WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14517/18

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Citation Count: 0
A 3-year-old child with multi-drug resistant epilepsy responding to pharmacological and nonpharmacological treatments
(Taylor & Francis Ltd, 2023) Coskun, Yesim; Yildirim, Canan
Introduction: Despite the development of new antiseizure drugs (ASDs), around one third of epilepsy patients become refractory to treatment or experience adverse events due to ASDs. Therefore, discovery of new ASDs and new therapy options are crucial to improve the quality of life. Herein, we report a 3-year-old child with multi-drug resistant epilepsy caused by perinatal asphyxia whose seizures were reduced by 90% after the introduction of ketogenic diet, vagal nerve stimulation (VNS) AspireSR (SR-seizure response) and oral cannabidiol.Case presentation: A 9-month-old female infant had a history of multidrug resistant epilepsy due to perinatal asphyxia. At admission, she was experiencing up to 20-25 seizures per day lasting for 2-3 minutes. In addition to antiseizure drugs (ASDs), she was put on ketogenic diet (KD), vagal nerve stimulation (VNS) aspire seizure response (AspireSR) was inserted and oral cannabidiol (CBD) was started sequentially. Using pharmacological and nonph armacological therapies, her seizures have been reduced by 90%.Conclusion: The concurrent use of pharmacological and nonpharmacological therapies may be beneficial to improve seizures in infants with multi- Furthermore, our patient is the youngest child inserted VNS AspireSR in Turkey.
Citation Count: 4
Abstract Differential Equations with VMO Coefficients in Half Space and Applications
(Springer Basel Ag, 2016) Shakhmurov, Veli
In this paper, L (p) -separability properties of boundary value problems for elliptic and parabolic differential-operator equations with VMO coefficients are studied in half plane. In application, the maximal regularity properties of the anisotropic elliptic equation and system of equations with VMO coefficients are derived.
Citation Count: 2
Abstract elliptic operators appearing in atmospheric dispersion
(Springeropen, 2014) Shakhmurov, Veli B.; Sahmurova, Aida
In this paper, the boundary value problem for the differential-operator equation with principal variable coefficients is studied. Several conditions for the separability and regularity in abstract L-p-spaces are given. Moreover, sharp uniform estimates for the resolvent of the corresponding elliptic differential operator are shown. It is implies that this operator is positive and also is a generator of an analytic semigroup. Then the existence and uniqueness of maximal regular solution to nonlinear abstract parabolic problem is derived. In an application, maximal regularity properties of the abstract parabolic equation with variable coefficients and systems of parabolic equations are derived in mixed L-p-spaces.
Citation Count: 0
Abstract elliptic operators appearing in atmospheric dispersion (vol 2014, pg 43, 2014)
(Springer international Publishing Ag, 2014) Shakhmurov, Veli B.; Sahmurova, Aida
[No Abstract Available]
Citation Count: 0
Academic Vocabulary in Learner Writing: From Extraction to Analysis
(Sage Publications Ltd, 2011) Yigitoglu, Nur
[No Abstract Available]
Citation Count: 11
Accuracy of Digital Impressions Obtained Using Six Intraoral Scanners in Partially Edentulous Dentitions and the Effect of Scanning Sequence
(Quintessence Publishing Co inc, 2021) Diker, Burcu; Tak, Onjen
Purpose: To compare the accuracy of six intraoral scanners in two different partially edentulous maxillary models and to evaluate the effect of scanning sequence on accuracy. Materials and Methods: Maxillary Kennedy Class I and Class IV situations were used as reference models. The reference datasets were obtained by scanning the models using a highly accurate industrial scanner (ATOS Core 80, GOM). The following six intraoral scanners were evaluated: Trios 3 (3Shape), iTero Element 2 (Align Technology), Emerald (Planmeca), CEREC Omnicam (Dentsply Sirona), CEREC Primescan (Dentsply Sirona), and Virtuo Vivo (Dental Wings). A total of 120 scans from both models were obtained using the six intraoral scanners and divided into two groups based on scanning sequence. Accuracy was evaluated by deviation analysis using 3D image processing software (Geomagic Studio 12, 3D Systems). Kruskal Wallis and Mann-Whitney U tests were performed (P <= .05) for statistical analysis. Results: There were significant differences in the accuracy of digital impressions among intraoral scanners and scanning sequences. The trueness of the Trios scanner and the precision of the Trios, Primescan, and iTero scanners were significantly higher than for the other scanners. The Emerald had the lowest accuracy among the six intraoral scanners tested. Accuracy was affected by scanning sequence when using the Virtuo Vivo, Emerald, Primescan, and iTero. Conclusion: In Kennedy Class I and Class IV partially edentulous cases, it is useful to consider that the intraoral scanner used may affect the accuracy of the digital impression.
Citation Count: 6
The Acute Effects of Different Intensity Whole-Body Vibration Exposure on Muscle Tone and Strength of the Lower Legs, and Hamstring Flexibility: A Pilot Study
(Human Kinetics Publ inc, 2021) Saldiran, Tulay Cevik; Atici, Emine; Rezaei, Derya Azim; Ozturk, Ozgul; Uslu, Burcu; Ozcan, Burcu Ates; Okudan, Begum; Fizyoterapi ve Rehabilitasyon / Physiotherapy and Rehabilitation
Context: The research on the change in properties of the lower leg muscles by different intensity sinusoidal vertical whole-body vibration (SV-WBV) exposures has not yet been investigated. Objective: The purpose of this study was to determine effect of a 20-minute different intensity SV-WBV application to the ankle plantar flexor and dorsiflexor muscles properties and hamstring flexibility. Design: Prospective preintervention-postintervention design. Setting: Physiotherapy department. Participants: A total of 50 recreationally active college-aged individuals with no history of a lower leg injury volunteered. Interventions: The SV-WBV was applied throughout the session with an amplitude of 2 to 4 mm and a frequency of 25 Hz in moderate-intensity vibration group and 40 Hz in a vigorous-intensity vibration group. Main Outcome Measures: The gastrocnemius and tibialis anterior muscle tone was assessed with MyotonPRO, and the strength evaluation was made on the same lower kg muscles using hand-held dynamometer. The sit and reach test was used for the lower leg flexibility evaluation. Results: The gastrocnemius muscle tone decreased on the right side (d = 0.643, P = .01) and increased on the left (d = 0.593, P = .04) when vigorous-intensity vibration was applied. Bilateral gastrocnemius muscle strength did not change in both groups (P> .05). Without differences between groups, bilateral tibialis anterior muscle strength increased in both groups (P < .01). Bilateral gastrocnemius and tibialis anterior muscle tone did not change in the moderate-intensity vibration group (P> .05). Flexibility increased in both groups (P < .01); however, there was no statistically significant difference between the groups (d = 0.169, P = .55). Conclusions: According to study results, if SV-WBV is to be used in hamstring flexibility or ankle dorsiflexor muscle strengthening, both vibration exposures should be preferred. Different vibration programs could be proposed to increase ankle plantar flexor muscle strength in the acute results. Vigorous-intensity vibration exposure is effective in altering ankle plantar flexor muscle tone, but it is important to be aware of the differences between the lower legs.
Citation Count: 0
Addressing urinary incontinence by gender: a nationwide population-based study in Turkiye
(Bmc, 2023) Yavuz, Melike; Etiler, Nilay
BackgroundUrinary incontinence (UI), which usually occurs in women but affects both sexes, is a significant public health challenge. This study aims to comprehensively investigate the prevalence and determinants of UI in men and women, considering gender-specific factors.MethodsThe study performed a secondary analysis on data obtained from 13,383 individuals surveyed in the 2019 Turkish Health Survey, providing a representation of the Turkish population. The dataset included sociodemographic and health-related variables like UI, body mass index (BMI), physical activity, smoking, and chronic diseases-statistical analysis employed chi-square tests and gender-stratified logistic regression models to identify UI-associated factors.ResultsOur results showed that UI affected 8.8% of the population, with a striking gender disparity. Women had a notably higher prevalence at 11.2%, while men had a lower rate of 5.5%. Importantly, this gender gap narrowed with age. For example, in the 34-44 age group, the female/male ratio was 6.9, but it decreased to 1.4 in the 65-74 age group. Marital status and employment status played significant roles. Separated, divorced, or widowed individuals, particularly women, had the highest prevalence at 19.3%. Employment status influenced UI prevalence, with employed men having the lowest rate (2.1%), while retired women faced the highest rate (15.0%). Higher BMI, especially in obese individuals, significantly raised UI prevalence, reaching 7.9% for men and 15.8% for women. Physical inactivity, notably in women (17.0%), and prolonged sedentary hours (13.9%) were associated with higher UI rates. Former smokers, especially women (15.9%), had a notable impact on UI. Poor perceived health and chronic conditions like Chronic Obstructive Pulmonary Disease (COPD), hypertension, and diabetes were significantly associated with higher UI prevalence. Logistic regression analysis revealed that age, education, perceived health status, COPD, and diabetes were significant factors associated with UI in both sexes, while in women, BMI, physical activity, and smoking also played notable roles.ConclusionsThis extensive UI study has unveiled notable gender disparities and determinants. Notably, these disparities decrease with age, underlining UI's changing nature over time. Modifiable factors impact women more, while non-modifiable factors are linked to men. The study underscores the importance of tailoring healthcare strategies to address UI based on gender.
Citation Count: 2
Adhesion of conventional and self-adhesive resin cements to indirect resin composite using different surface conditioning methods
(Taylor & Francis Ltd, 2017) Cilingir, Aylin; Bilhan, Hakan; Cilingir, Altug; Gomec, Yavuz; Ozcan, Mutlu
This study evaluated the adhesion of conventional and self-adhesive resin cements to indirect resin composite (IRC) using different surface conditioning methods. Cylindrical IRC specimens (N=192) were randomly assigned to four surface conditioning methods (n=8 per group): (a) Control group, (b) Hydrofluoric acid, (c) Tribochemical silica-coating, and (d) 50m Al2O3 air-abrasion. Specimen surfaces were finished using silicon carbide papers up to 600 grit under water irrigation, rinsed and dried. Direct composite blocks were bonded to IRC specimens using three conventional resin cements (Multilink, Panavia F2.0, and Resicem) and three self-adhesive resin cements (RelyX U100, Gcem, Speed Cem). Specimens were subjected to shear bond strength test in a Universal Testing Machine (0.5mm/min). Failure types were categorized as mixed, adhesive and cohesive. Data were analyzed using 2-way ANOVA and Tukey's tests. Two-parameter Weibull modulus, scale (m) and shape (0) were calculated. The bond strength results (MPa) were significantly affected by the surface conditioning method (p<0.0001) and cement type (p<0.001). For Panavia F2.0, Resicem, air-abrasion with 50m Al2O3 significantly increased the results (22.6 +/- 6.5, 26.2 +/- 6.5, respectively) compared to other conditioning methods (13.6 +/- 1.4-21.9 +/- 3.1) but for Multilink, hydrofluoric acid etching (20.5 +/- 3.5) showed significantly higher results (p<0.01). For the self-adhesive resin cements, air-abrasion with 50m Al2O3 significantly increased the results compared to other conditioning methods, except for RelyX U100 (p<0.05). After air-abrasion with Al2O3, Gcem, (11.64), RelyX U100 (9.05), and SpeedCem (8.29) presented higher Weilbul moduli. Exclusively cohesive failure in the IRC was observed with RelyX U100 and Speedcem after Al2O3 air-abrasion.
Citation Count: 1
Advancing dentistry: fractal assessment of bone health in pediatric patients with celiac disease using dental images
(Quintessence Publishing Co inc, 2023) Bulut, Muge; Tokuc, Muge; Aydin, Merve Nur; Civan, Hasret Ayyildiz; Polat, Esra; Dogan, Guzide; Beser, Omer Faruk; Pedodonti / Pedodontic
Objectives: To assess the effects of a gluten-free diet on bone structure in children with celiac disease using fractal analysis on panoramic radiographs. Method and materials: A total of 49 patients with celiac disease aged 6 to 13 years, separated into two groups as previously and newly diagnosed, and a control group of 32 healthy individuals were evaluated. In previously and newly diagnosed patients with celiac disease, body mass index Z-scores were calculated, calcium, alkaline phosphatase, vitamin D3, and parathormone levels were measured, and bone mineral density Z-scores were obtained from dual energy x-ray absorpti-ometry. In all patients, the fractal dimensions of the right and left temporomandibular condyles were evaluated with the fractal analysis method on panoramic radiographs. Results: The mean values of serum biomarker levels and the body mass index and bone mineral density Z-scores for both celiac groups were within the normal reference range. No statistically significant difference was determined between right and left condyle fractal dimen-sions values in the three groups examined. In terms of both right and left condyle fractal dimensions values, there was a statis-tically significant difference between groups. The highest fractal dimensions values were determined in the previously diagnosed group. Conclusions: Differences in fractal dimensions values were observed among patients with celiac disease following the glu-ten-free diet. Utilizing fractal analysis on panoramic radiographs can prove valuable for dental practitioners in evaluating bone min-eral density due to its cost-effect iveness, easy accessibility, and reduced radiation exposure for patients, enabling them to provide comprehensive oral health care and potential early interventions for patients with celiac disease. (Quintessence Int 2023;54: 822-831; doi:
Citation Count: 9
AFFORDANCES OF HISTORIC URBAN LANDSCAPES: AN ECOLOGICAL UNDERSTANDING OF HUMAN INTERACTION WITH THE PAST
(Lodz Univ Press, 2014) Alves, Susana
Heritage has been defined differently in European contexts. Despite differences, a common challenge for historic urban landscape management is the integration of tangible and intangible heritage. Integration demands an active view of perception and human-landscape interaction where intangible values are linked to specific places and meanings are attached to particular cultural practices and socio-spatial organisation. Tangible and intangible values can be examined as part of a system of affordances (potentialities) a place, artefact or cultural practice has to offer. This paper discusses how an 'affordance analysis' may serve as a useful tool for the management of historic urban landscapes.
Citation Count: 8
Aging Changes of the Superficial Fat Compartments of the Midface Over Time: A Magnetic Resonance Imaging Study
(Lippincott Williams & Wilkins, 2020) Cenkeri, Halime Cevik; Guduk, Sukran Sarigul; Cicek, Esin Derin
BACKGROUND Studies involving superficial facial fat compartments are few in number with conflicting results. Most of them involved small study groups and compared measurements between different populations of young and old subjects either on cadavers or living subjects. OBJECTIVE To clarify volumetric and dimensional changes in midfacial superficial fat compartment retrospectively in patients who underwent a repeat magnetic resonance imaging (MRI) without gross pathology. MATERIALS AND METHODS A total of 70 patients with a mean age of 60 years (range: 33-82 years) and a median elapsed time of 44.5 months (range: 32-64 months) between 2 MRIs were included. Magnetic resonance imaging scans were analyzed in the axial and sagittal planes to obtain measurements of the medial part of the superficial cheek fat. Superficial cheek fat was divided into 3 compartments. Thickness, width, and height were measured, and volumes were calculated for each compartment on both hemifaces. RESULTS Volume and thickness were decreased significantly in all compartments (p < .05). The width was decreased in superior and middle compartments, whereas increased in lower compartment indicating dislocation of the fat tissue (p < .05). Height was also significantly increased (p < .05). A subgroup analysis has shown that there was no significant difference between men and women. CONCLUSION This study clarifies that aging is associated with a significant decrease in superficial midfacial fat tissue volume and thickness both in women and men. The decrease in width in upper and middle compartments, but increase in lower compartment suggests a volume shift within superficial fat tissue.
Citation Count: 1
Air Injection and Transillumination in Phonosurgery: A Novel Technique
(Mosby-elsevier, 2020) Kocak, Ismail; Alkan, Zeynep; Ovunc, Okan
Objectives/Hypothesis. The goal of this study was to introduce two novel techniques in phonomicrosurgery, air injection (AIR), and transillumination (TI), to improve the diagnosis and surgical excision of pathological tissue in vocal folds during suspension laryngoscopy while preserving the healthy tissue as much as possible. Study design. Prospective clinical case series. Methods. Thirty-four patients with benign vocal cord lesions who underwent phonomicrosurgery between January 2016 and May 2017 were evaluated. Pre- and intraoperative recordings were evaluated by three experienced laryngologists. Stroboscopic video images taken during the preoperative diagnosis and interoperative video recordings made before and after AIR and TI were performed were reviewed and compared. During the preoperative evaluation, the surgeons declared their surgical plans and noted changes while observing the intraoperative evaluation during AIR and TI. Results. Sixty-eight vocal folds were evaluated. The initial diagnosis was found to be consistent with the final diagnosis in only 10 patients (29.4%). The diagnoses of 29 vocal folds (42.6%) and the surgical plans changed after AIR and TI. In six cases, submucosal bands, additional morphological structures in the vicinity of the primary pathology, were observed; these could only be visualized with AIR and TI. AIR and TI revealed new pathologies in four vocal folds that were noted to be normal in the preoperative evaluation. Conclusion. AIR and TI are useful and promising techniques to identify undiagnosed lesions in vocal folds and to increase the success of minimally invasive phonosurgery.
Citation Count: 1
Alterations in right ventricular mechanics in patients with Behcet's disease
(Springer, 2022) Dinc Asarcikli, Lale; Saritas, Fatih; Guvenc, Tolga Sinan; Can, Fatma; Sert, Sena; Cetin Guvenc, Rengin; Unal, Sennur
Manifest myocardial involvement is somewhat rare in patients with Behcet's disease (BD), although echocardiographic studies suggest that subclinical alterations in left ventricular (LV) contractility is rather common. Data on right ventricular (RV) involvement in BD is rather scarce. This study aims to determine whether RV systolic performance is affected in BD patients, and to understand the clinical and echocardiographic correlates of RV contractility in these patients. Forty-five patients who fulfilled criteria for BD and 45 age and gender matched controls were enrolled. All participants underwent a comprehensive echocardiographic examination, including deformation imaging, to characterize RV mechanics. Conventional morphologic and echocardiographic indicators of RV morphology and function were not different between groups, but RV apical strain and RV free wall strain (FWS) were significantly lower in BD patients as compared to the controls (P < 0.001 and P = 0.02, respectively). The only significant correlates of FWS were tricuspid regurgitation velocity and related indices in healthy controls, while FWS correlated with LV global longitudinal strain (GLS), morphologic measures of left and right atria and ventricles, and with conventional measures of right ventricular contractility. The relationship between FWS and GLS remained statistically significant after adjusting for other clinical and echocardiographic parameters (beta = 0.379, P = 0.01). In patients with BD, there is a subclinical alteration in RV contractility and the degree of alteration in the RV systolic performance paralleled that of LV. Thus, present results support the presence of RV involvement in these patients.
Citation Count: 0
Amelioration of propionic acid-induced autism spectrum disorder in rats through dapagliflozin: The role of IGF-1/IGFBP-3 and the Nrf2 antioxidant pathway
(Pergamon-elsevier Science Ltd, 2024) Erdogan, Mumin Alper; Nesil, Pemra; Altuntas, Ilknur; Sirin, Cansin; Uyanikgil, Yigit; Erbas, Oytun
The biological effects of dapagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, reveal its antioxidant and anti-inflammatory properties, suggesting therapeutic benefits beyond glycemic control. This study explores the neuroprotective effects of dapagliflozin in a rat model of autism spectrum disorder (ASD) induced by propionic acid (PPA), characterized by social interaction deficits, communication challenges, repetitive behaviors, cognitive impairments, and oxidative stress. Our research aims to find effective treatments for ASD, a condition with limited therapeutic options and significant impacts on individuals and families. PPA induces ASD-like symptoms in rodents, mimicking biochemical and behavioral features of human ASD. This study explores dapagliflozin's potential to mitigate these symptoms, providing insights into novel therapeutic avenues. The findings demonstrate that dapagliflozin enhances the activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant pathway and increases levels of neurotrophic and growth factors such as brainderived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1), and insulin-like growth factorbinding protein-3 (IGFBP-3). Additionally, dapagliflozin reduces pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-17 (IL-17), and decreases the oxidative stress marker malondialdehyde (MDA). Dapagliflozin's antioxidant properties support cognitive functions by modulating apoptotic mechanisms and enhancing antioxidant capacity. These combined effects contribute to reducing learning and memory impairments in PPA-induced ASD, highlighting dapagliflozin's potential as an adjunctive therapy for oxidative stress and inflammation-related cognitive decline in ASD. This study underscores the importance of exploring new therapeutic strategies targeting molecular pathways involved in the pathophysiology of ASD, potentially improving the quality of life for individuals affected by this disorder.
Citation Count: 3
Analyses of Mossbauer experiments in a rotating system: Proper and improper approaches
(Academic Press inc Elsevier Science, 2020) Kholmetskii, Alexander L.; Yarman, Tolga; Yarman, O.; Arik, M.; Enerji Sistemleri Mühendisliği / Energy Systems Engineering
We examine various attempts to interpret the results of modern Mossbauer rotor experiments and show that the most recent approach developed by Podosenov et al. (0000) to understand these results implies an experimental configuration which has never been realized in the known experiments on this subject, and thus leaves the problem of the physical interpretation of the observed energy shift between emission and absorption lines in a rotating system under the framework of general relativity open. (C) 2020 Elsevier Inc. All rights reserved.
Citation Count: 11
Analysis of cable structures through energy minimization
(Techno-press, 2017) Toklu, Yusuf Cengiz; Bekdas, Gebrail; Temur, Rasim
In structural mechanics, traditional analyses methods usually employ matrix operations for obtaining displacement and internal forces of the structure under the external effects, such as distributed loads, earthquake or wind excitations, and temperature changing inter alia. These matrices are derived from the well-known principle of mechanics called minimum potential energy. According to this principle, a system can be in the equilibrium state only in case when the total potential energy of system is minimum. A close examination of the expression of the well-known equilibrium condition for linear problems, P=K Delta, where P is the load vector, K is the stiffness matrix and A is the displacement vector, it is seen that, basically this principle searches the displacement set (or deformed shape) for a system that minimizes the total potential energy of it. Instead of using mathematical operations used in the conventional methods, with a different formulation, meta-heuristic algorithms can also be used for solving this minimization problem by defining total potential energy as objective function and displacements as design variables. Based on this idea the technique called Total Potential Optimization using Meta-heuristic Algorithms (TPO/MA) is proposed. The method has been successfully applied for linear and non-linear analyses of trusses and truss-like structures, and the results have shown that the approach is much more successful than conventional methods, especially for analyses of nonlinear systems. In this study, the application of TPO/MA, with Harmony Search as the selected meta-heuristic algorithm, to cables net system is presented. The results have shown that the method is robust, powerful and accurate.
Citation Count: 2
An analysis of economic benefits of the Southern Gas Corridor
(Taylor & Francis inc, 2016) Hasanov, Mubariz
In this paper, we examine economic benefits and viability of the Southern Gas Corridor (SGC) for supplying natural gas to Europe from the Caspian Basin. In particular, we examine what will be the effects of natural gas supplies from the Caspian Basin on import prices and social welfare of the EU countries and Turkey. We also analyze profits of exporters and oil companies engaged in production and transportation of natural gas to Europe. We find that the SGC will reduce import prices and increase social welfare in the EU and Turkey. Our results also suggest that the SGC will generate noteworthy profits for exporters and oil companies engaged in the project and thus bring significant economic gains to all parties.
Citation Count: 5
Analysis of pedestrian crossing speed - the case of Istanbul
(Ice Publishing, 2017) Dundar, Selim; İnşaat Mühendisliği / Civil Engineering
Pedestrians, as the most vulnerable road users, are more severely affected when involved in an accident. For this reason, it is important to reduce the risk of pedestrian accidents to increase the safety of highway traffic. The majority of accidents involving pedestrians occur during street crossings where motor vehicles are present. Hence, pedestrians are encouraged to cross safely at crosswalks that are either controlled by a signal or not. Accidents involving pedestrians can be reduced by analysing pedestrian crossing behaviours and designing crosswalks accordingly. Crosswalk design as well as traffic signal phasing need to give enough time for pedestrians to complete their crossing during the green signal phase. For this reason, pedestrian crossing speed and factors affecting this have been analysed in this study. The outcomes can be used to help decision makers and engineers to design ideal pedestrian facilities.
Citation Count: 5
Analysis of the effects of subthalamic nucleus deep brain stimulation on somatosensation in Parkinson's disease patients
(Springer-verlag Italia Srl, 2020) Huzmeli, Esra Dogru; Yilmaz, Atilla; Okuyucu, Esra
Objective Despite the subthalamic nucleus (STN) deep brain stimulation (DBS) is a treatment commonly used to ameliorate the motor symptoms of Parkinson's disease (PD), its effects on somatosensation is unclear. The purpose of this study was to investigate the potential effects of DBS on temperature, proprioceptive, tactile, exteroceptive, pain and cortical sensations, and odor identification in PD patients. Methods The study included 14 patients (with a mean age of 59.78 +/- 11.03 years; range, 44-70 years) with idiopathic PD who underwent DBS surgery for movement disorders caused by PD at the same Neurosurgery Department. All patients were tested while DBS was turned on (DBS-ON) and off (DBS-OFF). To clearly observe the effect of removing stimulation off, DBS devices were turned off by experimental clinical personnel for a minimum duration of 30 min prior to examination. Temperature, proprioceptive, tactile, exteroceptive, pain and cortical sensations, and odor identification were examined. Results We found that two-point discrimination was significantly lower during DBS-ON than DBS-OFF (p = 0.031). Tactile sensation and kinesthesia deviation degree were lower during DBS-ON than DBS-OFF, but were non-significant (p > 0.05). The number of correct answers on an assessment of graphesthesia was higher during DBS-ON, but was non-significant as well (p > 0.05). Odor identification was better during DBS-OFF. Conclusions DBS may have an effective role to improve somatosensation and DBS-related benefits may not be explained by improvements in motor function alone, but rather by enhanced somatosensory processing. Further studies with larger study groups are needed.

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