PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection

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Analysis of morphological parameters in pelvic radiography and hip MRI: A practical reporting recommendation
(ARSMB-KVBMG, 2021) Cicek,E.D.; Cevik,H.
Although numerous criteria have been proposed to define abnormal hip morphology, mostly used in the diagnosis of femoroacetabular impingement, it is not a practical approach to measure all of these parameters in all cases without clinical suspicion. In this study, our aim was to develop an evaluating and reporting standardization for routine hip examinations to define both hip morphology and impingement. A total of 108 patients with routine hip magnetic resonance imaging (MRI) and antero-posterior pelvic radiograph (PR) were included in this retrospective study. Alpha angle (AA), acetabular depth (AD), acetabular protrusion, acetabular anteversion, collodiaphyseal angle (CDA), lateral center-edge angle (LCEA) and Tönnis angle (TA) were measured. The differences and associations between these parameters were evaluated according to imaging modality or plane, and sex. Although a significant difference has been found between the axial AA and the coronal AA mean values measured on MRI, there was also a strong correlation. Coronal measurements were significantly higher. AA values measured in PR and coronal MRI were comparable. Males had higher AA in both planes as compared to females. There were no significant differences between CDA values in MRI and PR. There was a significant difference and a moderate correlation between AD values in MRI and PR. We suggest that routine reports should include a measurement of AA in two planes, and measurement of CDA in PR or MRI. Due to the difference in AD between MRI and radiography, LCEA or TA may represent better alternatives. Checking for a negative Tönnis sign would represent a practical approach. © 2021, Acta Orthopædica Belgica.
Anatomical and Morphometric Features of the Profunda Brachii Artery
(Medrang, 2024) Sanliturk, Yuesra Nur; Zeybek, Nursen; Gayretli, Ozcan; Ozturk, Adnan
When the literature is examined, studies evaluating the profunda brachii artery (PBA) are limited as most studies only investigate the artery's origin. In 44 upper extremities belonging to 24 human anatomical specimens, single and double PBAs were observed in 39 and five cases, respectively. In cases with a single PBA, the origin was the brachial artery (BA) in 35 cases and the posterior circumflex humeral artery in four cases. In cases with double PBAs, the artery's origin was the BA. Morphometric measurements of single and double arteries originating from the first branch BA were evaluated separately and compared according to sex and side. Our study, in which the PBA was examined morphologically and morphometrically, contributes to the literature anatomically and radiologically in treating humerus fractures and lateral arm-flap applications by surgeons.
The antidepressant-like effects of kisspeptin-10 are reversed by kisspeptin antagonist peptide 234 in male rats
(Cellular and Molecular Biology Association, 2024) Serhatlioglu, I.; Kacar, E.; Yardimci, A.; Ertugrul, N.U.; Bulmus, O.; Ercan, Z.; Kelestimur, H.
Kisspeptins are reported to be the most potent activators of the hypothalamus-pituitary-gonadal (HPG) axis known to date. Kisspeptin potently elicits gonadotropin-releasing hormone (GnRH) release and luteinizing hormone (LH) secretion, even in the pre-pubertal period. Beyond the hypothalamus, kisspeptin is also expressed in limbic and paralimbic brain regions, which are areas of the neurobiological network primarily implicated in emotional behaviors alongside sexual functions. Therefore, an increasing body of studies has implicated kisspeptin as having many influences on emotional behaviors. The study was set out to explore if the kisspeptin/GPR54 signaling system is required for the anti-depressant-like effect of kisspeptin-10 (KP-10), besides the regulation of the HPG axis. To test this concept, peptide 234 (P234), a kisspeptin antagonist, was given to the male rats, and its modulatory effect on the anti-depressant-like effects of kisspeptin was investigated by using a forced swimming test (FST). The study has also sought to know whether kisspeptin can exert its effects through adrenergic and serotonergic receptors. To investigate this, the agents yohimbine (Yoh), an alpha-2 adrenergic receptor antagonist, and cyproheptadine (Cry), a non-selective 5-HT2 serotonergic receptor antagonist, were administered in the experiments. Our results indicate that, in rats, the anti-depressant-like effects of KP-10 in a modified rat FST are mediated by GPR54 receptors since the kisspeptin antagonist peptide 234 reversed kisspeptin-induced anti-depressant-like effects. Our data also demonstrate that the antidepressant-like effects of kisspeptin, at least in part, are mediated by an interaction of the alpha-2 adrenergic and 5-HT2 serotonergic receptors. © 2024 Cellular and Molecular Biology Association. All rights reserved.
Assessment of IL-7RA T244I Polymorphism as a Risk Factor of Multiple Sclerosis in Turkish Population
(Turkish Neuropsychiatry Assoc-turk Noropsikiyatri dernegi, 2020) Unsal, Mirac Aysen; Manukyan, Nuket Yildiz; Isik, Nihal; Direskeneli, Guher Saruhan
Introduction: The T244I variant of the IL-7RA gene, rs6897932, is one of the first polymorphisms found to be associated with the development of multiple sclerosis (MS). Although several studies provided evidence for the association of MS and this variant, other studies could not confirm this result. These inconsistent results suggest that the role of this polymorphism in the development of disease is associated with ethnicity. Methods: We investigated rs6897932 polymorphisms in a large cohort of patients with MS and healthy controls in a turkish population. Results: In our study, there were no significant differences in genotype frequencies in the IL-7RA rs6897932 polymorphism and no significant difference between C and T alleles in patients with MS and controls. Conclusion: This study is the first to evaluate the risk of the rs6897932 polymorphism in turkish patients with MS.
Assessment of Stiffness-Dependent Autophagosome Formation and Apoptosis in Embryonal Rhabdomyosarcoma Tumor Cells
(2025) Sezen, S.; Adiguzel, S.; Zarepour, A.; Khosravi, A.; Gordon, J.W.; Ghavami, S.; Zarrabi, A.
Remodeling of the extracellular matrix (ECM) eventually causes the stiffening of tumors and changes to the microenvironment. The stiffening alters the biological processes in cancer cells due to altered signaling through cell surface receptors. Autophagy, a key catabolic process in normal and cancer cells, is thought to be involved in mechano-transduction and the level of autophagy is probably stiffness-dependent. Here, we provide a methodology to study the effect of matrix stiffness on autophagy in embryonal rhabdomyosarcoma cells. To mimic stiffness, we seeded cells on GelMA hydrogel matrices with defined stiffness and evaluated autophagy-related endpoints. We also evaluated autophagy-dependent pathways, apoptosis, and cell viability. Specifically, we utilized immunocytochemistry and confocal microscopy to track autophagosome formation through LC3 lipidation. This approach suggests that the use of GelMA hydrogels with defined stiffness represents a novel method to evaluate the role of autophagy in embryonal rhabdomyosarcoma and other cancer cells. © 2024. Springer Science+Business Media, LLC.
Can the development of lung fibrosis be prevented after COVID-19 infection?
(Termedia Publishing House Ltd, 2022) Kalemci, Serdar; Zeybek, Arife; Kargi, Ahmet Bulent
[No Abstract Available]
Clinical Features and Short-Term Outcomes of Bariatric Surgery in Morbidly Obese Patients: Institutional Experience at a Rural Hospital
(Mary Ann Liebert, inc, 2021) Senol, Kazim; Ferhatoglu, Murat Ferhat; Kocaeli, Aysen Akkurt; Dundar, Halit Ziya; Kaya, Ekrem
Objective: To prospectively evaluate the postoperative morbidity, mortality, and weight loss evolution of patients who underwent a bariatric procedure during 1 year of follow-up. Methods: Since July 2016, a total of 101 patients' data have been prospectively registered in a database. Comorbidities, operating time, hospital stay, early and late complications rate, and weight loss evolution after 1 year of follow-up were recorded. Results: The mean age was 38.41 +/- 11.05 years with a mean body mass index (BMI) of 49.02 +/- 5.89 kg/m(2) (range 38-67). Laparoscopic sleeve gastrectomy (LSG) was performed in 93 patients (92.07%) and Roux-en-Y gastric bypass (RNYGB) in 8 patients (7.92%). Thirty-day morbidity rate was 7.92% (8/101). Within a mean 9.32 +/- 2.25 (range 1-19) months follow-up time, mean percent of the excess of weight loss of 1st, 6th, and 12th months were 22.7 +/- 6.1, 67.2 +/- 11.2, and 81.4 +/- 10.5, respectively. Diabetes (n = 38, 37.6%), hypertension (n = 13, 12.9%), and obstructive sleep apnea (n = 5, 4.9%) were resolved in 76%, 68.4%, and 100% of the patients, respectively (p < 0.001). Conclusions: LSG and RNYGB are safe and highly effective, particularly in patients with a BMI >50 kg/m(2). Both techniques have been presented with better clinical outcomes regarding significant comorbidity resolution in the early evolution of weight loss.
Clinical impact of depression and anxiety in patients with non-cystic fibrosis bronchiectasis
(Turkish Assoc Tuberculosis & Thorax, 2020) Bekir, Melahat; Kocakaya, Derya; Balcan, Baran; Olgun Yildizeli, Sehnaz; Eryuksel, Emel; Ceyhan, Berrin
Introduction: Bronchiectasis is a chronic suppurative disease characterized by abnormal bronchial dilatation. The nature of bronchiectasis may have negative impact on psychological status, however it is poorly studied in relation to clinical indices, particularly the severity of disease. Primary aim of this study is to detect depression and anxiety in patients with non-cystic fibrosis bronchiectasis and to evaluate its relationship with disease severity indexes. Materials and Methods: Ninety (male/female= 37/53; median age 45 years) stable non-cystic fibrosis bronchiectatic adult patients were enrolled into this study. Dyspnea scores, number of exacerbations and hospital admissions within the last year, body-mass index, pulmonary function tests, sputum cultures, bronchiectasis disease severity indexes (BSI and FACED) were assessed. Anxiety and depression were evaluated by using the Turkish version of the hospital anxiety and depression scale questionaire. Results: Anxiety was diagnosed in 30% of patients and depression was diagnosed in 41% of the participants. Female participants had significantly higher rates of depression (55% vs. 22%; p= 0.002). Exacerbation rates within the last year were higher among the subjects with anxiety, moreover, patients with depression had shorter duration of disease. 851 and FACED severity indexes increased with longer duration of disease (5.6 +/- 5.0 yrs in mild group vs. 10.1 +/- 9.2 yrs in moderate-to-severe group, p= 0.035 and 5.7 +/- 5.4 yrs in mild group vs. 12.1 +/- 9.7 yrs in moderate-to-severe group, p= 0.001, respectively), however, anxiety and depression were not related with BSI and FACED severity indexes. Conclusion: Patients with non-cystic fibrosis bronchiectasis have an increased risk for depression and anxiety. Duration of disease and higher exacerbation rate are related with psychological status and indexes increased with longer duration of disease. Lady detection and taking the necessary measures to improve the psychological state is necessary for the overall management of these patients.
Comparison of percutaneous access and open femoral cutdown in elective endovascular aortic repair of abdominal aortic aneurysms
(Baycinar Medical Publ-baycinar Tibbi Yayincilik, 2022) Akbulut, Mustafa; Ak, Adnan; Arslan, Ozgur; Akardere, Omer Faruk; Karakoc, Ayse Zehra; Gume, Serkan; Tuncer, Mehmet Altug
Background: The aim of this study was to compare postoperative outcomes of percutaneous access and femoral cutdown methods for elective bifurcated endovascular abdominal aortic aneurysm repair. Methods: Between November 2013 and September 2020, a total of 152 patient (135 males, 17 females; mean age: 70.6 +/- 6, range, 57 to 87 years) who underwent endovascular repair due to infrarenal abdominal aortic aneurysm were retrospectively analyzed. According to femoral access type, the patients were grouped into two groups as the total percutaneous femoral access and open cutdown femoral access endovascular repair. Intra-and postoperative data were compared, including operative time, amount of contrast media, bleeding requiring transfusion, return to the operating room, access vessel complications, wound complications, and overall length of hospital stay. Results: Eighty-seven (57.2%) femoral cutdown access repair and 65 (42.8%) percutaneous femoral access repair cases were evaluated in the study. The two groups were comparable in terms of demographic and clinical characteristics (p>0.05), except for chronic obstructive pulmonary disease which was more frequent in the percutaneous access group (p=0.014). After adjustment, age, diabetes mellitus, chronic obstructive pulmonary disease, and obesity were not predictive of percutaneous access failure. Percutaneous femoral access was observed as the only preventing factor for wound infection (odds ratio=0.166, 95% confidence interval: 0.036-0.756; p=0.021). Conclusion: Although femoral access preference does not affect mortality and re-intervention rates, percutaneous endovascular repair reduces operation time, hospital stay, and wound site complications compared to femoral artery exposures.
DIAGNOSIS AND TREATMENT OF RETAINED WOODEN FOREIGN BODIES IN THE EXTREMITIES USING ULTRASOUND
(Atha Comunicacao & Editora, 2018) Polat, Baris; Atici, Yunus; Gurpinar, Tahsin; Polat, Ayse Esin; Karaguven, Dogac; Benli, Ismet Teoman
Objective: This study investigates ultrasonography as an effective tool for localizing and measuring the depth and size of wooden foreign bodies to perform less invasive and easier surgery without the need for any additional radiological techniques. Methods: Fifteen patients were operated to remove foreign bodies in the extremities in 2016. The side of the affected extremity, the material, size, and location of the foreign body and time of admission after injury were noted, along with CRP, WBC, and erythrocyte sedimentation rate; length of incision, surgery duration, and complications were evaluated. Results: The mean patient age was 39.66 (range: 6 to 68). Of the total, 8 of the foreign bodies were in the plantar surfaces of the feet, 3 were in the cruris, 2 were in the palm of the hand, and 2 were in the fingers. All patients underwent ultrasound evaluation before surgery. The surgeries lasted less than 10 min in 13 (87%) of the cases and from 10 to 20 min in 2 cases. No complications were observed in any of the patients. Conclusion: Delayed extraction of foreign bodies can lead to local infections. Ultrasonography can be a reliable option for diagnosing and localizing radiolucent foreign bodies such as wooden objects.
The Effect of Whole Body Vibration Treatment on Balance and Gait in Patients with Stroke
(Turkish Neuropsychiatry Assoc-turk Noropsikiyatri dernegi, 2020) Sade, Ilgin; Cekmece, Cigdem; Inanir, Murat; Selcuk, Barin; Dursun, Nigar; Dursun, Erbil
Introduction: In patients with neurological disorders Whole Body Vibration (WBV) has been reported to improve motor function. Our aim was to assess the effects of WBV on both balance and walking performance in adult stroke patients. Methods: Forty three post-stroke patients were randomly divided into two groups. One would receive WBV therapy (WBV group) while the control group would not. All patients participated in a conventional rehabilitation program for three weeks while the vibration group also received WBV over the same period. Patients balance and walking performance were evaluated using the Berg Balance Scale (BBS), Timed Up and Go Test (TUG) and computerized gait analysis. All evaluations were performed before and after therapy. Results: The median (range) age of all patients was 51.00 (18-66) years. The groups numbered 26 and 17 patients for the WBV and control groups respectively. After intervention, significant improvements were found in the WBV group for BBS score (p=0.004), TUG score (p=0.035), step length (p=0.004) and walking speed (p=0.031) when compared to the controls. Conclusion: WBV is effective for the improvement of balance and gait performance in stroke patients.
Effectiveness of artificial neochordae implantation in tricuspid valve repair
(Texas Heart Institute, 2019) Salihi,S.; Kiziltan,H.T.; Huraibat,A.; Korkmaz,A.A.; Kara,I.; Guden,M.
Various techniques for treating tricuspid regurgitation have been described; however, because of scarce data about the long-term outcomes of different repairs, the optimal technique has not been established. We evaluated the effectiveness and durability of artificial neochordae implantation in the treatment of tricuspid regurgitation. From 2009 through 2014, 507 patients underwent tricuspid valve repair at our institution. Of those, 48 patients implanted with artificial neochordae were included in our study. The median age of the participants was 62 years (range, 4–77 yr) and 50% were women. Thirty patients (63%) were in New York Heart Association functional class III, and 11 (23%) were in class II. The cause of tricuspid regurgitation was functional in 33 patients (69%) and rheumatic in 15 (31%). In 46 patients, neochordae implantation was performed in addition to Kay annuloplasty (n=13) or ring annuloplasty (n=33). Forty-two patients were discharged from the hospital with absent or mild tricuspid regurgitation. The mean follow-up period was 44.3 ± 20.2 months. Follow-up echocardiograms revealed that tricuspid regurgitation was absent, minimal, or mild in 38 patients (80.8%), moderate in 7, and severe in 2. Our results indicate that the use of artificial neochordae implantation as an adjunct procedure to annuloplasty leads to effective and durable repair in comparison with conventional techniques for treating tricuspid regurgitation. Various techniques for treating tricuspid regurgitation have been described; however, because of scarce data about the long-term outcomes of different repairs, the optimal technique has not been established. We evaluated the effectiveness and durability of artificial neochordae implantation in the treatment of tricuspid regurgitation. From 2009 through 2014, 507 patients underwent tricuspid valve repair at our institution. Of those, 48 patients implanted with artificial neochordae were included in our study. The median age of the participants was 62 years (range, 4–77 yr) and 50% were women. Thirty patients (63%) were in New York Heart Association functional class III, and 11 (23%) were in class II. The cause of tricuspid regurgitation was functional in 33 patients (69%) and rheumatic in 15 (31%). In 46 patients, neochordae implantation was performed in addition to Kay annuloplasty (n=13) or ring annuloplasty (n=33). Forty-two patients were discharged from the hospital with absent or mild tricuspid regurgitation. The mean follow-up period was 44.3 ± 20.2 months. Follow-up echocardiograms revealed that tricuspid regurgitation was absent, minimal, or mild in 38 patients (80.8%), moderate in 7, and severe in 2. Our results indicate that the use of artificial neochordae implantation as an adjunct procedure to annuloplasty leads to effective and durable repair in comparison with conventional techniques for treating tricuspid regurgitation. © 2019 by the Texas Heart ® Institute, Houston.
The Effects of Bundles on Catheter-Associated Urinary Tract Infections in the Pediatric Intensive Care Unit
(Lippincott Williams & Wilkins, 2016) Duzkaya, Duygu Sonmez; Bozkurt, Gulcin; Uysal, Gulzade; Yakut, Tulay
Background: There are few studies in the literature from developing countries regarding the rates of catheter-associated urinary tract infection (CAUTI), which is frequently encountered in pediatric intensive care units (PICUs). Aim: The aim of this study is to evaluate the 2-year rates of CAUTI in a PICU where a CAUTI Prevention Bundle was implemented. Design: This was an interventional prospective study. Methods: The study was conducted with 390 patients in the PICU of Istanbul Faculty of Medicine, Turkey, from July 2013 to July 2015. The patients were selected based on the diagnostic criteria of the Centers for Disease Control and Prevention. Results: Urinary colonization occurred in 8 (2.2%) patients in the prebundle group and 3 (0.8%) patients in the postbundle group, and contamination occurred in 10 (2.8%) patients in the prebundle group and 6 (1.5%) patients in the postbundle group. The CAUTI incidence and rates were 5.8% and 6.1 per 1000 urinary catheter days and 1.5% and 1.8 per 1000 urinary catheter days prebundle and postbundle, respectively. There was a statistically significant difference between the prebundle and postbundle CAUTI rates. Conclusion: Our findings support that clinical nurse specialists in developing countries should consider the use of CAUTI bundles to prevent CAUTIs.
Evaluation of a School-Based Program for Internet Addiction of Adolescents in Turkey
(Lippincott Williams & Wilkins, 2018) Uysal, Gulzade; Balci, Serap
This study aimed to evaluate a school-based program for Internet addiction, the Healthy Internet Use Program, with adolescents in Turkey. Forty-one students were included in the intervention group, and the control group was composed of 43 students. All students were from two primary schools. Students in the intervention group participated in the Healthy Internet Use Program, which was developed in accordance with the literature. The intervention group was given eight training sessions over a 3-month period, and their parents were given two training and consultancy sessions. Data were collected using a data collection form and the Internet Addiction Scale. The third evaluation of the Internet Addiction Scale scores showed a significant difference between the intervention group and the control group (p < .05). The fourth evaluation of the Internet Addiction Scale points showed a highly significant difference between the two groups (p < .001). The findings suggest that use of the Healthy Internet Use Program decreases the rate of Internet addiction among adolescents.
Evaluation of frequency of nausea and vomiting as well as depression level in pregnant women
(I R O G Canada, inc, 2016) Sahin, S.; Ozdemir, K.; Unsal, A.; Cevrioglu, A. S.; Beydag, K. D.
Objective: To determine the frequency of nausea and vomiting in pregnant (NVP) women, review associated factors, and evaluate the depression level. Materials and Methods: The study is a cross-sectional research conducted in pregnant women who applied to Sakarya Training and Research Hospital and Sakarya Maternity and Children Hospital between January 13, 2013 and March 23, 2013. The study group consisted of 606 pregnant women who were below 20 weeks gestation and agreed to take part in the study. The questionnaire form prepared in line with the study objective was completed by the pregnant women under supervision. The women who had a complaint of nausea and vomiting at least once a day during their pregnancy were deemed as "having a history of nausea and vomiting". Rhodes index was used to evaluate the severity of nausea and vomiting. Depression level was evaluated with the Beck Depression Inventory. Chi-square test and Spearman's Correlation Analysis were used to analyze the data. Statistical significance value was accepted asp < 0.05. Results: The age of pregnant women in the study group ranged from 17 to 39 years (mean age: 25.55 +/- 4.95). The frequency of having nausea and vomiting in the pregnant women was determined to be 35.1% (n = 213). The frequency of having nausea and vomiting was determined to be higher in those with a nuclear family, working women, those with a poor family income, those who used any contraception method before the pregnancy, and those who had a history of nausea and vomiting in their previous pregnancy(ies) (p < 0.05 for each). The pregnant women with a history of nausea and vomiting reported that their complaints increased the most with the smell of food as well as perfume/cigarette/body odor. In the women with a history of nausea and vomiting, frequency of depression was significantly higher (p < 0.05). A positive relationship was found between the severity of nausea and vomiting and depression level (p < 0.05). Conclusions: Nausea and vomiting were determined to be a major health problem in pregnancy. Depression frequency was higher in those with a history of nausea and history. The severity of nausea and vomiting increased with higher depression levels. More detailed studies are required to determine the causes of NVP as well as the risk factors.
Extreme Appraisals of Internal States and Duration of Remission in Remitted Bipolar Patients
(Aves, 2015) Tosun, Ahmet; Mackali, Zeynep; Cagin Tosun, Ozlem; Kapucu Eryar, Aycan; Mansell, Warren
Introduction: To identify dysfunctional attitudes seen in bipolar disorder (BPD) is important for the cognitive theories of BPD and corresponding psychosocial interventions. Cognitions are seen as vulnerability factors in the development and maintenance of BPD. The present study aims to contribute to the cognitive literature on BPD by examining depressive and hypomanic attitudes and their contribution to the prediction of BPD diagnosis as well as by exploring the relationship between dysfunctional cognitions and clinical features (types of episodes experienced, duration of illness, and duration of remission). Methods: One hundred and eighteen remitted bipolar patients and 103 healthy controls completed the Mood Disorder Questionnaire (MDQ), Turkish Brief-Hypomanic Interpretations and Positive Predictions Inventory (HAPPI), and Dysfunctional Attitudes Scale. Results: The bipolar group had significantly higher depressive and hypomanic attitudes than the control group. No significant differences were found regarding the types of episodes experienced and duration of illness. However, both types of attitudes decreased as the duration of remission increased. They were also found to contribute to the prediction of bipolar diagnosis together with the screening of the MDQ. Conclusion: The results pointed out that dysfunctional cognitions may be utilized as possible indicators for the risk of relapse in clinical groups and vulnerability for BPD among other populations.
The value of parathyroid scintigraphy on lesion detection in patients with normocalcemic primary hyperparathyroidism
(Elsevier Espana Slu, 2020) Gungor, S.; Dede, F.; Can, B.; Keskin, H.; Aras, M.; Ones, T.; Turoglu, H. T.
Objective: Primary hyperparathyroidism (PHPT) is one of the most frequent endocrine diseases. Most of the patients with PHPT are asymptomatic, and only 20% of them become symptomatic with increasing levels of calcium. It has been reported that normocalcemic primary hyperparathyroidism (NPHPT) may be the incipient period of PHPT where calcium (Ca) levels are in normal range, and it may advance to overt PHPT. Early diagnosis of PHPT is important in order to prevent its complications. In this retrospective study, we aimed to evaluate the role of 99mTc-MIBI parathyroid scintigraphy on lesion detection in patients with NPHPT.& nbsp;Material and methods: The parathyroid scintigraphy database was reviewed retrospectively in patients with PHPT. 117 patients who underwent 99mTc-MIBI scintigraphy were recruited to the study. Serum calcium level above 10.5 mg/dl was considered as hypercalcemia.& nbsp;Results: A total of 117 patients' (female/male:98/19) mean serum PTH levels (mean & PLUSMN;SD) were 149 +/- 97 pg/ml in normocalcemic group (Ca:9.6 +/- 0.6 mg/dL, n:38) and 189 +/- 135 pg/ml in hypercalcemic group (Ca:11.4 +/- 0.6 mg/dL, n:79) (p:0.072). The sex and ages were not different between the scintigraphy positive and negative groups, but the lesion detection rates with parathyroid scintigraphy were 42% in normocalcemic group and 81% in hypercalcemic group (p < 0.0001).& nbsp;Conclusions: Several factors including serum Ca, the imaging protocol, existence of multiglandular disease, the size and MIBI biokinetics of the adenoma may influence lesion detectability in parathyroid scinti-graphy. Although high serum Ca level is an important parameter in predicting its success, parathyroid scintigraphy remains a valuable diagnostic method even in patients with NPHPT. (C)& nbsp;2020 Sociedad Espanola de Medicina Nuclear e Imagen Molecular. Published by Elsevier Espa na, S.L.U. All rights reserved.
Potentially Inappropriate Medication Use in Older People: A Crosssectional Study Using Beers Criteria
(Bentham Science Publ, 2022) Yuksel, Gulsum Hatice; Ozaydin, Fuat Nihat; Ozaydin, Ayse Nilufer
Background: The use of Potentially Inappropriate Medications (PIMs) is common and negatively affects elderly health and disease prognosis. Objective: This study aims to analyze the frequency of PIMs in the elderly health records registered to a family health center and to identify risk factors, prescription/nonprescription distribution, distribution by healthcare institutions, number of doctors visits, and health literacy. Methods: In this cross-sectional study, a stratified sampling method was used to select individuals aged >= 65 years. The health records of the participants up to the last 12 months were examined, and medicines used by participants were evaluated according to Beers 2019 criteria. Results: Most of the participants (89.7%, n:183) had PIMs in health records. The mean number of PIMs used by the elderly was 2.9 +/- 1.9 (min:0, max:8). A positive linear relationship was observed between multimorbidity and the number of PIMs (p=0.001). There was no significant difference in terms of PIMs frequency among healthcare institutions. Prescription and non-prescription PIMs were found to belong to the same drug groups (Pain relievers and stomach medications). A linear and significant correlation was found between the number of PIMs and doctor visits (p=0.047). Conclusion: The doctor should examine prescription and over-the-counter medications used by the elderly during the visit. It will be useful to establish a warning system stating that PIMs are available while registering the medications in the electronic system. So, it will be possible for health authorities to re-evaluate the treatment and replace PIMs with rational drug options.
Repair of residual aortic dissections with frozen elephant trunk technique
(Baycinar Medical Publ-baycinar Tibbi Yayincilik, 2020) Akbulut, Mustafa; Ak, Adnan; Tas, Serpil; Arslan, Ozgur; Antal, Arzu; Cekmecelioglu, Davut; Tuncer, Altug
Background: In this study, we present our mid-term results of reoperation with the frozen elephant trunk procedure due to patent false lumen-related complications in patients previously undergoing supracoronary aortic repair for acute type A aortic dissection. Methods: Between January 2013 and September 2018, a total of 23 patients (17 males, 6 females; mean age 51.5 +/- 9.7 years; range, 30 to 67 years) who underwent ascending aortic replacement due to type A aortic dissection and, later, frozen elephant trunk procedure for residual distal dissection were included. For diagnostic purposes and follow-up, computed tomography angiography was performed in all patients, and both re-entry and aortic diameters were evaluated. Echocardiography was used to evaluate cardiac function and valve pathologies. Results: The Ishimaru zone 0 (n=11, 47.8%), Ishimaru zone 1 (n=1, 4.3%), Ishimaru zone 2 (n=4, 17.4%), and Ishimaru zone 3 (n=7, 30.4%) were used for frozen elephant trunk stent graft fixation. The mean duration of cardiopulmonary bypass and antegrade selective cerebral perfusion was 223.9 +/- 71.2 min and 88.9 +/- 60.3 min, respectively. In-hospital mortality was 13%, while there was one (4.3%) aortic-related death and four (17.4%) re-interventions during follow-up. Conclusion: Early repair should be considered in the presence of persistent dissections due to alarmingly high mortality rates of reoperations. Reoperation with the frozen elephant trunk procedure has acceptable results and the decision of the procedure to be performed should be based on preoperative risk factors of the patient.
SARS-CoV-2 reinfection in patients with a history of MIS-C. Presentation of two cases
(Soc Argentina Pediatria, 2023) Soysal, Ahmet; Topcu, Burcu; Atici, Serkan; Gonullu, Erdem; Oner, Cevat N.
Pediatric multisystem inflammatory syndrome (MIS-C) is a rare disease. It is unknown whether children who have recovered from MIS-C are at risk of MIS-C recurrence when reinfected with SARS-CoV-2. The objective of this study is to describe the cases of two girls who recovered from MIS-C and presented reinfection with SARS-CoV-2 without recurrence of MIS-C.

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