p < 0.001). In 40 patients that underwent transplantation, TAPSE/PASP ratio increased significantly from (0.97 [0.72–1.42] to 1.30 [1.01–1.82], p = 0.03), while in 27 patients remained on dialysis, there was a nonsignificant reduction in TAPSE/PASP ratio (1.21 [0.71–1.62] vs. 0.84 [0.61–1.38], p = 0.44). The change in TAPSE/PASP ratio correlated significantly with the change in pulmonary vascular resistance (OR: 0.61, 95% CI: 0.51–0.72, p < 0.001) and left ventricular mass index (OR: 0.97, 95% CI: 0.96–0.99, p = 0.001) after adjustment. Conclusions: Patients with ESKD had abnormal RV-PA coupling, as indicated by a reduced TAPSE/PASP ratio, which normalizes 6 months after renal transplantation. © 2025 S. Karger AG, Basel

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