PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14517/21

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Recognizing the Unexpected: a Rare Cause of Rice Bodies in Brucellosis
(Wiley, 2025) Kalender, Ayse; Akcin, Ali Izzet; Eyvaz, Nuran; Dundar, Umit; Fazli, Sakhi Ahmad
Brucella is a gram-negative zoonotic agent transmitted by consumption of raw milk and infected meat. Among musculoskeletal manifestations, axial involvement such as spondylodiscitis and sacroiliitis is well documented, while peripheral manifestations like tenosynovitis and rice bodies remain underreported. In this case, flexor tenosynovitis and associated rice body involvement due to Brucella, which developed progressive swelling, pain, and restricted movement in the wrist and third finger of the hand after a minor abrasion, were investigated ultrasonographically. As far as we know, this is the first reported case of primary brucellosis with flexor tenosynovitis and associated rice bodies demonstrated ultrasonographically in the literature.
Effect of Osteotomy Strategy on Primary Stability and Intraosseous Temperature Rise: an Ex-Vivo Study
(BMC, 2025) Gokce Uckun, Gozde; Saygili, Sina; Cakir, Merve; Geckili, Onur
Background Primary stability is a perquisite for achieving successful osseointegration. Additionally thermal effect of implant bed preparation plays an important role in success of a dental implant. This ex vivo study was conducted to compare one step implant specific osteotomy and conventional osteotomy in terms of primary stability and thermal changes during surgery. Methods Forty eight implants were inserted into the sheep iliac crest bones each with a safe distance to each other and divided into six groups. In two of the groups implant specific osteotomy and in the remaining 4 groups conventional osteotomy was performed. In the groups, the primary stability of the trioval implants designed for the implant specific osteotomy were compared with the oval active threaded implants. The two osteotomy methods were also compared. Additionally the thermal changes during the two osteotomy methods were compared using a double-channel temperature monitoring device. Results Statistically significant differences (P <.05) were observed between the stability groups and the thermal evaluation groups (P <.05). Implant specific osteotomy revealed significantly higher stability than the conventional osteotomy (P <.001). Osteotomy without irrigation caused significantly higher thermal changes than the conventional osteotomy wit irrigation (P <.001). Conclusion Although the implant specific osteotomy reveals better primary stability, it causes higher temperature during drilling. However, since this increase is within the limits and doesn't cause a risk in terms of osseointegration, it may be used safely in clinical practice.
Deploying a Novel Deep Learning Framework for Segmentation of Specific Anatomical Structures on Cone-Beam CT
(Springer, 2025) Yuce, Fatma; Buyuk, Cansu; Bilgir, Elif; Celik, Ozer; Bayrakdar, Ibrahim Sevki
AimCone-beam computed tomography (CBCT) imaging plays a crucial role in dentistry, with automatic prediction of anatomical structures on CBCT images potentially enhancing diagnostic and planning procedures. This study aims to predict anatomical structures automatically on CBCT images using a deep learning algorithm.Materials and methodsCBCT images from 70 patients were analyzed. Anatomical structures were annotated using a regional segmentation tool within an annotation software by two dentomaxillofacial radiologists. Each volumetric dataset comprised 405 slices, with relevant anatomical structures marked in each slice. Seventy DICOM images were converted to Nifti format, with seven reserved for testing and the remaining sixty-three used for training. The training utilized nnUNetv2 with an initial learning rate of 0.01, decreasing by 0.00001 at each epoch, and was conducted for 1000 epochs. Statistical analysis included accuracy, Dice score, precision, and recall results.ResultsThe segmentation model achieved an accuracy of 0.99 for nasal fossa, maxillary sinus, nasopalatine canal, mandibular canal, foramen mentale, and foramen mandible, with corresponding Dice scores of 0.85, 0.98, 0.79, 0.73, 0.78, and 0.74, respectively. Precision values ranged from 0.73 to 0.98. Maxillary sinus segmentation exhibited the highest performance, while mandibular canal segmentation showed the lowest performance.ConclusionThe results demonstrate high accuracy and precision across most structures, with varying Dice scores indicating the consistency of segmentation. Overall, our segmentation model exhibits robust performance in delineating anatomical features in CBCT images, promising potential applications in dental diagnostics and treatment planning.
Is It Possible To Predict Severe Postpartum Hemorrhage and the Need for Massive Transfusion in Placenta Previa Cases
(Via Medica, 2025) Kole, Emre; Akar, Bertan; Doger, Emek; Kole, Merve Cakir; Anik, Yonca; Caliskan, Eray
Objectives: The aim was to construct a reliable working model for patients with placenta previa (PP) that aids in the prediction of postpartum bleeding potential with data from antenatal imaging studies using both ultrasound (US) and magnetic resonance imaging (MRI). Material and methods: Forty-three patients with PP were evaluated initially with the US and then by 3-Tesla MRI. The placenta accreata index (PAI) was used during the US evaluation in order to define the risks. Uterine bulging, heterogeneous signal, dark placental bands, focal interruption of myometrium and tenting of bladder wall were regarded as predictive criteria in MRI evaluation. The correlation between the findings from US and MRI studies and subsequent haemorrhage, < 1000 mL, > 1000 mL and severe haemorrhage (> 2000 mL) and massive transfusion [> 5 units of red blood cells (RBC)] were used to build this predictive model. The findings from the imaging studies were also confirmed histopathologically. Results: In the multivariate analysis of data from patients stratified by bleed size either < 1000 mL or > 1000 mL, none of the MRI and ultrasound findings were found to be predictive. The multivariate analysis was done using the second stratification cut-point of 2000 mL, in patients bleeding > 2000 mL PAI values [OR: 2.3 (1.4-3.8)] and overall MRI reported placenta accreata spectrum [OR: 4.9 (1.8-12.9)] were found to be predictive. While MRI findings were not discriminative between transfusion groups, grade 3 loculation on US examination was found to be predictive for the need of transfusion of > 5 units [OR: 67.5 (8.2-549.4)]. There were no cases needing hysterectomy. Conclusions: Ultrasound and MRI findings in cases of PP can be helpful in predicting postpartum bleeding.
Evaluation of Phenol Treatment for Pilonidal Sinus in Adolescents
(Frontiers Media Sa, 2025) Kilic, Ayten Basak; Acar, Merve Nur Muti; Kilic, Sinan; Ekingen, Guelsen
Objective Pilonidal sinus disease (PSD) is chronic condition predominantly affecting adolescents, often associated with risk factors such as obesity, poor hygiene, and prolonged sitting. Minimally invasive treatments like phenol procedure have gained attention as alternatives to traditional surgical methods due to their simplicity and potential for shorter recovery. This study aims to evaluate the efficacy and safety of phenol procedure in adolescents with pilonidal sinus, focusing on success rates, recurrence, and complications.Material and method Total number of 28 adolescent patients with non-complicated PSD were included in this retrospective study.Results This study included 28 adolescent patients (mean age: 15.04 +/- 1.40 years), of which 60.7% were female. A total of 46.4% of the patients presented with a single sinus opening, while 53.6% had multiple sinus openings. Phenol procedure was administered with a mean of 3.32 +/- 1.49 courses, resulting in complete healing in 75.0% of patients and an overall success rate of 82.1% after pre- or post-surgical procedure. Complications were observed in 14.3% of cases, while recurrence occurred in 21.4%. Persistent discharge was reported in 7.1% of patients, necessitating surgical excision.Conclusions Our findings support that phenol treatment is a safe and effective minimally invasive approach for managing pilonidal sinus, demonstrating success rates comparable to conventional surgical methods. Furthermore, phenol procedure offers notable advantages, including preservation of tissue integrity, ease of implementation, and reduced recovery times, rendering it particularly advantageous for adolescent patients.
The Effect of Topiramate on the Cerebellum of the Obese Female Rats: a Stereological, Histochemical and Bioinformatical Study by Investigation of Tnf-Α Interaction
(Wiley, 2025) Alkan, Isinsu; Altunkaynak, Berrin Zuhal; Akbari, Amir Mahdi; Altun, Ceren Erdem; Baycu, Cengiz
The rising incidence of obesity underscores the necessity for alternative obesity treatments. Patients commonly prefer medication aiding in weight reduction. Topiramate, an antiepileptic drug, is gaining popularity among obese patients for its weight loss benefits. This study aims to explore Topiramate's impact on the cerebella of obese female rats. In the experiment, 24 female rats (200-250 g) were divided into four groups: non-obese control (NOC), obese control (OC), non-obese topiramate (NOT) and obese topiramate (OT). The non-obese rats were given a standard diet, while the obese rats received a high-fat diet (40% fat). After 9 weeks, topiramate was administered intraperitoneally daily for 6 weeks. Following this, the rats were euthanised, and their cerebella were removed. The volume of the cerebellum and mean numerical density of the molecular neurons, granular neurons and Purkinje cells were estimated using stereological methods, and the link between obesity-caused cerebellum damage and TNF-alpha was assessed through immunohistochemical and bioinformatic techniques. Additionally, histopathological evaluations of the tissues were conducted. The cerebellar volume in the OC group was decreased compared to the NOC group. The topiramate groups exhibited a decrease in molecular or/and granular neuron numbers in the NOT and OT groups. Notably, neurons with dark cytoplasm were observed in the topiramate-treated groups, alongside neuronal degeneration was seen in the obese groups. The connection between TNF-alpha and obesity or obesity-caused cerebellum damage was confirmed through both immunohistochemical and bioinformatics analyses. These findings suggest that topiramate might have a degenerative effect on the cerebellum, especially following obesity.
Stilbenes Against Alzheimer's Disease: a Comprehensive Review of Preclinical Studies of Natural and Synthetic Compounds Combined With the Contributions of Developed Nanodrug Delivery Systems
(Mdpi, 2025) Akkol, Esra Kupeli; Karatoprak, Gokce Seker; Dumlupinar, Berrak; Acikara, Ozlem Bahadir; Arici, Reyhan; Yucel, Cigdem; Sanchez, Eduardo Sobarzo
This review covers preclinical studies of stilbene derivative compounds (both natural and synthetic) with potential preventive and therapeutic effects against Alzheimer's disease (AD). AD is a worldwide neurodegenerative disease characterized by the destruction of nerve cells in the brain and the loss of cognitive function due to aging. Stilbenes are a unique class of natural phenolic compounds distinguished by a C6-C2-C6 (1,2-diphenylethylene) structure and two aromatic rings connected by an ethylene bridge. Stilbenes' distinct features make them an intriguing subject for pharmacological research and development. Several preclinical studies have suggested that stilbenes may have neuroprotective effects by reducing A beta generation and oligomerization, enhancing A beta clearance, and regulating tau neuropathology through the prevention of aberrant tau phosphorylation and aggregation, as well as scavenging reactive oxygen species. Synthetic stilbene derivatives also target multiple pathways involved in neuroprotection and have demonstrated promising biological activity in vitro. However, some properties of stilbenes, such as sensitivity to physiological conditions, low solubility, poor permeability, instability, and low bioavailability, limit their usefulness in clinical applications. To address this issue, current investigations have developed new drug delivery systems based on stilbene derivative molecules. This review aims to shed light on the development of next-generation treatment strategies by examining in detail the role of stilbenes in Alzheimer's pathophysiology and their therapeutic potential.
Lercanidipine Enhances Cisplatin Activity: Dual Anticancer and Anti-Inflammatory Effects Via Caspase Activation and Mapk Inhibition
(Mdpi, 2025) Uskur, Tugce; Biltekin, Sevde Nur; Faikoglu, Gokhan; Saygisever-Faikoglu, Kubra; Berk, Barkin
Background/Objectives: Lercanidipine is a third-generation dihydropyridine calcium channel blocker. In addition to their well-established cardiovascular effects, calcium channel blockers are increasingly recognized for their therapeutic potential in various cancers. This study aimed to investigate the potential anticancer effects of lercanidipine on cancer cell lines-particularly in combination with cisplatin-by assessing parameters such as cell viability (MTT assay), proliferation, MAPK pathway activity, caspase enzyme levels, and TNF-alpha expression. Methods: In this study, the effects of lercanidipine, both alone and in combination with cisplatin, on cell viability were evaluated using the MTT assay in MCF-7, SH-SY5Y, PC3, and HEK293 cell lines. To assess intracellular signaling and apoptotic pathways, MAPK inhibition, as well as caspase-3 and caspase-8 activities, were measured using ELISA. Additionally, to evaluate the anti-inflammatory potential, TNF-alpha levels in LPS-stimulated RAW264.7 cells were analyzed via. Results: The study revealed that lercanidipine showed significant cytotoxic effects, particularly in SH-SY5Y and PC3 cancer cell lines, while it did not induce a 50% loss of viability in healthy HEK293 cells. When combined with cisplatin, lercanidipine enhanced cytotoxicity by 2.7-fold in neuroblastoma (SH-SY5Y) cells, 1.6-fold in breast cancer (MCF7) cells, and 1.9-fold in prostate cancer (PC3) cells. MAPK activity was inhibited by 83.6% at 20 mu M lercanidipine, while dose-dependent increases in caspase-3 and caspase-8 activities were observed. Additionally, lercanidipine decreased TNF-alpha levels in LPS-stimulated RAW264.7 cells, indicating its potential anti-inflammatory effect. Conclusions: In conclusion, lercanidipine demonstrated selective anticancer effects in cancer cell lines and showed synergistic cytotoxicity when combined with cisplatin. It also significantly inhibited MAPK signaling, activated apoptotic caspases, and reduced TNF-alpha levels, suggesting potential anti-inflammatory activity. These findings highlight lercanidipine's potential for repurposing as an adjunct in cancer therapy.
Asymmetric Sinus Excision and Primary Closure With Additional Skin Excision Technique. Effect of Reduction of Dead-Space With Karydakis Modification
(Edizioni Luigi Pozzi, 2019) Kartal, Abdulcabbar; Yalcin, Metin; Oter, Volkan; Ferhatoglu, Murat Ferhat; Uzunkoy, Ali
OBJECTIVE: Pilonidal sinus is one of the common diseases, although there is still no gold standard of treatment available. The aim of this study was to reduce the residual dead-space volume with a modification following the standard Karydakis procedure. METHODS: A total of 100 patients were included in a randomised controlled trial, who were divided into two groups. Each group included 50 patients, and the patients in Group-I were treated with the new technique, whereas in Group-2, the standard Karydakis technique was performed. In the new technique, following total sinus excision, an advancement tissue flap was performed using additional skin excision, in order to reduce the dead-space volume. RESULTS: There was no significant difference in terms of sex, age, and sinus volume. Operation time was longer in first group (p=0,002). Seroma formation rate was higher in the secound group (p=0.036). There was no significant difference in terms of soft tissue infection (p=0.339) and wound dehiscence (p=0.218). The mean follow-up period was 30 months and no recurrence was observed in both groups. CONCLUSIONS: The results of the study suggest that this technique may be considered as an alternative surgical method in pilonidal sinus surgery.
Analysis of Morphological Parameters in Pelvic Radiography and Hip Mri : a Practical Reporting Recommendation
(Acta Medica Belgica, 2021) Cicek, Esin Derin; Cevik, Halime
Although numerous criteria have been proposed to define abnormal hip morphology, mostly used in the diagnosis of femoroacetabular impingement, it is not a practical approach to measure all of these parameters in all cases without clinical suspicion. In this study, our aim was to develop an evaluating and reporting standardization for routine hip examinations to define both hip morphology and impingement. A total of 108 patients with routine hip magnetic resonance imaging (MRI) and antero-posterior pelvic radiograph (PR) were included in this retrospective study. Alpha angle (AA), acetabular depth (AD), acetabular protrusion, acetabular anteversion, collodiaphyseal angle (CDA), lateral center-edge angle (LCEA) and Tonnis angle (TA) were measured. The differences and associations between these parameters were evaluated according to imaging modality or plane, and sex. Although a significant difference has been found between the axial AA and the coronal AA mean values measured on MRI, there was also a strong correlation. Coronal measurements were significantly higher. AA values measured in PR and coronal MRI were comparable. Males had higher AA in both planes as compared to females. There were no significant differences between CDA values in MRI and PR. There was a significant difference and a moderate correlation between AD values in MRI and PR. We suggest that routine reports should include a measurement of AA in two planes, and measurement of CDA in PR or MRI. Due to the difference in AD between MRI and radiography, LCEA or TA may represent better alternatives. Checking for a negative Tonnis sign would represent a practical approach.
Evidence for the Higgs Boson Decay To a Z Boson and a Photon at the Lhc
(Amer Physical Soc, 2024) Aad, G.; Abbott, B.; Abeling, K.; Abicht, N. J.; Abidi, S. H.; Aboulhorma, A.; Zhokin, A.
The first evidence for the Higgs boson decay to a Z boson and a photon is presented, with a statistical significance of 3.4 standard deviations. The result is derived from a combined analysis of the searches performed by the ATLAS and CMS Collaborations with proton -proton collision datasets collected at the CERN Large Hadron Collider (LHC) from 2015 to 2018. These correspond to integrated luminosities of around 140 fb-1 for each experiment, at a center -of -mass energy of 13 TeV. The measured signal yield is 2.2 +/- 0.7 times the standard model prediction, and agrees with the theoretical expectation within 1.9 standard deviations.
Tolerability To Paracetamol and Preferential Cox-2 Inhibitors in Patients With Cross-Reactive Nonsteroidal Anti-Inflammatory Drugs Hypersensitivity
(Asia Pacific Assoc Allergy, Asthma & Clinical Immunology, 2020) Terzioglu, Kadriye; Sancar, Ozgur; Ekerbicer, Hasan Cetin; Ozturk, Raziye Tulumen; Epozturk, Kursat
Background: Acetylsalicylic acid/aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used drugs that may cause hypersensitivity reactions in a substantial proportion of patients. Physicians ought to be aware of these situations. Objective: We aimed to present the clinical characteristics and rates of tolerability to cyclooxygenase (COX)-2 inhibitor analgesics in patients who had admitted due to multiple cross-reactive type of NSAID hypersensitivity. Methods: The files of the patients who had admitted with multiple NSAIDs-induced symptoms were investigated retrospectively. Age, sex, underlying diseases, clinical manifestation, skin test results, and drug provocation test results were analyzed. Results: In 105 patients with multiple cross-reactive type of NSAID hypersensitivity, we found the rate of cross-reactivity to any of the relatively safe alternatives including paracetamol, meloxicam, and nimesulide to be 16.1%. The rate of cross-reactivity to these relatively safe drugs was significantly higher in patients with a history of anaphylaxis induced by NSAID intake (p= 0.006). Conclusion: The diagnosis of COX-1-mediated multiple NSAID hypersensitivity can be often established with a detailed history. Although rare, severe hypersensitivity reactions may be observed in these patients. Undesired situations for both patients and physicians may be avoided by testing relatively safe paracetamol and COX-2 inhibitors in experienced centers.
The Test-Retest Reliability and Concurrent Validity of 360° Turn Test in Patients With Knee Osteoarthritis
(Taylor & Francis Ltd, 2024) Yarar, Haci Ahmet; Narin, Selnur; Erduran, Mehmet; Gurbanov, Iftikhar
PurposeThe aim of this study is to determine whether the 360 degrees turn test is a reliable and valid evaluator that can be used to assess dynamic balance in patients with early (radiographic grades I and II) and advanced (radiographic grades III and IV) knee osteoarthritis.Materials and MethodsThis study is a methodological research. For the test time and step count of 360 degrees turn test; test-retest reliability were determined by calculating the intraclass correlation coefficient and concurrent validity in patients with knee osteoarthritis was investigated by correlation with the timed up and go test time.ResultsThe final analysis was made on 117 participants. The intraclass correlation coefficient values for the test time and step count of 360 degrees turn test in patients with early knee osteoarthritis are 0.931 and 0.902, respectively, while they are 0.923 and 0.943 in patients with advanced knee osteoarthritis. The Pearson correlation coefficients between the time and step count of 360 degrees turn test and the test time of the timed up and go test in patients with early knee osteoarthritis, respectively; while they are 0.547 and 0.388, the correlation in patients with advanced knee osteoarthritis are 0.697 and 0.700, respectively (p < 0.01).ConclusionsThe 360 degrees turn test is a evaluator that has excellent test-retest reliability and moderate to strong concurrent validity in patients with both early and advanced knee osteoarthritis and can be used in the assessment of dynamic balance in this population.
Comparison of Posterior and Antero-Lateral Renal Tumors in Retroperitoneal Laparoscopic Partial Nephrectomy: a Propensity Score Matching Analysis
(Codon Publications, 2023) Anil, Hakan; Yildiz, Ali; Guzel, Ahmet; Akdemir, Serkan; Karamik, Kaan; Arslan, Murat
This study aimed to compare the antero-lateral and posterior localized renal masses in laparoscopic partial nephrectomy with the retroperitoneal approach in terms of operative, functional, and oncological outcomes. Patients who underwent retroperitoneal laparoscopic partial nephrec-tomy by a single surgeon between January 2013 and January 2021 were included in the study. A one-to-one propensity score matching (PSM) analysis was conducted to obtain two balanced groups. The patients were divided into two groups as posterior and antero-lateral according to the localization of the mass. A total of 239 patients were included in the PSM analysis, with 65 patients allocated to each group. The mean operative time was 79.2 & PLUSMN; 11.2 min in the posterior group, while it was 90.0 & PLUSMN; 11.6 min in the antero-lateral group (P < 0.001). Warm ischemia time was 15.9 & PLUSMN; 2.4 min in the posterior group and 18.6 & PLUSMN; 2.7 min in the antero-lateral group (P < 0.001). The median decrease in eGFR at 1 year was 4.8 (IQR, 2.9-6.9) mL/min in the posterior group and 5.0 (IQR, 2.8-11) mL/min in the antero-lateral group (P = 0.219). The warm isch-emia time and clamping technique were found to be significant factors for predicting eGFR change after surgery (13:0.693, 95% CI: 0.39-0.99, P < 0.001; 13:6.43, 95% CI: 1.1-11.7, P = 0.017, respectively). We report that retroperitoneal laparoscopic partial nephrectomy provided longer warm ischemia and operative time for antero-lateral renal masses than posterior masses. However, long-term oncological and functional results were similar for both localizations.
Comparison of Three Different Modalities for the Treatment of Bladder Calculi by Size
(Sage Publications Ltd, 2022) Yildiz, Ali; Anil, Hakan; Erol, Ibrahim; Karamik, Kaan; Ercil, Hakan
Purpose: Treatment recommendations for kidney or ureteral stones are based on stone size; however, this is uncertain for bladder stones. This study aims to determine the best approach to bladder stones based on their size. Materials and methods: We retrospectively analyzed 401 patients with bladder stones. Patients were divided into three different groups according to stone size (11-20 mm, 21-30 mm, 31-40 mm as groups 1, 2, and 3 respectively). Patients had transurethral cystolithotripsy (TUCL), percutaneous cystolithotripsy (PCCL), and open cystolithotomy (OCL) performed. Results: Stone fragments were removed completely in all patients. When catheter time, postoperative stay, and hematocrit decrease values were compared, the results were significantly higher for OCL in all three groups (p: 0.001). When the relationship between stone sizes and operation time is evaluated, TUCL had shorter operation times (34.1 +/- 10.6 min) in group 1. However, TUCL had longer operation times in group 2 and group 3 compared to OCL and PCCL. Conclusion: TUCL may be preferable due to better postoperative outcomes and shorter operative time for <= 2 cm stones. As the stone size increases, PCCL is more favorable in terms of operation time.
Exploring Task Completion Times and Text Performance in Pedestrians in Single and Dual-Tasking: Comparative Analysis of Laboratory and Outdoor Environments
(Sage Publications inc, 2024) Girgin, Nuray; Okudan, Begum; Celebi, Sadik Emre; Dundar, Selim
Background: Increased cell phone use causes individuals to divide their attentional resources between dual tasks in daily life. It is emphasized that this divided attention negatively affects task performance and makes pedestrian cell phone use an increasing safety concern. There is a lack of research on how dual tasks involving cell phone use affect pedestrian movements in laboratory and real-world settings and the time saved by text messaging while walking. Object & imath;ve: The main purpose of this study is to investigate how dual-tasking affects pedestrians by analyzing task completion time and texting performance, as well as investigating potential gender differences. Methods: 119 students were included in the study. Expanded-Timed Up and Go Test was applied as a single task 1. As a single task 2; text messaging was used on a mobile phone. Dual-task was defined as performing both tasks simultaneously. All evaluations were recorded both in the laboratory and outdoor environment. Results: Between all parameters, task completion times showed a significant difference in favor of dual-task in both environments (p <= 0.05). There was no significant difference in texting performance when comparing the results of two environments (p >= 0.05). Performing texting and walking tasks simultaneously resulted in approximately 43-45% time savings. Conclus & imath;ons: However, dual-task increases events such as falling or hitting other pedestrians. We recommend that pedestrians do not endanger their health and the health of other pedestrians to save more or less time.
Test of Lepton Flavor Universality in B± → K± Μ+μ- and B± → K± E+ E- Decays in Proton-Proton Collisions at √s=13 Tev
(Iop Publishing Ltd, 2024) Hayrapetyan, A.; Tumasyan, A.; Adam, W.; Andrejkovic, J. W.; Bergauer, T.; Chatterjee, S.; Zhokin, A.
A test of lepton flavor universality in B-+/- -> K +/- mu(+) mu(-) and B-+/- -> (K)+/- e(+) e(-) decays, as well as a measurement of differential and integrated branching fractions of a nonresonant B-+/- -> K-+/- mu(+)mu(-) decay are presented. The analysis is made possible by a dedicated data set of proton-proton collisions at root s = 13 TeV recorded in 2018, by the CMS experiment at the LHC, using a special high-rate data stream designed for collecting about 10 billion unbiased b hadron decays. The ratio of the branching fractions B(B-+/- -> K-+/- mu(+) mu(-)) to B(B-+/- -> K-+/- e(+) e(-)) is determined from the measured double ratio R(K) of these decays to the respective branching fractions of the B-+/- -> J/psi K-+/- with J/psi -> mu(+)mu(-) and e(+) e(-) decays, which allow for significant cancellation of systematic uncertainties. The ratio R(K) is measured in the range 1.1 < q(2) < 6.0 GeV2, where q is the invariant mass of the lepton pair, and is found to be R(K) = 0.78(-0.23)(+0.47), in agreement with the standard model expectation R(K) approximate to 1. This measurement is limited by the statistical precision of the electron channel. The integrated branching fraction in the same q(2) range, B(B-+/- -> K-+/- mu(+) mu(-)) = (12.42 +/- 0.68) x 10(-8), is consistent with the present world-average value and has a comparable precision.
New Structures in the J/Ψj Mass Spectrum in Proton-Proton Collisions at √ S=13 Tev
(Amer Physical Soc, 2024) Hayrapetyan, A.; Tumasyan, A.; Adam, W.; Andrejkovic, J. W.; Bergauer, T.; Chatterjee, S.; Zhokin, A.
A search is reported for near-threshold structures in the J=psi J=psi invariant mass spectrum produced in proton-proton collisions at ffiffi s p 1/4 13 TeV from data collected by the CMS experiment, corresponding to an integrated luminosity of 135 fb-1. Three structures are found, and a model with quantum interference among these structures provides a good description of the data. A new structure is observed with a local significance above 5 standard deviations at a mass of 6638 thorn 43 -38 ostat thorn thorn 16 -31 osyst thorn MeV. Another structure with even higher significance is found at a mass of 6847 thorn 44 -28 ostat thorn thorn 48 -20 osyst thorn MeV, which is consistent with the Xo6900 thorn resonance reported by the LHCb experiment and confirmed by the ATLAS experiment. Evidence for another new structure, with a local significance of 4.7 standard deviations, is found at a mass of 7134 thorn 48 -25 ostat thorn thorn 41 -15 osyst thorn MeV. Results are also reported for a model without interference, which does not fit the data as well and shows mass shifts up to 150 MeV relative to the model with interference
The Effect of Muscles in the Treatment of Lower Limb Lymphedema: Respiratory Muscles or Leg Muscles
(Springer, 2025) Akgul, Ahmet; Mazi, Ilknur; Aydin, Gamze; Yavuz, Mumine; Yeldan, Ipek
Purpose This study aimed to compare the effects of manual lymphatic drainage and bandaging (MLDB) combined with calf muscle exercise training (CMT) and/or inspiratory muscle training (IMT) on edema, muscle strength, functional capacity, functionality, and quality of life (QoL) in patients with secondary lower limb lymphedema (LLL). Method A total of 76 patients (mean age: 47.06 +/- 16.16 years; 84.2% female) with LLL were included in the study and randomized into four groups: MLDB alone (Group 1), MLDB + CMT (Group 2), MLDB + IMT (Group 3), and MLDB + CMT + IMT (Group 4). The training programs were administered for 30 min per day, five days per week, over three weeks. Edema was assessed using circumference measurements (CM) and tissue dielectric constant (TDC). Muscle strength was evaluated using maximum inspiratory/expiratory pressure (MIP/MEP) and a dynamometer. Functional capacity was assessed with the 6-Minute Walk Test (6MWT), functionality with the Lower Extremity Functional Scale (LEFS), and QoL with the Lymphedema Quality of Life Scale (LYMQOL). Results In the intra-group analyses, all assessments improved in all groups, except for MIP, MEP, and gastrocnemius muscle strength in Group 1 and MIP in Group 2 (p < 0.05). In the inter-group analyses, Group 3 showed the largest effect sizes (ES) for reductions in TDC (ES: 2.34) and improvements in LYMQOL (ES: 1.74), MEP (ES: 1.46), and LEFS (ES: 1.44) (p < 0.001 for all). Group 4 had the largest ES for increases in MIP (ES: 1.42, p < 0.001). Group 2 showed the largest ES for improvements in gastrocnemius muscle strength (ES: 1.41, p < 0.001). However, there were no significant differences among the groups in CM or 6MWT results (p > 0.05). Conclusion Compared to enhancing leg muscle strength, improving respiratory muscle function in addition to MLDB had a greater impact on reducing edema and enhancing functionality and QoL. Trial Registration Number NCT05609526. Registration Date: 14.11.2022.
Autoimmune Encephalitis and Musicogenic Epilepsy: a Case of Gad65 Antibody-Associated Seizure
(Wiley, 2025) Mohammadi-Asl, Ali; Bahadori, Amir Reza; Sabzgolin, Iman; Davari, Afshan; Razmafrooz, Mohammad; Tafakhori, Abbas; Ranji, Sara
Musicogenic epilepsy (ME) is a rare form of reflex epilepsy with a prevalence of 1 in 10,000,000. Recent research suggests a potential link between ME and autoimmune encephalitis, particularly involving glutamic acid decarboxylase 65-isoform (GAD65) antibodies. A 48-year-old female presented with a one-year history of music-triggered seizures. Her episodes were characterized by an initial aura followed by unresponsiveness and oral automatisms. Electroencephalography revealed abnormalities in the left anterior temporal lobe and temporal leads. Laboratory studies showed positive anti-GAD65 antibodies. The patient was treated with a combination of antiepileptic medication (Lamotrigine) and corticosteroids and intravenous immunoglobulin. This case contributes to the growing evidence supporting an association between ME and autoimmune mechanisms, particularly GAD65 antibody-mediated autoimmunity. It highlights the importance of screening autoimmune factors in ME patients and highlights the need for further research into targeted treatment strategies.

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