WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14517/18

Browse

Now showing 1 - 20 of 569

Academic domains as political battlegrounds: A global enquiry by 99 academics in the fields of education and technology
(Sage Publications Ltd, 2017) Al Lily, Abdulrahman E.; Foland, Jed; Stoloff, David; Gogus, Aytac; Erguvan, Inan Deniz; Awshar, Mapotse Tome; Schrader, P. G.
This article theorizes the functional relationship between the human components (i.e., scholars) and non-human components (i.e., structural configurations) of academic domains. It is organized around the following question: in what ways have scholars formed and been formed by the structural configurations of their academic domain? The article uses as a case study the academic domain of education and technology to examine this question. Its authorship approach is innovative, with a worldwide collection of academics (99 authors) collaborating to address the proposed question based on their reflections on daily social and academic practices. This collaboration followed a three-round process of contributions via email. Analysis of these scholars' reflective accounts was carried out, and a theoretical proposition was established from this analysis. The proposition is of a mutual (yet not necessarily balanced) power (and therefore political) relationship between the human and non-human constituents of an academic realm, with the two shaping one another. One implication of this proposition is that these non-human elements exist as political actors', just like their human counterparts, having agency' - which they exercise over humans. This turns academic domains into political (functional or dysfunctional) battlefields' wherein both humans and non-humans engage in political activities and actions that form the identity of the academic domain. For more information about the authorship approach, please see Al Lily AEA (2015) A crowd-authoring project on the scholarship of educational technology. Information Development. doi: 10.1177/0266666915622044.
Academic Vocabulary in Learner Writing: From Extraction to Analysis
(Sage Publications Ltd, 2011) Yigitoglu, Nur
[No Abstract Available]
The Acute Effects of Different Intensity Whole-Body Vibration Exposure on Muscle Tone and Strength of the Lower Legs, and Hamstring Flexibility: A Pilot Study
(Human Kinetics Publ inc, 2021) Saldiran, Tulay Cevik; Atici, Emine; Rezaei, Derya Azim; Ozturk, Ozgul; Uslu, Burcu; Ozcan, Burcu Ates; Okudan, Begum
Context: The research on the change in properties of the lower leg muscles by different intensity sinusoidal vertical whole-body vibration (SV-WBV) exposures has not yet been investigated. Objective: The purpose of this study was to determine effect of a 20-minute different intensity SV-WBV application to the ankle plantar flexor and dorsiflexor muscles properties and hamstring flexibility. Design: Prospective preintervention-postintervention design. Setting: Physiotherapy department. Participants: A total of 50 recreationally active college-aged individuals with no history of a lower leg injury volunteered. Interventions: The SV-WBV was applied throughout the session with an amplitude of 2 to 4 mm and a frequency of 25 Hz in moderate-intensity vibration group and 40 Hz in a vigorous-intensity vibration group. Main Outcome Measures: The gastrocnemius and tibialis anterior muscle tone was assessed with MyotonPRO, and the strength evaluation was made on the same lower kg muscles using hand-held dynamometer. The sit and reach test was used for the lower leg flexibility evaluation. Results: The gastrocnemius muscle tone decreased on the right side (d = 0.643, P = .01) and increased on the left (d = 0.593, P = .04) when vigorous-intensity vibration was applied. Bilateral gastrocnemius muscle strength did not change in both groups (P> .05). Without differences between groups, bilateral tibialis anterior muscle strength increased in both groups (P < .01). Bilateral gastrocnemius and tibialis anterior muscle tone did not change in the moderate-intensity vibration group (P> .05). Flexibility increased in both groups (P < .01); however, there was no statistically significant difference between the groups (d = 0.169, P = .55). Conclusions: According to study results, if SV-WBV is to be used in hamstring flexibility or ankle dorsiflexor muscle strengthening, both vibration exposures should be preferred. Different vibration programs could be proposed to increase ankle plantar flexor muscle strength in the acute results. Vigorous-intensity vibration exposure is effective in altering ankle plantar flexor muscle tone, but it is important to be aware of the differences between the lower legs.
Adaptation of Ventilation Strategies From Acute RDS To Severe BPD: a National Multicenter Survey of Practices in Extremely Preterm Infants
(Lippincott Williams & Wilkins, 2025) Akyildiz, Can; Tuzun, Funda; Duman, Nuray; Akcan, Abdullah Baris; Alp Unkar, Zeynep; Aygun, Canan; Ozkan, Hasan
Advances in diagnostic and therapeutic methods have led to a paradigm shift in the management of bronchopulmonary dysplasia (BPD). The lack of evidence-based data in this area has led to variations in clinical practice. The aim of this study was to identify these differences and compare them with recommendations based on pathophysiology. The study was designed as an observational online survey of neonatologists from level 3 to 4 neonatal intensive care units caring for premature infants at increased risk of BPD and born before 28 weeks' gestation. Respondents were invited to participate in the study through the portal of the Turkish Neonatal Society. Participants were surveyed online about preferred ventilation modes, settings and clinical management of these patients through each respiratory distress syndrome, evolving BPD and severe BPD phases. A total of 39 centers involved in the study. Pressure-control assist-control volume-guaranteed was the most commonly preferred ventilation mode in respiratory distress syndrome and evolving BPD, while high frequency oscillatory ventilation was most commonly used in severe BPD. The use of synchronized intermittent mandatory ventilation volume-guaranteed pressure support ventilation increased with disease progression. Ventilation settings were found to be changed according to pathophysiological recommendations, but not to the extent recommended. The study shows that early ventilation strategies are predominantly maintained in the later phases of BPD, although there are notable differences between centers.
Adjacent Segment Disease (ASD) in Incidental Segmental Fused Vertebra and Comparison With the Effect of Stabilization Systems on ASD
(Springernature, 2021) Hekimoglu, Mehdi; Basak, Ahmet; Yilmaz, Atilla; Yildirim, Hakan; Aydin, Ahmet Levent; Karadag, Kursat; ozer, Ali Fahir
Objective Adjacent segment disease is a controversial process after spine stabilization. The two important factors discussed are natural aging and hypermobility in incidental segmental fusion anomalies; patients have two or more fused vertebrae from birth, which are the results of spinal movement restriction due to the fusion of some spinal units. This article's main purpose is to determine the degree of relationship of hypermobility and the aging process in the deterioration of the disks adjacent to fusion. Methods In this study, the degenerative process developed by hypermobility in the adjacent segment due to incidental segmental fusion was evaluated. The MRI images of 52 adjacent and nonadjacent disks of 45 patients in total were analyzed according to the Pfirrmann grading systems. The average Pfirrmann rating of the disks just above and below the fused segment and the distant first, second, and third non-neighboring levels were evaluated and calculated, respectively. Results The highest rate of incidental fusion is determined on the cervical area with 51.9%, followed by the thoracal area with 32.7%, and the lumbar area with 15.4%. Damage to the adjacent segment disks in cases with incidental fusion can still be seen at any age, with fusion, indicating that the hypermobility effect plays a more prominent role. The evidence of hypermobility without aging is that the segments adjacent to fusion undergo more degeneration than the distant disks. Conclusion Adjacent segment disease is under the influence of many factors. Our findings suggest that its incidence is increasing with the pathological processes initiated by hypermobility. It seems that, at least, it carries equal importance as compared to age. Fusion surgeries damage the adjacent segments under the influence of the passage of time beyond the physiological aging of the patient.
Advanced Competent Bayesian Regularization Neural Network for Mathematical Modeling of the Immune Diabetes Regulation System
(Elsevier Sci Ltd, 2026) Sabir, Zulqurnain; Abdelkawy, M. A.; Umar, Muhammad; Salahshour, Soheil; Bhatti, Saira; Al-Mdallal, Qasem; Mohamed, Mohamed
In this research, the numerical investigations of the fractional order immune diabetes regulation system by using a competent Bayesian regularization neural network procedure have been provided. The fractional order derivatives are used to get better results in comparison with the integer order. The division of the mathematical system is performed in resting and activated macrophages, and the antigen, autolytic, and beta cells. The data generalization is accessible by using the traditional Adam scheme in order to decrease the mean square error, while the data is separated into testing 16%, training 70%, and substantiation 14%. The designed neural network structure is updated by using the optimization tests through Bayesian regularization, a single layer sigmoid activation function, and twenty-five neurons. As conventional modeling schemes depend on shortening traditions or linear calculations, while the stochastic BRNN can perform complicated data patterns and deliver precise calculations of system performance. The correctness of the designed optimizer is obtained through the overlapping of the outcomes and lesser absolute error for each class of the model. Moreover, few curves based on state transitions, regression, error histograms provide the competences of the proposed solver.
Advanced Competent Bayesian Regularization Neural Network for Mathematical Modeling of the Immune Diabetes Regulation System (Vol 113, 109036, 2026)
(Elsevier Sci Ltd, 2026) Sabir, Zulqurnain; Abdelkawy, M. A.; Umar, Muhammad; Salahshour, Soheil; Bhatti, Saira; Al-Mdallal, Qasem; Mohamed, Mohamed
Advancements in MXenes and mechanochemistry: exploring new horizons and future applications
(Royal Society of Chemistry, 2024) Iravani, S.; Zarepour, A.; Nazarzadeh Zare, E.; Makvandi, P.; Khosravi, A.; Varma, R.S.; Zarrabi, A.
MXenes, a class of two-dimensional (2D) materials derived from transition metal carbides, nitrides, and carbonitrides, have garnered significant attention due to their unique properties and potential applications in various fields, including energy storage, catalysis, and electronics. Mechanochemistry, the study of chemical reactions driven by mechanical forces, offers a novel approach to synthesize and manipulate MXenes, enhancing their properties and expanding their functional applications. This review explores the intersection of MXenes and mechanochemistry, highlighting recent advancements in the mechanochemical synthesis of MXenes and their derivatives. We discuss the mechanisms underlying the mechanochemical processes, including the role of shear forces, ball milling, and other mechanical techniques in facilitating the exfoliation and functionalization of MXenes. Furthermore, we examine the impact of mechanochemical methods on the structural integrity, surface chemistry, and electronic properties of MXenes, which are crucial for their performance in applications such as supercapacitors, batteries, and sensors. This review also addresses the challenges and limitations associated with mechanochemical approaches, including scalability and reproducibility, while proposing future directions for research in this promising field. By integrating mechanochemistry with MXene research, we aim to provide insights into innovative strategies for the development of advanced materials that can meet the demands of next-generation technologies. This synthesis of knowledge not only underscores the versatility of MXenes but also emphasizes the transformative potential of mechanochemistry in materials science. © 2024 RSC.
Advances and Future Directions in Sodium Borohydride-Based Hydrogen Storage: A Comprehensive Review
(Elsevier Ltd, 2025) Agyekum, E.B.; Oriquat, G.A.; Rashid, F.L.
Metal complex hydrides offer high hydrogen storage capacity and safety advantages. This comprehensive review analyzes sodium borohydride (NaBH4)-based hydrogen storage studies from 2000 to 2025, confirming strong annual publication growth rate of 13.36% and a mean of 30.1 citations per article, indicating ongoing global interest. Literature has evolved from the early storage and kinetic research to advanced work on hydrolysis, methanolysis, catalysts design, and regeneration techniques on the basis of additives like ZrF4, TiF3, LaF3, and Mg-based materials to maximize hydrogen yield and minimize the energy requirements. Emerging themes like hybrid hydrogen carriers, graphene-supported catalysts, and synergistic systems reflect a shift towards versatile materials and real-world integration. According to the study, despite advances, challenges remain significant in the development of cost-effective, energy-efficient, and scalable regenerative methods. The factorial and thematic analyses reveal overlooked topics like solid-state storage and metathesis reactions. Also, publication trends worldwide, dominated by China (953 articles), reveal collaborative action and global imbalance, with low multiple-country publications registered in countries like Malaysia and India. To bridge gaps and accelerate commercialization, future research must focus on sustainable catalyst discovery, closed-loop technologies, and strengthening of global contribution through fair partnerships and collaborative innovation frameworks, putting NaBH4 on the table in the future hydrogen economy. © 2025 Elsevier Ltd.
Advancing Micromixing Techniques: the Role of Surface Acoustic Waves and Fluid–structure Interaction in Non-Newtonian Fluids
(Springer Science and Business Media Deutschland GmbH, 2025) Faradonbeh, V.R.; Salahshour, S.; Toghraie, D.
This study numerically investigated the enhancement of micromixing efficiency through integrating surface acoustic waves (SAWs) and hyper-elastic channel walls, modeled using a power-law fluid representative of human blood flow. The governing equations are systematically divided into zeroth, first, and second orders based on perturbation theory. This facilitates the development of a fully coupled two-way fluid–structure interaction (FSI) framework implemented via the Arbitrary Lagrangian–Eulerian (ALE) method. The combination of SAWs and hyper-elastic materials demonstrated a marked improvement in mixing efficiency, increasing from 0 to 0.99, alongside a significant reduction in pressure drop within the microchannel. The interaction between SAWs and the deformable walls induces localized instabilities and shear stresses that effectively disrupt the laminar flow, promoting enhanced mixing. The study highlights the critical role of hyper-elastic walls in modulating normal forces on the fluid and reducing pressure drop, offering insights into the interaction between fluid viscosity, acoustic pressure fields, and flow dynamics. These findings provide a framework for designing micromixers with optimized efficiency and reduced channel length, offering practical advancements in microfluidic systems. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025.
Advancing Ovarian Cancer Care: Recent Innovations and Challenges in the Use of MXenes and Their Composites for Diagnostic and Therapeutic Applications
(Royal Soc Chemistry, 2025) Farzizadeh, Neda; Zarepour, Atefeh; Khosravi, Arezoo; Iravani, Siavash; Zarrabi, Ali
Ovarian cancer remains the deadliest form of gynecologic malignancy, largely owing to the absence of reliable early diagnostic tools and the limited effectiveness of current therapeutic strategies. Recent advances in nanotechnology-particularly the emergence of two-dimensional materials known as MXenes-offer promising avenues to address these challenges. This review highlights the emerging role of MXenes and their composites in the management of ovarian cancer, focusing on their potential in biomarker detection and targeted treatment strategies. We provide a comprehensive analysis of the latest studies examining the physicochemical features of MXenes, their synthesis and surface functionalization approaches, and their application in ovarian cancer, including biosensing, drug delivery, and combinatorial therapeutic systems. MXene-based biosensors have shown remarkable detection limits in detecting ovarian cancer biomarkers, such as cancer antigen 125 (CA125), human epididymis protein 4 (HE4), lipolysis-stimulated lipoprotein receptor (LSR), and carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5). However, several challenges remain, including issues of biocompatibility, structural stability, and clinical scalability. Continued interdisciplinary research is essential to address these limitations, optimize MXene functionalization, and translate their laboratory success into clinical settings. With appropriate advancements, MXenes hold significant promise for enabling more precise, efficient, and patient-specific approaches to ovarian cancer diagnosis and therapy.
Aging Changes of the Superficial Fat Compartments of the Midface Over Time: A Magnetic Resonance Imaging Study
(Lippincott Williams & Wilkins, 2020) Cenkeri, Halime Cevik; Guduk, Sukran Sarigul; Cicek, Esin Derin
BACKGROUND Studies involving superficial facial fat compartments are few in number with conflicting results. Most of them involved small study groups and compared measurements between different populations of young and old subjects either on cadavers or living subjects. OBJECTIVE To clarify volumetric and dimensional changes in midfacial superficial fat compartment retrospectively in patients who underwent a repeat magnetic resonance imaging (MRI) without gross pathology. MATERIALS AND METHODS A total of 70 patients with a mean age of 60 years (range: 33-82 years) and a median elapsed time of 44.5 months (range: 32-64 months) between 2 MRIs were included. Magnetic resonance imaging scans were analyzed in the axial and sagittal planes to obtain measurements of the medial part of the superficial cheek fat. Superficial cheek fat was divided into 3 compartments. Thickness, width, and height were measured, and volumes were calculated for each compartment on both hemifaces. RESULTS Volume and thickness were decreased significantly in all compartments (p < .05). The width was decreased in superior and middle compartments, whereas increased in lower compartment indicating dislocation of the fat tissue (p < .05). Height was also significantly increased (p < .05). A subgroup analysis has shown that there was no significant difference between men and women. CONCLUSION This study clarifies that aging is associated with a significant decrease in superficial midfacial fat tissue volume and thickness both in women and men. The decrease in width in upper and middle compartments, but increase in lower compartment suggests a volume shift within superficial fat tissue.
AI-Assisted Floor Plan Design Incorporating Structural Constraints
(Birkhauser, 2025) Okuyucu, Elif Bahar; Öztürk Kösenciĝ, Kamile
Automatic layout generation studies remain limited in their ability to ensure structural continuity in floor plans. In response, this study considers structural schema as a design constraint. Generative Adversarial Network algorithms for image-to-image translation were utilised to generate floor plans. The dataset, consisting of 552 housing floor plans with structural layouts, was labelled and trained to generate house plan alternatives to assist the interior layout design process in early design phases. The dataset was trained with the machine-learning algorithms Pix2Pix and BicycleGAN. The comparative evaluation of the results using Learned Perceptual Image Patch Similarity indicates that BicycleGAN performs better than Pix2Pix, and the suggested workflow is quite promising. However, the lack of circulation areas was identified as a common limitation in both models. This workflow also has the potential to be used for renovation purposes. © 2025 Elsevier B.V., All rights reserved.
Airborne pathogen projection during ophthalmic examination
(Springer, 2020) Bostanci Ceran, Basak; Karakoc, Alp; Taciroglu, Ertugrul
Purpose Microscale droplets act as coronaviruses (CoV) carriers in the air when released from an infected person and may infect others during close contact such as ophthalmic examination. The main objective of the present work is to demonstrate how CoV deposited droplets are projected during biomicroscopy and to discuss what kind of precautions should be taken in ophthalmic practice. Methods A coupled fluid-structure system comprising smoothed particle hydrodynamics and the finite element method has been built to assess the projection of droplets spreading from an infected person. Different conditions based on the maximum exit flow velocity from the infector's mouth during the ophthalmic examination were modeled. Results During exhalation, for which the exit flow is similar to 1000 mm/s, the average horizontal distance of the flow front was similar to 200 mm while individual particles can reach up to similar to 500 mm. In case of coughing or sneezing (corresponding to an exit flow of similar to 12,000 mm/s), the average horizontal distance of the flow front was similar to 1300 mm. Conclusion During the ophthalmic examination, the proximity to the patient's nose and mouth was observed to be less than the horizontal distance of flow front particles. Even though mounted breath shields are used, particles flew beyond the shield and contaminate the ophthalmologist. Compared with the current protective breath shields, the use of a larger shield with a minimum radius of 18 cm is needed to decrease viral transmission.
Analyses of Mossbauer experiments in a rotating system: Proper and improper approaches
(Academic Press inc Elsevier Science, 2020) Kholmetskii, Alexander L.; Yarman, Tolga; Yarman, O.; Arik, M.
We examine various attempts to interpret the results of modern Mossbauer rotor experiments and show that the most recent approach developed by Podosenov et al. (0000) to understand these results implies an experimental configuration which has never been realized in the known experiments on this subject, and thus leaves the problem of the physical interpretation of the observed energy shift between emission and absorption lines in a rotating system under the framework of general relativity open. (C) 2020 Elsevier Inc. All rights reserved.
Analysis of a Normalized Structure of a Complex Fractal-Fractional Integral Transform Using Special Functions
(Mdpi, 2024) Ibrahim, Rabha W.; Salahshour, Soheil; Pall-szabo, Agnes Orsolya
By using the most generalized gamma function (parametric gamma function, or p-gamma function), we present the most generalized Rabotnov function, called the p-Rabotnov function. Consequently, new fractal-fractional differential and integral operators of a complex variable in an open unit disk are defined and investigated analytically and geometrically. We address some inequalities involving the generalized fractal-fractional integral operator in some spaces of analytic functions. A novel complex fractal-fractional integral transform (CFFIT) is presented. A normalization of the proposed CFFIT is observed in the open unit disk. Examples are illustrated for power series of analytic functions.
Analysis of cable structures through energy minimization
(Techno-press, 2017) Toklu, Yusuf Cengiz; Bekdas, Gebrail; Temur, Rasim
In structural mechanics, traditional analyses methods usually employ matrix operations for obtaining displacement and internal forces of the structure under the external effects, such as distributed loads, earthquake or wind excitations, and temperature changing inter alia. These matrices are derived from the well-known principle of mechanics called minimum potential energy. According to this principle, a system can be in the equilibrium state only in case when the total potential energy of system is minimum. A close examination of the expression of the well-known equilibrium condition for linear problems, P=K Delta, where P is the load vector, K is the stiffness matrix and A is the displacement vector, it is seen that, basically this principle searches the displacement set (or deformed shape) for a system that minimizes the total potential energy of it. Instead of using mathematical operations used in the conventional methods, with a different formulation, meta-heuristic algorithms can also be used for solving this minimization problem by defining total potential energy as objective function and displacements as design variables. Based on this idea the technique called Total Potential Optimization using Meta-heuristic Algorithms (TPO/MA) is proposed. The method has been successfully applied for linear and non-linear analyses of trusses and truss-like structures, and the results have shown that the approach is much more successful than conventional methods, especially for analyses of nonlinear systems. In this study, the application of TPO/MA, with Harmony Search as the selected meta-heuristic algorithm, to cables net system is presented. The results have shown that the method is robust, powerful and accurate.
Anti-Lipid Accumulation and Antioxidant Effects of the Root Extract From Rubus Discolor and Its Phytochemical Analysis
(Springer, 2025) Sekerler, Turgut; Gulmez, Gizem; Algul, Kader Fatma; Goger, Fatih; Senkardes, Ismail; Sen, Ali; Sener, Azize
Rubus species exhibit potent antioxidant properties due to their high phenolic compound content. In our study, phytochemical composition of the extract obtained from roots of Rubus discolor (RDE) was determined using LC-MS/MS. Subsequently, effect of this extract on lipid accumulation was investigated in HepG2 liver cells. For this purpose, HepG2 cells were treated with oleic acid to induce lipid accumulation. The effect of RDE on lipid accumulation was assessed using Oil-Red staining and measuring intracellular triglyceride, cholesterol levels. Melatonin was used as a positive control. Enzymes involved in lipid synthesis, including acetyl-CoA carboxylase (ACC1), fatty acid synthase (FAS), and transcription factor sterol regulatory element-binding protein 1 (SREBP-1c), as well as the antioxidant status, were evaluated by RT-PCR. As dose-dependent, RDE significantly reduced lipid accumulation and each concentrations (25, 50, 100 mu g/mL) of RDE showed 78%, 48%, 38% ratio, respectively for Oil Red O staining. TG was found 1.92 +/- 0.03, 1.76 +/- 0.40, 1.22 +/- 0.13, 1.41 +/- 0.08 mg/mg protein for oleic acid and each concentrations (25, 50, 100 mu g/mL) of RDE, respectively It significantly suppressed ACC1, FAS, and SREBP-1c (p < 0.001, p < 0.001, p < 0.01, respectively) at a dose of 50 g/mL. The extract also exhibited in vitro strong antioxidant and good anti-inflammatory properties. Pedunculagin isomer, ellagic acid and ellagic acid pentoside compounds were found to be the main compounds of RDE with high total phenolic content. The results indicate that RDE has the potential to prevent lipid accumulation. These findings could provide a basis for further studies on the potential therapeutic effect of Rubus discolor in the treatment of NAFLD.
The antioxidant, anti-inflammatory, and antiplatelet effects of Ribes rubrum L. fruit extract in the diabetic rats
(Wiley, 2022) Gulmez, Gizem; Sen, Ali; Sekerler, Turgut; Algul, Fatma Kader; Cilingir-Kaya, Ozlem Tugce; Sener, Azize
The prothrombotic and inflammatory state plays a significant role in the occurrence of cardiovascular complications in type 2 diabetes mellitus. In this study, the antidiabetic, anti-inflammatory, and antiplatelet potentials of the extracts obtained from Ribes rubrum were investigated. The antidiabetic, anti-inflammatory, and antioxidant activities of the ethanol and water extracts of R. rubrum were evaluated by in vitro methods. The total phenolic and flavonoid contents were also determined. The experimental diabetes model in rats was induced with streptozotocin (STZ). After hyperglycemia occurred, the ethanol extracts of R. rubrum (RRE, at 100 mg/kg and 500 mg/kg doses) were administered to the treatment groups for 14 days. Blood glucose, lipid profile, plasma, and pancreas tumor necrosis factor-alpha (TNF-alpha) levels were determined and compared at the end of the experiments. P-selectin levels and mitochondrial membrane polarization (MMP) of platelets were also measured. In vitro study, the RRE showed potent anti-inflammatory activity. Administration of RRE (at 100 mg/kg doses) to diabetic rats lowered blood glucose level insignificantly. The results showed that there was an increment in levels of TNF-alpha in plasma and pancreas tissue of the diabetic group compared to the control group. R. rubrum extract regulated and normalized their levels in plasma and pancreatic tissue. RRE at both doses significantly decreased platelet P-selectin levels and prevented STZ-induced loss of MMP in platelets. The results of current research indicate that RRE extract has potent anti-platelet and anti-inflammatory effects and may be beneficial in preventing diabetic complications. Practical applications Hyperglycemia causes dyslipidemia, advanced oxidative stress, platelet activation, and inflammation in diabetes mellitus. Plants with various medicinal properties are of worldwide interest for the treatment of diseases due to their biological activities. In this study, the antidiabetic, anti-inflammatory, and antioxidant effects of extracts of Ribes rubrum (%100 ethanol, 50% ethanol, water) were evaluated by in vitro and in vivo methods. The diabetes model was induced with streptozotocin (STZ). The rats were divided into control, diabetic control, R. rubrum-100 mg/kg, and R. rubrum-500 mg/kg doses groups. Blood glucose levels, tumor necrosis factor-alpha (TNF-alpha), platelet P-selectin levels, mitochondrial membrane polarization of platelets were examined. The present study has shown that R. rubrum has anti-inflammatory and antiplatelet activity. R. rubrum may be beneficial in the prevention and treatment of DM complications due to its anti-inflammatory and antithrombotic effects.
Any Instrument in a Surgeon's Hand can be Fatal: Unusual Iliac Artery Injury in Lumbar Spinal Deformity Surgery
(Elsevier Science inc, 2020) Koban, Orkun; Akar, Ezgi; Ogrenci, Ahmet; Yilmaz, Mesut; Dalbayrak, Sedat
BACKGROUND: Vascular complications, which we rarely encounter during lumbosacral stabilization surgeries, can be life-threatening if they are not treated quickly. These arterial injuries occur during screw insertion. Our presentation with the common iliac artery injury during the decortication process in transverse processes with the "pedicle awl" will be the first case in the literature to our knowledge. CASE DESCRIPTION: Lumbosacral decompression and stabilization surgery was performed in a 57-year-old patient with L1-S1 spinal stenosis and scoliosis. After the stabilization process was completed, while decorticating the transverse processes with the pedicle awl, the tool fell to the paravertebral region, and then active arterial hemorrhage was observed at the surgical site. Hemostasis was achieved in the surgical field, but a rapid progressive drop was observed in the patient's blood pressure. The surgery was quickly terminated, and the patient was turned to the supine position. Vascular surgeons opened the abdomen with a midline laparotomy, and approximately 2600 mL hematoma was evacuated from the retroperitoneum. The 5-mm defect in the left common iliac artery was repaired by primary suturing. The patient had no problem in postoperative follow-up and was discharged on the 10th postoperative day. CONCLUSIONS: In these complications that we rarely encounter in lumbosacral stabilization surgeries, perioperative findings should be well evaluated, and rapid intervention should be made in cases in which vascular injury is considered. One must remember that every tool used during surgery can be dangerous even in an experienced hand.

Browse

Browsing WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection by WoS Q "Q2"