PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14517/21

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Citation Count: 0
A 3-year-old child with multi-drug resistant epilepsy responding to pharmacological and nonpharmacological treatments
(Taylor & Francis Ltd, 2023) Coskun, Yesim; Yildirim, Canan
Introduction: Despite the development of new antiseizure drugs (ASDs), around one third of epilepsy patients become refractory to treatment or experience adverse events due to ASDs. Therefore, discovery of new ASDs and new therapy options are crucial to improve the quality of life. Herein, we report a 3-year-old child with multi-drug resistant epilepsy caused by perinatal asphyxia whose seizures were reduced by 90% after the introduction of ketogenic diet, vagal nerve stimulation (VNS) AspireSR (SR-seizure response) and oral cannabidiol.Case presentation: A 9-month-old female infant had a history of multidrug resistant epilepsy due to perinatal asphyxia. At admission, she was experiencing up to 20-25 seizures per day lasting for 2-3 minutes. In addition to antiseizure drugs (ASDs), she was put on ketogenic diet (KD), vagal nerve stimulation (VNS) aspire seizure response (AspireSR) was inserted and oral cannabidiol (CBD) was started sequentially. Using pharmacological and nonph armacological therapies, her seizures have been reduced by 90%.Conclusion: The concurrent use of pharmacological and nonpharmacological therapies may be beneficial to improve seizures in infants with multi- Furthermore, our patient is the youngest child inserted VNS AspireSR in Turkey.
Citation Count: 0
3D and 4D printing of MXene-based composites: from fundamentals to emerging applications
(Royal Soc Chemistry, 2024) Bigham, Ashkan; Zarepour, Atefeh; Khosravi, Arezoo; Iravani, Siavash; Zarrabi, Ali; Genetik ve Biyomühendislik / Genetic and Bio-Engineering
The advent of three-dimensional (3D) and four-dimensional (4D) printing technologies has significantly improved the fabrication of advanced materials, with MXene-based composites emerging as a particularly promising class due to their exceptional electrical, mechanical, and chemical properties. This review explores the fundamentals of MXenes and their composites, examining their unique characteristics and the underlying principles of their synthesis and processing. We highlight the transformative potential of 3D and 4D printing techniques in tailoring MXene-based materials for a wide array of applications. In the field of tissue regeneration, MXene composites offer enhanced biocompatibility and mechanical strength, making them ideal for scaffolds and implants. For drug delivery, the high surface area and tunable surface chemistry of MXenes enable precise control over drug release profiles. In energy storage, MXene-based electrodes exhibit superior conductivity and capacity, paving the way for next-generation batteries and supercapacitors. Additionally, the sensitivity and selectivity of MXene composites make them excellent candidates for various (bio)sensing applications, from environmental monitoring to biomedical diagnostics. By integrating the dynamic capabilities of 4D printing, which introduces time-dependent shape transformations, MXene-based composites can further adapt to complex and evolving functional requirements. This review provides a comprehensive overview of the current state of research, identifies key challenges, and discusses future directions for the development and application of 3D and 4D printed MXene-based composites. Through this exploration, we aim to underscore the significant impact of these advanced materials and technologies on diverse scientific and industrial fields. This review highlights the developments in the 3D/4D printing of MXene-based composites, focusing on their application in tissue regeneration, drug delivery, sensing, and energy storage.
Citation Count: 11
Accuracy of Digital Impressions Obtained Using Six Intraoral Scanners in Partially Edentulous Dentitions and the Effect of Scanning Sequence
(Quintessence Publishing Co inc, 2021) Diker, Burcu; Tak, Onjen
Purpose: To compare the accuracy of six intraoral scanners in two different partially edentulous maxillary models and to evaluate the effect of scanning sequence on accuracy. Materials and Methods: Maxillary Kennedy Class I and Class IV situations were used as reference models. The reference datasets were obtained by scanning the models using a highly accurate industrial scanner (ATOS Core 80, GOM). The following six intraoral scanners were evaluated: Trios 3 (3Shape), iTero Element 2 (Align Technology), Emerald (Planmeca), CEREC Omnicam (Dentsply Sirona), CEREC Primescan (Dentsply Sirona), and Virtuo Vivo (Dental Wings). A total of 120 scans from both models were obtained using the six intraoral scanners and divided into two groups based on scanning sequence. Accuracy was evaluated by deviation analysis using 3D image processing software (Geomagic Studio 12, 3D Systems). Kruskal Wallis and Mann-Whitney U tests were performed (P <= .05) for statistical analysis. Results: There were significant differences in the accuracy of digital impressions among intraoral scanners and scanning sequences. The trueness of the Trios scanner and the precision of the Trios, Primescan, and iTero scanners were significantly higher than for the other scanners. The Emerald had the lowest accuracy among the six intraoral scanners tested. Accuracy was affected by scanning sequence when using the Virtuo Vivo, Emerald, Primescan, and iTero. Conclusion: In Kennedy Class I and Class IV partially edentulous cases, it is useful to consider that the intraoral scanner used may affect the accuracy of the digital impression.
Citation Count: 21
Accuracy of six intraoral scanners for scanning complete-arch and 4-unit fixed partial dentures: An in vitro study
(Mosby-elsevier, 2022) Diker, Burcu; Tak, Onjen
Statement of problem. The digital scan accuracy of different intraoral scanners (IOSs) for long-span fixed prosthesis and the effect of the starting quadrant on accuracy is unclear. Purpose. The purpose of this in vitro study was to evaluate the accuracy of 6 IOSs for complete-arch and prepared teeth digitally isolated from the complete-arch and to determine the effect of the starting quadrant on accuracy. Material and methods. A maxillary model containing bilaterally prepared canines, first molar teeth, and edentulous spans between the prepared teeth was used. The model was scanned by using a highly accurate industrial scanner to create a digital reference data set. Six IOSs were evaluated: TRIOS, iTero, Planmeca Emerald, Cerec Omnicam, Primescan, and Virtuo Vivo. The model was scanned 10 times with each IOS by 1 operator according to the protocols described by the manufacturers. Five scans were made starting from the right quadrant (ScanR), followed by 5 scans starting from the left quadrant (ScanL). All data sets were obtained in standard tessellation language (STL) file format and were used to evaluate accuracy (trueness and precision) with a 3D analyzing software program (Geomagic Studio 12; 3D Systems) by using a best-fit alignment. The prepared teeth were digitally isolated from the complete-arch and evaluated with the analyzing software program. The Kruskal-Wallis and Mann-Whitney U statistical tests were used to detect differences for trueness and precision (alpha=.05). Results. Statistically significant differences were found regarding IOSs (P<.003) and scanning sequence (P<.05). The TRIOS showed the best trueness for the complete-arch, but not statistically different from Primescan, Virtuo Vivo, and iTero (P>.003). The lowest median values for precision of the complete-arch were also found using TRIOS, but no significant difference was found among the scanners (P>.003). In terms of trueness and precision, Primescan had the best accuracy for preparations. Emerald showed significant differences depending on the scanning sequence for complete-arch accuracy. ScanR for trueness (P=.021) and ScanL for precision (P=.004) showed improved results. However, Emerald, TRIOS, and Virtuo Vivo showed statistically significant differences in precision of preparations depending on scanning sequence. ScanL deviated less than ScanR when scanned with TRIOS (P=.025) and Emerald (P=.004), and the opposite with Virtuo Vivo (P=.008). In terms of preparations trueness, no significant difference was found between the ScanR and ScanL of any IOS (P>.05). Conclusions. Based on this in vitro study, the accuracy of the complete-arch and prepared teeth differed according to the IOS and scanning sequence.
Citation Count: 0
Addendum to Spinal Schwannomatosis: Case Report of a Rare Condition
(Turkish Neurosurgical Soc, 2017) Hakan, Tayfun; Celikoglu, Erhan; Aker, Fugen; Barisik, Nagehan
[No Abstract Available]
Citation Count: 8
Aging Changes of the Superficial Fat Compartments of the Midface Over Time: A Magnetic Resonance Imaging Study
(Lippincott Williams & Wilkins, 2020) Cenkeri, Halime Cevik; Guduk, Sukran Sarigul; Cicek, Esin Derin
BACKGROUND Studies involving superficial facial fat compartments are few in number with conflicting results. Most of them involved small study groups and compared measurements between different populations of young and old subjects either on cadavers or living subjects. OBJECTIVE To clarify volumetric and dimensional changes in midfacial superficial fat compartment retrospectively in patients who underwent a repeat magnetic resonance imaging (MRI) without gross pathology. MATERIALS AND METHODS A total of 70 patients with a mean age of 60 years (range: 33-82 years) and a median elapsed time of 44.5 months (range: 32-64 months) between 2 MRIs were included. Magnetic resonance imaging scans were analyzed in the axial and sagittal planes to obtain measurements of the medial part of the superficial cheek fat. Superficial cheek fat was divided into 3 compartments. Thickness, width, and height were measured, and volumes were calculated for each compartment on both hemifaces. RESULTS Volume and thickness were decreased significantly in all compartments (p < .05). The width was decreased in superior and middle compartments, whereas increased in lower compartment indicating dislocation of the fat tissue (p < .05). Height was also significantly increased (p < .05). A subgroup analysis has shown that there was no significant difference between men and women. CONCLUSION This study clarifies that aging is associated with a significant decrease in superficial midfacial fat tissue volume and thickness both in women and men. The decrease in width in upper and middle compartments, but increase in lower compartment suggests a volume shift within superficial fat tissue.
Citation Count: 33
Analysis of Entanglement Measures and LOCC Maximized Quantum Fisher Information of General Two Qubit Systems
(Nature Portfolio, 2014) Erol, Volkan; Ozaydin, Fatih; Altintas, Azmi Ali
Entanglement has been studied extensively for unveiling the mysteries of non-classical correlations between quantum systems. In the bipartite case, there are well known measures for quantifying entanglement such as concurrence, relative entropy of entanglement (REE) and negativity, which cannot be increased via local operations. It was found that for sets of non-maximally entangled states of two qubits, comparing these entanglement measures may lead to different entanglement orderings of the states. On the other hand, although it is not an entanglement measure and not monotonic under local operations, due to its ability of detecting multipartite entanglement, quantum Fisher information (QFI) has recently received an intense attraction generally with entanglement in the focus. In this work, we revisit the state ordering problem of general two qubit states. Generating a thousand random quantum states and performing an optimization based on local general rotations of each qubit, we calculate the maximal QFI for each state. We analyze the maximized QFI in comparison with concurrence, REE and negativity and obtain new state orderings. We show that there are pairs of states having equal maximized QFI but different values for concurrence, REE and negativity and vice versa.
Citation Count: 5
The antioxidant, anti-inflammatory, and antiplatelet effects of Ribes rubrum L. fruit extract in the diabetic rats
(Wiley, 2022) Gulmez, Gizem; Sen, Ali; Sekerler, Turgut; Algul, Fatma Kader; Cilingir-Kaya, Ozlem Tugce; Sener, Azize; Tıbbi Biyokimya / Medical Biochemistry
The prothrombotic and inflammatory state plays a significant role in the occurrence of cardiovascular complications in type 2 diabetes mellitus. In this study, the antidiabetic, anti-inflammatory, and antiplatelet potentials of the extracts obtained from Ribes rubrum were investigated. The antidiabetic, anti-inflammatory, and antioxidant activities of the ethanol and water extracts of R. rubrum were evaluated by in vitro methods. The total phenolic and flavonoid contents were also determined. The experimental diabetes model in rats was induced with streptozotocin (STZ). After hyperglycemia occurred, the ethanol extracts of R. rubrum (RRE, at 100 mg/kg and 500 mg/kg doses) were administered to the treatment groups for 14 days. Blood glucose, lipid profile, plasma, and pancreas tumor necrosis factor-alpha (TNF-alpha) levels were determined and compared at the end of the experiments. P-selectin levels and mitochondrial membrane polarization (MMP) of platelets were also measured. In vitro study, the RRE showed potent anti-inflammatory activity. Administration of RRE (at 100 mg/kg doses) to diabetic rats lowered blood glucose level insignificantly. The results showed that there was an increment in levels of TNF-alpha in plasma and pancreas tissue of the diabetic group compared to the control group. R. rubrum extract regulated and normalized their levels in plasma and pancreatic tissue. RRE at both doses significantly decreased platelet P-selectin levels and prevented STZ-induced loss of MMP in platelets. The results of current research indicate that RRE extract has potent anti-platelet and anti-inflammatory effects and may be beneficial in preventing diabetic complications. Practical applications Hyperglycemia causes dyslipidemia, advanced oxidative stress, platelet activation, and inflammation in diabetes mellitus. Plants with various medicinal properties are of worldwide interest for the treatment of diseases due to their biological activities. In this study, the antidiabetic, anti-inflammatory, and antioxidant effects of extracts of Ribes rubrum (%100 ethanol, 50% ethanol, water) were evaluated by in vitro and in vivo methods. The diabetes model was induced with streptozotocin (STZ). The rats were divided into control, diabetic control, R. rubrum-100 mg/kg, and R. rubrum-500 mg/kg doses groups. Blood glucose levels, tumor necrosis factor-alpha (TNF-alpha), platelet P-selectin levels, mitochondrial membrane polarization of platelets were examined. The present study has shown that R. rubrum has anti-inflammatory and antiplatelet activity. R. rubrum may be beneficial in the prevention and treatment of DM complications due to its anti-inflammatory and antithrombotic effects.
Citation Count: 0
Application of 3D, 4D, 5D, and 6D bioprinting in cancer research: what does the future look like?
(Royal Soc Chemistry, 2024) Khorsandi, Danial; Rezayat, Dorsa; Sezen, Serap; Ferrao, Rafaela; Khosravi, Arezoo; Zarepour, Atefeh; Zarrabi, Ali; Genetik ve Biyomühendislik / Genetic and Bio-Engineering
The application of three- and four-dimensional (3D/4D) printing in cancer research represents a significant advancement in understanding and addressing the complexities of cancer biology. 3D/4D materials provide more physiologically relevant environments compared to traditional two-dimensional models, allowing for a more accurate representation of the tumor microenvironment that enables researchers to study tumor progression, drug responses, and interactions with surrounding tissues under conditions similar to in vivo conditions. The dynamic nature of 4D materials introduces the element of time, allowing for the observation of temporal changes in cancer behavior and response to therapeutic interventions. The use of 3D/4D printing in cancer research holds great promise for advancing our understanding of the disease and improving the translation of preclinical findings to clinical applications. Accordingly, this review aims to briefly discuss 3D and 4D printing and their advantages and limitations in the field of cancer. Moreover, new techniques such as 5D/6D printing and artificial intelligence (AI) are also introduced as methods that could be used to overcome the limitations of 3D/4D printing and opened promising ways for the fast and precise diagnosis and treatment of cancer. Recent advancements pertaining to the application of 3D, 4D, 5D, and 6D bioprinting in cancer research are discussed, focusing on important challenges and future perspectives.
Citation Count: 2
Approach of the Clinicians Practicing in Intensive Care Units to Brain Death Diagnosis and Training Expectations in Turkey: A Web-Based Survey
(Elsevier Science inc, 2020) Ferhatoglu, Sibel Yilmaz; Ferhatoglu, Murat Ferhat; Gurkan, Alp; Genel Cerrahi / General Surgery
Background. For health professionals, recognizing and diagnosing brain death is vital for the development of organ transplantation. However, cadaveric organ donation rates remain insufficient, and this problem has become one of the most serious obstacles in the treatment of end-organ failure. Objectives. This study examines the attitude and knowledge level of clinicians who practice in intensive care units (ICUs) concerning the determination of brain death and describes the hindrances in diagnosing brain death. Materials and Methods. A survey study was designed with 26 questions, including questions regarding the determination of characteristics of respondents' trainings, prac-ticing preferences, and their knowledge and approach toward brain death diagnosis. Clinicians practicing in ICUs in Turkey were invited to the survey. Results. A total of 244 surveys were fully completed. Physicians working at the university hospitals or university-affiliated hospitals answered the basic knowledge questions about brain death more accurately (P < .001). Also, physicians employed in university or university-affiliated hospitals feel more capable in diagnosing brain death (P 1/4 .002) and are more willing to receive education on the brain death issue (P < .001). Conclusion. There is a gap separating the practices suggested in guidelines and the daily practice of ICU clinicians working in state hospitals or private institutions. Academic organizations producing and leading the education curricula may assist in informing ICU clinicians who should be trained.
Citation Count: 70
Assessment of the trabecular structure of mandibular condyles in patients with temporomandibular disorders using fractal analysis
(Elsevier Science inc, 2017) Arsan, Belde; Kose, Taha Emre; Cene, Erhan; Ozcan, Ilknur
Objectives. The aim of this study was to evaluate changes in the trabecular structure of the mandibular condyle in patients with temporomandibular disorders (TMDs) using fractal analysis. Study Design. A total of 100 patients ages 18 to 73 years were clinically assessed using the Diagnostic Criteria for Temporomandibular Disorders. The control group was age-and sex-matched with the patient group. Panoramic radiographs were obtained using a Kodak 8000 digital device with 73 kVp and 5 mA fixed parameters. The degree of degeneration in the mandibular condyles was calculated. Regions of interest (84 X 84 pixels) were selected within the cortical boundary of the mandibular condyle, and the fractal dimension (FD) was calculated using ImageJ version 1.48. Results. Radiographic degenerative changes were more frequently present and more severe in the patient group (P < .001). The mean value of FD was 1.22 +/- 0.06 in the patient group and 1.25 +/- 0.06 in the control group (P = .001). A significant decrease in FD was observed (P = .001) in the left temporomandibular joints of the patient group, whereas a nonsignificant decrease in FD was observed in the right temporomandibular joints (P = .073) as degenerative changes increased. Conclusions. Lower FD values were associated with more severe degenerative changes in the patient group. The trabecular structure of condyles in patients with TMD exhibited decreased complexity when erosive and sclerotic changes were evident. As a result, fractal analysis enhanced the use of panoramic radiography in detecting degenerative changes in patients with TMD. (Oral Surg Oral Med Oral Pathol Oral Radiol 2017;123: 382-391)
Citation Count: 0
Biotin-functionalized nanoparticles: an overview of recent trends in cancer detection
(Royal Soc Chemistry, 2024) Fathi-karkan, Sonia; Sargazi, Saman; Shojaei, Shirin; Farasati Far, Bahareh; Mirinejad, Shekoufeh; Cordani, Marco; Ghavami, Saeid; Genetik ve Biyomühendislik / Genetic and Bio-Engineering
Electrochemical bio-sensing is a potent and efficient method for converting various biological recognition events into voltage, current, and impedance electrical signals. Biochemical sensors are now a common part of medical applications, such as detecting blood glucose levels, detecting food pathogens, and detecting specific cancers. As an exciting feature, bio-affinity couples, such as proteins with aptamers, ligands, paired nucleotides, and antibodies with antigens, are commonly used as bio-sensitive elements in electrochemical biosensors. Biotin-avidin interactions have been utilized for various purposes in recent years, such as targeting drugs, diagnosing clinically, labeling immunologically, biotechnology, biomedical engineering, and separating or purifying biomolecular compounds. The interaction between biotin and avidin is widely regarded as one of the most robust and reliable noncovalent interactions due to its high bi-affinity and ability to remain selective and accurate under various reaction conditions and bio-molecular attachments. More recently, there have been numerous attempts to develop electrochemical sensors to sense circulating cancer cells and the measurement of intracellular levels of protein thiols, formaldehyde, vitamin-targeted polymers, huwentoxin-I, anti-human antibodies, and a variety of tumor markers (including alpha-fetoprotein, epidermal growth factor receptor, prostate-specific Ag, carcinoembryonic Ag, cancer antigen 125, cancer antigen 15-3, etc.). Still, the non-specific binding of biotin to endogenous biotin-binding proteins present in biological samples can result in false-positive signals and hinder the accurate detection of cancer biomarkers. This review summarizes various categories of biotin-functional nanoparticles designed to detect such biomarkers and highlights some challenges in using them as diagnostic tools. Biotin-functionalized nanoparticles enhance cancer detection by targeting biotin receptors, which are overexpressed on cancer cells. This targeted approach improves imaging accuracy and efficacy in identifying cancerous tissues.
Citation Count: 0
Can Myelography Residues Have an Incidental Finding on Panoramic Radiography? Two Case Reports
(W B Saunders Co-elsevier inc, 2021) Gunacar, Dilara Nil; Kose, Taha Emre; Sandirac, Aysun Atasoy; Uyanik, Sadik Ahmet
Oil-based contrast medium agents (Iofendylate) are cleared from cerebrospinal fluid very slowly, but it may remain within the tissues of the central nervous system. These substances, which were used for purposes such as myelography, cisternography, and ventriculography approximately 70 years ago and were replaced by water-soluble agents after 30 years, can rarely be detected incidentally. In this report, by presenting the intracranial radiopacities seen in 2 patients, it is aimed to increase awareness that these myeloid residues, which are rarely seen in panoramic radiography, can be diagnosed by clinicians. (C) 2021 The American Association of Oral and Maxillofacial Surgeons.
Citation Count: 0
Can the development of lung fibrosis be prevented after COVID-19 infection?
(Termedia Publishing House Ltd, 2022) Kalemci, Serdar; Zeybek, Arife; Kargi, Ahmet Bulent
[No Abstract Available]
Citation Count: 0
Cardiac Failure Associated with Medical Therapy of Benign Prostatic Hyperplasia: A Population Based Study. Letter
(Lippincott Williams & Wilkins, 2021) Coner, Ali; Yildiz, Ali; Ipekci, Tumay
[No Abstract Available]
Citation Count: 0
Cardiac Failure Associated with Medical Therapy of Benign Prostatic Hyperplasia: A Population Based Study. Letter.
(Wolters Kluwer Health, 2021) Çoner,A.; Yildiz,A.; İpekçi,T.
[No abstract available]
Citation Count: 1
Causality Association Between COVID-19 Infection and Aortic Dissection
(Turkish Society of Cardiology, 2022) Altuğ Tuncer,M.; Sadeghian,H.; Sheikhvatan,M.; Toulany,M.; Tıbbi Biyoloji Anabilim Dalı / Department of Medical Biology
[No abstract available]
Citation Count: 17
Chlorhexidine-Impregnated Dressings and Prevention of Catheter-Associated Bloodstream Infections in a Pediatric Intensive Care Unit
(Amer Assoc Critical Care Nurses, 2016) Duzkaya, Duygu Sonmez; Sahiner, Nejla Canbulat; Uysal, Gulzade; Yakut, Tulay; Citak, Agop
[No Abstract Available]
Citation Count: 0
Clinical Performance of Samfilcon A Contact Lenses in Intensive Digital Device Users: A Multicenter, Prospective Clinical Study (Aug, 10.1007/s40123-021-00389-4, 2021)
(Springer int Publ Ag, 2021) Ucakhan, Omur O.; Tasindi, Emrullah; Toker, Ebru; ciftci, Ferda; Kurna, Sevda Aydin; Acar, Mutlu; Barakat, Maxime; Tıbbi Mikrobiyoloji / Medical Microbiology
[No Abstract Available]
Citation Count: 0
Comment on: Effect of anti-inflammatory regimen on early postoperative inflammation after cataract surgery
(Lippincott Williams and Wilkins, 2021) Yusuf,I.H.; Bostanci,B.; Morselli,S.; Day,A.C.
[No abstract available]

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