PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14517/21

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Effects of Sugammadex and Rocuronium on Electro-Mechanical Activity of Cardiac Myocytes
(2025) Arun, O.; Öztürk, N.; Erkan, O.; Ozdemir, S.; Arun, F.; Yanardag, S.B.; Ayaz, M.
BACKGROUND: Sugammadex reverses the effects of steroidal neuromuscular-blocking agents, such as rocuronium, by encapsulating these agents. Its cardiovascular adverse effects include QTc prolongation, hypotension, bradycardia, atrioventricular block, atrial fibrillation, and asystole. Additionally, rocuronium has cardiac side effects, such as bradycardia, hypotension, cardiac arrest, circulatory collapse, and ventricular fibrillation. Herein, we investigated the effects of sugammadex, rocuronium, and combined rocuronium + sugammadex on cardiac electrophysiological parameters. METHODS: In vitro experiments were performed using ventricular myocytes obtained from male Wistar rats. Myocyte contraction and relaxation responses were recorded along with action potential (AP), and L-type calcium (ICaL) and potassium channel currents (Ito, Iss, and IK1). RESULTS: Sugammadex caused dose-dependent decreases in myocyte contraction and relaxation responses. Rocuronium had no effect in this respect, whereas its co-administration with sugammadex led to decreased contraction responses. Sugammadex prolonged the AP repolarization phase, whereas rocuronium prolonged all AP phases. Co-administration of sugammadex and rocuronium did not significantly affect AP parameters. Sugammadex suppressed the peak ICaL value, while rocuronium caused an even greater decrease. Co-administration of these drugs further decreased the current-voltage characteristics of the ICaL. However, no significant effects were observed on the potassium currents. CONCLUSIONS: Separate or combined administration of sugammadex and rocuronium had various effects on myocyte contractility, AP, and ICaL, which could cause significant changes leading to adverse cardiac events. Further experimental and clinical studies are required to understand the clinical consequences of the modulatory effects of these drugs on cardiac electrophysiological parameters. This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
Psychometric Evaluation of the Person-Centred Climate Questionnaire - Staff Version
(BMC, 2025) Arici, Furkan Cihat; Harmanci Seren, Arzu Kader; Edvardsson, David
BackgroundValid and reliable instruments are needed to assess person-centredness that serve as quality care indicators. Person-Centred Climate Questionnaire - staff version is an interculturally used tool to evaluate person-centredness in clinical settings. This study aimed to examine the psychometrics of the tool in the Turkish language.MethodsThis was a methodological study involving a sample of 140 nurses. One of the researchers collected data using the Turkish version of the questionnaire-staff version in a private hospital in Istanbul. After performing the language validity steps, the researchers analysed the content validity ratios of the items and the questionnaire's content validity index, and they performed exploratory and confirmatory factor analysis to validate the construct. The internal consistency of the subdimensions and the questionnaire was determined utilising a Cronbach's Alpha test.ResultsThe content validity ratios of the items ranged from 0.84 to 1, and the correlation coefficients ranged from 0.50 to 0.69. The three-factor structure accounted for 70.40% of the total variance. The items' standardised factor loads were between 0.501 and 1.140. The Cronbach's alpha consistency value was 0.90.ConclusionThe staff version of the questionnaire is an adequately valid and reliable instrument in the Turkish language.
Assessing Congenital Muscular Torticollis Using Myotonometry: A Novel Approach
(JMNI, 2025) Azim, Derya; Acar, Gonul; Atici, Emine; Duzel, Turku
Objective: This study aimed to evaluate sternocleidomastoid (SCM) muscle properties in infants with Congenital Muscular Torticollis (CMT) using myotonometry and determine its sensitivity to changes following physiotherapy. Methods: Twentyfive infants (0-12 months) diagnosed with CMT participated in this study from May 2023 to February 2024. They underwent an 8-week physiotherapy program. Muscle tone, elasticity, and stiffness were measured using myotonometry, muscle strength by the Muscle Function Scale (MFS), and neck range of motion by an arthrodial protractor before and after treatment. Results: The mean age was 4 +/- 1.56 months. Significant differences in SCM tone and stiffness between affected and intact sides were observed pre-treatment (p<0.05) but were not significant post-treatment (p>0.05). Intragroup improvements were significant for muscle tone (p=0.005), elasticity (p=0.009), stiffness (p=0.009), strength (p=0.006), and neck range of motion (p=0.021). Muscle tone decreased by 19.65%, muscle stiffness by 24.99%, and muscle elasticity improved by 9.42%. Passive lateral flexion increased by 59.09% and passive rotation by 25.40%. Conclusions: SCM muscle properties differ between sides in individuals with CMT; however, myotonometry effectively detects improvements following physiotherapy, making it a valuable clinical evaluation tool. Nevertheless, the relatively small sample size should be taken into account when interpreting the findings.
Massive Cystic Nephroma in a 13-Month Girl: Case Report and Differential Diagnostic Outcome
(AVES, 2025) Malkoc, Barkin; Bilgili, Yusuf Doruk; Kutlu, Filiz; Guvenc, B. Haluk
Impact of High-Concentration Office-Type Bleaching Agent on Physical Properties of Different Types of Bulk-Fill Composites
(BMC, 2025) Kaynar, Zeynep Buket; Donmez, Nazmiye; Kazak, Magrur; Duc, Bugra
Background: This study investigated the effect of a 45% carbamide peroxide-containing office-type bleaching agent on the microhardness (MH) and surface roughness (SR) of flowable and paste-type bulk-fill composite resins. Methods: This study used two bulk-fill composite resins, 3 M Filtek Bulk-Fill (paste) and Estelite Bulk-Fill Flow (flowable). Twenty disc-shaped specimens were prepared and divided into two groups according to the type of bulk-fill materials. All samples were stored at room temperature for 24 h with artificial saliva. Initial MH and surface SR values were measured. High-concentration office-type (HCOT) bleaching agent was applied to the samples for 30 min, and then the same procedure was repeated after one week. Following completion of bleaching procedures, final MH and surface SR values were evaluated. The MH values were analyzed by ANOVA and Kruskal-Wallis tests was used for SR values with a significance of 0.05. Results: A statistically significant difference was found between the MH values of the groups before and after bleaching (p = .002). SR value of 3 M Filtek Bulk-Fill was found statistically higher than Estelite Bulk-Fill Flow after or before bleaching treatment. Statistically significant difference was found SR value of 3 M Filtek Bulk-Fill when compared to before and after bleaching procedures (p = .024). Conclusions:Bleaching with high-concentration office-type material significantly reduced the MH of both bulk-fill composites. While HCOT was applied, Estelite Bulk-Fill Flow did not cause a significant change in surface SR. In contrast, the SR value of 3 M Filtek Bulk-Fill was statistically higher. Therefore, if bleaching with a high-concentration office-type bleaching material is planned, it is recommended not to use 3 M Filtek Bulk-Fill as a restorative material, or it may be recommended to renew existing composite resin restorations after bleaching treatment.
Factors Affecting the Formation of Lymphedema Due to Breast Cancer (Is Primary Systemic Treatment an Independent Factor in the Formation of Breast Cancer Related Lymphedema?)
(Galenos Publ House, 2025) Kumcuoglu, Melek; Gunay, Semra; Gokcek, Berk
Objective: This study aimed to evaluate the local and systemic risk factors associated with breast cancer-related lymphedema (BCRL), with a focus on whether primary systemic treatment (PST), particularly taxane-based chemotherapy, is an independent risk factor. Material and Methods: A prospective clinical study was conducted on 80 breast cancer patients discussed at our institution's weekly breast cancer council. Patients were grouped based on PST status. Clinical examinations and measurements were performed preoperatively and postoperatively at 1, 6, 12, 18, and 24 months. Only the operated arm was assessed using tape measurements and the truncated cone formula. Arm volumes were calculated, and lymphedema (LE) was diagnosed based on a volume difference (>= 200 mL or >= 2 cm circumference). Results: No statistically significant differences were found between PST and non-PST groups regarding age, body mass index, menopausal status, smoking, or tumor characteristics. LEwas detected in 7 (8.8%) patients, all Stage 1. PST and taxane-based chemotherapy were not significantly associated with LE development. However, seroma presence (p=0.038) and axillary radiotherapy (p=0.043) were significantly associated with LE. Arm volume increase was most significant at 1 and 18 months postoperatively (p=0.055 and p=0.044, respectively). Conclusion: PST, including taxane-based chemotherapy, does not appear to be an independent riskfactor for BCRL.In contrast, postoperative seroma and axillary radiotherapy are significantly associated with LEdevelopment. Early identification and management strategies should target these modifiable factors to reduce the risk of LE.
Pathophysiology, Diagnosis, and Management of Coronary Artery Aneurysms: A Review
(IMR Press, 2025) Guvenc, Rengin Cetin; Al Arfaj, Abdullah Ayar; Razouk, Hola; Guvenc, Tolga Sinan
Coronary artery aneurysms (CAAs) are frequent entities that are encountered in up to 8% of patients undergoing coronary imaging. The most frequent cause of CAAs is atherosclerotic "positive remodeling" of coronary arteries, while congenital, inflammatory, and traumatic etiologies could also be seen. Aneurysms serve as foci for thrombus formation, which may occlude the aneurysmatic segment or embolize distally. Rupture of an aneurysm is a rare yet potentially catastrophic complication of a CAA. Most aneurysms can be managed medically, while percutaneous exclusion of an aneurysm from coronary circulation is appropriate for CAAs that are prone to rupture or thrombosis. Surgical correction remains the ultimate option for patients who are not amenable to percutaneous management or those with a compelling indication for surgery. This review summarizes the available knowledge on the nomenclature, classification, pathophysiology, diagnosis, and management of CAAs, with a particular emphasis on treatment strategies to mitigate the risks associated with CAAs.
Personalized Alginate Encapsulation: The Role of Autologous Blood Additives in Parathyroid Cell Transplantation
(Wiley, 2025) Acar, Ozge Karabiyik; Bozdag, Gulnihal; Tuncer, Ahmed Alperen; Hacihasanoglu, Ezgi; Aydogan, Lal Era; Nozhatzadeh, Gulcin Delal; Kose, Gamze Torun
The only therapeutic intervention for hypoparathyroidism is parathyroid transplantation, but graft rejection is a concern. This study sought to mitigate this problem by utilizing the patient's blood, serum, or plasma in the transplant. To accomplish this objective, blood additives derived from Sprague-Dawley rats are incorporated within alginate, and human parathyroid cells are encapsulated. The prepared microbeads are monitored for mechanical properties, followed by xenotransplantation into rats for the evaluation of cell function and immunological response. Biodegradation data showed that the structural integrity of the microbeads containing blood and plasma is superior to serum, while the durability of plasma-including microbeads is only comparable to that of the alginate-only group. Plasma-including microbeads released the highest levels of parathyroid hormone (PTH), both in vitro and in vivo. This behavior could be attributed to the beneficial impact of plasma on cellular function while regulating immune response. Blood incorporation provoked an elevated immune response while concurrently offering minimal support to the encapsulated cells. A notable elevation in CCL2 (MCP-1) chemokine levels is observed in both blood and alginate-only microbead groups, correlating with CD68 expression. These findings demonstrated that autologous plasma addition may regulate the immune system, thereby diminishing the risk of rejection in cell transplantations.
Biomedical Potentials of MXenes-Based Self-Powered Wearable Devices: The Future of Next-Generation Wearables
(Royal Soc Chemistry, 2025) Mohammadi Shahandashti, Yeganeh; Larijani, Sepehr; Eskandari, Mahnaz; Zarepour, Atefeh; Khosravi, Arezoo; Iravani, Siavash; Zarrabi, Ali
MXene-based self-powered wearable devices have emerged as a groundbreaking innovation in the biomedical field, offering significant advancements in health monitoring, disease diagnosis, and therapeutic interventions. This review delves into the unique properties of MXene-based composites, including their excellent electrical conductivity, high mechanical strength, tunable surface chemistry, promising biocompatibility and biodegradability, antibacterial activity, photothermal properties, electrochemical activity, and enzyme-mimicking capabilities, which render them ideal candidates for powering advanced biosensors and other wearable technologies. By capturing energy from body movements or thermal gradients, these devices can operate autonomously, eliminating reliance on external power sources and enhancing user convenience. The integration of MXenes into biosensing applications allows for the continuous and non-invasive monitoring of vital signs and biomarkers, facilitating early detection of diseases such as cancer and diabetes. Additionally, the potential for localized therapeutic applications, such as photothermal therapy, positions MXene-based devices as versatile tools in personalized medicine. Herein, we aim to critically examine the biomedical potentials of MXene-based self-powered wearable devices, focusing on their applications in health monitoring, disease diagnosis, and therapeutic interventions. Additionally, this review focuses on the challenges confronting MXene-based self-powered wearable devices, while also exploring future perspectives and innovations that could enhance their performance and applicability in biomedical fields.
Cluster and Correspondence Analyses for Oral Ulcer Activity Related Factors in Behçet's Syndrome
(Medicina Oral S L, 2025) Polat-Akmansoy, Berceste; Aksoy, Burcu; Sisman-Kitapci, Nur; Akmansoy, Sukru Can; Candereli, Zehra Ozge; Sari, Fatma Bilsra; Mumcu, Gonca
Background: Beh & ccedil;et's Syndrome (BS) is a multisystemic vasculitis characterized by a heterogeneous clinical profile, including mucocutaneous, musculoskeletal, neurological, ocular, vascular and gastrointestinal manifestations. BS patients often experience a continuous, low-level disease activity state due to persistent oral ulcers. This study aimed to define relations among oral ulcer activity (OUA), gender and treatments through K-Means Cluster and Correspondence Analyses (CA) in patients with BS. Material and Methods: In this cross-sectional study, 526 BS patients from two tertiary centres in Turkey and the United Kingdom were included. The K-Means Cluster Analysis was performed to identify homogeneous clinical profiles for OUA by combining the disease severity score reflecting organ involvement and the number of oral ulcers. Then, CA was performed to visualize associations between gender and medications (non-immunosuppressive: non-IS vs. IS) in clusters. Results: K-Means Analysis identified three clusters regarding mucocutaneous and major organ involvement and one with major organ involvement. Clusters were named according to OUA and the disease severity. The number of oral ulcers was found to be similar in the "Low OUA" cluster (n=202, 65.03%; 2.18 +/- 1.13) and the "Low OUA with Major Organ Involvement" cluster (n=63, 19.25%; 2.19 +/- 1.37)(p=0.368). These were lower than those in the "Moderate OUA" Cluster (n=30, 9.8%; 7.60 +/- 1.88) and the "High OUA" cluster (n=11, 3,59%; 14.91 +/- 2.34) (p<0.001). CA visualized that non-ISs in "Low OUA" cluster, ISs in "Low OUA with Major Organ" cluster for both genders as well as male patients treated with non-ISs or ISs in "Moderate OUA" cluster were predominant groups. Conclusions: The presence of two oral ulcers might be accepted as the cut-off value for low OUA. Moreover, intensive treatment protocols must be provided for elevated oral ulcer activity in male patients who were treated with non-IS medications in BS.
Evaluating the Diagnostic Potential of CC-125 and miRNA Levels in Endometriosis: A Narrative Review
(Wiley, 2025) Shokrnejad-Namin, Taha; Farzizadeh, Neda; Najmi, Zahra; Amoozgar, Morteza; Hariri, Amirali; Amini, Elnaz; Zarrabi, Ali
Endometriosis, a common and complex gynecologic disorder, continues to pose a challenge to clinicians in diagnosis process due to its complexity. The aim of this review was to examine cancer antigen-125 (CA-125) and microRNAs (miRNAs) as biomarkers in endometriosis pathophysiology and their investigational potential roles in clinical diagnostics and prognostics. In this narrative review, a variety of studies are reviewed, including cross-sectional, case-control, and prospective designs, examining a broad spectrum of patient demographics, clinical features, and biomarker (CA-125 and miRNA) expression levels. While frequently elevated in endometriosis, CA-125 is limited by low specificity and sensitivity, preventing its use as a standalone diagnostic tool; its primary utility remains in monitoring established disease and, adjunctively, with other clinical parameters. miRNAs have gained attention as molecular regulators implicated in the disease process, suggesting potential avenues for noninvasive diagnostics and a better understanding of pathogenesis. The combined analysis of biomarker panels, rather than single markers, may present a shift towards more personalized strategies. The convergence of CA-125 and miRNA research represents a promising advance, potentially leading to more accurate diagnostics and personalized treatment. Future research should focus on standardizing methodologies, expanding study cohorts, and integrating findings into clinical practice to fully harness the potential of these biomarkers.image
Reweighting Simulated Events Using Machine-Learning Techniques in the CMS Experiment
(Springer, 2025) Hayrapetyan, A.; Tumasyan, A.; Adam, W.; Andrejkovic, J. W.; Benato, L.; Bergauer, T.; Druzhkin, D.
Data analyses in particle physics rely on an accurate simulation of particle collisions and a detailed simulation of detector effects to extract physics knowledge from the recorded data. Event generators together with a geant-based simulation of the detectors are used to produce large samples of simulated events for analysis by the LHC experiments. These simulations come at a high computational cost, where the detector simulation and reconstruction algorithms have the largest CPU demands. This article describes how machine-learning (ML) techniques are used to reweight simulated samples obtained with a given set of parameters to samples with different parameters or samples obtained from entirely different simulation programs. The ML reweighting method avoids the need for simulating the detector response multiple times by incorporating the relevant information in a single sample through event weights. Results are presented for reweighting to model variations and higher-order calculations in simulated top quark pair production at the LHC. This ML-based reweighting is an important element of the future computing model of the CMS experiment and will facilitate precision measurements at the High-Luminosity LHC.
Concerns of Earthquake Survivor Mothers for Their Children and the Role of School Leadership in Addressing Them
(Frontiers Media S.A., 2025) Taner Derman, Meral; Turen, Seyma
Introduction This study aims to examine the change in the concerns of mothers with preschool children before and after the earthquake and the role of school administrators in relieving these concerns. Understanding these concerns is essential for improving post-disaster support strategies for families.Methods The research was carried out in a holistic multi-case study design, which is one of the qualitative methods, with a study group consisting of 20 mothers and 5 school administrators living in the temporary housing area in Hatay. The data were collected through semi-structured interview forms and analyzed by content analysis method.Results The findings showed that games and entertainment activities were at the forefront of mother-child relationships, but they were also a reflection of the earthquake. It has been revealed that mothers' future plans focused on positive goals such as their children growing up in a healthy environment before the earthquake and becoming successful individuals by receiving a good education, but after the earthquake, these plans were negatively affected due to financial and social losses, uncertainties and disruptions in education. It has been shown that mothers had general concerns about the education, security and social development of their children before the earthquake, but these concerns became more concrete and intense after the earthquake. Mothers reported serious concerns, particularly about living conditions, psychological effects, education, and the future. School administrators, on the other hand, resorted to methods such as summer schools, social activities, guidance services and financial support to alleviate the concerns of mothers. They suggested improving housing conditions, opening vocational courses, strengthening infrastructure and involving psychosocial support teams.Conclusion The research emphasized that the physical, social and psychological effects of natural disasters on individuals are multidimensional and revealed the critical role of school administrators in crisis management. It also highlights the need for coordinated efforts between families and schools in navigating post-disaster challenges.
Cancer Stem Cell Enrichment in in Vitro Models: Techniques, Insights, and Applications
(Elsevier Ireland Ltd, 2025) Ranjbar-Niavol, Fazeleh; Barisam, Maryam; Khosravi, Arezoo; Kashaninejad, Navid; Zarrabi, Ali; Vosough, Massoud
Due to the substantial role of cancer stem cells (CSCs) in therapeutic resistance and metastasis, the study of them is of great importance. However, their low abundance within the tumor cells makes it challenging to study their molecular pathophysiology. This limitation highlighted the critical need for reliable enrichment techniques to provide enough cells for in vitro tests. This review focuses on various methods that implemented for enrichment of cancer stem-like cells' subpopulations from the heterogeneous population of cancer cells. In this regard, various key physicochemical parameters such as hypoxia, shear stress, high glucose concentration, autophagy, and chemotherapy-induced stress have been explored for their potential to enhance CSC enrichment. The results presented in the literature confirmed that modifying these parameters can improve the enrichment of CSCs by promoting stem-like cells phenotype. However, there is still a necessity for comprehensive studies that compare the impact of these parameters on CSC enrichment, which should be addressed in future works.
Assessment of Color Stability of Various Flowable Composite Resins with Different Viscosities
(MDPI, 2025) Yenier Yurdaguven, Gulsah
Biomimetic restorative dentistry aims to preserve tooth structure and achieve optimal aesthetic harmony with surrounding dentition. The principles and protocols associated with biomimetic restorative dentistry are designed to enhance the longevity of the restoration. The use of flowable CRs is increasingly common; however, the effect of viscosity on the discoloration has not been clearly established. This in vitro study aimed to assess the color stability of flowable CRs with varying viscosities following immersion in common staining solutions and subsequent repolishing. A total of 250 disc-shaped specimens (8 mm x 2 mm) were prepared from five CRs with different viscosity profiles: high-viscosity (Spectra STHV, Dentsply, Milford, DE, USA), medium-viscosity (Estelite Universal Flow Medium, Tokuyama Dental Co., Tokyo, Japan), bulk-fill (Estelite Bulk-Fill Flow, Tokuyama Dental Co., Tokyo, Japan; SDR Plus, Dentsply, Milford, DE, USA), and packable (Estelite Posterior, Tokuyama Dental Co., Tokyo, Japan). After polymerization and baseline color measurements, specimens were immersed in coffee, tea, cola, red wine, or distilled water for 144 h. Color values were recorded before and after staining, and again following repolishing. Color changes (Delta E1, Delta E2, Delta E3) were calculated using the CIE Lab system and statistically analyzed via two-way ANOVA and Tukey HSD (alpha = 0.05). Both the CR type and the staining solution substantially affected the color change. SDR Plus exhibited the highest Delta E values. Red wine caused the most discoloration. Repolishing enhanced color in selected groups.
Enhancing Thermal Performance of Phase Change Materials Using Conductive Rods with Length Dependent Melting Dynamics
(Nature Portfolio, 2025) Khalaf, Abbas Fadhil; Rashid, Farhan Lafta; Al-Obaidi, Mudhar A.; Mohammed, Hayder I.; Ameen, Arman; Agyekum, Ephraim Bonah
Phase change materials (PCMs) suffer from slow melting rates due to their low thermal conductivity, limiting their efficiency in thermal energy storage systems. This study numerically investigates the novel use of copper rods as conductive enhancers to accelerate PCM melting in a horizontally placed hemispherical cell. Using the ANSYS/FLUENT 16 with an enthalpy-porosity model, the impact of rod integration is examined to determine the optimal rod configuration for maximising heat transfer while minimising melting time. The results indicate that copper rods dramatically improved melting performance: a 20 mm rod can reduce total melting time by 70% (from 300 to 90 min), while 10 mm and 15 mm rods achieve reductions of 40% (to 180 min) and 50% (to 150 min), respectively. Clearly, the 20 mm rod enables 70% liquid fraction in 30 min, showing a melting speed four times faster than the no-rod case. Nonlinear scaling reveals diminishing returns beyond 15 mm, suggesting a cost-performance trade-off at this length. The 15 mm rod emerged as a practical balance between attaining 85% of maximum gain with a 50% reduction in melting time while utilising 25% less copper than 20 mm rod. Accordingly, this research provides critical insights for designing high-efficiency thermal storage systems, offering a roadmap to optimise conductive enhancements for real-world applications. By bridging the gap between material properties and system-level performance, the findings advance the deployment of PCMs in renewable energy and waste heat recovery systems.
Mitochondrial Dysfunction in Hepatocellular Carcinoma: From Metabolism to Targeted Therapies
(Springer, 2025) Sharafi, Faezeh; Rismani, Elham; Rhmanian, Mohamad; Khosravi, Arezoo; Zarrabi, Ali; Vosough, Massoud
Globally, liver cancer is reported to be the third leading cause of cancer-related mortality. The most common type of these cancers is hepatocellular carcinoma (HCC). Current preventive strategies, including lifestyle modifications, antiviral therapies, and surveillance, are limited in their effectiveness. Mitochondria play critical roles in regulating cellular metabolism, oxidative stress, and apoptosis. Mitochondrial dysfunction can accelerate HCC progression, particularly in patients with liver diseases such as metabolic-associated fatty liver disease (MAFLD) and metabolic dysfunction-associated steatohepatitis (MASH). In this review, we discuss the mechanisms of mitochondrial dysfunction in HCC from a molecular point of view, including oxidative stress, mitophagy dysregulation, mitochondrial dynamics dysregulation, and mitochondrial DNA (mtDNA)-mediated dysregulation of innate immune responses. Additionally, we explore molecular-targeted therapies aimed at restoring mitochondrial function. Critical approaches include targeting reactive oxygen species pathways through agents such as iridium (III) complexes and Mito Rh S, which induce cancer cell death through apoptosis and ferroptosis. Other compounds, including dehydrocrenatidine, enhance oxidative phosphorylation and promote apoptosis. Inhibitors of dynamin-related protein 1 (Drp1) target mitochondrial fission to reduce tumor growth. Furthermore, mitophagy modulators, such as SIRT1 activators, improve mitochondrial quality control, minimize the negative effects of oxidative stress, and reduce cancer development. Clinical trials are ongoing for the mitochondrial enzyme-targeting agents CPI-613 and Gamitrinib, a heat shock protein-targeting agent, which have hence shown great promise for these therapies. With further investigation, mitochondrial-targeted interventions could be promising for preventing or reducing HCC incidence and recurrence, increasing long-term survival, and improving the quality of life of patients with advanced-stage disease.
MXenes-Based Wearable Contact Lenses: Integrating Smart Technology into Vision Care
(Springer Science and Business Media B.V., 2026) Khosravi, A.; Zarepour, A.; Zarrabi, A.; Iravani, S.
MXene-based smart contact lenses seamlessly combine real-time biosensing, therapeutic functions, and enhanced user comfort, revolutionizing ocular health monitoring and treatment. The use of transparent MXene films enables features like photothermal therapy, antimicrobial protection, and dehydration resistance, significantly improving eye protection and disease management. While stability, scalability, and wireless integration pose hurdles, ongoing advancements suggest these lenses hold tremendous potential for transforming digital healthcare and ophthalmic care. © 2025 Elsevier B.V., All rights reserved.
Glanular Ischemia Following Glans Penis Augmentation: A Rare Case Report
(S. Karger AG, 2025) Karamlk, K.; Yildiz A.; Koraş, Ö.; Arslan, M.
Introduction: Premature ejaculation is a common problem in men and filler injection into the glans penis has become a prevalent practice in treatment. Since the glans penis augmentation is an invasive treatment method, it also carries the risk of complications. Herein, we aimed to present a case of glans penis ischemia due to hyaluronic acid filler injection. Case Presentation: The patient was a 29-year-old male with premature ejaculation. The physical examination was normal, and sensory testing with a biothesiometer revealed vibration perception threshold values of 5.3V for the glans, 4.1V for the frenulum, and 3.9V for the penile shaft. Under local anesthesia, hyaluronic acid filler was applied with the multiple puncture technique, 2 mL in total, 0.2 mL per injection. One day after the procedure, the patient referred with complaints of discoloration of the glans penis. The physical examination revealed blackening at the distal tip of the glans with a visible demarcation line. Hyaluronidase was applied for the treatment of glanular glans penis ischemia secondary to hyaluronic acid filler injection. A significant improvement in the glans penis color was observed after hyaluronidase injection. The patient was prescribed 100 mg of aspirin, a warm saline dressing, and a nitroglycerin-containing cream and was discharged for daily follow-up. Conclusion: Although vascular complications are rare after hyaluronic acid filling into the glans penis, early diagnosis and treatment are crucial. Patients should be informed about possible adverse events. The main treatment method for vascular complications is urgent hyaluronidase injection. In addition, prevention of clot propagation with oral aspirin and vasodilatation treatments should be applied. In the glans penis ischemia after hyaluronic acid injection, early diagnosis and immediate hyaluronidase administration can reverse ischemia without necrosis or surgical intervention. © 2025 Elsevier B.V., All rights reserved.
Model-Agnostic Search for Dijet Resonances with Anomalous Jet Substructure in Proton-Proton Collisions at S=13 TeV
(IOP Publishing Ltd, 2025) Chekhovsky, V.; Hayrapetyan, A.; Makarenko, V.; Tumasyan, A.; Adam, W.; Andrejkovic, J. W.; Kaur, A.
This paper presents a model-agnostic search for narrow resonances in the dijet final state in the mass range 1.8-6 TeV. The signal is assumed to produce jets with substructure atypical of jets initiated by light quarks or gluons, with minimal additional assumptions. Search regions are obtained by utilizing multivariate machine-learning methods to select jets with anomalous substructure. A collection of complementary anomaly detection methods-based on unsupervised, weakly supervised, and semisupervised algorithms-are used in order to maximize the sensitivity to unknown new physics signatures. These algorithms are applied to data corresponding to an integrated luminosity of 138 fb-1, recorded by the CMS experiment at the LHC, at a center-of-mass energy of 13 TeV. No significant excesses above background expectations are seen. Exclusion limits are derived on the production cross section of benchmark signal models varying in resonance mass, jet mass, and jet substructure. Many of these signatures have not been previously sought, making several of the limits reported on the corresponding benchmark models the first ever. When compared to benchmark inclusive and substructure-based search strategies, the anomaly detection methods are found to significantly enhance the sensitivity to a variety of models.

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